Healthy AdultNCT07716319
Comparison Between Eccentric Hamstring Training and Sprint-Specific Training
A study testing RDL, NHE and Sprint testing in people with Healthy Adult and Athlete, run by University of Wisconsin, Madison at 1 site in United States.
Trial summary
The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific training program on hamstring muscle architecture, volume, sprint… Read more about this study
- Who is it for?
- Ages 18 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Adult, Athlete, Exercise Training
- What is being tested?
- RDL, NHE and Sprint testing
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteUnited States
- Study dates
- Oct 2026to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18-25 years
- Actively participating in a club team
- >6 months experience with resistance training
- Minimum of 1 year experience at the high school level in organized team sport
- No history of hamstring injury within the last 6 months
- No history of major lower extremity surgery (including back)
- No acute musculoskeletal injury to the lower extremity
- Not currently pregnant
Who cannot join
- Unable to refrain from resistance training outside the study
- Unable to make at least 80% of the training sessions
- Hamstring injury in the last 6 months
- History of major lower extremity surgery (including back)
- Acute musculoskeletal injury to the lower extremity
- Currently pregnant
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
University of Wisconsin - Madison
Madison, Wisconsin, 53705
Scott K Crawford, PhD, 608-265-1308, skcrawford2@wisc.edu
About this study
Official title: Comparison Between Eccentric Hamstring Strength Training and Sprint-Specific Training on Muscle Hypertrophy, Strength, Power, and Sprint Performance in Club Sport Collegiate Athletes
The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific training program on hamstring muscle architecture, volume, sprint performance, strength, and power.
Participants will be assigned to complete one of the 3 hamstring interventions for 10 weeks.
Read the detailed description
Prior to the intervention, participants will undergo baseline testing which will include a) ultrasound imaging of the hamstrings muscles for measures of biceps femoris long head fascicle length, pennation angle, muscle thickness, anatomical cross-sectional area, and muscle volume b) passive and active ranges of motion, c) 3 repetition maximum (3RM) RDL strength, d) peak NHE force, e) countermovement jump height, f) broad jump distance, g) Pro Agility change of direction, and h) a 60 m sprint with sprint kinematics assessed via inertial measurement units.
Participants will be randomly assigned to either the RDL, NHE, or sprint training group. After randomization, each participant will undergo the intervention program based upon their group allocation.
Performance testing and imaging will be repeated mid-intervention, following the intervention, and after 2 weeks of deloading.
- Conditions
- Healthy Adult, Athlete, Exercise Training, Sport, Running, Ultrasound Imaging
- Being tested
- RDL, NHE, Sprint testing
- Keywords
- strength, agility, sprint, hypertrophy, countermovement jump, fascicle length, hamstring, range of motion
- Medical subject headings
- Hypertrophy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RDLOther
The RDL will be performed with a 6 second eccentric component with the athlete returning to the start position with a maximal concentric hip extension.
NHEOther
The NHE will be performed with a 6 second eccentric component.
Sprint testingOther
The sprint training program will be performed twice per week with the first day of training focused on shorter distances to focus on acceleration and the second training day focused on maximal velocity. The relative efforts and distances for each training day will mimic a similar prescription to that of the resistance training program.
| Study group | Role | What they receive |
|---|---|---|
| Romanian dead lift (RDL) group | Experimental | The training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The RDL arm will perform RDL. Receives: Other: RDL |
| Nordic hamstring exercise (NHE) group | Experimental | The training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The NHE arm will performed NHE Receives: Other: NHE |
| Sprint group | Experimental | The training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The sprint training program will be performed twice per week with the first day of training focused on shorter distances to focus on acceleration and the second training day focused on maximal velocity. The relative efforts and distances for each training day will mimic a similar prescription to that of the resistance training program. Receives: Other: Sprint testing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in fascicle length (FL)
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in muscle cross-sectional area (CSA)
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in muscle volume
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in pennation angle (PA)
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Secondary outcomes (8)
Change in eccentric strength
Eccentric hamstring strength of each limb will be assessed during the hamstring exercise.
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in inertial measurement units (IMU)-based sprinting biomechanics
Sprinting biomechanics will be assessed using seven IMUs (sacrum, both thighs, both shanks, both feet). Lower extremity joint motions referenced to upright stance will be calculated throughout an on-field sprint and other football drills.
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in countermovement jump (CMJ) performance
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in standing broad jump (SBJ) performance
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in change of direction (CoD) performance
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in range of motion (ROM) performance
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in hip flexion
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in anterior pelvic tilt
Measured: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2026
- Study startOct 2026 (estimated)
- Primary completionSep 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy AdultStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Wisconsin, Madison
- Sponsor type
- University, hospital or other
- Collaborators
- National Strength and Conditioning Association (NSCA) Foundation
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07716319
- Sponsor's protocol ID
- 2026-0704
- Other IDs
- UWMSN | SOE | Kinesiology Oper, Protocol Version 5/5/26
- Status last verified
- Jul 2026
- First submitted
- 7 Jul 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Between Eccentric Hamstring Strength Training and Sprint-Specific Training on Muscle Hypertrophy, Strength, Power, and Sprint Performance in Club Sport Collegiate Athletes
- ClinicalTrials.gov ID
- NCT07716319
- Acronym / sponsor ID
- 2026-0704
- Conditions
- Healthy Adult, Athlete, Exercise Training, Sport, Running, Ultrasound Imaging
- Keywords
- strength, agility, sprint, hypertrophy, countermovement jump, fascicle length, hamstring, range of motion
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- University of Wisconsin, MadisonUniversity, hospital or other
- Collaborators
- National Strength and Conditioning Association (NSCA) Foundation
- Study start
- Oct 2026 (estimated)
- Primary completion
- Sep 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 21 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific training program on hamstring muscle architecture, volume, sprint performance, strength, and power.
Participants will be assigned to complete one of the 3 hamstring interventions for 10 weeks.
Detailed description
Prior to the intervention, participants will undergo baseline testing which will include a) ultrasound imaging of the hamstrings muscles for measures of biceps femoris long head fascicle length, pennation angle, muscle thickness, anatomical cross-sectional area, and muscle volume b) passive and active ranges of motion, c) 3 repetition maximum (3RM) RDL strength, d) peak NHE force, e) countermovement jump height, f) broad jump distance, g) Pro Agility change of direction, and h) a 60 m sprint with sprint kinematics assessed via inertial measurement units.
Participants will be randomly assigned to either the RDL, NHE, or sprint training group. After randomization, each participant will undergo the intervention program based upon their group allocation.
Performance testing and imaging will be repeated mid-intervention, following the intervention, and after 2 weeks of deloading.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Romanian dead lift (RDL) group | Experimental | Other: RDLThe training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The RDL arm will perform RDL. |
| Nordic hamstring exercise (NHE) group | Experimental | Other: NHEThe training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The NHE arm will performed NHE |
| Sprint group | Experimental | Other: Sprint testingThe training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The sprint training program will be performed twice per week with the first day of training focused on shorter distances to focus on acceleration and the second training day focused on maximal velocity. The relative efforts and distances for each training day will mimic a similar prescription to that of the resistance training program. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Age 18-25 years
- Actively participating in a club team
- >6 months experience with resistance training
- Minimum of 1 year experience at the high school level in organized team sport
- No history of hamstring injury within the last 6 months
Key exclusion criteria (6 listed)
- Unable to refrain from resistance training outside the study
- Unable to make at least 80% of the training sessions
- Hamstring injury in the last 6 months
- History of major lower extremity surgery (including back)
- Acute musculoskeletal injury to the lower extremity
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| RDLThe RDL will be performed with a 6 second eccentric component with the athlete returning to the start position with a maximal concentric hip extension. | Other | Romanian dead lift (RDL) group |
| NHEThe NHE will be performed with a 6 second eccentric component. | Other | Nordic hamstring exercise (NHE) group |
| Sprint testingThe sprint training program will be performed twice per week with the first day of training focused on shorter distances to focus on acceleration and the second training day focused on maximal velocity. The relative efforts and distances for each training day will mimic a similar prescription to that of the resistance training program. | Other | Sprint group |
Primary outcome
Change in fascicle length (FL)
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in muscle cross-sectional area (CSA)
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in muscle volume
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in pennation angle (PA)
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
8 secondary outcomes
Change in eccentric strength
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in inertial measurement units (IMU)-based sprinting biomechanics
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in countermovement jump (CMJ) performance
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in standing broad jump (SBJ) performance
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in change of direction (CoD) performance
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in range of motion (ROM) performance
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in hip flexion
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Change in anterior pelvic tilt
Time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: No
Related trials for Healthy Adult
RecruitingPhase 1
A Single Ascending Dose Study of DTI-117 Given Intramuscularly in Healthy Participants.
Healthy Adult
RecruitingPhase 1
mRNA Vaccine Targeting Epstein-Barr Virus (EBV) in Healthy Young Adults
EBV
Active, not recruitingPhase 1/2
Safety and Immunogenicity Study of SCB-1022 and SCB-1033 in Healthy Older Adults
RSV Infection, Human Metapneumovirus Infection
Recruiting
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
Healthy Volunteer
Not yet recruiting
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
Corneal Topography, Dry Eye Syndromes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing RDL, NHE and Sprint testing in people with Healthy Adult and Athlete, run by University of Wisconsin, Madison at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Scott K Crawford, PhD (608) 265-1308, skcrawford2@wisc.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in fascicle length (FL) (time frame: Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.