Fat MetabolismNCT07094191
The Effects of Acute Chicory Coffee Consumption on Exercise Performance and Metabolism
A study testing Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root) and arabica coffee in people with Fat Metabolism and Sport Nutrition, run by Fatma Özsel Özcan at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to evaluate the acute effects of chicory coffee on metabolism and exercise performance in healthy, moderately active male participants aged 18-25. Read more about this study
- Who is it for?
- Ages 18 to 25 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Fat Metabolism, Sport Nutrition, Exercise Metabolism
- What is being tested?
- Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root) and arabica coffee
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2024to 16 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male participants aged 18 to 25 years
- Healthy status based on self-report and screening (no diagnosed chronic disease)
- Moderately physically active (minimum 3 days/week of physical activity)
- No regular use of medication or dietary supplements
- Non-smoker
- No caffeine consumption for at least 7 days prior to and during the study
- Willing and able to provide informed consent
- Able to complete the shuttle-run test as instructed
Who cannot join
- Diagnosed with metabolic, cardiovascular, or inflammatory disease
- Regular caffeine use or caffeine withdrawal symptoms
- Use of alcohol, stimulants, or performance-enhancing substances during the study
- Known allergy or intolerance to chicory or coffee
- Participation in another clinical study within the last 30 days
- Any musculoskeletal or respiratory condition that prevents safe participation in exercise
- Inability to comply with the dietary or testing protocol
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Acute Effects of Caffeine-Free Chicory and Arabica Coffee on Inflammatory and Metabolic Responses to Exercise in Healthy Men: A Randomized Crossover Trial
The goal of this clinical trial is to evaluate the acute effects of chicory coffee on metabolism and exercise performance in healthy, moderately active male participants aged 18-25. The main questions it aims to answer are:
Does chicory coffee influence glucose, lipid, and energy metabolism after exercise?
Read more
Does chicory coffee affect physical performance and perceived fatigue levels?
Researchers will compare chicory coffee (CC), arabica coffee (AC), and a no-drink control to see if chicory coffee has similar or unique metabolic and performance effects compared to caffeinated coffee or no intervention.
Participants will:
Consume one of the test beverages (chicory coffee, arabica coffee, or no drink) 45 minutes before performing a shuttle-run test
Complete a standardized shuttle-run exercise test
Undergo blood sample collection before and after exercise to assess glucose, lactate, LPL, TNF-α, adiponectin, and IL-6
Rate their perceived exertion and record symptoms
Read the detailed description
This study used a single-blind, randomized, controlled crossover design involving 22 healthy, moderately active male participants aged 18-25. Each participant underwent three intervention conditions in a randomized order:
Chicory coffee (CC)
Arabica coffee (AC)
Control (no beverage)
Before each trial, baseline data-including health status, dietary habits, and body composition-were collected. Participants consumed the assigned beverage 45 minutes before performing a shuttle-run test designed to assess endurance and physical performance. A 3-day washout period separated each intervention session to eliminate carryover effects.
During each session, pre- and post-exercise measurements included:
Blood glucose, lactate, blood pressure, and oxygen saturation
Subjective fatigue assessed by the Borg Rating of Perceived Exertion (RPE)
Additionally, venous blood samples were collected after exercise and analyzed for key metabolic and inflammatory biomarkers:
Lipoprotein lipase (LPL)
Tumor necrosis factor-alpha (TNF-α)
Adiponectin
Interleukin-6 (IL-6)
All blood samples were processed under cold-chain conditions and analyzed using ELISA methods. Dietary intake was monitored, and participants were instructed to maintain their usual eating habits while avoiding other caffeinated beverages during the study period.
Statistical analysis included MANOVA and ANOVA, with Bonferroni corrections used for multiple comparisons.
- Being tested
- Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root), arabica coffee, no beverage control
- Keywords
- arabica coffee, chicory coffee, metabolism, Inflammation, Plant-based ergogenic aids
- Medical subject headings
- Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root)Dietary supplement
A single oral dose of 180 mL chicory coffee prepared by steeping 20 grams of roasted and ground chicory root in hot water (approximately 90°C) for 5 minutes. The beverage was administered once, exactly 45 minutes before exercise, as part of a single session within a randomized crossover design. Chicory coffee is naturally caffeine-free, and rich in inulin and polyphenols, which are standardized in each preparation. No additional ingredients (milk, sugar, or flavoring) were added.
Blood lactate, glucose, blood pressure, and oxygen saturation (SpO₂) levels were measured both before and after the exercise. In addition, venous blood samples were collected post-exercise to assess serum levels of adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and LPL.
arabica coffeeDietary supplement
A single oral dose of 180 mL Arabica coffee prepared by steeping 20 grams of roasted and ground chicory root in hot water (approximately 90°C) for 5 minutes. The beverage was administered once, exactly 45 minutes before exercise, as part of a single session within a randomized crossover design. Chicory coffee is naturally caffeine-free, and rich in inulin and polyphenols, which are standardized in each preparation. No additional ingredients (milk, sugar, or flavoring) were added. Blood lactate, glucose, blood pressure, and oxygen saturation (SpO₂) levels were measured both before and after the exercise. In addition, venous blood samples were collected post-exercise to assess serum levels of adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and LPL.
no beverage controlDietary supplement
Participants underwent the shuttle run exercise protocol in a fasted state, without consuming any food or beverages prior to the test. Blood lactate, glucose, blood pressure, and oxygen saturation (SpO₂) levels were measured both before and after the exercise. In addition, venous blood samples were collected post-exercise to assess serum levels of adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and LPL.
| Study group | Role | What they receive |
|---|---|---|
| Chicory Coffee Arm | Active comparator | Participants in this arm consumed a standardized dose of chicory coffee (180 mL), a caffeine-free beverage rich in polyphenols and inulin, 45 minutes prior to the shuttle-run test. This arm was designed to assess the effects of chicory coffee on metabolism, inflammation, and exercise performance. Receives: Dietary Supplement: Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root) |
| Arabica Coffee Arm | Active comparator | Participants in this arm consumed a standardized dose of arabica coffee (180 mL), a regular caffeinated coffee, 45 minutes prior to the shuttle-run test. This arm served as a comparison to evaluate how caffeine-containing coffee influences metabolic and performance-related parameters. Receives: Dietary Supplement: arabica coffee |
| Control Arm | Other | CONTROL ARM Receives: Dietary Supplement: no beverage control |
What is being measured
The primary outcome is the main question the study is designed to answer.
This outcome measures blood lactate concentration in mmol/L to evaluate the metabolic response to shuttle run exercise. Capillary blood samples were taken from the fingertip at three time points: before, during, and immediately after exercise.
lactate measurement
Measured: At baseline (immediately before exercise), mid-exercise, and immediately after exercise
Venous Blood Glucose Level
This outcome measures venous blood glucose concentration (mg/dL) after completion of the shuttle run exercise protocol. Blood samples were collected from finger. Post-exercise glucose levels provide insight into glycemic regulation, insulin sensitivity, and metabolic response under fasting and exertional conditions.
Measured: At baseline (pre-exercise) and within 10 minutes post-exercise
Systolic and diastolic blood pressure
This outcome measures systolic and diastolic blood pressure (mmHg) to evaluate acute cardiovascular response to exercise. Measurements were taken at rest and immediately after the shuttle run using a digital sphygmomanometer.
Measured: Systolic and diastolic blood pressure measured immediately before and immediately after exercise
Plasma Lipoprotein Lipase (LPL) Level (ng/mL)
This outcome measures the concentration of plasma lipoprotein lipase (LPL) in ng/mL after completion of the shuttle run exercise protocol. Blood samples were collected post-exercise, and serum was analyzed to determine LPL levels using ELISA-based methods. This parameter reflects lipid metabolism activity in response to acute exercise under fasting conditions.
Measured: At baseline and within 10 minutes post-exercise
Subjective Fatigue Score (Borg Scale)
This outcome assesses perceived fatigue using the Borg Rating of Perceived Exertion (RPE) Scale immediately following the shuttle run exercise. Participants rated their level of physical exertion on a scale from 6 (no exertion at all) to 20 (maximal exertion). The Borg Scale is a validated tool for evaluating subjective fatigue and exercise intensity.
Measured: Immediately after completion of the shuttle run exercise protocol
Tumor Necrosis Factor-alpha (TNF-α)
This outcome measures the concentration of tumor necrosis factor-alpha (TNF-α) in serum samples collected after the shuttle run exercise protocol. TNF-α levels were analyzed using enzyme-linked immunosorbent assay (ELISA) techniques. TNF-α is a key pro-inflammatory cytokine, and its elevation post-exercise is indicative of acute inflammatory response and immune system activation.
Measured: At baseline and within 10 minutes post-exercise
Adiponectin
This outcome measures the concentration of adiponectin in serum samples collected after the shuttle run exercise protocol. Serum adiponectin levels were determined using enzyme-linked immunosorbent assay (ELISA) methods. Adiponectin is an anti-inflammatory adipokine involved in glucose regulation and lipid metabolism, and its measurement provides insight into the metabolic response to acute exercise.
Measured: At baseline and within 10 minutes post-exercise
Interleukin-6 (IL-6)
This outcome measures the concentration of interleukin-6 (IL-6) in serum samples collected after the shuttle run exercise protocol. IL-6 levels were determined using an enzyme-linked immunosorbent assay (ELISA). IL-6 is a pro-inflammatory cytokine known to respond acutely to physical exertion and is used as a biomarker of systemic inflammation and exercise-induced stress.
Measured: At baseline and within 10 minutes post-exercise
Secondary outcomes (1)
Oxygen saturation
This outcome measures peripheral oxygen saturation (SpO₂) using a fingertip pulse oximeter. Measurements were taken at three time points: before, during, and immediately after the shuttle run exercise protocol. SpO₂ reflects the percentage of hemoglobin saturated with oxygen and is used to assess cardiopulmonary dynamics in response to physical exertion.
Measured: At baseline (immediately before exercise), mid-exercise, and immediately after exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jul 2025
- Study start1 Jan 2024
- Primary completion18 May 2025
- Study completion16 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Fat MetabolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study used a single-blind, randomized, controlled, crossover design in which each participant received all three interventions (chicory coffee, arabica coffee, and control) in a randomized order. A 3-day washout period was implemented between each intervention to minimize carryover effects. The crossover model allowed within-subject comparisons of metabolic and performance responses to each beverage condition.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fatma Özsel Özcan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Fatma Özsel Özcan, Halic University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07094191
- Sponsor's protocol ID
- 2015-KAEK-79-23-03
- Status last verified
- Jul 2025
- First submitted
- 21 Jul 2025
- Last updated
- 30 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The individual participant data (IPD) collected in this study will not be made available to other researchers due to ethical considerations, limited scope of consent, and privacy protection of participants.
Publications
Saunders TJ, Palombella A, McGuire KA, Janiszewski PM, Despres JP, Ross R. Acute exercise increases adiponectin levels in abdominally obese men. J Nutr Metab. 2012;2012:148729. doi: 10.1155/2012/148729. Epub 2012 May 30.
PubMed 22701167Yamashita K, Yatsuya H, Muramatsu T, Toyoshima H, Murohara T, Tamakoshi K. Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study. Nutr Diabetes. 2012 Apr 2;2(4):e33. doi: 10.1038/nutd.2012.6.
PubMed 23169586Diaz-Lara FJ, Del Coso J, Garcia JM, Portillo LJ, Areces F, Abian-Vicen J. Caffeine improves muscular performance in elite Brazilian Jiu-jitsu athletes. Eur J Sport Sci. 2016 Nov;16(8):1079-86. doi: 10.1080/17461391.2016.1143036. Epub 2016 Feb 10.
PubMed 26863885Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc. 2010 Jun;110(6):865-8. doi: 10.1016/j.jada.2010.03.025.
PubMed 20497775
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Acute Effects of Caffeine-Free Chicory and Arabica Coffee on Inflammatory and Metabolic Responses to Exercise in Healthy Men: A Randomized Crossover Trial
- ClinicalTrials.gov ID
- NCT07094191
- Acronym / sponsor ID
- 2015-KAEK-79-23-03
- Keywords
- arabica coffee, chicory coffee, metabolism, Inflammation, Plant-based ergogenic aids
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Fatma Özsel ÖzcanUniversity, hospital or other
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- 18 May 2025 (actual)
- Study completion
- 16 Jun 2025 (actual)
- First posted
- 30 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate the acute effects of chicory coffee on metabolism and exercise performance in healthy, moderately active male participants aged 18-25. The main questions it aims to answer are:
Does chicory coffee influence glucose, lipid, and energy metabolism after exercise?
Does chicory coffee affect physical performance and perceived fatigue levels?
Researchers will compare chicory coffee (CC), arabica coffee (AC), and a no-drink control to see if chicory coffee has similar or unique metabolic and performance effects compared to caffeinated coffee or no intervention.
Participants will:
Consume one of the test beverages (chicory coffee, arabica coffee, or no drink) 45 minutes before performing a shuttle-run test
Complete a standardized shuttle-run exercise test
Undergo blood sample collection before and after exercise to assess glucose, lactate, LPL, TNF-α, adiponectin, and IL-6
Rate their perceived exertion and record symptoms
Detailed description
This study used a single-blind, randomized, controlled crossover design involving 22 healthy, moderately active male participants aged 18-25. Each participant underwent three intervention conditions in a randomized order:
Chicory coffee (CC)
Arabica coffee (AC)
Control (no beverage)
Before each trial, baseline data-including health status, dietary habits, and body composition-were collected. Participants consumed the assigned beverage 45 minutes before performing a shuttle-run test designed to assess endurance and physical performance. A 3-day washout period separated each intervention session to eliminate carryover effects.
During each session, pre- and post-exercise measurements included:
Blood glucose, lactate, blood pressure, and oxygen saturation
Subjective fatigue assessed by the Borg Rating of Perceived Exertion (RPE)
Additionally, venous blood samples were collected after exercise and analyzed for key metabolic and inflammatory biomarkers:
Lipoprotein lipase (LPL)
Tumor necrosis factor-alpha (TNF-α)
Adiponectin
Interleukin-6 (IL-6)
All blood samples were processed under cold-chain conditions and analyzed using ELISA methods. Dietary intake was monitored, and participants were instructed to maintain their usual eating habits while avoiding other caffeinated beverages during the study period.
Statistical analysis included MANOVA and ANOVA, with Bonferroni corrections used for multiple comparisons.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 3
- Model description
- This study used a single-blind, randomized, controlled, crossover design in which each participant received all three interventions (chicory coffee, arabica coffee, and control) in a randomized order. A 3-day washout period was implemented between each intervention to minimize carryover effects. The crossover model allowed within-subject comparisons of metabolic and performance responses to each beverage condition.
| Arm | Type | Receives |
|---|---|---|
| Chicory Coffee Arm | Active comparator | Dietary Supplement: Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root)Participants in this arm consumed a standardized dose of chicory coffee (180 mL), a caffeine-free beverage rich in polyphenols and inulin, 45 minutes prior to the shuttle-run test. This arm was designed to assess the effects of chicory coffee on metabolism, inflammation, and exercise performance. |
| Arabica Coffee Arm | Active comparator | Dietary Supplement: arabica coffeeParticipants in this arm consumed a standardized dose of arabica coffee (180 mL), a regular caffeinated coffee, 45 minutes prior to the shuttle-run test. This arm served as a comparison to evaluate how caffeine-containing coffee influences metabolic and performance-related parameters. |
| Control Arm | Other | Dietary Supplement: no beverage controlCONTROL ARM |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Male participants aged 18 to 25 years
- Healthy status based on self-report and screening (no diagnosed chronic disease)
- Moderately physically active (minimum 3 days/week of physical activity)
- No regular use of medication or dietary supplements
- Non-smoker
Key exclusion criteria (7 listed)
- Diagnosed with metabolic, cardiovascular, or inflammatory disease
- Regular caffeine use or caffeine withdrawal symptoms
- Use of alcohol, stimulants, or performance-enhancing substances during the study
- Known allergy or intolerance to chicory or coffee
- Participation in another clinical study within the last 30 days
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root)A single oral dose of 180 mL chicory coffee prepared by steeping 20 grams of roasted and ground chicory root in hot water (approximately 90°C) for 5 minutes. The beverage was administered once, exactly 45 minutes before exercise, as part of a single session within a randomized crossover design. Chicory coffee is naturally caffeine-free, and rich in inulin and polyphenols, which are standardized in each preparation. No additional ingredients (milk, sugar, or flavoring) were added. Blood lactate, glucose, blood pressure, and oxygen saturation (SpO₂) levels were measured both before and after the exercise. In addition, venous blood samples were collected post-exercise to assess serum levels of adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and LPL. | Dietary supplement | Chicory Coffee Arm |
| arabica coffeeA single oral dose of 180 mL Arabica coffee prepared by steeping 20 grams of roasted and ground chicory root in hot water (approximately 90°C) for 5 minutes. The beverage was administered once, exactly 45 minutes before exercise, as part of a single session within a randomized crossover design. Chicory coffee is naturally caffeine-free, and rich in inulin and polyphenols, which are standardized in each preparation. No additional ingredients (milk, sugar, or flavoring) were added. Blood lactate, glucose, blood pressure, and oxygen saturation (SpO₂) levels were measured both before and after the exercise. In addition, venous blood samples were collected post-exercise to assess serum levels of adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and LPL. | Dietary supplement | Arabica Coffee Arm |
| no beverage controlParticipants underwent the shuttle run exercise protocol in a fasted state, without consuming any food or beverages prior to the test. Blood lactate, glucose, blood pressure, and oxygen saturation (SpO₂) levels were measured both before and after the exercise. In addition, venous blood samples were collected post-exercise to assess serum levels of adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and LPL. | Dietary supplement | Control Arm |
Primary outcome
This outcome measures blood lactate concentration in mmol/L to evaluate the metabolic response to shuttle run exercise. Capillary blood samples were taken from the fingertip at three time points: before, during, and immediately after exercise.
Time frame: At baseline (immediately before exercise), mid-exercise, and immediately after exercise
lactate measurement
Venous Blood Glucose Level
Time frame: At baseline (pre-exercise) and within 10 minutes post-exercise
This outcome measures venous blood glucose concentration (mg/dL) after completion of the shuttle run exercise protocol. Blood samples were collected from finger. Post-exercise glucose levels provide insight into glycemic regulation, insulin sensitivity, and metabolic response under fasting and exertional conditions.
Systolic and diastolic blood pressure
Time frame: Systolic and diastolic blood pressure measured immediately before and immediately after exercise
This outcome measures systolic and diastolic blood pressure (mmHg) to evaluate acute cardiovascular response to exercise. Measurements were taken at rest and immediately after the shuttle run using a digital sphygmomanometer.
Plasma Lipoprotein Lipase (LPL) Level (ng/mL)
Time frame: At baseline and within 10 minutes post-exercise
This outcome measures the concentration of plasma lipoprotein lipase (LPL) in ng/mL after completion of the shuttle run exercise protocol. Blood samples were collected post-exercise, and serum was analyzed to determine LPL levels using ELISA-based methods. This parameter reflects lipid metabolism activity in response to acute exercise under fasting conditions.
Subjective Fatigue Score (Borg Scale)
Time frame: Immediately after completion of the shuttle run exercise protocol
This outcome assesses perceived fatigue using the Borg Rating of Perceived Exertion (RPE) Scale immediately following the shuttle run exercise. Participants rated their level of physical exertion on a scale from 6 (no exertion at all) to 20 (maximal exertion). The Borg Scale is a validated tool for evaluating subjective fatigue and exercise intensity.
Tumor Necrosis Factor-alpha (TNF-α)
Time frame: At baseline and within 10 minutes post-exercise
This outcome measures the concentration of tumor necrosis factor-alpha (TNF-α) in serum samples collected after the shuttle run exercise protocol. TNF-α levels were analyzed using enzyme-linked immunosorbent assay (ELISA) techniques. TNF-α is a key pro-inflammatory cytokine, and its elevation post-exercise is indicative of acute inflammatory response and immune system activation.
Adiponectin
Time frame: At baseline and within 10 minutes post-exercise
This outcome measures the concentration of adiponectin in serum samples collected after the shuttle run exercise protocol. Serum adiponectin levels were determined using enzyme-linked immunosorbent assay (ELISA) methods. Adiponectin is an anti-inflammatory adipokine involved in glucose regulation and lipid metabolism, and its measurement provides insight into the metabolic response to acute exercise.
Interleukin-6 (IL-6)
Time frame: At baseline and within 10 minutes post-exercise
This outcome measures the concentration of interleukin-6 (IL-6) in serum samples collected after the shuttle run exercise protocol. IL-6 levels were determined using an enzyme-linked immunosorbent assay (ELISA). IL-6 is a pro-inflammatory cytokine known to respond acutely to physical exertion and is used as a biomarker of systemic inflammation and exercise-induced stress.
1 secondary outcome
Oxygen saturation
Time frame: At baseline (immediately before exercise), mid-exercise, and immediately after exercise
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2025.
- Background: PubMed 22701167Saunders TJ, Palombella A, McGuire KA, Janiszewski PM, Despres JP, Ross R. Acute exercise increases adiponectin levels in abdominally obese men. J Nutr Metab. 2012;2012:148729. doi: 10.1155/2012/148729. Epub 2012 May 30.
- Background: PubMed 23169586Yamashita K, Yatsuya H, Muramatsu T, Toyoshima H, Murohara T, Tamakoshi K. Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study. Nutr Diabetes. 2012 Apr 2;2(4):e33. doi: 10.1038/nutd.2012.6.
- Background: PubMed 26863885Diaz-Lara FJ, Del Coso J, Garcia JM, Portillo LJ, Areces F, Abian-Vicen J. Caffeine improves muscular performance in elite Brazilian Jiu-jitsu athletes. Eur J Sport Sci. 2016 Nov;16(8):1079-86. doi: 10.1080/17461391.2016.1143036. Epub 2016 Feb 10.
- Background: PubMed 20497775Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc. 2010 Jun;110(6):865-8. doi: 10.1016/j.jada.2010.03.025.
- Individual participant dataSharing planned: No. The individual participant data (IPD) collected in this study will not be made available to other researchers due to ethical considerations, limited scope of consent, and privacy protection of participants.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root) and arabica coffee in people with Fat Metabolism and Sport Nutrition, run by Fatma Özsel Özcan at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
This outcome measures blood lactate concentration in mmol/L to evaluate the metabolic response to shuttle run exercise. Capillary blood samples were taken from the fingertip at three time points: before, during, and immediately after exercise. (time frame: At baseline (immediately before exercise), mid-exercise, and immediately after exercise). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07094191, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2025.