Alveolar Bone LossNCT07449806
Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zone
A study testing Immediate Implant Placement with Medpark S1 xenograft and Immediate Implant Placement with bio-Oss xenograft in people with Alveolar Bone Loss and Tooth Extraction Status Nos, run by Basma Gamal Mohamed Ahmed at 1 site in Egypt.
Trial summary
This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in the esthetic zone . Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Alveolar Bone Loss, Tooth Extraction Status Nos, Immediate Implant Placement
- What is being tested?
- Immediate Implant Placement with Medpark S1 xenograft and Immediate Implant Placement with bio-Oss xenograft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Sep 2025to 25 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Patients with one or more non-restorable teeth or remaining roots without signs of acute infection in the maxillary anterior region.
- Type II extraction sockets.
- Sufficient bone (>3 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥ 30 N cm).
- Good compliance.
Who cannot join
- Teeth with current acute periapical infection.
- Medically compromised patients.
- Heavy smokers (smoking of more than 10 cigarettes per day ).
- Alcohol or drug abuse.
- Patients undergoing chemotherapy and radiotherapy.
- Poor oral hygiene.
- Vulnerable groups (pregnant females and decision- impaired individual).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Faculty of Dentistry, Alexandria University, Egypt
Alexandria
Basma Gamal, BDS, +20 10 10231477, basmagamal816@gmail.com
About this study
Official title: Assessment of Labial Plate Thickness After Immediate Implant Placement in Type II Extraction Sockets Using Two Different Xenografts in the Esthetic Zone: a Randomized Controlled Clinical Trial
This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in the esthetic zone . Patients requiring extraction and immediate implant placement will be randomly allocated into two groups according to the xenograft material used for defect grafting. Clinical and radiographic outcomes will be assessed to determine dimensional bone changes and implant success
Read the detailed description
Immediate implant placement in the esthetic zone has become a predictable treatment modality aiming to reduce treatment time while preserving alveolar bone and soft tissue architecture. However, dimensional alterations of the labial bone plate remain a clinical concern, particularly in Type II extraction sockets.
The present randomized controlled clinical trial will compare the effect of two different xenograft materials and de-epithelialized free gingival graft used for defect grafting during immediate implant placement. Eligible patients indicated for tooth extraction and immediate implant placement will be randomly assigned into two parallel groups based on the grafting material used.
Clinical evaluation and standardized radiographic assessment using CBCT will be performed to measure labial plate thickness changes, peri-implant bone stability, and implant success outcomes over a defined follow-up period. The findings of this study aim to provide clinical evidence regarding the most effective xenograft material for preserving peri-implant hard tissue contours in the esthetic zone
- Being tested
- Immediate Implant Placement with Medpark S1 xenograft, Immediate Implant Placement with bio-Oss xenograft
- Keywords
- immediate implant placement, type II extraction socket, esthetic zone., xenograft, randomized controlled clinical trial
- Medical subject headings
- Alveolar Bone Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate Implant Placement with Medpark S1 xenograftProcedure or surgery
Immediate implant placement in Type II extraction sockets, with gap grafting using Medpark S1 xenograft .
Immediate Implant Placement with bio-Oss xenograftProcedure or surgery
Immediate implant placement in Type II extraction sockets, with gap grafting using bio-Oss xenograft
| Study group | Role | What they receive |
|---|---|---|
| Medpark S1 xenograft | Experimental | Patients undergoing immediate implant placement in Type II extraction sockets with defect grafting using Medpark S1 xenograft . Receives: Procedure: Immediate Implant Placement with Medpark S1 xenograft |
| bio-Oss xenograft | Experimental | Patients undergoing immediate implant placement in Type II extraction sockets with defect grafting using bio-Oss xenograft. Receives: Procedure: Immediate Implant Placement with bio-Oss xenograft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Labial Bone Plate Thickness Change
Dimensional changes of the labial alveolar bone plate will be measured using standardized CBCT images to assess the effectiveness of the two xenograft materials in preserving bone contour
Measured: 6 months post-implant placement
Secondary outcomes (1)
Peri-implant mucosal level (PML)
Intraoral scanning will be performed preoperative, immediate postoperative (baseline) and six months postoperatively. The 3D software will be used to align the baseline and six month models using the best-fit algorithm of the software to perfect the superimposition process. The superimposed models will be assessed using specific software, where the measurements will be performed to compare soft tissue outcomes between the two xenograft materials
Measured: 6 months post-implant placement
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Mar 2026
- Study start5 Sep 2025
- Primary completion5 May 2026 (estimated)
- Study completion25 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone LossStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 26 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Basma Gamal Mohamed Ahmed
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Basma Gamal Mohamed Ahmed, Alexandria University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07449806
- Sponsor's protocol ID
- 1077-05/2025
- Status last verified
- Mar 2026
- First submitted
- 27 Feb 2026
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: This study is a randomized clinical trial designed to evaluate labial bone plate preservation following immediate implant placement in Type II extraction sockets using two different xenograft materials in the esthetic zone. Eligible participants will be randomly assigned to one of two parallel groups based on the xenograft material used for gap grafting. Clinical and radiographic assessments will be conducted to monitor dimensional changes of the labial bone plate, peri-implant tissue health, and implant success over a six-month follow-up period. All procedures will be performed under standard clinical protocols at the Faculty of Dentistry, Alexandria University
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Labial Plate Thickness After Immediate Implant Placement in Type II Extraction Sockets Using Two Different Xenografts in the Esthetic Zone: a Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07449806
- Acronym / sponsor ID
- 1077-05/2025
- Keywords
- immediate implant placement, type II extraction socket, esthetic zone., xenograft, randomized controlled clinical trial
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 26 participants (estimated)
- Lead sponsor
- Basma Gamal Mohamed AhmedUniversity, hospital or other
- Study start
- 5 Sep 2025 (actual)
- Primary completion
- 5 May 2026 (estimated)
- Study completion
- 25 Sep 2026 (estimated)
- First posted
- 4 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in the esthetic zone . Patients requiring extraction and immediate implant placement will be randomly allocated into two groups according to the xenograft material used for defect grafting. Clinical and radiographic outcomes will be assessed to determine dimensional bone changes and implant success
Detailed description
Immediate implant placement in the esthetic zone has become a predictable treatment modality aiming to reduce treatment time while preserving alveolar bone and soft tissue architecture. However, dimensional alterations of the labial bone plate remain a clinical concern, particularly in Type II extraction sockets.
The present randomized controlled clinical trial will compare the effect of two different xenograft materials and de-epithelialized free gingival graft used for defect grafting during immediate implant placement. Eligible patients indicated for tooth extraction and immediate implant placement will be randomly assigned into two parallel groups based on the grafting material used.
Clinical evaluation and standardized radiographic assessment using CBCT will be performed to measure labial plate thickness changes, peri-implant bone stability, and implant success outcomes over a defined follow-up period. The findings of this study aim to provide clinical evidence regarding the most effective xenograft material for preserving peri-implant hard tissue contours in the esthetic zone
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Medpark S1 xenograft | Experimental | Procedure: Immediate Implant Placement with Medpark S1 xenograftPatients undergoing immediate implant placement in Type II extraction sockets with defect grafting using Medpark S1 xenograft . |
| bio-Oss xenograft | Experimental | Procedure: Immediate Implant Placement with bio-Oss xenograftPatients undergoing immediate implant placement in Type II extraction sockets with defect grafting using bio-Oss xenograft. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (4 listed)
- Patients with one or more non-restorable teeth or remaining roots without signs of acute infection in the maxillary anterior region.
- Type II extraction sockets.
- Sufficient bone (>3 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥ 30 N cm).
- Good compliance.
Key exclusion criteria (7 listed)
- Teeth with current acute periapical infection.
- Medically compromised patients.
- Heavy smokers (smoking of more than 10 cigarettes per day ).
- Alcohol or drug abuse.
- Patients undergoing chemotherapy and radiotherapy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate Implant Placement with Medpark S1 xenograftImmediate implant placement in Type II extraction sockets, with gap grafting using Medpark S1 xenograft . | Procedure or surgery | Medpark S1 xenograft |
| Immediate Implant Placement with bio-Oss xenograftImmediate implant placement in Type II extraction sockets, with gap grafting using bio-Oss xenograft | Procedure or surgery | bio-Oss xenograft |
Primary outcome
Labial Bone Plate Thickness Change
Time frame: 6 months post-implant placement
Dimensional changes of the labial alveolar bone plate will be measured using standardized CBCT images to assess the effectiveness of the two xenograft materials in preserving bone contour
1 secondary outcome
Peri-implant mucosal level (PML)
Time frame: 6 months post-implant placement
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Individual participant dataSharing planned: No. This study is a randomized clinical trial designed to evaluate labial bone plate preservation following immediate implant placement in Type II extraction sockets using two different xenograft materials in the esthetic zone. Eligible participants will be randomly assigned to one of two parallel groups based on the xenograft material used for gap grafting. Clinical and radiographic assessments will be conducted to monitor dimensional changes of the labial bone plate, peri-implant tissue health, and implant success over a six-month follow-up period. All procedures will be performed under standard clinical protocols at the Faculty of Dentistry, Alexandria University
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate Implant Placement with Medpark S1 xenograft and Immediate Implant Placement with bio-Oss xenograft in people with Alveolar Bone Loss and Tooth Extraction Status Nos, run by Basma Gamal Mohamed Ahmed at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Basma Gamal, BDS (+20 10 10231477, basmagamal816@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Labial Bone Plate Thickness Change (time frame: 6 months post-implant placement). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.