Aphasia Non FluentMSENCT06829420
Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia
A study testing Mirror speech entrainment, Traditional speech entrainment: auditory-only and Traditional speech entrainment: auditory-visual in people with Aphasia Non Fluent and Stroke, run by University of South Florida at 2 sites in United States.
Trial summary
The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Aphasia Non Fluent, Stroke, Aphasia
- What is being tested?
- Mirror speech entrainment, Traditional speech entrainment: auditory-only and Traditional speech entrainment: auditory-visual
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 2 sitesUnited States
- Study dates
- 1 May 2025to 1 Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults between the ages of 18-70 years old
- Dominant English-speaking
- Aphasia due to left hemisphere stroke
Who cannot join
- Individuals with aphasia due to other causes such as dementia, Alzheimer's disease and Parkinsonism
- Non-dominant English adult speakers
- Persons with significant difficulties with language comprehension
- Persons with concomitant cognitive disability
- Persons with uncorrected sensory deficits.
Trial locations and contacts
2 sites in 1 country.
United States2 sites
University of South Florida
Tampa, Florida, 33612
University of South Florida
Tampa, Florida, 33614
About this study
The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is:
- What is the impact of personalized voice on speech entrainment in PWA compared to traditional speech entrainment?
Read more
Speech entrainment is a technique used by speech-language pathologists to improve the speech production of PWA. Traditionally, speech therapists act as the model for participants to speak along with to improve their speech production. This study proposes the use of one's own voice (digitally altered) to improve speech production.
The study uses a mobile health approach to administer speech entrainment treatment through a mobile app.
- Smartphones with the mobile app pre-installed will be mailed to participants at no cost.
- Participants will complete treatment in the comfort of their homes.
- The experimental treatments involve: mirror speech entrainment (speaking along to one's own voice) and traditional speech entrainment (speaking along to someone else's voice).
- Conditions
- Aphasia Non Fluent, Stroke, Aphasia
- Being tested
- Mirror speech entrainment, Traditional speech entrainment: auditory-only, Traditional speech entrainment: auditory-visual
- Keywords
- Aphasia, Nonfluent aphasia, Speech entrainment, Speech synchronization
- Medical subject headings
- Aphasia, Broca, Stroke, Aphasia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mirror speech entrainmentBehavioural
Speech entrainment with the user's own voice using auditory-only and auditory-visual modalities.
Traditional speech entrainment: auditory-onlyBehavioural
Traditional speech entrainment (speech entrainment using an external agent's voice) using the auditory-only modality (users only listen and speak along to auditory stimuli)
Traditional speech entrainment: auditory-visualBehavioural
Traditional speech entrainment (speech entrainment using an external agent's voice) using the auditory-visual modality (users listen and speak along to both auditory and visual stimuli (mouth movements)
| Study group | Role | What they receive |
|---|---|---|
| Experiment 1: Feasibility Study | Experimental | Participants will receive two treatments sequentially: mirror speech entrainment using the auditory-only modality followed by mirror speech entrainment using the auditory-visual modality. Receives: Behavioral: Mirror speech entrainment |
| Experiment 2: Mirror SE versus Traditional SE (Auditory-only) | Experimental | This arm investigates the use of mirror speech entrainment using auditory only feedback and traditional speech entrainment using auditory only feedback. Receives: Behavioral: Mirror speech entrainment; Behavioral: Traditional speech entrainment: auditory-only |
| Experiment 3: Mirror SE versus Traditional SE (Auditory-visual) | Experimental | This arm will investigate the effect of mirror speech entrainment in the auditory-visual modality versus traditional speech entrainment in the auditory-visual modality. Receives: Behavioral: Mirror speech entrainment; Behavioral: Traditional speech entrainment: auditory-visual |
What is being measured
The primary outcome is the main question the study is designed to answer.
Speaking rate
Language production as assessed by number of correct words produced per minute
Measured: From enrollment to the end of treatment at 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2025
- Study start1 May 2025
- Primary completion31 Dec 2026 (estimated)
- Study completion1 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aphasia Non FluentStudies of the same condition, open and under way.
- More trials run by University of South FloridaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of South Florida
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Celine Davis, University of South Florida
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06829420
- Sponsor's protocol ID
- 007481
- Acronym
- MSE
- Status last verified
- Sep 2026
- First submitted
- 11 Feb 2025
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will only be shared with approved members of the research team.
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia
- ClinicalTrials.gov ID
- NCT06829420
- Acronym / sponsor ID
- MSE / 007481
- Conditions
- Aphasia Non Fluent, Stroke, Aphasia
- Keywords
- Aphasia, Nonfluent aphasia, Speech entrainment, Speech synchronization
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University of South FloridaUniversity, hospital or other
- Study start
- 1 May 2025 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 1 Aug 2027 (estimated)
- First posted
- 17 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is:
- What is the impact of personalized voice on speech entrainment in PWA compared to traditional speech entrainment?
Speech entrainment is a technique used by speech-language pathologists to improve the speech production of PWA. Traditionally, speech therapists act as the model for participants to speak along with to improve their speech production. This study proposes the use of one's own voice (digitally altered) to improve speech production.
The study uses a mobile health approach to administer speech entrainment treatment through a mobile app.
- Smartphones with the mobile app pre-installed will be mailed to participants at no cost.
- Participants will complete treatment in the comfort of their homes.
- The experimental treatments involve: mirror speech entrainment (speaking along to one's own voice) and traditional speech entrainment (speaking along to someone else's voice).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Experiment 1: Feasibility Study | Experimental | Behavioral: Mirror speech entrainmentParticipants will receive two treatments sequentially: mirror speech entrainment using the auditory-only modality followed by mirror speech entrainment using the auditory-visual modality. |
| Experiment 2: Mirror SE versus Traditional SE (Auditory-only) | Experimental | Behavioral: Mirror speech entrainment, Behavioral: Traditional speech entrainment: auditory-onlyThis arm investigates the use of mirror speech entrainment using auditory only feedback and traditional speech entrainment using auditory only feedback. |
| Experiment 3: Mirror SE versus Traditional SE (Auditory-visual) | Experimental | Behavioral: Mirror speech entrainment, Behavioral: Traditional speech entrainment: auditory-visualThis arm will investigate the effect of mirror speech entrainment in the auditory-visual modality versus traditional speech entrainment in the auditory-visual modality. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults between the ages of 18-70 years old
- Dominant English-speaking
- Aphasia due to left hemisphere stroke
Key exclusion criteria (5 listed)
- Individuals with aphasia due to other causes such as dementia, Alzheimer's disease and Parkinsonism
- Non-dominant English adult speakers
- Persons with significant difficulties with language comprehension
- Persons with concomitant cognitive disability
- Persons with uncorrected sensory deficits.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mirror speech entrainmentSpeech entrainment with the user's own voice using auditory-only and auditory-visual modalities. | Behavioural | Experiment 1: Feasibility Study, Experiment 2: Mirror SE versus Traditional SE (Auditory-only), Experiment 3: Mirror SE versus Traditional SE (Auditory-visual) |
| Traditional speech entrainment: auditory-onlyTraditional speech entrainment (speech entrainment using an external agent's voice) using the auditory-only modality (users only listen and speak along to auditory stimuli) | Behavioural | Experiment 2: Mirror SE versus Traditional SE (Auditory-only) |
| Traditional speech entrainment: auditory-visualTraditional speech entrainment (speech entrainment using an external agent's voice) using the auditory-visual modality (users listen and speak along to both auditory and visual stimuli (mouth movements) | Behavioural | Experiment 3: Mirror SE versus Traditional SE (Auditory-visual) |
Primary outcome
Speaking rate
Time frame: From enrollment to the end of treatment at 6 weeks
Language production as assessed by number of correct words produced per minute
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
- Individual participant dataSharing planned: No. Individual participant data will only be shared with approved members of the research team.
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Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation
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Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mirror speech entrainment, Traditional speech entrainment: auditory-only and Traditional speech entrainment: auditory-visual in people with Aphasia Non Fluent and Stroke, run by University of South Florida at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Speaking rate (time frame: From enrollment to the end of treatment at 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.