MINSNCT07079891
Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults
An observational study of MINS, run by Hao Li.
Trial summary
This single-center retrospective cohort study enrolled patients aged ≥18 years who underwent noncardiac surgery between January 2014 and December 2023. The exposure variable was the 7-day average preoperative ambient temperature in Beijing. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- MINS
- What is being tested?
- MINS
- How many people
- 143,095 participants
- Where
- No sites listed yet
- Study dates
- 1 Jan 2013to 31 Dec 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: This retrospective single-center cohort study included 143,095 adult (≥18 years) patients who underwent noncardiac surgery under general anesthesia between January 2014 and December 2023. The exclusion criteria were as follows: (1) American Society of Anesthesiologists (ASA) classification V; (2) outpatient, hysteroscopic, or body surface surgeries; (3) surgery duration ≤30 min; (4) absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days; and (5) incomplete clinical data (≥20% missing data).
Who may be able to join
- ≥18 years
- underwent noncardiac surgery under general anesthesia
Who cannot join
- American Society of Anesthesiologists (ASA) classification V;
- outpatient, hysteroscopic, or body surface surgeries
- surgery duration ≤30 min
- absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days
- incomplete clinical data (≥20% missing data)
About this study
Official title: Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults: a Retrospective Single-center Cohort Study
This single-center retrospective cohort study enrolled patients aged ≥18 years who underwent noncardiac surgery between January 2014 and December 2023. The exposure variable was the 7-day average preoperative ambient temperature in Beijing. Univariate and multivariate logistic regression models were used to evaluate the association between temperature and MINS. Inverse probability of treatment weighting (IPTW) analysis was performed to enhance the robustness of the findings. Subgroup analyses were performed across predefined clinical strata.
- Conditions
- MINS
- Being tested
- MINS
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MINSOther
MINS
| Study group | Role | What they receive |
|---|---|---|
| moderate heat (22.8℃-29.2℃) | Not described Receives: Other: MINS | |
| extreme heat (≥29.2℃) | Not described Receives: Other: MINS | |
| extreme cold (≤-3.5℃) | Not described Receives: Other: MINS | |
| moderate cold (-3.5℃-22.8℃) | Not described Receives: Other: MINS |
What is being measured
The primary outcome is the main question the study is designed to answer.
incidence of MINS
Measured: POSTOPERATIVE 30 DAYS
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jul 2025
- Study start1 Jan 2013
- Primary completion31 Dec 2023
- Study completion31 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MINSStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 143,095 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hao Li
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Hao Li, Chinese PLA General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07079891
- Sponsor's protocol ID
- 20256030
- Status last verified
- Jul 2025
- First submitted
- 30 Jun 2025
- Last updated
- 23 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults: a Retrospective Single-center Cohort Study
- ClinicalTrials.gov ID
- NCT07079891
- Acronym / sponsor ID
- 20256030
- Conditions
- MINS
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 143,095 participants (actual)
- Lead sponsor
- Hao LiUniversity, hospital or other
- Study start
- 1 Jan 2013 (actual)
- Primary completion
- 31 Dec 2023 (actual)
- Study completion
- 31 Dec 2023 (actual)
- First posted
- 23 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single-center retrospective cohort study enrolled patients aged ≥18 years who underwent noncardiac surgery between January 2014 and December 2023. The exposure variable was the 7-day average preoperative ambient temperature in Beijing. Univariate and multivariate logistic regression models were used to evaluate the association between temperature and MINS. Inverse probability of treatment weighting (IPTW) analysis was performed to enhance the robustness of the findings. Subgroup analyses were performed across predefined clinical strata.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| moderate heat (22.8℃-29.2℃) | – | Other: MINS |
| extreme heat (≥29.2℃) | – | Other: MINS |
| extreme cold (≤-3.5℃) | – | Other: MINS |
| moderate cold (-3.5℃-22.8℃) | – | Other: MINS |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- This retrospective single-center cohort study included 143,095 adult (≥18 years) patients who underwent noncardiac surgery under general anesthesia between January 2014 and December 2023. The exclusion criteria were as follows: (1) American Society of Anesthesiologists (ASA) classification V; (2) outpatient, hysteroscopic, or body surface surgeries; (3) surgery duration ≤30 min; (4) absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days; and (5) incomplete clinical data (≥20% missing data).
Key inclusion criteria (2 listed)
- ≥18 years
- underwent noncardiac surgery under general anesthesia
Key exclusion criteria (5 listed)
- American Society of Anesthesiologists (ASA) classification V;
- outpatient, hysteroscopic, or body surface surgeries
- surgery duration ≤30 min
- absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days
- incomplete clinical data (≥20% missing data)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MINSMINS | Other | extreme cold (≤-3.5℃), extreme heat (≥29.2℃), moderate cold (-3.5℃-22.8℃), moderate heat (22.8℃-29.2℃) |
Primary outcome
incidence of MINS
Time frame: POSTOPERATIVE 30 DAYS
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jul 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of MINS, run by Hao Li.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
incidence of MINS (time frame: POSTOPERATIVE 30 DAYS). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2025.