StrokeNCT06458153
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
A study testing Neural responses to speech functional localizer, Neural responses to silent articulation and Neural responses to self vs. externally generated speech in people with Stroke and Cerebellum, run by University of Pittsburgh at 1 site in United States.
Trial summary
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Stroke, Cerebellum
- What is being tested?
- Neural responses to speech functional localizer, Neural responses to silent articulation and Neural responses to self vs. externally generated speech
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 27 May 2025to Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Cohort 1 (neurotypical adults):
- Age 18-49
- Right-handed
- Native English speaker
- Cohort 2 (people with cerebellar lesions):
- Age 18 or older
Show all 13Show fewer
- Right-handed
- Native English speaker
- History of cerebellar stroke
- Cohort 3 (controls matched to Cohort 2)
- Age 18 or older
- Right-handed
- Native English speaker
Who cannot join
- Cohort 1 (neurotypical adults):
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
Show all 32Show fewer
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Clinically diagnosed with or treated for a speech, language, or hearing disorder
- Head circumference greater than 60cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant
- Cohort 2 (people with cerebellar lesions):
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury other than stroke
- Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Head circumference greater than 60cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant
- Cohort 3 (controls matched to Cohort 2):
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Clinically diagnosed with or treated for a speech, language, or hearing disorder
- Head circumference greater than 60cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Alexander Ocampo, B.A. contact
United States1 site, 1 recruiting
- Recruiting
University of Pittsburgh
Pittsburgh, Pennsylvania, 15260
Jason Bohland, Ph.D., 412-383-3416, j.bohland@pitt.edu
Alexander Ocampo, BA, amo104@pitt.edu
About this study
Official title: High-resolution Functional Imaging of Speech-induced Sensory Modulation
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
- What regions of the brain's sensory systems show changes in their activity related to speech?
- To what extent do these regions help listeners detect and correct speech errors?
- What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Read the detailed description
This study aims to provide an integrated view of brain systems underlying predictive coding in speech with unprecedented detail using ultra-high field (7 Tesla) functional magnetic resonance imaging. The overall approach is a condition-intensive within-subjects design, with extensive sampling of individual participants, including a group who have had strokes impacting the cerebellum, across multiple sessions.
Participants will be asked to complete up to 6 sessions. Passing a hearing assessment using standard audiological procedures, conducted at the start of the first session, is a requirement for participation. The experimental sessions involve behavior and non-invasive brain imaging.
Investigators will ask participants to perform several short tasks to measure different aspects of their speech production and speech perception (e.g., reading passages or words aloud, making judgements about sounds).
In one session, Investigators will measure electroencephalography (EEG) while participants complete tasks involving producing and hearing speech sounds. Participants will be fitted with an elastic cap and up to 32 non-invasive recording electrodes.
In other sessions, investigators will measure structural and functional magnetic resonance imaging (fMRI). Structural images demonstrate the unique brain anatomy of the participant. Functional images will be obtained while the participant completes specific tasks involving listening, speaking, or completing other motor actions (e.g., pressing a button). All participants will be screened for MRI risk factors prior to each session.
- Conditions
- Stroke, Cerebellum
- Being tested
- Neural responses to speech functional localizer, Neural responses to silent articulation, Neural responses to self vs. externally generated speech, Event-related potentials for speech, Neural responses to induced speech errors
- Keywords
- fmri, speech production, cerebellum, auditory-motor integration, speech motor control, neuroimaging
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neural responses to speech functional localizerBehavioural
Measuring speech-related brain activity using fMRI during a speech listening task.
Neural responses to silent articulationBehavioural
Measuring speech-related brain activity using fMRI during a silent articulation task.
Neural responses to self vs. externally generated speechBehavioural
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
Event-related potentials for speechBehavioural
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
Neural responses to induced speech errorsBehavioural
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Neural responses to sensory-motor adaptationBehavioural
Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
Speech production behaviorsBehavioural
Behavioral measurements of speech during reading passages and words
Auditory acuity testingBehavioural
Measurements of auditory acuity during listening tasks.
Neural responses to learning a non-speech auditory motor behaviorBehavioural
Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
| Study group | Role | What they receive |
|---|---|---|
| Speech behavior and functional imaging | Experimental | Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions. Receives: Behavioral: Neural responses to speech functional localizer; Behavioral: Neural responses to silent articulation; Behavioral: Neural responses to self vs. externally generated speech; Behavioral: Event-related potentials for speech; Behavioral: Neural responses to induced speech errors; Behavioral: Neural responses to sensory-motor adaptation; Behavioral: Speech production behaviors; Behavioral: Auditory acuity testing; Behavioral: Neural responses to learning a non-speech auditory motor behavior |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features.
Measured: One session lasting 2-3 hours, within 12 months of enrollment
BOLD responses related to pre-speech auditory modulation
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses to auditory stimuli across conditions (e.g., SPEAK, REHEARSE, PLAN, SILENT).
Measured: One session lasting 2-3 hours, within 12 months of enrollment
EEG responses to self vs. externally generated speech
The dependent variables are evoked responses, aligned to sound onset, measured with EEG during task performance. We will contrast evoked responses across conditions (e.g., TALK, LISTEN).
Measured: One session lasting 2-3 hours, within 12 months of enrollment
BOLD responses to induced auditory errors
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will determine activations in regions of interest that correlate with applied perturbations during speech. We will also compare SPEAK vs. LISTEN activations in perturbed and unperturbed conditions.
Measured: One session lasting 2-3 hours, within 12 months of enrollment
BOLD responses during adaptation to auditory perturbations
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during the HOLD and BASELINE phases of the adaptation paradigm. We will determine areas where activation is associated with changes in formant frequencies in early and late windows in speech recordings.
Measured: One session lasting 2-3 hours, within 12 months of enrollment
BOLD responses during learning of non-speech auditory motor targets
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during PRESS trials across runs. We will contrast LISTEN vs. PRESS trials to measure motor induced sensory modulation.
Measured: One session lasting 2-3 hours, within 12 months of enrollment
Secondary outcomes (5)
BOLD responses to speech listening task
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations for the SPEECH vs. signal correlated noise (SCN) and SPEECH vs. SILENT conditions.
Measured: One session lasting 2-3 hours, within 12 months of enrollment
BOLD responses to silent articulation task
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations for silent articulation vs. a resting baseline condition.
Measured: One session lasting 2-3 hours, within 12 months of enrollment
Speech formant frequencies
We will measure participant-specific phonetic variables (formant frequencies) based on participant speech from reading passages and word production.
Measured: First session lasting 2-3 hours, within 12 months of enrollment
Spontaneous Speech Synchronization Index
We will measure the Spontaneous Speech Synchronization Index based on behavioral speech data.
Measured: First session lasting 2-3 hours, within 12 months of enrollment
Auditory acuity
We will measure auditory acuity (just noticeable difference) for changes in formant frequencies based on behavioral speech samples.
Measured: First session lasting 2-3 hours, within 12 months of enrollment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jun 2024
- Study start27 May 2025
- Primary completionJul 2028 (estimated)
- Study completionJul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by University of PittsburghThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- The single group model involves assessing the neural basis of multiple behavioral tasks in three cohorts. Cohort 1 is neurotypical adults. Cohort 2 is people with post-stroke cerebellar lesions. Cohort 3 is a group of control participants that will be matched to Cohort 2. The behavioral interventions are overlapping between cohorts, though Cohort 1 will complete additional sessions.
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Pittsburgh
- Sponsor type
- University, hospital or other
- Collaborators
- Northwestern University, National Institute on Deafness and Other Communication Disorders (NIDCD)
- Responsible party
- Principal investigator, Jason Bohland, University of Pittsburgh
- Investigators
- Jason W Bohland, Ph.D., Principal investigator, University of Pittsburgh
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06458153
- Sponsor's protocol ID
- STUDY23070083
- Other IDs
- 1R01DC020963-01A1
- Status last verified
- Jun 2026
- First submitted
- 3 Jun 2024
- Last updated
- 18 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The study will produce behavioral, audio, electroencephalography (EEG), and structural and functional magnetic resonance imaging (MRI) data. Data will be de-identified (MRI images will be defaced and all identifiers will be scrubbed) and made available for sharing at the individual level using community accepted formats for data and metadata.
Study at a glance
From the registry record, last updated by the sponsor on 18 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- High-resolution Functional Imaging of Speech-induced Sensory Modulation
- ClinicalTrials.gov ID
- NCT06458153
- Acronym / sponsor ID
- STUDY23070083
- Conditions
- Stroke, Cerebellum
- Keywords
- fmri, speech production, cerebellum, auditory-motor integration, speech motor control, neuroimaging
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- University of PittsburghUniversity, hospital or other
- Collaborators
- Northwestern University, National Institute on Deafness and Other Communication Disorders (NIDCD)
- Study start
- 27 May 2025 (actual)
- Primary completion
- Jul 2028 (estimated)
- Study completion
- Jul 2028 (estimated)
- First posted
- 13 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
- What regions of the brain's sensory systems show changes in their activity related to speech?
- To what extent do these regions help listeners detect and correct speech errors?
- What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Detailed description
This study aims to provide an integrated view of brain systems underlying predictive coding in speech with unprecedented detail using ultra-high field (7 Tesla) functional magnetic resonance imaging. The overall approach is a condition-intensive within-subjects design, with extensive sampling of individual participants, including a group who have had strokes impacting the cerebellum, across multiple sessions.
Participants will be asked to complete up to 6 sessions. Passing a hearing assessment using standard audiological procedures, conducted at the start of the first session, is a requirement for participation. The experimental sessions involve behavior and non-invasive brain imaging.
Investigators will ask participants to perform several short tasks to measure different aspects of their speech production and speech perception (e.g., reading passages or words aloud, making judgements about sounds).
In one session, Investigators will measure electroencephalography (EEG) while participants complete tasks involving producing and hearing speech sounds. Participants will be fitted with an elastic cap and up to 32 non-invasive recording electrodes.
In other sessions, investigators will measure structural and functional magnetic resonance imaging (fMRI). Structural images demonstrate the unique brain anatomy of the participant. Functional images will be obtained while the participant completes specific tasks involving listening, speaking, or completing other motor actions (e.g., pressing a button). All participants will be screened for MRI risk factors prior to each session.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- The single group model involves assessing the neural basis of multiple behavioral tasks in three cohorts. Cohort 1 is neurotypical adults. Cohort 2 is people with post-stroke cerebellar lesions. Cohort 3 is a group of control participants that will be matched to Cohort 2. The behavioral interventions are overlapping between cohorts, though Cohort 1 will complete additional sessions.
| Arm | Type | Receives |
|---|---|---|
| Speech behavior and functional imaging | Experimental | Behavioral: Neural responses to speech functional localizer, Behavioral: Neural responses to silent articulation, Behavioral: Neural responses to self vs. externally generated speech, Behavioral: Event-related potentials for speech, Behavioral: Neural responses to induced speech errors, Behavioral: Neural responses to sensory-motor adaptation, Behavioral: Speech production behaviors, Behavioral: Auditory acuity testing, Behavioral: Neural responses to learning a non-speech auditory motor behaviorAssessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- Age 18-49
- Right-handed
- Native English speaker
- Age 18 or older
- Right-handed
Key exclusion criteria (32 listed)
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neural responses to speech functional localizerMeasuring speech-related brain activity using fMRI during a speech listening task. | Behavioural | Speech behavior and functional imaging |
| Neural responses to silent articulationMeasuring speech-related brain activity using fMRI during a silent articulation task. | Behavioural | Speech behavior and functional imaging |
| Neural responses to self vs. externally generated speechMeasuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech. | Behavioural | Speech behavior and functional imaging |
| Event-related potentials for speechMeasuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech | Behavioural | Speech behavior and functional imaging |
| Neural responses to induced speech errorsMeasuring speech-related brain activity using fMRI during conditions that induce auditory speech errors. | Behavioural | Speech behavior and functional imaging |
| Neural responses to sensory-motor adaptationMeasuring brain activity using fMRI during a learning task with sustained altered auditory feedback. | Behavioural | Speech behavior and functional imaging |
| Speech production behaviorsBehavioral measurements of speech during reading passages and words | Behavioural | Speech behavior and functional imaging |
| Auditory acuity testingMeasurements of auditory acuity during listening tasks. | Behavioural | Speech behavior and functional imaging |
| Neural responses to learning a non-speech auditory motor behaviorMapping of brain areas using fMRI during learning of non-speech sound-evoking movements. | Behavioural | Speech behavior and functional imaging |
Primary outcome
Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features.
BOLD responses related to pre-speech auditory modulation
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses to auditory stimuli across conditions (e.g., SPEAK, REHEARSE, PLAN, SILENT).
EEG responses to self vs. externally generated speech
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables are evoked responses, aligned to sound onset, measured with EEG during task performance. We will contrast evoked responses across conditions (e.g., TALK, LISTEN).
BOLD responses to induced auditory errors
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will determine activations in regions of interest that correlate with applied perturbations during speech. We will also compare SPEAK vs. LISTEN activations in perturbed and unperturbed conditions.
BOLD responses during adaptation to auditory perturbations
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during the HOLD and BASELINE phases of the adaptation paradigm. We will determine areas where activation is associated with changes in formant frequencies in early and late windows in speech recordings.
BOLD responses during learning of non-speech auditory motor targets
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during PRESS trials across runs. We will contrast LISTEN vs. PRESS trials to measure motor induced sensory modulation.
5 secondary outcomes
BOLD responses to speech listening task
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
BOLD responses to silent articulation task
Time frame: One session lasting 2-3 hours, within 12 months of enrollment
Speech formant frequencies
Time frame: First session lasting 2-3 hours, within 12 months of enrollment
Spontaneous Speech Synchronization Index
Time frame: First session lasting 2-3 hours, within 12 months of enrollment
Auditory acuity
Time frame: First session lasting 2-3 hours, within 12 months of enrollment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jun 2026.
- Individual participant dataSharing planned: Yes. The study will produce behavioral, audio, electroencephalography (EEG), and structural and functional magnetic resonance imaging (MRI) data. Data will be de-identified (MRI images will be defaced and all identifiers will be scrubbed) and made available for sharing at the individual level using community accepted formats for data and metadata.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Alexander Ocampo, B.A. contact
Jason W Bohland, Ph.D. principal investigator
University of Pittsburgh
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neural responses to speech functional localizer, Neural responses to silent articulation and Neural responses to self vs. externally generated speech in people with Stroke and Cerebellum, run by University of Pittsburgh at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 32 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 18 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jason W Bohland, Ph.D. (412-383-3416, j.bohland@pitt.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech (time frame: One session lasting 2-3 hours, within 12 months of enrollment). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jun 2026.