Mild Cognitive ImpairmentNCT06601751
Neurobic Exercise Program on Cognitive Abilities
A study testing Neurobic Exercise Program and Traditional Brain Exercise in people with Mild Cognitive Impairment, run by Riphah International University at 1 site in Pakistan.
Trial summary
This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Mild Cognitive Impairment
- What is being tested?
- Neurobic Exercise Program and Traditional Brain Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 sitePakistan
- Study dates
- 22 Sep 2024to 25 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Older adults above 60
- Both male and female.
- Scored <24 on the Montreal Cognitive Assessment (MoCA).
- Scored >12 on the Modified Barthel ADL index (BAI).
- Ability to write and read as well as communicate well, willingness to participate in the study throughout the program
Who cannot join
- Neurological, musculoskeletal, psychiatric conditions, hearing loss and visual impairment.
- Older adults with a history of allergies to the food or flowers used in the activities.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
ZUK old home and health care center, Ghulam Haider Road, House# I-546-547, 342, 343, Faiz Building St#5, Committee Chowk, Rawalpindi.
Rawalpindi, Punjab Province
About this study
Official title: Effects of Neurobic Exercise Program on Cognitive Abilities Among Older Adults With Mild Cognitive Impairment. A Randomised Controlled Trial.
This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life.
Read the detailed description
MCI is a condition marked by a noticeable decline in cognitive functions, it is often considered a precursor to more severe forms of dementia, making early intervention crucial. Neurobic exercises are designed to stimulate the brain through multiple senses and to create a novel thinking pattern. These exercises might include activities involving sight, smell, touch, taste, and hearing, structured over six weeks to challenge the brain with non-routine tasks that promote creative thinking and memory retention.
Neurobic exercise aims to maintain strength, flexibility, and mental health as you age.
However, most research has focused on older, healthy individuals or those with chronic conditions. Studies on elderly persons with MCI are rare, and there are limited studies on the long-term effects of improved memory function. This research aims to investigate the significance of a neurobic exercise program on cognitive abilities in older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life. The findings will give insight to physiotherapists and multidisciplinary teams to improve memory retention, delay brain deterioration, and promote memory health and quality of life, making the intervention program a valuable guide.
- Conditions
- Mild Cognitive Impairment
- Being tested
- Neurobic Exercise Program, Traditional Brain Exercise
- Keywords
- Cognitive impairment, Neurobic exercise, Memory, ADL
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neurobic Exercise ProgramOther
6 weeks to improve cognitive function, memory and overall brain health by introducing non-routine activities that require participants to utilise their multiple senses and remember sequences and patterns. Each activity would be performed 2-3 times/ session, for recalling the observation period set at 1 minute and at the end of the 9th week, the memory retention effect will be measured.
Traditional Brain ExerciseOther
activities like calculation or memory games. These exercises will be conducted in 2 days/week for 60-minute sessions in 6 weeks. The memory retention effect will be measured at the end of the 9th week. It is intended to be the baseline for comparing the effectiveness of a neurobic exercise program.
| Study group | Role | What they receive |
|---|---|---|
| Neurobic exercise program | Experimental | Neurobic exercise program + Traditional Brain Exercises Receives: Other: Neurobic Exercise Program |
| Traditional brain exercises | Active comparator | Traditional brain exercises calculation or memory games. Receives: Other: Traditional Brain Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
MOCA (Montreal Cognitive Assessment)
The MOCA is a popular screening tool used to determine if cognitive impairment is present. It takes approximately ten minutes to complete. It evaluates visuospatial skills, attention, language, abstract reasoning, delayed recall, executive function, and orientation. MoCA is scored out of 30. A cut-off score of 26 signifies mild cognitive impairment.
Measured: 9 weeks
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
It is used to measure subjective memory. This test measures the informant's perception of the older person's cognitive decline. Older adults are required to compare their performance today with their performance ten years ago. Informants were asked to indicate the change on a 16-item scale from 1 (much improved) to 5 (much worse).
The cut-off scores were based on the total score divided by the number of questions (average item score range 1- 5). Lower scores indicated better subjective memory performance.
Measured: 9 weeks
Common Object Memory Test (COMT)
It is used to measure objective memory. The COMT was designed to assess age related memory impairments in individuals with various educational, language, and cultural backgrounds. It included repeated presentations of colour photographs containing 10 common objects (button, chair, clock, comb, cup, key, knife, leaf, scissors and umbrella) and multiple opportunities for participants to recall and recognise the original list. The total COMT scores were summed across these three steps, and the possible range was 0-90. Higher scores indicated better objective memory performance.
Measured: 9 weeks
Secondary outcomes (1)
Modified Barthel ADL Index (BAI)
The Barthel Index for Activities of Daily Living is an ordinal scale used to measure a person\'s ability to perform ten common daily activities, including feeding, bathing, grooming, dressing, bowel and bladder control, toilet use, transfers (bed-to-chair), mobilityon level surfaces, and stair negotiation. A modified version by Collin and Wade uses a three-point scoring system (0 = unable, 1 = needs assistance, 2 = independent) with a total score ranging from 0 to 20. The assessment takes 2-5 minutes to complete.
Measured: 9 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2024
- Study start22 Sep 2024
- Primary completion25 May 2025
- Study completion25 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mild Cognitive ImpairmentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Dr.Aroosa Tariq, MS-NMPT, Principal investigator, RIPHAH INTERNATIONAL UNIVERSITY ISLAMABAD
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06601751
- Sponsor's protocol ID
- Memoona Awan
- Status last verified
- Jul 2025
- First submitted
- 16 Sep 2024
- Last updated
- 8 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Neurobic Exercise Program on Cognitive Abilities Among Older Adults With Mild Cognitive Impairment. A Randomised Controlled Trial.
- ClinicalTrials.gov ID
- NCT06601751
- Acronym / sponsor ID
- Memoona Awan
- Conditions
- Mild Cognitive Impairment
- Keywords
- Cognitive impairment, Neurobic exercise, Memory, ADL
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 22 Sep 2024 (actual)
- Primary completion
- 25 May 2025 (actual)
- Study completion
- 25 Jun 2025 (actual)
- First posted
- 19 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life.
Detailed description
MCI is a condition marked by a noticeable decline in cognitive functions, it is often considered a precursor to more severe forms of dementia, making early intervention crucial. Neurobic exercises are designed to stimulate the brain through multiple senses and to create a novel thinking pattern. These exercises might include activities involving sight, smell, touch, taste, and hearing, structured over six weeks to challenge the brain with non-routine tasks that promote creative thinking and memory retention.
Neurobic exercise aims to maintain strength, flexibility, and mental health as you age.
However, most research has focused on older, healthy individuals or those with chronic conditions. Studies on elderly persons with MCI are rare, and there are limited studies on the long-term effects of improved memory function. This research aims to investigate the significance of a neurobic exercise program on cognitive abilities in older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life. The findings will give insight to physiotherapists and multidisciplinary teams to improve memory retention, delay brain deterioration, and promote memory health and quality of life, making the intervention program a valuable guide.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Neurobic exercise program | Experimental | Other: Neurobic Exercise ProgramNeurobic exercise program + Traditional Brain Exercises |
| Traditional brain exercises | Active comparator | Other: Traditional Brain ExerciseTraditional brain exercises calculation or memory games. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Older adults above 60
- Both male and female.
- Scored <24 on the Montreal Cognitive Assessment (MoCA).
- Scored >12 on the Modified Barthel ADL index (BAI).
- Ability to write and read as well as communicate well, willingness to participate in the study throughout the program
Key exclusion criteria (2 listed)
- Neurological, musculoskeletal, psychiatric conditions, hearing loss and visual impairment.
- Older adults with a history of allergies to the food or flowers used in the activities.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neurobic Exercise Program6 weeks to improve cognitive function, memory and overall brain health by introducing non-routine activities that require participants to utilise their multiple senses and remember sequences and patterns. Each activity would be performed 2-3 times/ session, for recalling the observation period set at 1 minute and at the end of the 9th week, the memory retention effect will be measured. | Other | Neurobic exercise program |
| Traditional Brain Exerciseactivities like calculation or memory games. These exercises will be conducted in 2 days/week for 60-minute sessions in 6 weeks. The memory retention effect will be measured at the end of the 9th week. It is intended to be the baseline for comparing the effectiveness of a neurobic exercise program. | Other | Traditional brain exercises |
Primary outcome
MOCA (Montreal Cognitive Assessment)
Time frame: 9 weeks
The MOCA is a popular screening tool used to determine if cognitive impairment is present. It takes approximately ten minutes to complete. It evaluates visuospatial skills, attention, language, abstract reasoning, delayed recall, executive function, and orientation. MoCA is scored out of 30. A cut-off score of 26 signifies mild cognitive impairment.
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Time frame: 9 weeks
It is used to measure subjective memory. This test measures the informant's perception of the older person's cognitive decline. Older adults are required to compare their performance today with their performance ten years ago. Informants were asked to indicate the change on a 16-item scale from 1 (much improved) to 5 (much worse). The cut-off scores were based on the total score divided by the number of questions (average item score range 1- 5). Lower scores indicated better subjective memory performance.
Common Object Memory Test (COMT)
Time frame: 9 weeks
It is used to measure objective memory. The COMT was designed to assess age related memory impairments in individuals with various educational, language, and cultural backgrounds. It included repeated presentations of colour photographs containing 10 common objects (button, chair, clock, comb, cup, key, knife, leaf, scissors and umbrella) and multiple opportunities for participants to recall and recognise the original list. The total COMT scores were summed across these three steps, and the possible range was 0-90. Higher scores indicated better objective memory performance.
1 secondary outcome
Modified Barthel ADL Index (BAI)
Time frame: 9 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jul 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Dr.Aroosa Tariq, MS-NMPT principal investigator
RIPHAH INTERNATIONAL UNIVERSITY ISLAMABAD
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neurobic Exercise Program and Traditional Brain Exercise in people with Mild Cognitive Impairment, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
MOCA (Montreal Cognitive Assessment) (time frame: 9 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jul 2025.