GlaucomaG-SEARCHNCT06854198
Glaucoma Screening to Enhance At-Risk Californians' Health
A study testing Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry and Educational Brochure in people with Glaucoma, run by University of California, San Francisco at 3 sites in United States.
Trial summary
The vast majority of glaucoma cases in the United States go undetected and untreated until the late stages of the disease. Open-angle glaucoma is a progressive condition that is asymptomatic in its early to moderate stages and may be amenable to screening through telemedicine-based approaches. Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Glaucoma
- What is being tested?
- Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry and Educational Brochure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2,000 participants
- Where
- 3 sitesUnited States
- Study dates
- 10 Feb 2026to Sep 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Black people aged 50 years or older
- Hispanic people aged 65 years or older
- People with diabetes aged 50 years or older
- Must have been seen at the Federally Qualified Health Center (FQHC) within the past month
Who cannot join
- Patients without a valid phone number or mailing address
- Patients who have had an optometry appointment within the past year
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Jeremy Keenan, MD MPH contact
United States3 sites, 3 recruiting
- Recruiting
Bay Area Community Health
Fremont, California, 94538
Piper Bahr, OD, FAAO, 510-770-8133, pbahr1@bach.health
- Recruiting
Baywell Health
Oakland, California, 94607
Angela Shahbazian, OD, FAAO, 510-835-9610, a.shahbazian@berkeley.edu
- Not yet recruiting
University of California, San Francisco
San Francisco, California, 94158
About this study
Official title: Novel Telehealth Technologies to Detect and Manage Glaucoma and Vision-threatening Eye Diseases in High-risk Populations
The vast majority of glaucoma cases in the United States go undetected and untreated until the late stages of the disease. Open-angle glaucoma is a progressive condition that is asymptomatic in its early to moderate stages and may be amenable to screening through telemedicine-based approaches. This study is a randomized trial to evaluate whether glaucoma screening with established tests (e.g., optical coherence tomography, fundus photography, and tonometry) is more effective for detecting undiagnosed glaucoma cases compared to education alone or delayed intervention.
Read the detailed description
Specific Aim 1: To determine the effectiveness of a telemedicine-based glaucoma screening program for detecting glaucoma. The investigators hypothesize that a mobile screening intervention incorporating optical coherence tomography (OCT), fundus photography, and tonometry will result in a greater number of new glaucoma diagnoses compared to education alone or delayed treatment.
Specific Aim 2: To determine whether a telemedicine-based glaucoma screening program provides benefits beyond glaucoma detection. The investigators hypothesize that (A) individuals randomized to the screening intervention will have higher rates of cataract surgery and distance vision correction one year after screening, and (B) those in the screening intervention will report higher vision-related quality of life one year after screening.
- Conditions
- Glaucoma
- Being tested
- Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry, Educational Brochure
- Keywords
- optical coherence tomography, tonometry, glaucoma, screening
- Medical subject headings
- Glaucoma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometryOther
Participants will be called and offered a screening appointment. At the appointment, visual acuity, OCT, color fundus photography, tonometry, and visual field testing will be performed. The images will be assessed for abnormalities. Participants meeting referral criteria will be referred for a comprehensive eye examination with an eye care provider.
Educational BrochureOther
A brochure about glaucoma screening will be mailed to participants. The brochure will include contact information of a staff member who can schedule an appointment for a comprehensive eye examination.
| Study group | Role | What they receive |
|---|---|---|
| Screening | Experimental | Not described Receives: Other: Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry |
| Education | Active comparator | Not described Receives: Other: Educational Brochure |
| Delayed Education | No intervention | The same as the Educational Brochure arm, but delivered at the conclusion of the study. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Glaucoma Diagnosis or Glaucoma Suspect Requiring Treatment
Measured: 6 months from randomization
Secondary outcomes (3)
Cataract surgery
Self-reported cataract surgery
Measured: 12 months
Eyeglasses
Self-reported purchase of new distance eyeglasses
Measured: 12 months
Quality of Life survey
Self-reported quality of life on VisQol instrument
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2025
- Study start10 Feb 2026
- Primary completionMar 2029 (estimated)
- Study completionSep 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for GlaucomaStudies of the same condition, open and under way.
- More trials run by University of California, San FranciscoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, San Francisco
- Sponsor type
- University, hospital or other
- Collaborators
- Centers for Disease Control and Prevention
- Responsible party
- Sponsor
- Investigators
- Jeremy D Keenan, MD, MPH, Principal investigator, University of California, San FranciscoYvonne Ou, MD, Principal investigator, University of California, San Francisco
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06854198
- Sponsor's protocol ID
- 24-43132
- Other IDs
- U01DP006820
- Acronym
- G-SEARCH
- Status last verified
- Oct 2026
- First submitted
- 25 Feb 2025
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: treatment arm, age, gender, results of diagnostic tests, 6-month and 12-month questionnaires
Study at a glance
From the registry record, last updated by the sponsor on 14 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Novel Telehealth Technologies to Detect and Manage Glaucoma and Vision-threatening Eye Diseases in High-risk Populations
- ClinicalTrials.gov ID
- NCT06854198
- Acronym / sponsor ID
- G-SEARCH / 24-43132
- Conditions
- Glaucoma
- Keywords
- optical coherence tomography, tonometry, glaucoma, screening
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- University of California, San FranciscoUniversity, hospital or other
- Collaborators
- Centers for Disease Control and Prevention
- Study start
- 10 Feb 2026 (actual)
- Primary completion
- Mar 2029 (estimated)
- Study completion
- Sep 2029 (estimated)
- First posted
- 3 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The vast majority of glaucoma cases in the United States go undetected and untreated until the late stages of the disease. Open-angle glaucoma is a progressive condition that is asymptomatic in its early to moderate stages and may be amenable to screening through telemedicine-based approaches. This study is a randomized trial to evaluate whether glaucoma screening with established tests (e.g., optical coherence tomography, fundus photography, and tonometry) is more effective for detecting undiagnosed glaucoma cases compared to education alone or delayed intervention.
Detailed description
Specific Aim 1: To determine the effectiveness of a telemedicine-based glaucoma screening program for detecting glaucoma. The investigators hypothesize that a mobile screening intervention incorporating optical coherence tomography (OCT), fundus photography, and tonometry will result in a greater number of new glaucoma diagnoses compared to education alone or delayed treatment.
Specific Aim 2: To determine whether a telemedicine-based glaucoma screening program provides benefits beyond glaucoma detection. The investigators hypothesize that (A) individuals randomized to the screening intervention will have higher rates of cataract surgery and distance vision correction one year after screening, and (B) those in the screening intervention will report higher vision-related quality of life one year after screening.
Study design
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Screening | Experimental | Other: Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry |
| Education | Active comparator | Other: Educational Brochure |
| Delayed Education | No intervention | –The same as the Educational Brochure arm, but delivered at the conclusion of the study. |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Black people aged 50 years or older
- Hispanic people aged 65 years or older
- People with diabetes aged 50 years or older
- Must have been seen at the Federally Qualified Health Center (FQHC) within the past month
Key exclusion criteria (2 listed)
- Patients without a valid phone number or mailing address
- Patients who have had an optometry appointment within the past year
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometryParticipants will be called and offered a screening appointment. At the appointment, visual acuity, OCT, color fundus photography, tonometry, and visual field testing will be performed. The images will be assessed for abnormalities. Participants meeting referral criteria will be referred for a comprehensive eye examination with an eye care provider. | Other | Screening |
| Educational BrochureA brochure about glaucoma screening will be mailed to participants. The brochure will include contact information of a staff member who can schedule an appointment for a comprehensive eye examination. | Other | Education |
Primary outcome
Glaucoma Diagnosis or Glaucoma Suspect Requiring Treatment
Time frame: 6 months from randomization
3 secondary outcomes
Cataract surgery
Time frame: 12 months
Eyeglasses
Time frame: 12 months
Quality of Life survey
Time frame: 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Oct 2026.
- Individual participant dataSharing planned: Yes. treatment arm, age, gender, results of diagnostic tests, 6-month and 12-month questionnaires
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jeremy Keenan, MD MPH contact
Jeremy D Keenan, MD, MPH principal investigator
University of California, San Francisco
Yvonne Ou, MD principal investigator
University of California, San Francisco
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry and Educational Brochure in people with Glaucoma, run by University of California, San Francisco at 3 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dionna Wittberg, MPH (3306083016, dionna.wittberg@ucsf.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Glaucoma Diagnosis or Glaucoma Suspect Requiring Treatment (time frame: 6 months from randomization). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026.