Post Operative Pain ControlNCT06951204
Evaluation of the Role of Genicular Nerve Block When Combined With Adductor Canal Block for Pain Control Following Knee Arthroscopy
A study testing Adductor Canal Block (ACB) Only and Adductor canal block (ACB) combined with Genicular nerve block (GNB) in people with Post Operative Pain Control, run by Ain Shams University at 1 site in Egypt.
Trial summary
The intervention tests the efficacy of Genicular nerve block when combined with Adductor canal block in comparison with Adductor canal block alone to control post operative pain in knee arthroscopy Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Post Operative Pain Control
- What is being tested?
- Adductor Canal Block (ACB) Only and Adductor canal block (ACB) combined with Genicular nerve block (GNB)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Apr 2024to 28 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Physical status: ASA 1 or 2 and candidates for knee arthroscopy.
- Age group: 18-50 years.
- No sex predilection.
Who cannot join
- Physical status: ASA III or above.
- Patients with a history of drug allergies to study drugs.
- Previous trauma or surgery to the leg.
- Opioids or alcohol abuse.
- Bleeding tendency.
- Dysesthesia, loss of sensation around the knee or medial aspect of the thigh.
- Inability to cooperate.
Trial locations and contacts
1 site in 1 country.
About this study
The intervention tests the efficacy of Genicular nerve block when combined with Adductor canal block in comparison with Adductor canal block alone to control post operative pain in knee arthroscopy
Read the detailed description
- Preoperative settings:
All patients will be assessed preoperatively by careful history taking, full physical examination, and laboratory evaluation. An informed written consent will be taken from every patient just before the surgery.
Intraoperative and postoperative settings:
On arrival to the operating room, baseline parameters such as ECG, mean arterial blood pressure, heart rate, and oxygen saturation will be recorded. Intravenous line will be inserted, and IV Ringer's solution will be started, then induction of general anesthesia: Preoxygenation with 100% oxygen will be carried out for 2-3 minutes. Induction of anesthesia will be done using intravenous fentanyl 1-2 µg/kg and propofol 1-2 mg/kg. Endotracheal intubation will be facilitated with atracurium 0.4-0.5 mg/kg. Proper intubation will be confirmed by ETCO2 and bilateral auscultation of the chest. Anesthesia will be maintained with 60:40 oxygen mixed with air and isoflurane 1.2%. Lungs will be ventilated using volume-controlled ventilation with tidal volumes and respiratory rate adjusted to maintain end tidal CO2 at 35-40 MMGH.
After induction of general anesthesia and intubation:
Group A: • All patients will receive adductor canal block under complete aseptic conditions using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA ). while patient is laying supine lower limbs will slightly abducted at the hips and flexed at the knees , using linear ultrasound probe(2.5-7.5MHZ) on the anterior aspect of the patient's thigh, At the level of mid-thigh, by moving probe medially until the boat shaped Sartorius muscle is visualized , at which the adductor canal is identified beneath the sartorius muscle, a, 20ml bupivacaine (0.25%) will be injected in the canal after a careful negative aspiration. The spread of the drug lateral and around the femoral artery will be seen real time on ultrasound.
Group B: All patients will receive adductor canal block as described above under complete aseptic conditions then they will receive the genicular nerve block using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA ), genicular nerve block will be done at three locations, i.e., superomedial, superolateral, and inferomedial locations of the condyle-shaft junction, while patient is lying supine linear ultrasound probe(2.5-7.5MHZ) will be used to target the superomedial, superolateral, and inferomedial genicular nerves, 2ml bupivacaine (0.25%) will be injected in the 3 mentioned points after a careful negative aspiration.
- Conditions
- Post Operative Pain Control
- Being tested
- Adductor Canal Block (ACB) Only, Adductor canal block (ACB) combined with Genicular nerve block (GNB)
- Keywords
- Genicular nerve block, Adductor canal block, motor sparing analgesia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adductor Canal Block (ACB) OnlyProcedure or surgery
All patients will receive adductor canal block under complete aseptic conditions using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington,USA ). while patient is laying supine lower limbs will slightly abducted at the hips and flexed at the knees , using linear ultrasound probe(2.5-7.5MHZ) on the anterior aspect of the patient's thigh, At the level of mid-thigh, by moving probe medially until the boat shaped Sartorius muscle is visualized , at which the adductor canal is identified beneath the sartorius muscle, 20ml bupivacaine (0.25%) will be injected in the canal after a careful negative aspiration. The spread of the drug lateral and around the femoral artery will be seen real time on ultrasound
Adductor canal block (ACB) combined with Genicular nerve block (GNB)Procedure or surgery
All patients will receive adductor canal block as described above under complete aseptic conditions then they will receive the genicular nerve block using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington,USA ), genicular nerve block will be done at three locations, i.e., superomedial, superolateral, and inferomedial locations of the condyle-shaft junction, while patient is lying supine linear ultrasound probe(2.5-7.5MHZ) will be used to target the superomedial, superolateral, and inferomedial genicular nerves,2ml bupivacaine (0.25%) will be injected in the 3 mentioned points after a careful negative aspiration
| Study group | Role | What they receive |
|---|---|---|
| Adductor canal block (ACB) only | Active comparator | This group will receive Adductor canal block only (control group) Receives: Procedure: Adductor Canal Block (ACB) Only |
| Adductor canal block (ACB) combined with Genicular nerve block (GNB) | Active comparator | This group will receive Adductor canal block and Genicular nerve block Receives: Procedure: Adductor canal block (ACB) combined with Genicular nerve block (GNB) |
What is being measured
The primary outcome is the main question the study is designed to answer.
post-operative pain after 6 hours after the time of administration of the block according to VAS score.
- To assess postoperative pain and its intensity a segmented numeric version of the visual analogue scale (VAS) is the score that used. The patient will select a whole number (0- 10 integers) that best reflects the intensity of his pain; 1-10 is recorded by a blinded investigator during 24 hours
- All patients receive intravenous paracetamol IV/8 hours, Patients receive intravenous pethidine 0.5mg/kg as rescue analgesia when the VAS is equal or more than 4.
Measured: During 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Apr 2025
- Study start1 Apr 2024
- Primary completion28 Sep 2024
- Study completion28 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Operative Pain ControlStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06951204
- Sponsor's protocol ID
- FMASU MS170/2024
- Status last verified
- Mar 2024
- First submitted
- 6 Mar 2025
- Last updated
- 30 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Role of Genicular Nerve Block When Combined With Adductor Canal Block for Pain Control Following Knee Arthroscopy
- ClinicalTrials.gov ID
- NCT06951204
- Acronym / sponsor ID
- FMASU MS170/2024
- Conditions
- Post Operative Pain Control
- Keywords
- Genicular nerve block, Adductor canal block, motor sparing analgesia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 1 Apr 2024 (actual)
- Primary completion
- 28 Sep 2024 (actual)
- Study completion
- 28 Sep 2024 (actual)
- First posted
- 30 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The intervention tests the efficacy of Genicular nerve block when combined with Adductor canal block in comparison with Adductor canal block alone to control post operative pain in knee arthroscopy
Detailed description
- Preoperative settings:
All patients will be assessed preoperatively by careful history taking, full physical examination, and laboratory evaluation. An informed written consent will be taken from every patient just before the surgery.
Intraoperative and postoperative settings:
On arrival to the operating room, baseline parameters such as ECG, mean arterial blood pressure, heart rate, and oxygen saturation will be recorded. Intravenous line will be inserted, and IV Ringer's solution will be started, then induction of general anesthesia: Preoxygenation with 100% oxygen will be carried out for 2-3 minutes. Induction of anesthesia will be done using intravenous fentanyl 1-2 µg/kg and propofol 1-2 mg/kg. Endotracheal intubation will be facilitated with atracurium 0.4-0.5 mg/kg. Proper intubation will be confirmed by ETCO2 and bilateral auscultation of the chest. Anesthesia will be maintained with 60:40 oxygen mixed with air and isoflurane 1.2%. Lungs will be ventilated using volume-controlled ventilation with tidal volumes and respiratory rate adjusted to maintain end tidal CO2 at 35-40 MMGH.
After induction of general anesthesia and intubation:
Group A: • All patients will receive adductor canal block under complete aseptic conditions using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA ). while patient is laying supine lower limbs will slightly abducted at the hips and flexed at the knees , using linear ultrasound probe(2.5-7.5MHZ) on the anterior aspect of the patient's thigh, At the level of mid-thigh, by moving probe medially until the boat shaped Sartorius muscle is visualized , at which the adductor canal is identified beneath the sartorius muscle, a, 20ml bupivacaine (0.25%) will be injected in the canal after a careful negative aspiration. The spread of the drug lateral and around the femoral artery will be seen real time on ultrasound.
Group B: All patients will receive adductor canal block as described above under complete aseptic conditions then they will receive the genicular nerve block using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA ), genicular nerve block will be done at three locations, i.e., superomedial, superolateral, and inferomedial locations of the condyle-shaft junction, while patient is lying supine linear ultrasound probe(2.5-7.5MHZ) will be used to target the superomedial, superolateral, and inferomedial genicular nerves, 2ml bupivacaine (0.25%) will be injected in the 3 mentioned points after a careful negative aspiration.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Adductor canal block (ACB) only | Active comparator | Procedure: Adductor Canal Block (ACB) OnlyThis group will receive Adductor canal block only (control group) |
| Adductor canal block (ACB) combined with Genicular nerve block (GNB) | Active comparator | Procedure: Adductor canal block (ACB) combined with Genicular nerve block (GNB)This group will receive Adductor canal block and Genicular nerve block |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Physical status: ASA 1 or 2 and candidates for knee arthroscopy.
- Age group: 18-50 years.
- No sex predilection.
Key exclusion criteria (7 listed)
- Physical status: ASA III or above.
- Patients with a history of drug allergies to study drugs.
- Previous trauma or surgery to the leg.
- Opioids or alcohol abuse.
- Bleeding tendency.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adductor Canal Block (ACB) OnlyAll patients will receive adductor canal block under complete aseptic conditions using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington,USA ). while patient is laying supine lower limbs will slightly abducted at the hips and flexed at the knees , using linear ultrasound probe(2.5-7.5MHZ) on the anterior aspect of the patient's thigh, At the level of mid-thigh, by moving probe medially until the boat shaped Sartorius muscle is visualized , at which the adductor canal is identified beneath the sartorius muscle, 20ml bupivacaine (0.25%) will be injected in the canal after a careful negative aspiration. The spread of the drug lateral and around the femoral artery will be seen real time on ultrasound | Procedure or surgery | Adductor canal block (ACB) only |
| Adductor canal block (ACB) combined with Genicular nerve block (GNB)All patients will receive adductor canal block as described above under complete aseptic conditions then they will receive the genicular nerve block using a high-frequency ultrasound guidance (Sonosite turbo M, Bothell, Washington,USA ), genicular nerve block will be done at three locations, i.e., superomedial, superolateral, and inferomedial locations of the condyle-shaft junction, while patient is lying supine linear ultrasound probe(2.5-7.5MHZ) will be used to target the superomedial, superolateral, and inferomedial genicular nerves,2ml bupivacaine (0.25%) will be injected in the 3 mentioned points after a careful negative aspiration | Procedure or surgery | Adductor canal block (ACB) combined with Genicular nerve block (GNB) |
Primary outcome
post-operative pain after 6 hours after the time of administration of the block according to VAS score.
Time frame: During 24 hours
* To assess postoperative pain and its intensity a segmented numeric version of the visual analogue scale (VAS) is the score that used. The patient will select a whole number (0- 10 integers) that best reflects the intensity of his pain; 1-10 is recorded by a blinded investigator during 24 hours * All patients receive intravenous paracetamol IV/8 hours, Patients receive intravenous pethidine 0.5mg/kg as rescue analgesia when the VAS is equal or more than 4.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adductor Canal Block (ACB) Only and Adductor canal block (ACB) combined with Genicular nerve block (GNB) in people with Post Operative Pain Control, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
post-operative pain after 6 hours after the time of administration of the block according to VAS score. (time frame: During 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2025.