Mobility LimitationPhase 1/2LIFTNCT07125378
Living Independence Through Functional Training
A Phase 1/2 study testing Task-oriented resistance exercise in people with Mobility Limitation and Cognitive Impairment, run by University of Florida at 2 sites in United States.
Trial summary
The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care. Read more about this study
- Who is it for?
- Ages 65 to 90 years
- Conditions the study is for
- Mobility Limitation, Cognitive Impairment
- What is being tested?
- Task-oriented resistance exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- 2 sitesUnited States
- Study dates
- 6 Jan 2026to 31 Dec 2026
- Phase
- Phase 1/2
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 to 90 years
- All sexes
- No healthy volunteers
- Older adult
Who may be able to join
- between the ages of 65 and 90 years
- community-dwelling
- live within a 50-mile radius of the study site with wireless connectivity in the area
- mobility limitations as indicated by self-reported of using a mobility aid or having unsteady gait or walking slower than before
- cognitive decline as indicated by a score < 12 on Mini MoCA Version 2.1
- a care partner or adult family member living in the home or nearby
- willing to wear an activity tracker during the study period
Who cannot join
- plan to receive skilled rehabilitation services
- plan to move away outside the study area in two months
- reside in an assisted living or long-term care facility or plan to relocate to such a facility in the next three months
- severe vision or hearing loss that impedes activity performance or communication
- unable to stand or walk even with a mobility aid
- unable to follow a one-step command or carry on a conversation over the phone
Show all 11Show fewer
- unable to commit to the six-week exercise program
- contradictions to resistance exercise, such as the end-stage heart failure
- a terminal disease or on hospice care
- a neurological condition affecting motor skills
- not able to provide consent.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Recruiting
College of Public Health and Health Professions, University of Florida
Gainesville, Florida, 32610
Chiung-ju Liu, PhD, 352-273-6495, c.liu1@phhp.ufl.edu
- Not yet recruiting
University of Florida
Gainesville, Florida, 32610
Chiung-ju Liu Associate Professor, PhD, 352-273-6496, c.liu1@phhp.ufl.edu
About this study
Official title: Living Independence Through Functional Training (LIFT): Feasibility of Hybrid Task-Oriented Resistance Exercise Following Home Health Discharge
The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.
- Conditions
- Mobility Limitation, Cognitive Impairment
- Being tested
- Task-oriented resistance exercise
- Keywords
- Home-based intervention, Exercise, Older adults, Activities of daily living, Mobility, Cognition
- Medical subject headings
- Mobility Limitation, Cognitive Dysfunction, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Task-oriented resistance exerciseBehavioural
The intervention program includes progressive resistance exercise and daily activity exercise, delivered over a six-week period with an ideal frequency of three sessions per week. Progressive resistance exercise will be provided through a combination of in-person and online sessions, while daily activity exercise will be delivered exclusively in person.
| Study group | Role | What they receive |
|---|---|---|
| LIFT | Experimental | Participants will receive a task-oriented resistance exercise program at home. Receives: Behavioral: Task-oriented resistance exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Short Physical Performance Battery
The score ranges from 0 to 12, with a score of 12 indicating the best physical functioning of the lower extremity.
Measured: Baseline, 8 weeks, and 12 weeks.
Montreal Cognitive Assessment
The score ranges from 0 to 30, with a score of 30 indicating the best global cognitive function.
Measured: Baseline, 8 weeks, and 12 weeks.
Secondary outcomes (8)
Timed Up and Go Test-Single Task.
Time in seconds to complete the test, with a longer time indicating poor functional mobility.
Measured: Baseline, 8 weeks, and 12 weeks.
Timed Up and Go-Dual Task
Time in seconds to complete the task, a longer time indicating the interference of the dual task effect on mobility.
Measured: Baseline, 8 weeks, and 12 weeks.
List Sorting Working Memory Test
The raw score ranges from 0 to 24, with a higher score indicating better working memory. The raw score is converted to a Change Sensitive Score.
Measured: Baseline, 8 weeks, and 12 weeks.
Dimensional Change Card Sort Test
The raw score ranges from 0 to 30, with a higher score indicating better executive function. The raw score is converted to a Change Sensitive Score.
Measured: Baseline, 8 weeks, 12 weeks.
Flanker Inhibitory Control and Attention Test
The raw score ranges from 0 to 30, with a higher score indicating better executive function and attention. The raw score is converted to a Change Sensitive Score.
Measured: Baseline, 8 weeks, and 12 weeks
Pattern Comparison Processing Speed Test
The raw score ranges from 0-133, with a higher score indicating better processing speed. The raw score is converted to a Change Sensitive Score.
Measured: Baseline, 8 weeks, and 12 weeks
Speeded Matching Test
The score ranges from 0 to 130, with a higher score indicating better speed of processing. The raw score is converted to a Change Sensitive Score.
Measured: Baseline, 8 weeks, 12 weeks
Oral Symbol Digit Test
The raw score ranges from 0 to 143, with a higher score indicating better processing speed. The raw score is converted to a Rasch score.
Measured: Baseline, 8 weeks, and 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Aug 2025
- Study start6 Jan 2026
- Primary completion30 Nov 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mobility LimitationStudies of the same condition, open and under way.
- More trials run by University of FloridaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1/2
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- One group with repeated measures at baseline, post-intervention, and one-month follow-up.
- Masking
- None (open label)
- Enrolment
- 15 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Florida
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Chiung-ju Liu Associate Professor, phD, Principal investigator, University of Florida
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07125378
- Sponsor's protocol ID
- IRB202500835
- Acronym
- LIFT
- Status last verified
- Jan 2026
- First submitted
- 8 Aug 2025
- Last updated
- 31 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All IPD that underlie the results in a publication
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Living Independence Through Functional Training (LIFT): Feasibility of Hybrid Task-Oriented Resistance Exercise Following Home Health Discharge
- ClinicalTrials.gov ID
- NCT07125378
- Acronym / sponsor ID
- LIFT / IRB202500835
- Conditions
- Mobility Limitation, Cognitive Impairment
- Keywords
- Home-based intervention, Exercise, Older adults, Activities of daily living, Mobility, Cognition
- Phase
- Phase 1/2
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 15 participants (estimated)
- Lead sponsor
- University of FloridaUniversity, hospital or other
- Study start
- 6 Jan 2026 (actual)
- Primary completion
- 30 Nov 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 15 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- One group with repeated measures at baseline, post-intervention, and one-month follow-up.
| Arm | Type | Receives |
|---|---|---|
| LIFT | Experimental | Behavioral: Task-oriented resistance exerciseParticipants will receive a task-oriented resistance exercise program at home. |
Who may qualify
- Ages
- 65 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
Key inclusion criteria (7 listed)
- between the ages of 65 and 90 years
- community-dwelling
- live within a 50-mile radius of the study site with wireless connectivity in the area
- mobility limitations as indicated by self-reported of using a mobility aid or having unsteady gait or walking slower than before
- cognitive decline as indicated by a score < 12 on Mini MoCA Version 2.1
Key exclusion criteria (11 listed)
- plan to receive skilled rehabilitation services
- plan to move away outside the study area in two months
- reside in an assisted living or long-term care facility or plan to relocate to such a facility in the next three months
- severe vision or hearing loss that impedes activity performance or communication
- unable to stand or walk even with a mobility aid
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Task-oriented resistance exerciseThe intervention program includes progressive resistance exercise and daily activity exercise, delivered over a six-week period with an ideal frequency of three sessions per week. Progressive resistance exercise will be provided through a combination of in-person and online sessions, while daily activity exercise will be delivered exclusively in person. | Behavioural | LIFT |
Primary outcome
Short Physical Performance Battery
Time frame: Baseline, 8 weeks, and 12 weeks.
The score ranges from 0 to 12, with a score of 12 indicating the best physical functioning of the lower extremity.
Montreal Cognitive Assessment
Time frame: Baseline, 8 weeks, and 12 weeks.
The score ranges from 0 to 30, with a score of 30 indicating the best global cognitive function.
8 secondary outcomes
Timed Up and Go Test-Single Task.
Time frame: Baseline, 8 weeks, and 12 weeks.
Timed Up and Go-Dual Task
Time frame: Baseline, 8 weeks, and 12 weeks.
List Sorting Working Memory Test
Time frame: Baseline, 8 weeks, and 12 weeks.
Dimensional Change Card Sort Test
Time frame: Baseline, 8 weeks, 12 weeks.
Flanker Inhibitory Control and Attention Test
Time frame: Baseline, 8 weeks, and 12 weeks
Pattern Comparison Processing Speed Test
Time frame: Baseline, 8 weeks, and 12 weeks
Speeded Matching Test
Time frame: Baseline, 8 weeks, 12 weeks
Oral Symbol Digit Test
Time frame: Baseline, 8 weeks, and 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
- Individual participant dataSharing planned: Yes. All IPD that underlie the results in a publication
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Chiung-ju Liu Associate Professor, phD principal investigator
University of Florida
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1/2 study testing Task-oriented resistance exercise in people with Mobility Limitation and Cognitive Impairment, run by University of Florida at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this combined phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Chiung-ju Liu Associate Professor, PhD (352-273-6496, c.liu1@phhp.ufl.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Short Physical Performance Battery (time frame: Baseline, 8 weeks, and 12 weeks.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.