Auditory PerceptionCOMPRESSEDNCT06264245
Users of Remote Conferencing and Compression of Sound Dynamics : Auditory Effects
An observational study of Auditory Perception, run by Institut Pasteur at 2 sites in 2 countries.
Trial summary
The COMPRESSED project is a descriptive, bi-centric and non-invasive study carried out by the CERIAH - IDA - Institut Pasteur and the Haute École Léonard de Vinci in Brussels on volunteer participants identified in two groups : be subject to high exposure to compressed sound, as defined by professional participation… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Auditory Perception
- What is being tested?
- Audiological profile, Hearing self-assessments and Objective and subjective audiological tests
- How many people
- 200 participants
- Where
- 2 sitesin 2 countries
- Study dates
- 1 Jun 2024to 15 Jan 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Subjects with sustained exposure to compressed sounds, as defined by professional participation in broadcast platform events using sound signal processing systems, over the last 3 years, Or Subjects with moderate or limited exposure to compressed and manipulated sound, equivalent to that of a student taking distance-learning courses on a videoconferencing platform, alternating with other face-to-face courses, with the possibility of pauses in listening, exposed for a maximum of 2 years.
Who may be able to join
- For all participants:
- Age 18 or over,
- Work with platforms using sound signal processing systems,
- Fluent in English,
- Fluent in French,
- Declare that they have no hearing loss.
Show all 10Show fewer
- For participants in the high exposure group:
- Have had a professional activity over the last three years using broadcasting platforms with sound signal processing systems,
- For participants in the moderate or limited exposure group:
- Have worked between one semester and two years with platforms using sound signal processing systems.
Who cannot join
- Conductive or mixed hearing loss, i.e. where the hearing loss affects both the outer and/or middle ear and the inner ear.
- Have an asymmetric hearing loss, i.e. a difference in average hearing loss between the left and right ear of more than 20 dB,
- Have a history of otitis and/or an ENT disease that permanently affects hearing (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis),
- Not fluent in English
- Be under guardianship,
- Deprived of liberty by judicial or administrative decision, or subject to legal protection.
Trial locations and contacts
2 sites in 2 countries. Contact the study team or a site near you to ask about taking part.
2 sites in 2 countries
Belgium1 site, 1 recruiting
- Not yet recruiting
Haute Ecole Léonard De Vinci
Brussels
Patrick Vereheyden, MD, + 32 2 793 41 43, Patrick.Verheyden@vinci.be
France1 site, 1 recruiting
- Recruiting
CEntre de Recherche et d'Innovation en Audiologie Humaine
Paris, 75015
Paul Avan, MD
About this study
The COMPRESSED project is a descriptive, bi-centric and non-invasive study carried out by the CERIAH - IDA - Institut Pasteur and the Haute École Léonard de Vinci in Brussels on volunteer participants identified in two groups :
- be subject to high exposure to compressed sound, as defined by professional participation in events on broadcast platforms using sound signal processing systems, over the last 3 years,
- be subject to moderate or limited exposure to compressed and manipulated sound, equivalent to that of a student following certain distance learning courses. on a videoconferencing platform, alternating with other face-to-face courses, with the ability to listen during breaks, which have been taught for a maximum of 2 years.
The main objective of the COMPRESSED study is to evaluate the auditory effects of exposure to manipulated sounds (compression, filtering, equalisation, accentuation, etc.) from sound distribution platforms on the auditory system of participants who are regularly exposed to these sounds as a result of their professional activity.
- Conditions
- Auditory Perception
- Being tested
- Audiological profile, Hearing self-assessments, Objective and subjective audiological tests, Self-assessment of exposure sound quality
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Audiological profileOther
Video otoscopy Tympanometry High-frequency tonal audiometry
Hearing self-assessmentsOther
Hearing skills questionnaire Subjective assessment of tinnitus using a visual analogue scale Self-questionnaire on the impact of tinnitus Hyperacusis self-questionnaire
Objective and subjective audiological testsOther
Acoustic Omission Measurement of the stapedial reflex by tympanometry High-frequency tonal audiometry - exposed ear only Speech audiometry in noise Tinnitus and subjective discomfort thresholds Psychoacoustic intensity perception test
Self-assessment of exposure sound qualityOther
A self-assessment of the sound quality of the manipulated sounds heard during the exhibition will be carried out during the second follow-up visit. The elements on which the participant will be asked to make a qualitative judgement will relate to intelligibility difficulties or not; background noise (these two items in the form of a mark between 0 and 10); the clear, muffled or shrill nature of the sounds, their resonant or saturated side.
| Study group | Role | What they receive |
|---|---|---|
| High exposure to compressed sound | Not described Receives: Other: Audiological profile; Other: Hearing self-assessments; Other: Objective and subjective audiological tests; Other: Self-assessment of exposure sound quality | |
| Moderate or limited exposure to compressed sound | Not described Receives: Other: Audiological profile; Other: Hearing self-assessments; Other: Objective and subjective audiological tests; Other: Self-assessment of exposure sound quality |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hearing assessments of participants exposed to manipulated sounds after and before exposure
Measurement of the difference between the hearing assessments of participants exposed to manipulated sounds after and before exposure
Measured: 2 weeks
Secondary outcomes (5)
Audiometric thresholds in pure tone from 125 to 8000 Hz in the subject's exposed ear before and approximately one hour after exposure,
Measurement of the difference between audiometric thresholds in pure tone from 125 to 8000 Hz in the subject's exposed ear before and approximately one hour after exposure,
Measured: 2 weeks
Difference between the threshold of the protective reflex of the auditory pathways (middle ear muscles) measured by impedancemetry in the exposed ear when a contralateral noise is presented for a few seconds.
A contralateral noise is a low-pass filtered white noise with a cut-off at 3 kHz.
Measured: 2 weeks
Levels of otoemissions in acoustic distortion products in the exposed ear in response to pure tone sound stimuli
Comparison of the levels of otoemissions in acoustic distortion products in the exposed ear in response to pure tone sound stimuli at 65 dB SPL around 1, 2, 3 and 4 kHz, before and approximately one hour after exposure.
Measured: 2 weeks
Tinnitus or auditory distortion (hyperacusis) reported by participants before and after exposure.
Measurement of the difference in the perception of tinnitus or auditory distortion (hyperacusis) reported by participants before and after exposure.
Measured: 2 weeks
Effectiveness of the protective auditory reflexes (or acoustic reflexes), obtained by impedancemetry and derived from the reading of the otoemissions for each participant.
Measurement of the difference of the effectiveness of the protective auditory reflexes (or acoustic reflexes), obtained by impedancemetry and derived from the reading of the otoemissions for each participant.
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Feb 2024
- Study start1 Jun 2024
- Primary completion15 Jan 2026 (estimated)
- Study completion15 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Auditory PerceptionStudies of the same condition, open and under way.
- More trials run by Institut PasteurThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Institut Pasteur
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Institut de l'Audition
- Responsible party
- Sponsor
- Investigators
- Paul Avan, MD, Principal investigator, CERIAH
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06264245
- Sponsor's protocol ID
- 2022-126
- Other IDs
- 2023-A00985-40
- Acronym
- COMPRESSED
- Status last verified
- Feb 2025
- First submitted
- 29 Jan 2024
- Last updated
- 3 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Users of Remote Conferencing and Compression of Sound Dynamics : Auditory Effects
- ClinicalTrials.gov ID
- NCT06264245
- Acronym / sponsor ID
- COMPRESSED / 2022-126
- Conditions
- Auditory Perception
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Institut PasteurIndustry (pharma, biotech, devices)
- Collaborators
- Institut de l'Audition
- Study start
- 1 Jun 2024 (actual)
- Primary completion
- 15 Jan 2026 (estimated)
- Study completion
- 15 Jan 2026 (estimated)
- First posted
- 16 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The COMPRESSED project is a descriptive, bi-centric and non-invasive study carried out by the CERIAH - IDA - Institut Pasteur and the Haute École Léonard de Vinci in Brussels on volunteer participants identified in two groups :
- be subject to high exposure to compressed sound, as defined by professional participation in events on broadcast platforms using sound signal processing systems, over the last 3 years,
- be subject to moderate or limited exposure to compressed and manipulated sound, equivalent to that of a student following certain distance learning courses. on a videoconferencing platform, alternating with other face-to-face courses, with the ability to listen during breaks, which have been taught for a maximum of 2 years.
The main objective of the COMPRESSED study is to evaluate the auditory effects of exposure to manipulated sounds (compression, filtering, equalisation, accentuation, etc.) from sound distribution platforms on the auditory system of participants who are regularly exposed to these sounds as a result of their professional activity.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High exposure to compressed sound | – | Other: Audiological profile, Other: Hearing self-assessments, Other: Objective and subjective audiological tests, Other: Self-assessment of exposure sound quality |
| Moderate or limited exposure to compressed sound | – | Other: Audiological profile, Other: Hearing self-assessments, Other: Objective and subjective audiological tests, Other: Self-assessment of exposure sound quality |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Subjects with sustained exposure to compressed sounds, as defined by professional participation in broadcast platform events using sound signal processing systems, over the last 3 years, Or Subjects with moderate or limited exposure to compressed and manipulated sound, equivalent to that of a student taking distance-learning courses on a videoconferencing platform, alternating with other face-to-face courses, with the possibility of pauses in listening, exposed for a maximum of 2 years.
Key inclusion criteria (10 listed)
- Age 18 or over,
- Work with platforms using sound signal processing systems,
- Fluent in English,
- Fluent in French,
- Declare that they have no hearing loss.
Key exclusion criteria (6 listed)
- Conductive or mixed hearing loss, i.e. where the hearing loss affects both the outer and/or middle ear and the inner ear.
- Have an asymmetric hearing loss, i.e. a difference in average hearing loss between the left and right ear of more than 20 dB,
- Have a history of otitis and/or an ENT disease that permanently affects hearing (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis),
- Not fluent in English
- Be under guardianship,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Audiological profileVideo otoscopy Tympanometry High-frequency tonal audiometry | Other | High exposure to compressed sound, Moderate or limited exposure to compressed sound |
| Hearing self-assessmentsHearing skills questionnaire Subjective assessment of tinnitus using a visual analogue scale Self-questionnaire on the impact of tinnitus Hyperacusis self-questionnaire | Other | High exposure to compressed sound, Moderate or limited exposure to compressed sound |
| Objective and subjective audiological testsAcoustic Omission Measurement of the stapedial reflex by tympanometry High-frequency tonal audiometry - exposed ear only Speech audiometry in noise Tinnitus and subjective discomfort thresholds Psychoacoustic intensity perception test | Other | High exposure to compressed sound, Moderate or limited exposure to compressed sound |
| Self-assessment of exposure sound qualityA self-assessment of the sound quality of the manipulated sounds heard during the exhibition will be carried out during the second follow-up visit. The elements on which the participant will be asked to make a qualitative judgement will relate to intelligibility difficulties or not; background noise (these two items in the form of a mark between 0 and 10); the clear, muffled or shrill nature of the sounds, their resonant or saturated side. | Other | High exposure to compressed sound, Moderate or limited exposure to compressed sound |
Primary outcome
Hearing assessments of participants exposed to manipulated sounds after and before exposure
Time frame: 2 weeks
Measurement of the difference between the hearing assessments of participants exposed to manipulated sounds after and before exposure
5 secondary outcomes
Audiometric thresholds in pure tone from 125 to 8000 Hz in the subject's exposed ear before and approximately one hour after exposure,
Time frame: 2 weeks
Difference between the threshold of the protective reflex of the auditory pathways (middle ear muscles) measured by impedancemetry in the exposed ear when a contralateral noise is presented for a few seconds.
Time frame: 2 weeks
Levels of otoemissions in acoustic distortion products in the exposed ear in response to pure tone sound stimuli
Time frame: 2 weeks
Tinnitus or auditory distortion (hyperacusis) reported by participants before and after exposure.
Time frame: 2 weeks
Effectiveness of the protective auditory reflexes (or acoustic reflexes), obtained by impedancemetry and derived from the reading of the otoemissions for each participant.
Time frame: 2 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Mar 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Paul Avan, MD principal investigator
CERIAH
2 sites in 2 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Auditory Perception, run by Institut Pasteur at 2 sites in 2 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Belgium, France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Céline Quinsac, PhD (+33 (0)1 76 53 50 29, celine.quinsac@pasteur.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hearing assessments of participants exposed to manipulated sounds after and before exposure (time frame: 2 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2025.