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Anterior Knee Pain SyndromeAKPS NPRS FPINCT05917080

Efficacy of Neuromuscular Training and Manual Therapy With Augmented Low-Dye Taping Technique for Correction of Pronated Foot in the Management of Anterior Knee Pain

A study testing Manual Therapy in people with Anterior Knee Pain Syndrome and Pronated Foot, run by Mediclinic Al Noor Hospital at 1 site in United Arab Emirates.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Official record
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Trial summary

The goal of this clinical trial] is to To find out the effect of Neuromuscular Training and Manual therapy with Augmented Low - Dye Taping technique for correction of Pronated foot in the management of Anterior knee pain patients. Read more about this study

Who is it for?
Ages 18 to 35 yearsHealthy volunteers can take part
Conditions the study is for
Anterior Knee Pain Syndrome, Pronated Foot
What is being tested?
Manual Therapy
Could I receive a placebo?
No, everyone receives an active treatment
How many people
60 participants
Where
1 siteUnited Arab Emirates
Study dates
15 Jun 2023to 30 Jun 2025
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 35 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Age - 18 to 35 years
  • Sex - both males \& females
  • Clinically diagnosed patient of PFPS with Pronated foot
  • Anterior or posterior pain in the knee area lasting for more than 12 weeks
  • Excessive calcaneal eversion measured at 6° in the relaxed posture
  • Score of between three and seven points on the numerical pain rating in activities of daily living Kujala Scale Point 40 \& Above

Who cannot join

  • A history of diagnosis of meniscus or joint injury \& knee joint surgery
  • Taking nonsteroidal anti-inflammatory drugs or corticosteroids within 24 hrs before the test
  • History of brain injury or vestibular disorder within the last 6 months
  • Positive sign of Patellar Apprehension test
  • Congenital or traumatic deformity
  • Allergic reactions to taping
Show all 11Show fewer
  • Concomitant diagnosis of pre patellar bursitis or tendonitis
  • knee Ligamentous injury or laxity
  • Plica syndrome \& Osgood Schlatter's disease
  • Malignancy \& Skin Infection
  • Pregnant woman or lactating women.

Trial locations and contacts

1 site in 1 country.

Albert Anand.U, MPT contact

971 501224393

albertmpt@gmail.com

United Arab Emirates1 site, 1 recruiting
  • Mediclinic Al Noor Hospital

    Abu Dhabi, 46713

    Dr.Rakshinda Mujeeb, +971 4 512 2730, MCME-ResearchOffice@mediclinic.ae

    Recruiting

Other trials in United Arab Emirates

About this study

The goal of this clinical trial] is to To find out the effect of Neuromuscular Training and Manual therapy with Augmented Low - Dye Taping technique for correction of Pronated foot in the management of Anterior knee pain patients. The main question[s] it aims to answer are:

  • Is there any Kinematic association of biomechanical risk factors between anterior knee pain \& pronated foot?
  • Is there any potential impact of therapeutic foot interventions for correction of Pronated foot in the management of anterior knee pain?
Read the detailed description

Patellofemoral pain syndrome (PFPS) is one of the most prevalent musculoskeletal injuries seen by physiotherapists and sport medicine practitioners. The PFPS occurs in 17% of male and 33% of female knee pathology. The pain is usually aggravated by activities involving patellofemoral compressive forces such as remaining in the sitting position with the knees flexed for long periods of time (movie goers sign). Patellofemoral pain syndrome (PFPS) is an important clinical problem and the most prevalent disorder of the knee.

The etiology of PFPS is not fully understood and may consist of multiple factors including lower leg and foot malalignment. Patella femoral pain syndrome (PFPS) may arise from abnormal muscular and biomechanical factors that alter tracking of the patella within the femoral trochlear notch contributing to increased patellofemoral contact pressures that result in pain and dysfunction.

Excessive foot pronation during gait is frequently linked to patellofemoral pain syndrome (PFPS) development, due a proposed coupling of increased foot pronation with increased tibial and femoral internal rotation. This excessive pronation can result in increased soft tissue stress and changes in overall lower limb alignment, often predisposing the individual in question to injury of the lower extremity. Excessive rear foot pronation therefore may lead to abnormal tibia internal rotation which could possibly translate to greater stress on the knee structure, altering patella tracking. Excessive pronation of the subtalar joint particularly is thought to lead to patellofemoral disorders. The excessive subtalar joint pronation may delay external rotation of the leg, and therefore will inhibit supination of the foot. Physiotherapy consisted of a combined therapy approach that has proved efficacious in patellofemoral pain syndrome. Physical therapy is the mainstay in non-operative treatment.

Joint proprioceptors have historically been considered "limit detectors", stimulated at the extremes of joint range-of-motion (ROM). Joint proprioceptors provide input throughout a joint's entire ROM under both low and high load conditions stimulating strong discharges from the muscle spindle and are thus vital for joint stability.

The augmented low-Dye (ALD) is a taping technique frequently used by clinicians in the management of lower limb musculoskeletal pain and injury. A recent review of the literature concluded that ALD tape produces a biomechanical effect, specifically by increasing medial longitudinal arch height, reducing calcaneal eversion and tibial internal rotation, reducing medial forefoot pressures and increasing lateral midfoot pressures during standing, walking and jogging. The LD taping technique aims to reduce excessive pronation by creating an external supinating force medial to the subtalar joint axis, namely at the medial plantar surface of the foot.

Patients with plantar heel pain treated with the manual therapy demonstrated complete pain relief and full return to activities. Manual therapy helps in bringing back the malalignment of the foot and correcting foot problems which intern reduces the heel pain.

The Aim of the study is to find out the effect of Neuromuscular Training and Manual therapy with Augmented Low - Dye Taping technique for correction of Pronated foot in the management of Anterior knee pain. The previously available studies are mainly limited to foot orthoses \& focused on the knee joint interventions. There is a lack of research related to therapeutic interventions for the foot, an intrinsic risk factor, can address the fundamental component of anterior knee pain.

The Novelty of Study is to the find out potential impact of therapeutic foot interventions for correction of Pronated foot in the management of anterior knee pain.

The Objectives of the study is followed below

  • To find out the association of biomechanical risk factors between Anterior knee pain \& pronated foot.
  • To find out the effect of Manual therapy with Augmented Low- Dye taping technique on the selective outcome parameters.
  • To find out the effect of Neuromuscular Training with Augmented Low- Dye taping technique on the selective outcome parameters.
  • To compare the effect of Manual therapy and Neuromuscular Training with Augmented Low- Dye taping technique on the selective outcome parameters.

Null Hypothesis:

  • There is no significant improvement in the pain and functional Limitations, following Manual therapy \& Neuro muscular training with Augmented Low - Dye Taping technique for correction of Pronated foot in the management of Anterior knee pain.

Alternative Hypothesis:

  • There is a significant improvement in the pain and functional Limitations, following Manual therapy \& Neuro muscular training with Augmented Low - Dye Taping technique for correction of Pronated foot in the management of Anterior knee pain.
Being tested
Manual Therapy
Keywords
Anterior Knee pain, Pronated foot, Manual therapy, Neuro muscular exercise, low dye taping, Foot Posture index, Numerical pain rating scale, dynamic Knee valgus angle, Kujala Scale
Medical subject headings
Patellofemoral Pain Syndrome

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Manual TherapyOther

    Also called Neuromuscular Training Anti-Pronation Low- Dye Taping Technique Intrinsic Foot Muscles Exercises Calf Muscle & Plantar Fascia Stretching VMO Strengthening

    Manual Therapy: Manual therapy is the use of hands-on techniques to evaluate, treat, and improve the status of Neuro-musculoskeletal conditions.

    Augmented Low-Dye Taping: Augmented Low-Dye taping is designed to off-load the plantar fascia \& applied below the ankle and is hypothesised to generate a supinating force that controls the amount of pronation at the subtalar joint.

    Neuromuscular Exercises: Neuromuscular training could be defined as training enhancing unconscious motor responses by stimulating both afferent signals and central mechanisms responsible for dynamic joint control.

    Strengthening Exercises:The strengthening of the muscles promotes better overall functioning of the foot and thereby can help to take some of the tension out of the fascia.

    Stretching exercises:Static stretching is defined as passively stretching a given muscle-tendon unit by slowly placing it maximal position of stretch and sustaining it there for an extended period of time.

Study groups in NCT05917080
Study groupRoleWhat they receive
Group A (Experimental Group)ExperimentalManual Therapy Technique Anti-Pronation Low- Dye Taping Technique Intrinsic Foot Muscles Exercises Calf Muscle \& Plantar Fascia Stretching VMO Strengthening
Receives: Other: Manual Therapy
Group B (Experimental Group)ExperimentalNeuromuscular Training Anti-Pronation Low- Dye Taping Technique Intrinsic Foot Muscles Exercises Calf Muscle \& Plantar Fascia Stretching VMO Strengthening
Receives: Other: Manual Therapy
Group C (Control Group)OtherIntrinsic Foot Muscles Exercises Calf Muscle \& Plantar Fascia Stretching VMO Strengthening
Receives: Other: Manual Therapy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. AKPS (Kujala Scale)

    Anterior knee pain scale - measuring Functional Limitations, The AKPS contains 13 items self reported questionnaires. The AKPS graded on Scale of "0 to 100" with 100 being the highest possible score. lower scores reflect the greater pain \& disability.

    Measured: 6 months

  2. FPI

    Foot Posture index - Analyzing the Foot posture - The FPI-6 is a novel method of rating foot posture using set criteria and a simple scale, and is a quick, reliable diagnostic tool. neutral foot posture are graded as zero, while Pronated postures are given a positive value, the higher the value the more pronated. For a neutral foot the final FPI aggregate score should lie somewhere around zero.

    Measured: 6 months

  3. NPRS

    Numerical Pain rating Scale-Measuring the pain. The Numeric Pain Rating Scale (NPRS) (an outcome measure) that is a unidimensional measure of pain intensity in adults. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable").

    Measured: 6 months

  4. DVI

    Dynamic Valgus Index -Measuring the Dynamic knee valgus angulation. Two dimensional motion analysis of lower extremity movement typically focuses on the knee frontal plane projection angle, which considers the position of the femur and the tibia. A measure that includes the pelvis may provide a more comprehensive and accurate indicator of lower extremity movement. Dynamic knee valgus two-dimensional angular measures. 1a. Hip frontal plane projection angle, calculated as 90 ° minus the angle (α) between the pelvis segment and the thigh segment. Knee frontal plane projection angle, calculated as 180 ° minus the angle (β) between the thigh segment and the shank segment. 1b. Example of individual demonstrating an observable dynamic knee valgus, resulting in increased hip and knee frontal plane projection angles and a larger dynamic valgus index.

    Measured: 6 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted23 Jun 2023
  2. Study start15 Jun 2023
  3. Primary completion30 Jun 2024 (estimated)
  4. Study completion30 Jun 2025 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Biomechanical Relationship of pronated foot \& Anterior knee pain
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
60 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05917080
Sponsor's protocol ID
MCME.CR.310.MNOO.2023
Acronym
AKPS NPRS FPI
Status last verified
Jun 2023
First submitted
15 Jun 2023
Last updated
27 Jun 2023
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Anand Udhaya Kumar A, Ramalingam V, Rajendran V. Foot-Targeted Rehabilitation for Pronation-Related Anterior Knee Pain: A Two-Phase Case-Control Study and Single-Blind Randomized Controlled Trial of Manual Therapy Versus Neuromuscular Training Each With Augmented Low-Dye Taping. Physiother Res Int. 2026 Oct;31(4):e70318. doi: 10.1002/pri.70318.

    PubMed 42603849

Questions about this trial

What is this clinical trial studying?

A study testing Manual Therapy in people with Anterior Knee Pain Syndrome and Pronated Foot, run by Mediclinic Al Noor Hospital at 1 site in United Arab Emirates.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: status not confirmed, as of the sponsor's last update on 27 Jun 2023. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United Arab Emirates. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

Contact Albert Anand.U, MPT (971 501224393, albertmpt@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

AKPS (Kujala Scale) (time frame: 6 months). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05917080, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jun 2023; AzTrials last refreshed its copy on 7 Nov 2026.

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