Piriformis SyndromeNCT06808659
Effects of Neural Mobilization and Stretching in Piriformis Syndrome
A study testing Neural Mobilization and Stretching in people with Piriformis Syndrome, run by Bahria University at 1 site in Pakistan.
Trial summary
This study compares the effects of piriformis stretching and neural mobilization of the sciatic nerve in individuals with piriformis syndrome, a condition that is frequently characterized by hip and buttock pain and discomfort brought on by the piriformis muscle compressing the sciatic nerve. Read more about this study
- Who is it for?
- Ages 22 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Piriformis Syndrome
- What is being tested?
- Neural Mobilization and Stretching
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 sitePakistan
- Study dates
- 2 May 2018to 28 Dec 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 22 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Positive lasegue sign
- Positive piriformis sign
- Tenderness at sciatic notch (over piriformis muscle).
Who cannot join
- • Prior surgery of lumbar spine (laminectomy)
- Unrecognized pelvic fracture
- Known case of renal stones
- Disc herniation in lumbar spine
- Myositis ossificans of piriformis muscle.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Isra Institute of Rehabilitation Sciences
Karachi, Sindh, 74700
About this study
Official title: Comparative Effects of Neural Mobilization of Sciatic Nerve Versus Stretching Among Patients With Piriformis Syndrome
This study compares the effects of piriformis stretching and neural mobilization of the sciatic nerve in individuals with piriformis syndrome, a condition that is frequently characterized by hip and buttock pain and discomfort brought on by the piriformis muscle compressing the sciatic nerve.
Read the detailed description
In a study involving 40 patients diagnosed with sciatica, researchers aimed to investigate whether neural mobilization of the sciatic nerve or stretching of the piriformis muscle was more effective in treating piriformis syndrome. The patients were divided into two groups, each containing 20 individuals. Group A underwent neural mobilization therapy, while Group B performed piriformis muscle stretches, with both groups receiving treatment three times a week for two weeks. Assessments, including Visual Analog Scale (VAS) for pain, hip range of motion (ROM) in flexion, abduction, and external rotation, as well as the FAIR test, were conducted before and after the interventions.
- Conditions
- Piriformis Syndrome
- Being tested
- Neural Mobilization, Stretching
- Keywords
- Physiotherapy, Piriformis Stretching, Visual Analog Scale (VAS), Pain Management, FAIR Test, Range of Motion
- Medical subject headings
- Piriformis Muscle Syndrome, Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neural MobilizationOther
Also called Sciatic Nerve Mobilization
A total of 20 patients were selected in Group A received neural mobilization of sciatic nerves treatment for 3 days a week for 2 weeks
StretchingOther
Also called Piriformis Stretching
A total of 20 patients were selected in Group B received stretching of piriformis muscle treatment for 3 days a week for 2 weeks
| Study group | Role | What they receive |
|---|---|---|
| Group A / Sciatic Nerve Mobilization | Experimental | Sciatic Nerve Mobilization was given to group A participants. Receives: Other: Neural Mobilization |
| Group B / Piriformis Muscle Stretching | Experimental | Piriformis Muscles was stretched in group B participants. Receives: Other: Stretching |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Reduction
Two different interventions were applied in groups after which pain was recorded before and after through visual analogue scale. Highest score means high level of pain and lower score refers to low pain. Maximum score 9 was reported pre study and minmum score 2 was reported after study by both groups on average.
Measured: 2 weeks
Increase Range of Motion
Through neural mobilization and piriformis stretching renage of motion was assessed through inclino meter before and after study
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2025
- Study start2 May 2018
- Primary completion10 Nov 2018
- Study completion28 Dec 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Piriformis SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- In a study involving 40 patients diagnosed with sciatica, researchers aimed to investigate whether neural mobilization of the sciatic nerve or stretching of the piriformis muscle was more effective in treating piriformis syndrome. The patients were divided into two groups, each containing 20 individuals. Group A underwent neural mobilization therapy, while Group B performed piriformis muscle stretches, with both groups receiving treatment three times a week for two weeks. Assessments, including Visual Analog Scale (VAS) for pain, hip range of motion (ROM) in flexion, abduction, and external rotation, as well as the FAIR test, were conducted before and after the interventions.
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bahria University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rabia Khan, Bahria University
- Investigators
- Rabia Khan, Masters of Science, Principal investigator
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06808659
- Sponsor's protocol ID
- IERC/IIRS-IU-KC/18/005
- Status last verified
- Jan 2025
- First submitted
- 29 Nov 2024
- Last updated
- 5 Feb 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Confidentiality
Publications
Othman IK, Raj NB, Siew Kuan C, Sidek S, Wong LS, Djearamane S, Loganathan A, Selvaraj S. Association of Piriformis Thickness, Hip Muscle Strength, and Low Back Pain Patients with and without Piriformis Syndrome in Malaysia. Life (Basel). 2023 May 18;13(5):1208. doi: 10.3390/life13051208.
PubMed 37240853Hu YE, Ho GWK, Tortland PD. Deep Gluteal Syndrome: A Pain in the Buttock. Curr Sports Med Rep. 2021 Jun 1;20(6):279-285. doi: 10.1249/JSR.0000000000000848.
PubMed 34099604Danazumi MS, Yakasai AM, Ibrahim AA, Shehu UT, Ibrahim SU. Effect of integrated neuromuscular inhibition technique compared with positional release technique in the management of piriformis syndrome. J Osteopath Med. 2021 May 31;121(8):693-703. doi: 10.1515/jom-2020-0327.
PubMed 34049428Burke CJ, Walter WR, Adler RS. Targeted Ultrasound-Guided Perineural Hydrodissection of the Sciatic Nerve for the Treatment of Piriformis Syndrome. Ultrasound Q. 2019 Jun;35(2):125-129. doi: 10.1097/RUQ.0000000000000360.
PubMed 29727344Shahzad M, Rafique N, Shakil-Ur-Rehman S, Ali Hussain S. Effects of ELDOA and post-facilitation stretching technique on pain and functional performance in patients with piriformis syndrome: A randomized controlled trial. J Back Musculoskelet Rehabil. 2020;33(6):983-988. doi: 10.3233/BMR-181290.
PubMed 32894238Ahmad Siraj S, Dadgal R. Physiotherapy for Piriformis Syndrome Using Sciatic Nerve Mobilization and Piriformis Release. Cureus. 2022 Dec 26;14(12):e32952. doi: 10.7759/cureus.32952. eCollection 2022 Dec.
PubMed 36712711Ankar P, Ratnani GR, Ramteke SU, Jaiswal PR. Effect of Neuromuscular Training and Neurodynamic Solutions for Asymptomatic Prolapsed Intervertebral Disc and Coexisting Piriformis Syndrome in a 19-Year-Old: A Comprehensive Case Report. Cureus. 2024 Jan 27;16(1):e53050. doi: 10.7759/cureus.53050. eCollection 2024 Jan.
PubMed 38410291
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Neural Mobilization of Sciatic Nerve Versus Stretching Among Patients With Piriformis Syndrome
- ClinicalTrials.gov ID
- NCT06808659
- Acronym / sponsor ID
- IERC/IIRS-IU-KC/18/005
- Conditions
- Piriformis Syndrome
- Keywords
- Physiotherapy, Piriformis Stretching, Visual Analog Scale (VAS), Pain Management, FAIR Test, Range of Motion
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Bahria UniversityUniversity, hospital or other
- Study start
- 2 May 2018 (actual)
- Primary completion
- 10 Nov 2018 (actual)
- Study completion
- 28 Dec 2018 (actual)
- First posted
- 5 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study compares the effects of piriformis stretching and neural mobilization of the sciatic nerve in individuals with piriformis syndrome, a condition that is frequently characterized by hip and buttock pain and discomfort brought on by the piriformis muscle compressing the sciatic nerve.
Detailed description
In a study involving 40 patients diagnosed with sciatica, researchers aimed to investigate whether neural mobilization of the sciatic nerve or stretching of the piriformis muscle was more effective in treating piriformis syndrome. The patients were divided into two groups, each containing 20 individuals. Group A underwent neural mobilization therapy, while Group B performed piriformis muscle stretches, with both groups receiving treatment three times a week for two weeks. Assessments, including Visual Analog Scale (VAS) for pain, hip range of motion (ROM) in flexion, abduction, and external rotation, as well as the FAIR test, were conducted before and after the interventions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- In a study involving 40 patients diagnosed with sciatica, researchers aimed to investigate whether neural mobilization of the sciatic nerve or stretching of the piriformis muscle was more effective in treating piriformis syndrome. The patients were divided into two groups, each containing 20 individuals. Group A underwent neural mobilization therapy, while Group B performed piriformis muscle stretches, with both groups receiving treatment three times a week for two weeks. Assessments, including Visual Analog Scale (VAS) for pain, hip range of motion (ROM) in flexion, abduction, and external rotation, as well as the FAIR test, were conducted before and after the interventions.
| Arm | Type | Receives |
|---|---|---|
| Group A / Sciatic Nerve Mobilization | Experimental | Other: Neural MobilizationSciatic Nerve Mobilization was given to group A participants. |
| Group B / Piriformis Muscle Stretching | Experimental | Other: StretchingPiriformis Muscles was stretched in group B participants. |
Who may qualify
- Ages
- 22 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Positive lasegue sign
- Positive piriformis sign
- Tenderness at sciatic notch (over piriformis muscle).
Key exclusion criteria (5 listed)
- • Prior surgery of lumbar spine (laminectomy)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neural MobilizationAlso: Sciatic Nerve MobilizationA total of 20 patients were selected in Group A received neural mobilization of sciatic nerves treatment for 3 days a week for 2 weeks | Other | Group A / Sciatic Nerve Mobilization |
| StretchingAlso: Piriformis StretchingA total of 20 patients were selected in Group B received stretching of piriformis muscle treatment for 3 days a week for 2 weeks | Other | Group B / Piriformis Muscle Stretching |
Primary outcome
Pain Reduction
Time frame: 2 weeks
Two different interventions were applied in groups after which pain was recorded before and after through visual analogue scale. Highest score means high level of pain and lower score refers to low pain. Maximum score 9 was reported pre study and minmum score 2 was reported after study by both groups on average.
Increase Range of Motion
Time frame: 2 weeks
Through neural mobilization and piriformis stretching renage of motion was assessed through inclino meter before and after study
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2025.
- Background: PubMed 37240853Othman IK, Raj NB, Siew Kuan C, Sidek S, Wong LS, Djearamane S, Loganathan A, Selvaraj S. Association of Piriformis Thickness, Hip Muscle Strength, and Low Back Pain Patients with and without Piriformis Syndrome in Malaysia. Life (Basel). 2023 May 18;13(5):1208. doi: 10.3390/life13051208.
- Background: PubMed 34099604Hu YE, Ho GWK, Tortland PD. Deep Gluteal Syndrome: A Pain in the Buttock. Curr Sports Med Rep. 2021 Jun 1;20(6):279-285. doi: 10.1249/JSR.0000000000000848.
- Background: PubMed 34049428Danazumi MS, Yakasai AM, Ibrahim AA, Shehu UT, Ibrahim SU. Effect of integrated neuromuscular inhibition technique compared with positional release technique in the management of piriformis syndrome. J Osteopath Med. 2021 May 31;121(8):693-703. doi: 10.1515/jom-2020-0327.
- Background: PubMed 29727344Burke CJ, Walter WR, Adler RS. Targeted Ultrasound-Guided Perineural Hydrodissection of the Sciatic Nerve for the Treatment of Piriformis Syndrome. Ultrasound Q. 2019 Jun;35(2):125-129. doi: 10.1097/RUQ.0000000000000360.
- Background: PubMed 32894238Shahzad M, Rafique N, Shakil-Ur-Rehman S, Ali Hussain S. Effects of ELDOA and post-facilitation stretching technique on pain and functional performance in patients with piriformis syndrome: A randomized controlled trial. J Back Musculoskelet Rehabil. 2020;33(6):983-988. doi: 10.3233/BMR-181290.
- Background: PubMed 36712711Ahmad Siraj S, Dadgal R. Physiotherapy for Piriformis Syndrome Using Sciatic Nerve Mobilization and Piriformis Release. Cureus. 2022 Dec 26;14(12):e32952. doi: 10.7759/cureus.32952. eCollection 2022 Dec.
- Results publication: PubMed 38410291Ankar P, Ratnani GR, Ramteke SU, Jaiswal PR. Effect of Neuromuscular Training and Neurodynamic Solutions for Asymptomatic Prolapsed Intervertebral Disc and Coexisting Piriformis Syndrome in a 19-Year-Old: A Comprehensive Case Report. Cureus. 2024 Jan 27;16(1):e53050. doi: 10.7759/cureus.53050. eCollection 2024 Jan.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No. Confidentiality
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Rabia Khan, Masters of Science principal investigator
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neural Mobilization and Stretching in people with Piriformis Syndrome, run by Bahria University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Reduction (time frame: 2 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06808659, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2025.