Eccentric HypertrophyNCT06992271
Comparing Two Eccentric Protocols on Muscle Damage
A study testing Fast Eccentric and Slow Eccentric in people with Eccentric Hypertrophy and Muscle Damage, run by New York Institute of Technology at 1 site in United States.
Trial summary
The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Eccentric Hypertrophy, Muscle Damage
- What is being tested?
- Fast Eccentric and Slow Eccentric
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteUnited States
- Study dates
- 8 Mar 2023to 1 Jun 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Sixteen young adults (ages 18-35) will be enrolled in this study.
- In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.
Who cannot join
- Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded.
- Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded.
- Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
NYIT
Old Westbury, New York, 11568
Amerigo Rossi, EdD, 516-686-3884, arossi01@nyit.edu
About this study
Official title: A Novel Eccentric Resistance Training Strategy to Maximize Exercise Induced Muscle Damage in Young Adults
The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.
Read the detailed description
Participants will come to the lab for 3 sessions, plus two email follow-up questionnaires.
Session 1 (45 minutes)
- Complete a demographic questionnaire
- Self-assess muscle soreness
- Walk on the treadmill to warm-up
- Maximal voluntary contraction on the chest press
- Two sets of eccentric (lowering) bench press at 75% of max
Session 2 (45 minutes)
- Walk on the treadmill to warm up
- Maximal voluntary contraction on the chest press
- Three sets of 10 eccentric contractions at 75% of max
- Repeat the maximal voluntary contraction on the chest press
Session 2 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness
Session 3 (45 minutes) Walk on the treadmill to warm up Maximal voluntary contraction on the chest press Three sets of 10 eccentric contractions at 75% of max Repeat the maximal voluntary contraction on the chest press
Session 3 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness
- Conditions
- Eccentric Hypertrophy, Muscle Damage
- Being tested
- Fast Eccentric, Slow Eccentric
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fast EccentricBehavioural
Resistance training done quickly
Slow EccentricBehavioural
Resistance training done slowly
| Study group | Role | What they receive |
|---|---|---|
| Fast Eccentric | Experimental | Participants will perform fast eccentric resistance training Receives: Behavioral: Fast Eccentric |
| Slow eccentric | Active comparator | Participants will perform slow eccentric resistance training Receives: Behavioral: Slow Eccentric |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle soreness 1
Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Measured: 1 day
Muscle soreness 2
Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Measured: 2 days
Muscle soreness 3
Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Measured: 3 days
Maximal Voluntary Isometric Contraction Change
Change in MVIC will be used to indicated muscle damage.
Measured: pre-intervention, immediately after the intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 May 2025
- Study start8 Mar 2023
- Primary completion1 Jun 2025 (estimated)
- Study completion1 Jun 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eccentric HypertrophyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Crossover design with two groups
- Masking
- None (open label)
- Enrolment
- 16 participants (estimated)
Sponsor and investigators
- Lead sponsor
- New York Institute of Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Amerigo Rossi, Ed.D, Principal investigator, New York Institute of Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06992271
- Sponsor's protocol ID
- BHS-1835
- Status last verified
- Nov 2024
- First submitted
- 9 Mar 2023
- Last updated
- 28 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Novel Eccentric Resistance Training Strategy to Maximize Exercise Induced Muscle Damage in Young Adults
- ClinicalTrials.gov ID
- NCT06992271
- Acronym / sponsor ID
- BHS-1835
- Conditions
- Eccentric Hypertrophy, Muscle Damage
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 16 participants (estimated)
- Lead sponsor
- New York Institute of TechnologyUniversity, hospital or other
- Study start
- 8 Mar 2023 (actual)
- Primary completion
- 1 Jun 2025 (estimated)
- Study completion
- 1 Jun 2025 (estimated)
- First posted
- 28 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.
Detailed description
Participants will come to the lab for 3 sessions, plus two email follow-up questionnaires.
Session 1 (45 minutes)
- Complete a demographic questionnaire
- Self-assess muscle soreness
- Walk on the treadmill to warm-up
- Maximal voluntary contraction on the chest press
- Two sets of eccentric (lowering) bench press at 75% of max
Session 2 (45 minutes)
- Walk on the treadmill to warm up
- Maximal voluntary contraction on the chest press
- Three sets of 10 eccentric contractions at 75% of max
- Repeat the maximal voluntary contraction on the chest press
Session 2 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness
Session 3 (45 minutes) Walk on the treadmill to warm up Maximal voluntary contraction on the chest press Three sets of 10 eccentric contractions at 75% of max Repeat the maximal voluntary contraction on the chest press
Session 3 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Crossover design with two groups
| Arm | Type | Receives |
|---|---|---|
| Fast Eccentric | Experimental | Behavioral: Fast EccentricParticipants will perform fast eccentric resistance training |
| Slow eccentric | Active comparator | Behavioral: Slow EccentricParticipants will perform slow eccentric resistance training |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Sixteen young adults (ages 18-35) will be enrolled in this study.
- In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.
Key exclusion criteria (3 listed)
- Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded.
- Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded.
- Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fast EccentricResistance training done quickly | Behavioural | Fast Eccentric |
| Slow EccentricResistance training done slowly | Behavioural | Slow eccentric |
Primary outcome
Muscle soreness 1
Time frame: 1 day
Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Muscle soreness 2
Time frame: 2 days
Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Muscle soreness 3
Time frame: 3 days
Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Maximal Voluntary Isometric Contraction Change
Time frame: pre-intervention, immediately after the intervention
Change in MVIC will be used to indicated muscle damage.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 May 2025.
- Individual participant dataSharing planned: No
Related trials for Eccentric Hypertrophy
Not yet recruiting
Comparison Between Eccentric Hamstring Training and Sprint-Specific Training
Healthy Adult, Athlete
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Amerigo Rossi, Ed.D principal investigator
New York Institute of Technology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fast Eccentric and Slow Eccentric in people with Eccentric Hypertrophy and Muscle Damage, run by New York Institute of Technology at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Amerigo Rossi, Ed.D (516 686-3884, arossi01@nyit.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle soreness 1 (time frame: 1 day). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 May 2025.