Tooth Extraction Status NosNCT06770166
The Effect of Chamomile on Healing After Tooth Extraction
A study testing Physiological serum mouthwash, Chlorhexidine mouthwash and Chamomile mouthwash in people with Tooth Extraction Status Nos, run by reyhan saglam-dogu at 1 site in Turkey (Türkiye).
Trial summary
After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Tooth Extraction Status Nos
- What is being tested?
- Physiological serum mouthwash, Chlorhexidine mouthwash and Chamomile mouthwash
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2025to 30 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- American Society of Anesthesiologists (ASA) physical status I patients,
- did not have the medical history of being allergic to local anesthesia
- did not have the medical history of being allergic to CHX,
- did not have acute infection at the tooth area
- absence of any pathology at the area.
Who cannot join
- Participants with medically compromised condition,
- pregnant females
- smokers
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istanbul Medipol University Dental School
Istanbul, Unkapani, 34083
About this study
Official title: The Effect of Chamomile on Healing After Tooth Extraction: a Randomized Controlled Trial
After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. The antibacterial and anti-inflammatory effects of warm chamomile tea have been reported in the literature. In addition, the neuroprotective, antiallergic, antioxidant, antiseptic and spasmolytic properties of chamomile have been reported. The aim was to compare the effects of these gargles in terms of pain, mouth opening, burning sensation in the mouth, edema, and discoloration of the tongue and teeth.
Read the detailed description
The study was planned to be applied to 120 patients, 40 in each group. In the ASA 1 group, the mouth opening of the patients was recorded before the tooth extraction procedure. Impacted teeth were extracted using Ultracain D-S Forte (Articaine HCl: 40mg/ml, Epinephrine HCl: 0.012 mg/ml) as a local anesthetic. Dental units were prepared under sterile conditions. The patients were covered with a sterile drape. The lower wisdom tooth was extracted with open (surgical) extraction. The mucoperisoteal flap was lifted with a number 15 surgical scalpel, and the tooth was extracted using round and fissure-tipped steel burs with a handpiece. After tooth extraction, if there was granulation tissue in the extraction socket, it was curetted and irrigated with physiological serum [sodium chloride: 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)]. After bleeding control, patients were given written and verbal postoperative advice. Antibiotics and analgesics were prescribed to patients, chlorhexidine gargle was recommended to 30 patients, saline gargle to 30 patients, and chamomile tea gargle to 30 patients. Patients were given VAS pain scores, numbered 0-10, to record for 7 days after extraction. Patients were called back to the clinic on the 2nd and 7th days after tooth extraction to assess pain, burning sensation and color change in the tongue, mouth opening, and edema. Sutures were removed on the 7th postoperative day.
- Conditions
- Tooth Extraction Status Nos
- Being tested
- Physiological serum mouthwash, Chlorhexidine mouthwash, Chamomile mouthwash
- Keywords
- chamomile, chlorhexidine, tooth extraction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Physiological serum mouthwashOther
Physiological serum contains sodium chloride : 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)].
Chlorhexidine mouthwashOther
Chlorhexidine mouthwash contains 0.12% chlorhexidine digluconate and 0.15% benzydamine hydrochloride.
Chamomile mouthwashOther
Chamomile mouthwash contains 10% chamomile in physiological serum.
| Study group | Role | What they receive |
|---|---|---|
| physiological serum mouthwash group (control group) | Active comparator | After extraction, 40 patients were given saline mouthwash to use for 7 days. Receives: Other: Physiological serum mouthwash |
| chlorhexidine mouthwash group | Active comparator | After extraction, 40 patients were given chlorhexidine mouthwash to use for 7 days. Receives: Other: Chlorhexidine mouthwash |
| chamomile mouthwash group | Active comparator | After extraction, 40 patients were given chamomile mouthwash to use for 7 days. Receives: Other: Chamomile mouthwash |
What is being measured
The primary outcome is the main question the study is designed to answer.
Patients pain value
visual analog scale (VAS) is used for pain assessment. The patient marked the pain value on the 0-10 visual analog scale.
Measured: The patient marked the pain value every day for one week.
maximum mouth opening
maximum mouth openin were measured with the reference of 11 and 41 teeth. are used for interincisal distances
Measured: maximum mouth opening was measured preoperatively, postoperative 3rd and 7th days.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jan 2025
- Study start1 Jan 2025
- Primary completion30 Dec 2025
- Study completion30 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth Extraction Status NosStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Model description
- A prospective randomized controlled clinical trial
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- reyhan saglam-dogu
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, reyhan saglam-dogu, Istanbul Medipol University Hospital
- Investigators
- reyhan saglam, PhD, Principal investigator, İstanbul Medipol university
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06770166
- Sponsor's protocol ID
- 10840098-604.01.01-21824
- Status last verified
- Aug 2026
- First submitted
- 6 Jan 2025
- Last updated
- 27 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Chamomile on Healing After Tooth Extraction: a Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT06770166
- Acronym / sponsor ID
- 10840098-604.01.01-21824
- Conditions
- Tooth Extraction Status Nos
- Keywords
- chamomile, chlorhexidine, tooth extraction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 120 participants (actual)
- Lead sponsor
- reyhan saglam-doguUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 30 Dec 2025 (actual)
- Study completion
- 30 Dec 2025 (actual)
- First posted
- 13 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. The antibacterial and anti-inflammatory effects of warm chamomile tea have been reported in the literature. In addition, the neuroprotective, antiallergic, antioxidant, antiseptic and spasmolytic properties of chamomile have been reported. The aim was to compare the effects of these gargles in terms of pain, mouth opening, burning sensation in the mouth, edema, and discoloration of the tongue and teeth.
Detailed description
The study was planned to be applied to 120 patients, 40 in each group. In the ASA 1 group, the mouth opening of the patients was recorded before the tooth extraction procedure. Impacted teeth were extracted using Ultracain D-S Forte (Articaine HCl: 40mg/ml, Epinephrine HCl: 0.012 mg/ml) as a local anesthetic. Dental units were prepared under sterile conditions. The patients were covered with a sterile drape. The lower wisdom tooth was extracted with open (surgical) extraction. The mucoperisoteal flap was lifted with a number 15 surgical scalpel, and the tooth was extracted using round and fissure-tipped steel burs with a handpiece. After tooth extraction, if there was granulation tissue in the extraction socket, it was curetted and irrigated with physiological serum [sodium chloride: 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)]. After bleeding control, patients were given written and verbal postoperative advice. Antibiotics and analgesics were prescribed to patients, chlorhexidine gargle was recommended to 30 patients, saline gargle to 30 patients, and chamomile tea gargle to 30 patients. Patients were given VAS pain scores, numbered 0-10, to record for 7 days after extraction. Patients were called back to the clinic on the 2nd and 7th days after tooth extraction to assess pain, burning sensation and color change in the tongue, mouth opening, and edema. Sutures were removed on the 7th postoperative day.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- A prospective randomized controlled clinical trial
| Arm | Type | Receives |
|---|---|---|
| physiological serum mouthwash group (control group) | Active comparator | Other: Physiological serum mouthwashAfter extraction, 40 patients were given saline mouthwash to use for 7 days. |
| chlorhexidine mouthwash group | Active comparator | Other: Chlorhexidine mouthwashAfter extraction, 40 patients were given chlorhexidine mouthwash to use for 7 days. |
| chamomile mouthwash group | Active comparator | Other: Chamomile mouthwashAfter extraction, 40 patients were given chamomile mouthwash to use for 7 days. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- American Society of Anesthesiologists (ASA) physical status I patients,
- did not have the medical history of being allergic to local anesthesia
- did not have the medical history of being allergic to CHX,
- did not have acute infection at the tooth area
- absence of any pathology at the area.
Key exclusion criteria (3 listed)
- Participants with medically compromised condition,
- pregnant females
- smokers
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Physiological serum mouthwashPhysiological serum contains sodium chloride : 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)]. | Other | physiological serum mouthwash group (control group) |
| Chlorhexidine mouthwashChlorhexidine mouthwash contains 0.12% chlorhexidine digluconate and 0.15% benzydamine hydrochloride. | Other | chlorhexidine mouthwash group |
| Chamomile mouthwashChamomile mouthwash contains 10% chamomile in physiological serum. | Other | chamomile mouthwash group |
Primary outcome
Patients pain value
Time frame: The patient marked the pain value every day for one week.
visual analog scale (VAS) is used for pain assessment. The patient marked the pain value on the 0-10 visual analog scale.
maximum mouth opening
Time frame: maximum mouth opening was measured preoperatively, postoperative 3rd and 7th days.
maximum mouth openin were measured with the reference of 11 and 41 teeth. are used for interincisal distances
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2026.
- Individual participant dataSharing planned: No
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Comparison of Piezoelectric and Conventional Surgery for Germectomy of the Lower Third Molar
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Adjunctive Use of Polynucleotide and Hyaluronic Acid-based Gel in Alveolar Preservation After Tooth Extraction
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
reyhan saglam, PhD principal investigator
İstanbul Medipol university
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Physiological serum mouthwash, Chlorhexidine mouthwash and Chamomile mouthwash in people with Tooth Extraction Status Nos, run by reyhan saglam-dogu at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Patients pain value (time frame: The patient marked the pain value every day for one week.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2026.