Skin HydrationNCT06853899
Clinical Trial to Evaluate the Efficacy of Skin Products to Improve Skin Quality and Health
A study testing Truology A2, Truology C-Boost and Truology Barrier Restore in people with Skin Hydration and Skin Aging, run by Truology at 1 site in United States.
Trial summary
This clinical trial evaluates the efficacy of three skincare products-Truology A2 (0.2% Retinaldehyde Serum), Truology C-Boost, and Truology Barrier Restore-in improving skin quality and health. Read more about this study
- Who is it for?
- Ages 35 to 55 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Skin Hydration, Skin Aging
- What is being tested?
- Truology A2, Truology C-Boost and Truology Barrier Restore
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 33 participants
- Where
- 1 siteUnited States
- Study dates
- 21 Oct 2024to 10 Jan 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 55 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Be female-at-birth
- Be aged 35-55
- Anyone currently experiencing issues with skin health, including: Poor skin texture, Skin discoloration, Appearance of fine lines and wrinkles Dull skin, Poor skin firmness, Dry skin, Skin redness, Irritated and stressed skin
- Willing to use the test products as follows: Truology A2 - Once a day at night. Use 1 pump for the whole face. Use first after cleansing the skin on dry skin. C-Boost - Twice a day (AM \& PM). In the morning, first use one pump for the full face after cleansing the skin. At night, use the A2 first, then C-Boost. Barrier Restore - Twice a day (AM \& PM). Use one pump for the full face. Use it after C-Boost for the final step in the skincare routine, and complete questionnaires and take photos
- Have been using the same skincare routine for at least one month prior to the study, i.e., cleanser, toner, and make-up remover
- Willing to maintain the same skincare routine and products throughout the 6-week trial, e.g., moisturizer, cleanser, or SPF
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- Have been consistently taking medications, oral supplements, or herbal remedies targeted at skin health and appearance for at least 3 months prior to the study and willing to maintain this routine for the duration of the study
- Agree to avoid using any other products or new forms of regular medication or supplements that target skin health and appearance
- Anyone who is generally healthy - does not live with any uncontrolled chronic disease
- Anyone who is currently using or has used the past, exfoliating acids (AHAs/BHA) or retinoids in (i.e., salicylic acid, glycolic acid, mandelic acid, or lactic acid).
- Anyone willing to stop using exfoliating acids or retinoids for the duration of the study
- Anyone in good general health
- Anyone who resides in the United States
Who cannot join
- Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Anyone currently using a prescription skin treatment
- Anyone with known severe allergic reactions
- Anyone unwilling to avoid excessive sun exposure
- Any women who are pregnant, breastfeeding, or attempting to conceive
- Anyone unwilling to follow the study protocol
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- Anyone who identifies as having sensitive skin
- Anyone who has undergone any facial surgeries or invasive skin treatments in the last 6 months
- Anyone who is planning to undergo any facial treatments during the study period, including botox, dermal filler, or chemical peels
- Anyone who has not stopped using hormonal birth control within the past month
- Anyone with any chronic skin conditions on the face (e.g., eczema or psoriasis)
- Anyone with a history of skin cancer or pre-cancerous skin lesions on the face
- Anyone currently testing, or plans to in the next 6 weeks, a product for another research study
- Anyone with a history of substance abuse
- Anyone who is currently, or has been for the past 3 months, a smoker
- Anyone with any known allergies or hypersensitivities to any of the study product ingredients:
- Truology A2 - Water, Glycerin, Pentylene Glycol, Niacinamide, Cyclodextrin, Polysorbate 20, Squalane, Coco-Caprylate/-Caprate, Cetearyl Alcohol, Cetyl Alcohol, Sodium Hyaluronate, Palmitoyl Tripeptide-5, Caprooyl Tetrapeptide-3, Hydroxyethylcellulose, Ceteareth-20, Beta Glucan, Resveratrol, Dimethyl Sulfone, Retinal, Tocopherol, Tetrahexyldecyl Ascorbate, Dextran, Dipalmitoyl Hydroxyproline, Lactic Acid, Arnica Montana Flower Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Camellia Sinensis (Green Tea) Leaf Extract, Salix Nigra (Willow) Bark Extract, Epilobium Angustifolium Flower/Leaf/Stem Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Rubus Chamaemorus Seed Oil, Sclerotium Gum, Phenoxyethanol, Ethylhexylglycerin, Titanium Dioxide.
- C-Boost - Water, Tetrahexyldecyl Ascorbate, Squalane, Glycerin, Propanediol, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Sodium Hyaluronate, Trifluoroacetyl Tripeptide-2, Astaxanthin, Bisabolol, Glutathione, Ergothioneine, Cetearyl Olivate, Sorbitan Olivate, Ceteareth- 20, Dextran, Ferulic Acid, Fulvic Acid, Plankton Extract, Chlorella Vulgaris Extract, Zingiber Officinale (Ginger) Root Extract, Camellia Sinensis (Green Tea) Leaf Extract, Vitis Vinifera (Grape) Seed Extract, Curcuma Longa (Turmeric) Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Arctostaphylos Uva-Ursi-Leaf (Bearberry) Extract, Tocopherol, Magnesium Ascorbyl Phosphate, Lecithin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Sodium Hydroxide.
- Barrier Restore - Organic Aloe Barbadensis Leaf Juice, Glycerin, Squalane, Caprylic/Capric Triglyceride, Linoleic Acid, Pentylene Glycol, Cetyl Alcohol, Coco-Caprylate/Caprate, C12-15 Alkyl Benzoate, Cetearyl Alcohol, Fructooligosaccharides, Beta Vulgaris (Beet) Root Extract, Sodium Hyaluronate, Palmitoyl Tripeptide-38, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Hexapeptide-12, Ceramide Ng, Bisabolol, Tocopherol, Tetrahexyldecyl Ascorbate, Dimethicone, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Tribehenin, Peg 10 Rapeseed Sterol, (Oat) Beta Glucan, Ceteareth-20, Hydroxyethylcellulose, Cetearyl Olivate, Sorbitan Olivate, Hydroxypropyl Cyclodextrin, Cassia Angustifolia Seed Polysaccharide, Linolenic Acid, Tremella Fuciformis Sporocarp Extract, Sarcothalia Circumcincta Extract, Opuntia Ficus-Indica (Nopal Cactus) Extract, Saccharomyces Cerevisiae (Yeast) Extract, Cyathea Medullaris Leaf Extract, Opuntia Streptacantha Stem Extract, Symphytum Officinale (Comfrey) Rhizome/Root Extract, Lycium Chinense (Goji Berry) Extract, Hippophae Rhamnoids (Seabuckthorn) Oil, Lactobacillus Ferment, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium Edta, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Sodium Hydroxide
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Clinical Trial to Evaluate the Efficacy of Skin Products to Improve Skin Quality and Health
This clinical trial evaluates the efficacy of three skincare products-Truology A2 (0.2% Retinaldehyde Serum), Truology C-Boost, and Truology Barrier Restore-in improving skin quality and health. The study will assess improvements in skin firmness, evenness, brightness, hydration, fine lines/wrinkles, redness, and skin stress/irritation.
- Conditions
- Skin Hydration, Skin Aging
- Being tested
- Truology A2, Truology C-Boost, Truology Barrier Restore
- Keywords
- Skin Quality, Facial Skin Health
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Truology A2Dietary supplement
Truology A2 (0.2% Retinaldehyde Serum) - Applied once daily at night after cleansing.
Truology C-BoostDietary supplement
Truology C-Boost - Applied twice daily (morning \& night).
Truology Barrier RestoreDietary supplement
Applied twice daily (morning \& night) as the final skincare step.
| Study group | Role | What they receive |
|---|---|---|
| Truology Skincare Routine | Experimental | A single-arm study in which all participants will use the Truology Skincare Routine for 6 weeks. Receives: Dietary Supplement: Truology A2; Dietary Supplement: Truology C-Boost; Dietary Supplement: Truology Barrier Restore |
What is being measured
The primary outcome is the main question the study is designed to answer.
Improvement in self-reported skin health symptoms (measured via questionnaires)
Measured: Baseline, Day 1, Week 2, Week 4, Week 6
Secondary outcomes (1)
Changes in overall facial skin quality and health (measured via expert skin grading)
Measured: Baseline and Week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2025
- Study start21 Oct 2024
- Primary completion10 Jan 2025
- Study completion10 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skin HydrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 33 participants (actual)
Sponsor and investigators
- Lead sponsor
- Truology
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06853899
- Sponsor's protocol ID
- 20455
- Status last verified
- Feb 2025
- First submitted
- 25 Feb 2025
- Last updated
- 3 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Clinical Trial to Evaluate the Efficacy of Skin Products to Improve Skin Quality and Health
- ClinicalTrials.gov ID
- NCT06853899
- Acronym / sponsor ID
- 20455
- Conditions
- Skin Hydration, Skin Aging
- Keywords
- Skin Quality, Facial Skin Health
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 33 participants (actual)
- Lead sponsor
- TruologyIndustry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Study start
- 21 Oct 2024 (actual)
- Primary completion
- 10 Jan 2025 (actual)
- Study completion
- 10 Jan 2025 (actual)
- First posted
- 3 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial evaluates the efficacy of three skincare products-Truology A2 (0.2% Retinaldehyde Serum), Truology C-Boost, and Truology Barrier Restore-in improving skin quality and health. The study will assess improvements in skin firmness, evenness, brightness, hydration, fine lines/wrinkles, redness, and skin stress/irritation.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Truology Skincare Routine | Experimental | Dietary Supplement: Truology A2, Dietary Supplement: Truology C-Boost, Dietary Supplement: Truology Barrier RestoreA single-arm study in which all participants will use the Truology Skincare Routine for 6 weeks. |
Who may qualify
- Ages
- 35 to 55 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (13 listed)
- Be female-at-birth
- Be aged 35-55
- Anyone currently experiencing issues with skin health, including: Poor skin texture, Skin discoloration, Appearance of fine lines and wrinkles Dull skin, Poor skin firmness, Dry skin, Skin redness, Irritated and stressed skin
- Willing to use the test products as follows: Truology A2 - Once a day at night. Use 1 pump for the whole face. Use first after cleansing the skin on dry skin. C-Boost - Twice a day (AM \& PM). In the morning, first use one pump for the full face after cleansing the skin. At night, use the A2 first, then C-Boost. Barrier Restore - Twice a day (AM \& PM). Use one pump for the full face. Use it after C-Boost for the final step in the skincare routine, and complete questionnaires and take photos
- Have been using the same skincare routine for at least one month prior to the study, i.e., cleanser, toner, and make-up remover
Key exclusion criteria (19 listed)
- Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Anyone currently using a prescription skin treatment
- Anyone with known severe allergic reactions
- Anyone unwilling to avoid excessive sun exposure
- Any women who are pregnant, breastfeeding, or attempting to conceive
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Truology A2Truology A2 (0.2% Retinaldehyde Serum) - Applied once daily at night after cleansing. | Dietary supplement | Truology Skincare Routine |
| Truology C-BoostTruology C-Boost - Applied twice daily (morning \& night). | Dietary supplement | Truology Skincare Routine |
| Truology Barrier RestoreApplied twice daily (morning \& night) as the final skincare step. | Dietary supplement | Truology Skincare Routine |
Primary outcome
Improvement in self-reported skin health symptoms (measured via questionnaires)
Time frame: Baseline, Day 1, Week 2, Week 4, Week 6
1 secondary outcome
Changes in overall facial skin quality and health (measured via expert skin grading)
Time frame: Baseline and Week 6
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Mar 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Truology A2, Truology C-Boost and Truology Barrier Restore in people with Skin Hydration and Skin Aging, run by Truology at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 19 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Improvement in self-reported skin health symptoms (measured via questionnaires) (time frame: Baseline, Day 1, Week 2, Week 4, Week 6). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2025.