GeriatricINSIGHTNCT06946537
Nutritional Status and Patient Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Older Hospitalized Patients
An observational study of Geriatric and Malnutrition, run by Bispebjerg Hospital at 1 site in Denmark.
Trial summary
Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Geriatric, Malnutrition, Length of Stay
- What is being tested?
- Exposures and measurements
- How many people
- 1,500 participants
- Where
- 1 siteDenmark
- Study dates
- 12 May 2025to Nov 2028
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Study population: Patients acutely admitted at Bispebjerg Hospital
Who may be able to join
- Acutely admitted adults aged 65 years and above.
- Be able to comply with the study information, as assessed by the research personnel.
- Be able to understand Danish.
Who cannot join
- <24 hours admission
- Terminal illness in end stage of life
- Patients with temporary civil person registration number (CPR)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Denmark1 site, 1 recruiting
- Recruiting
Bispebjerg Hospital
Copenhagen, 2400
Jacob Jespersen, +4522321355, jacob.baekgaard.jespersen@regionh.dk
About this study
Official title: The Influence of Nutritional Status and Phenotypic Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Hospitalized Patients
Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival.
DRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood.
This project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.
- Conditions
- Geriatric, Malnutrition, Length of Stay
- Being tested
- Exposures and measurements
- Keywords
- Geriatric, Disease-related malnutrition, Physiology, Acute illness, Deep phenotyping, Nutritional status
- Medical subject headings
- Malnutrition
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exposures and measurementsOther
Anthropometry, Body composition (BIA), Nutritional screening (GLIM, SNAQ, NIS, NRS-2002), Functional tests, Seisomocardiography, Muscle strength, Blood tests, Fecal swabs, Indirect calorimetry Orientation-Memory-Concentration (OMC), Sarcopenia, Frailty (Clinical Frailty Scale), Comobidity, Polypharmacy, Portrait photo.
| Study group | Role | What they receive |
|---|---|---|
| The INSIGHT cohort | A geriatric cohort (age ≥ 65) established to investigate the coupling of phenotypical characteristics to nutritional and physiological status. The study intent to explore whether Disease-Related Malnutrition provides predictive value for patient prognosis based on specific phenotypic characteristics and establish different physiological stratifications to improve the identification of acutely admitted patients. Receives: Other: Exposures and measurements |
What is being measured
The primary outcome is the main question the study is designed to answer.
Length of Hospital Stay
Time (in hours) hospitalized from arrival to discharge
Measured: From date of hospital admission untill discharge, assessed up to 2 months
Secondary outcomes (3)
Readmission
Time to readmission from discharge
Measured: Time to readmission 30 days from discharge
Acute contact
Time to acute contact from discharge
Measured: Time to acute contact 30 days from discharge
Mortality
Time to mortality from index admission
Measured: Time to mortality 90 days from index admission
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Apr 2025
- Study start12 May 2025
- Primary completionApr 2027 (estimated)
- Study completionNov 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for GeriatricStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 1,500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Bispebjerg Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Charlotte Suetta, Bispebjerg Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06946537
- Sponsor's protocol ID
- H-25009586
- Acronym
- INSIGHT
- Status last verified
- Sep 2026
- First submitted
- 25 Apr 2025
- Last updated
- 2 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: The following will be available: Study Protocol and Statistical Analysis Plan (SAP).