PainNCT06934122
Effect of Audible Manipulation Sound in Non-specific Cervicothoracic Pain
A study testing manipulation with classical massage and spinal manipulation technique in people with Pain and Disability, run by Ayça Aytar at 2 sites in Turkey (Türkiye).
Trial summary
The aim of this study is to investigate the effect of auditory manipulation sound on perceived pain, satisfaction and disability in patients with nonspecific cervicothoracic pain.İndividuals with nonspecific cervicothoracic pain will be included. Read more about this study
- Who is it for?
- Ages 18 to 65 years, women only
- Conditions the study is for
- Pain, Disability
- What is being tested?
- manipulation with classical massage and spinal manipulation technique
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 10 Apr 2025to 30 Sep 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Clinical diagnosis of non-specific spinal pain
- Must be able to do exercise by alone
Who cannot join
- Clinical diagnosis of neurological problems (Alzheimer's, Demans)
- Clinical diagnosis of deep vein thrombosis
- Clinical diagnosis of systemic and uncontrolled metabolic diseases( Diabetes, Thyroid,hypertension)
- Don't have pain while doing exercise
Trial locations and contacts
2 sites in 1 country.
Turkey (Türkiye)2 sites
Başkent University
Ankara, Ankara, 06790
Baskent University
Ankara, Etimesgut, 06790
About this study
Official title: Effect of Audible Manipulation Sound on Perceived Pain, Satisfaction and Disability in Non-specific Cervicothoracic Pain
The aim of this study is to investigate the effect of auditory manipulation sound on perceived pain, satisfaction and disability in patients with nonspecific cervicothoracic pain.İndividuals with nonspecific cervicothoracic pain will be included. the first group will be determined as those with an audible sound at the end of manipulation, and the second group will be determined as those without an audible sound at the end of manipulation. all evaluations and the patient's satisfaction level will be made before the application and 48 hours after the application.
Read the detailed description
Before the application, the pain intensity of the individuals will be assessed with a visual analog scale, and the level of disability will be assessed with the 'neck pain and disability index'. neck mobility will be measured with a cervical inclinometer and spinal region fascia mobility modified schober test, and also the thoracolumbar fascia flexibility will be recorded. .
- Conditions
- Pain, Disability
- Being tested
- manipulation with classical massage and spinal manipulation technique
- Keywords
- Neck pain, Manuel therapy
- Medical subject headings
- Pain, Neck Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
manipulation with classical massage and spinal manipulation techniqueOther
All participants will first receive a massage to relax the muscles and then be manipulated with a spinal manipulation technique.
| Study group | Role | What they receive |
|---|---|---|
| spinal manipulation | Experimental | All participants will first receive a massage and then be manipulated with the spinal manipulation technique. Receives: Other: manipulation with classical massage and spinal manipulation technique |
What is being measured
The primary outcome is the main question the study is designed to answer.
Neck mobility
Neck mobility will be measured with a cervical inclinometer
Measured: immediately before starting the application and 48 hours after the application
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Apr 2025
- Study start10 Apr 2025
- Primary completion20 May 2025
- Study completion30 Sep 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- To decide on the sample size, an effect size of 0.25, a Type I error of 0.05, a test power of 80% and a confidence interval of 95% were determined using the G\*Power program. The first group was determined as those with an audible sound during the procedure, and the second group was determined as those with no audible sound at the end of the procedure.
- Masking
- None (open label)
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ayça Aytar
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ayça Aytar, Baskent University
- Investigators
- nihan özünlü pekyavaş, Principal investigator, prof
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06934122
- Sponsor's protocol ID
- KA24/199
- Status last verified
- May 2025
- First submitted
- 10 Apr 2025
- Last updated
- 19 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We prefer to share our data and study design once they are published
Publications
Munke Cross, P., & Ingvi Jacobsen, V. (2022). The Thrust-A Must?: a literature review of the effectiveness of thrust manipulation for pain relief in musculoskeletal conditions
de Sousa Almeida AP, Matsui EKK, da Silva FN, de Oliveira Vasconcelos FB, de Oliveira MR. Thoracic Spine Mobility and Posture: Correlation and Predictive Values in Physically Independent Older Adults. Eval Health Prof. 2024 Mar;47(1):133-138. doi: 10.1177/01632787231220612. Epub 2023 Dec 8.
PubMed 38065535Sun X, Chai L, Huang Q, Zhou H, Liu H. Effects of exercise combined with cervicothoracic spine self-mobilization on chronic non-specific neck pain. Sci Rep. 2024 Mar 4;14(1):5298. doi: 10.1038/s41598-024-55181-8.
PubMed 38438448
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Audible Manipulation Sound on Perceived Pain, Satisfaction and Disability in Non-specific Cervicothoracic Pain
- ClinicalTrials.gov ID
- NCT06934122
- Acronym / sponsor ID
- KA24/199
- Conditions
- Pain, Disability
- Keywords
- Neck pain, Manuel therapy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 38 participants (estimated)
- Lead sponsor
- Ayça AytarUniversity, hospital or other
- Study start
- 10 Apr 2025 (actual)
- Primary completion
- 20 May 2025 (actual)
- Study completion
- 30 Sep 2025 (estimated)
- First posted
- 18 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effect of auditory manipulation sound on perceived pain, satisfaction and disability in patients with nonspecific cervicothoracic pain.İndividuals with nonspecific cervicothoracic pain will be included. the first group will be determined as those with an audible sound at the end of manipulation, and the second group will be determined as those without an audible sound at the end of manipulation. all evaluations and the patient's satisfaction level will be made before the application and 48 hours after the application.
Detailed description
Before the application, the pain intensity of the individuals will be assessed with a visual analog scale, and the level of disability will be assessed with the 'neck pain and disability index'. neck mobility will be measured with a cervical inclinometer and spinal region fascia mobility modified schober test, and also the thoracolumbar fascia flexibility will be recorded. .
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- To decide on the sample size, an effect size of 0.25, a Type I error of 0.05, a test power of 80% and a confidence interval of 95% were determined using the G*Power program. The first group was determined as those with an audible sound during the procedure, and the second group was determined as those with no audible sound at the end of the procedure.
| Arm | Type | Receives |
|---|---|---|
| spinal manipulation | Experimental | Other: manipulation with classical massage and spinal manipulation techniqueAll participants will first receive a massage and then be manipulated with the spinal manipulation technique. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Clinical diagnosis of non-specific spinal pain
- Must be able to do exercise by alone
Key exclusion criteria (4 listed)
- Clinical diagnosis of neurological problems (Alzheimer's, Demans)
- Clinical diagnosis of deep vein thrombosis
- Clinical diagnosis of systemic and uncontrolled metabolic diseases( Diabetes, Thyroid,hypertension)
- Don't have pain while doing exercise
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| manipulation with classical massage and spinal manipulation techniqueAll participants will first receive a massage to relax the muscles and then be manipulated with a spinal manipulation technique. | Other | spinal manipulation |
Primary outcome
Neck mobility
Time frame: immediately before starting the application and 48 hours after the application
Neck mobility will be measured with a cervical inclinometer
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2025.
- BackgroundMunke Cross, P., & Ingvi Jacobsen, V. (2022). The Thrust-A Must?: a literature review of the effectiveness of thrust manipulation for pain relief in musculoskeletal conditions
- Results publication: PubMed 38065535de Sousa Almeida AP, Matsui EKK, da Silva FN, de Oliveira Vasconcelos FB, de Oliveira MR. Thoracic Spine Mobility and Posture: Correlation and Predictive Values in Physically Independent Older Adults. Eval Health Prof. 2024 Mar;47(1):133-138. doi: 10.1177/01632787231220612. Epub 2023 Dec 8.
- Results publication: PubMed 38438448Sun X, Chai L, Huang Q, Zhou H, Liu H. Effects of exercise combined with cervicothoracic spine self-mobilization on chronic non-specific neck pain. Sci Rep. 2024 Mar 4;14(1):5298. doi: 10.1038/s41598-024-55181-8.
- Individual participant dataSharing planned: No. We prefer to share our data and study design once they are published
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
nihan özünlü pekyavaş principal investigator
prof
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing manipulation with classical massage and spinal manipulation technique in people with Pain and Disability, run by Ayça Aytar at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 19 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neck mobility (time frame: immediately before starting the application and 48 hours after the application). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06934122, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2025.