Research institution
Yale University Clinical Trials
Studies where Yale University is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 292HIV, Pregnancy
Evaluating the Healthy Families PrEP Program for Women at Risk for HIV
Study investigators developed and piloted a counselling intervention, Healthy Families-PrEP, that supports women to use HIV prevention strategies while trying for and during pregnancy.
- Conditions
- HIV, Pregnancy, Pre-Exposure Prophylaxis of HIV Infection
- Trial name
- HFPT (NCT06746675)
- Testing
- Healthy Families PrEP Counselling Intervention
- Where
- Uganda
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Low Back Pain (CLBP), Physical Therapy
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
The purpose of this research study is to investigate whether a single administration of psilocybin can improve interoceptive awareness (awareness of bodily sensations) in individuals with chronic low back pain undergoing physical…
- Conditions
- Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin
- Trial name
- NCT07306364
- Testing
- Psilocybin 10 mg, Psilocybin 25 mg, Niacin 100 mg
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 1 Diabetes
T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes
Randomized controlled trial with a wait list control arm. Participants will be randomized 2:1 to T1CARE or wait list usual care arm. Participants will be recruited from the Yale Adult and Pediatric Diabetes Centers.
- Trial name
- T1CARE (NCT07059806)
- Testing
- T1CARE
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Yale University
RSV Infection
Real-World Effectiveness of Perinatal RSV Immunoprophylaxis
The purpose of this study is to continue evaluating how well the RSV vaccines work as they are currently being used in routine clinical practice.
- Trial name
- NCT06172660
- Testing
- Nirsevimab
- Where
- United States
- Volunteers
- 3,750 people
- Sponsor
- Yale University
Readmission, Readmission Rates
A Clinician-Patient Dual Behavior Change Framework to Leverage Informed Digital Nudges to Reduce Hospital Readmissions and Improve Patient Outcomes: A Trial for Scalable Strategy to Reduce Readmissions (PREVENT-R)
The PREVENT-R trial will evaluate an intervention targeting both clinician and patient behavior. The clinician-focused piece consists of an electronic medical record-based digital nudge presented to emergency department…
- Conditions
- Readmission, Readmission Rates, Readmission, Hospital, Elderly (People Aged 65 or More)
- Trial name
- PREVENT-R (NCT07890961)
- Testing
- Digital nudge prompting
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Yale University
Borderline Personality Disorder
MDMA in Borderline Personality Disorder
The purpose of this study is to test the effects of MDMA (3,4-methylenedioxymethamphetamine) on social cognition in adults with Borderline Personality Disorder.
- Trial name
- MDMA in BPD (NCT06683014)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Severe Mental Illness, Hospitalizations Psychiatric
Community-Based Intensive Treatment (CBIT): Meeting the Complex Needs of Rural Adults With Serious Mental Illness
The purpose for this research project is to successfully achieve the primary systems intervention outcome, maintaining fidelity to the intervention model and time to rehospitalization.
- Conditions
- Severe Mental Illness, Hospitalizations Psychiatric, Rural Healthcare-seeking Behaviour, Rural Health
- Trial name
- CBIT (NCT07887113)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT07886606
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Pain, Pituitary Surgery
Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery
This study is testing whether oxytocin can help lessen pain by changing how people process emotions and social experiences. The goal is to better understand how the brain links emotions, relationships, and pain, and whether this…
- Trial name
- NCT07730294
- Testing
- Oxytocin (Low dose), Oxytocin (High dose)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Substance Use Disorders
Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)
This study seeks to compare the effectiveness of two Patient Navigation models of care to evaluate the proportion who initiate PrEP/ART and substance use/substance use disorder (SU/SUD) treatment.
- Trial name
- NCT07223398
- Testing
- Standard PN, Patient Choice
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Yale University
Completed, with results posted
All 439Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Obsessive-Compulsive Disorder
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
This study aims to investigate the effects of oral psilocybin on OCD symptomatology and provide the first evidence of the neural mechanism that may mediate psilocybin's purported therapeutic effects on OCD.
- Trial name
- NCT03356483
- Testing
- Psilocybin (0.25mg/kg), Niacin (250mg)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Decompensated Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
This study is designed to investigate the quantitative effects of sodium-free chloride supplementation on electrolyte balance, volume status, and sodium avidity in stable heart failure patients in a highly controlled environment.
- Trial name
- NCT03440970
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University