Chronic Non-specific Low Back PainNCT05832918
Effects of Core Stability Exercises and Cognitive Tasks on Chronic Non-specific Back Pain
A study testing exercise therapy in people with Chronic Non-specific Low Back Pain, run by Iran University of Medical Sciences at 1 site in Iran.
Trial summary
This randomized control trial study aims to compare the effect of core stability exercises and cognitive tasks with general exercises and cognitive tasks on pain, disability, and postural control strategies of chronic non-specific low back pain patients. The main questions are: 1. Read more about this study
- Who is it for?
- Ages 18 to 55 years
- Conditions the study is for
- Chronic Non-specific Low Back Pain
- What is being tested?
- exercise therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 siteIran
- Study dates
- 2 May 2023to 15 Dec 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Orthopedist-confirmed diagnosis of chronic nonspecific low back pain that has lasted at least three months since its onset.
- Pain score of 3 or more on a visual analog scale.
- Pain during quiet standing.
- Cognitive level above 24 based on mini-mental state examination (MMSE).
Who cannot join
- Radicular pain and any neurological signs.
- Uncorrected vision impairment.
- Hearing problems.
- Vestibular dysfunctions.
- Cognitive deficit.
- Previous spinal surgery.
- Severe deformity or injury to the lower extremities.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Iran1 site, 1 recruiting
- Recruiting
Iran University of Medical Sciences
Tehran, Iran (the Islamic Republic Of), 1449614535
Reza Salehi, Associate Professor, 0098212222059, Salehi.re@iums.ac.ir
Zeinab Raoufi, PhD candidate, 0098212222059, zraoofi93@gmail.com
About this study
Official title: Effects of Core Stability Exercises and Cognitive Tasks Compared to General Exercises and Cognitive Tasks on Chronic Non-specific Back Pain
This randomized control trial study aims to compare the effect of core stability exercises and cognitive tasks with general exercises and cognitive tasks on pain, disability, and postural control strategies of chronic non-specific low back pain patients. The main questions are:
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the pain of chronic non-specific low back pain patients?
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the disability of chronic non-specific low back pain patients?
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving postural stability parameters of chronic non-specific low back pain patients?
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving stabilogram diffusion analysis parameters of chronic non-specific low back pain patients? This study is designed to apply two exercise protocols on two groups of 17 people with non-specific back pain. Group A will receive core stability exercises along with cognitive tasks, and group B will receive general exercises along with cognitive tasks.
Read the detailed description
Patients will be aged between 18-50 years. All patients meeting the inclusion criteria will receive 16 training sessions (thrice a week). The primary outcome measure will be pain and disability. Secondary outcome measures will be postural control strategies (including postural control stability and stabilogram diffusion analysis), quality of life, fear of movement, and fear-avoidance beliefs that will be assessed before and after training sessions and at 3-month follow-up; only primary outcomes will be evaluated in each group.
- Conditions
- Chronic Non-specific Low Back Pain
- Being tested
- exercise therapy
- Keywords
- Low back pain, Disability, Postural control, Core Stability Exercise, cognitive task
- Medical subject headings
- Low Back Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
exercise therapyOther
Exercise therapy is one of the rehabilitation methods that is defined as a regimen or plan of physical activities designed and prescribed to facilitate the patient's recovery from diseases and any conditions which disturb their movement and activity of daily life or maintain a state of well-being through neuro re-education, gait training, and therapeutic exercises.
| Study group | Role | What they receive |
|---|---|---|
| core stability exercises with cognitive tasks group | Experimental | This research will use core stability exercises to strengthen local muscles (transversus abdominis and multifidus) based on the training program provided by Shamsi et al., which is modified from the exercise program of Koumantakis et al.. Participants will be treated for six weeks, three sessions a week, and 16 sessions.
We will also combine stabilization exercises with cognitive tasks. Receives: Other: exercise therapy |
| general exercises with cognitive tasks group | Active comparator | This research will use general exercises to strengthen global muscles (abdominal flexor muscles and back extensor muscles) based on the training program provided by Shamsi et al.(110), which is modified by Koumantakis et al.. Participants will be treated for six weeks, three sessions a week, and 16 sessions.
We will also combine general exercises with cognitive tasks. Receives: Other: exercise therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Oswestry Disability Index
Questionnaire evaluating the level of disability. Total score range from 0-100 (higher scores mean more disability)
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks ", "change from baseline at three months "
Secondary outcomes (11)
Center of pressure (COP) sway range for anteroposterior (AP range)
AP range is one kind of COP displacement evaluation method characterized as traditional linear measures for evaluating postural control stability.
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
COP sway range for mediolateral (MA range)
MA range is one kind of COP displacement evaluation method characterized as traditional linear measures for evaluating postural control stability.
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
COP sway velocity
COP sway velocity is one kind of COP displacement evaluation method characterized as traditional linear measures for evaluating postural control stability.
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Sway area
Sway area is one kind of COP displacement evaluation method characterized as traditional linear measures for evaluating postural control stability.
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Short-term diffusion coefficient of stabilogram diffusion plot
The short-term diffusion coefficient is the slope of the open-loop part of the stabilogram diffusion plot, indicating stochastic activity in open loop control phase in a quiet standing position.
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Long-term diffusion coefficient of stabilogram diffusion plot
The long-term diffusion coefficient is the slope of the close loop part of the stabilogram diffusion plot, indicating stochastic activity in the immediate loop control phase in the quiet standing position.
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Critical point coordinates.
Critical point coordinates are the estimated values of the time intervals and mean square displacements defining the stabilogram-diffusion critical points (the point that open-loop control changed to close loop control)
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
12-item short form health survey
Questionnaire evaluating the quality of life. Total score range from 0-100 (higher scores mean better quality of life)
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Tampa scale for kinesiophobia
Questionnaire evaluating the kinesiophobia because of feeling re-injury. Total score range from 17-68 (higher scores mean more kinesiophobia)
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Fear-avoidance beliefs questionnaire
Questionnaire evaluating fear of pain and consequent avoidance of physical activity because of their fear. Total score range from 0-66 (higher scores mean more fear of pain)
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Visual analog scale
Questionnaire evaluating pain intensity. Total score range from 0-10 (higher scores mean more pain)
Measured: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks ", "change from baseline at three months "
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Apr 2023
- Study start2 May 2023
- Primary completion30 Nov 2025 (estimated)
- Study completion15 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (35)Papers the sponsor has linked to this study.
- Other trials for Chronic Non-specific Low Back PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 48 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Iran University of Medical Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Reza Salehi, Iran University of Medical Sciences
- Investigators
- Zeinab Raoufi, PhD student, Principal investigator, Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical SciencesReza Salehi, PhD, Study director, Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05832918
- Sponsor's protocol ID
- IUMS
- Status last verified
- May 2025
- First submitted
- 31 Mar 2023
- Last updated
- 7 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Frizziero A, Pellizzon G, Vittadini F, Bigliardi D, Costantino C. Efficacy of Core Stability in Non-Specific Chronic Low Back Pain. J Funct Morphol Kinesiol. 2021 Apr 22;6(2):37. doi: 10.3390/jfmk6020037.
PubMed 33922389Agnus Tom A, Rajkumar E, John R, Joshua George A. Determinants of quality of life in individuals with chronic low back pain: a systematic review. Health Psychol Behav Med. 2022 Jan 5;10(1):124-144. doi: 10.1080/21642850.2021.2022487. eCollection 2022.
PubMed 35003902van Tulder M, Becker A, Bekkering T, Breen A, del Real MT, Hutchinson A, Koes B, Laerum E, Malmivaara A; COST B13 Working Group on Guidelines for the Management of Acute Low Back Pain in Primary Care. Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J. 2006 Mar;15 Suppl 2(Suppl 2):S169-91. doi: 10.1007/s00586-006-1071-2. No abstract available.
PubMed 16550447Lamoth CJ, Stins JF, Pont M, Kerckhoff F, Beek PJ. Effects of attention on the control of locomotion in individuals with chronic low back pain. J Neuroeng Rehabil. 2008 Apr 25;5:13. doi: 10.1186/1743-0003-5-13.
PubMed 18439264Kanekar N, Aruin AS. Aging and balance control in response to external perturbations: role of anticipatory and compensatory postural mechanisms. Age (Dordr). 2014 Jun;36(3):9621. doi: 10.1007/s11357-014-9621-8. Epub 2014 Feb 16.
PubMed 24532389Hodges PW, Richardson CA. Inefficient muscular stabilization of the lumbar spine associated with low back pain. A motor control evaluation of transversus abdominis. Spine (Phila Pa 1976). 1996 Nov 15;21(22):2640-50. doi: 10.1097/00007632-199611150-00014.
PubMed 8961451Bussey MD, Aldabe D, Shemmell J, Jowett T. Anticipatory postural control differs between low back pain and pelvic girdle pain patients in the absence of visual feedback. Hum Mov Sci. 2020 Feb;69:102529. doi: 10.1016/j.humov.2019.102529. Epub 2019 Nov 11.
PubMed 31726292Hodges PW. Changes in motor planning of feedforward postural responses of the trunk muscles in low back pain. Exp Brain Res. 2001 Nov;141(2):261-6. doi: 10.1007/s002210100873.
PubMed 11713638Mitchell SL, Collins JJ, De Luca CJ, Burrows A, Lipsitz LA. Open-loop and closed-loop postural control mechanisms in Parkinson's disease: increased mediolateral activity during quiet standing. Neurosci Lett. 1995 Sep 8;197(2):133-6. doi: 10.1016/0304-3940(95)11924-l.
PubMed 8552278Collins JJ, De Luca CJ. Open-loop and closed-loop control of posture: a random-walk analysis of center-of-pressure trajectories. Exp Brain Res. 1993;95(2):308-18. doi: 10.1007/BF00229788.
PubMed 8224055Collins JJ, De Luca CJ, Burrows A, Lipsitz LA. Age-related changes in open-loop and closed-loop postural control mechanisms. Exp Brain Res. 1995;104(3):480-92. doi: 10.1007/BF00231982.
PubMed 7589299Wong JJ, Cote P, Sutton DA, Randhawa K, Yu H, Varatharajan S, Goldgrub R, Nordin M, Gross DP, Shearer HM, Carroll LJ, Stern PJ, Ameis A, Southerst D, Mior S, Stupar M, Varatharajan T, Taylor-Vaisey A. Clinical practice guidelines for the noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Eur J Pain. 2017 Feb;21(2):201-216. doi: 10.1002/ejp.931. Epub 2016 Oct 6.
PubMed 27712027Owen PJ, Miller CT, Mundell NL, Verswijveren SJJM, Tagliaferri SD, Brisby H, Bowe SJ, Belavy DL. Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis. Br J Sports Med. 2020 Nov;54(21):1279-1287. doi: 10.1136/bjsports-2019-100886. Epub 2019 Oct 30.
PubMed 31666220Koumantakis GA, Watson PJ, Oldham JA. Trunk muscle stabilization training plus general exercise versus general exercise only: randomized controlled trial of patients with recurrent low back pain. Phys Ther. 2005 Mar;85(3):209-25.
PubMed 15733046Hlaing SS, Puntumetakul R, Khine EE, Boucaut R. Effects of core stabilization exercise and strengthening exercise on proprioception, balance, muscle thickness and pain related outcomes in patients with subacute nonspecific low back pain: a randomized controlled trial. BMC Musculoskelet Disord. 2021 Nov 30;22(1):998. doi: 10.1186/s12891-021-04858-6.
PubMed 34847915
Study at a glance
From the registry record, last updated by the sponsor on 7 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Core Stability Exercises and Cognitive Tasks Compared to General Exercises and Cognitive Tasks on Chronic Non-specific Back Pain
- ClinicalTrials.gov ID
- NCT05832918
- Acronym / sponsor ID
- IUMS
- Conditions
- Chronic Non-specific Low Back Pain
- Keywords
- Low back pain, Disability, Postural control, Core Stability Exercise, cognitive task
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 48 participants (estimated)
- Lead sponsor
- Iran University of Medical SciencesUniversity, hospital or other
- Study start
- 2 May 2023 (actual)
- Primary completion
- 30 Nov 2025 (estimated)
- Study completion
- 15 Dec 2025 (estimated)
- First posted
- 27 Apr 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized control trial study aims to compare the effect of core stability exercises and cognitive tasks with general exercises and cognitive tasks on pain, disability, and postural control strategies of chronic non-specific low back pain patients. The main questions are:
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the pain of chronic non-specific low back pain patients?
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the disability of chronic non-specific low back pain patients?
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving postural stability parameters of chronic non-specific low back pain patients?
- Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving stabilogram diffusion analysis parameters of chronic non-specific low back pain patients? This study is designed to apply two exercise protocols on two groups of 17 people with non-specific back pain. Group A will receive core stability exercises along with cognitive tasks, and group B will receive general exercises along with cognitive tasks.
Detailed description
Patients will be aged between 18-50 years. All patients meeting the inclusion criteria will receive 16 training sessions (thrice a week). The primary outcome measure will be pain and disability. Secondary outcome measures will be postural control strategies (including postural control stability and stabilogram diffusion analysis), quality of life, fear of movement, and fear-avoidance beliefs that will be assessed before and after training sessions and at 3-month follow-up; only primary outcomes will be evaluated in each group.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| core stability exercises with cognitive tasks group | Experimental | Other: exercise therapyThis research will use core stability exercises to strengthen local muscles (transversus abdominis and multifidus) based on the training program provided by Shamsi et al., which is modified from the exercise program of Koumantakis et al.. Participants will be treated for six weeks, three sessions a week, and 16 sessions. We will also combine stabilization exercises with cognitive tasks. |
| general exercises with cognitive tasks group | Active comparator | Other: exercise therapyThis research will use general exercises to strengthen global muscles (abdominal flexor muscles and back extensor muscles) based on the training program provided by Shamsi et al.(110), which is modified by Koumantakis et al.. Participants will be treated for six weeks, three sessions a week, and 16 sessions. We will also combine general exercises with cognitive tasks. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Orthopedist-confirmed diagnosis of chronic nonspecific low back pain that has lasted at least three months since its onset.
- Pain score of 3 or more on a visual analog scale.
- Pain during quiet standing.
- Cognitive level above 24 based on mini-mental state examination (MMSE).
Key exclusion criteria (7 listed)
- Radicular pain and any neurological signs.
- Uncorrected vision impairment.
- Hearing problems.
- Vestibular dysfunctions.
- Cognitive deficit.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| exercise therapyExercise therapy is one of the rehabilitation methods that is defined as a regimen or plan of physical activities designed and prescribed to facilitate the patient's recovery from diseases and any conditions which disturb their movement and activity of daily life or maintain a state of well-being through neuro re-education, gait training, and therapeutic exercises. | Other | core stability exercises with cognitive tasks group, general exercises with cognitive tasks group |
Primary outcome
Oswestry Disability Index
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks ", "change from baseline at three months "
Questionnaire evaluating the level of disability. Total score range from 0-100 (higher scores mean more disability)
11 secondary outcomes
Center of pressure (COP) sway range for anteroposterior (AP range)
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
COP sway range for mediolateral (MA range)
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
COP sway velocity
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Sway area
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Short-term diffusion coefficient of stabilogram diffusion plot
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Long-term diffusion coefficient of stabilogram diffusion plot
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Critical point coordinates.
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
12-item short form health survey
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Tampa scale for kinesiophobia
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Fear-avoidance beliefs questionnaire
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks "
Visual analog scale
Time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks ", "change from baseline at three months "
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 May 2025.
- Background: PubMed 33922389Frizziero A, Pellizzon G, Vittadini F, Bigliardi D, Costantino C. Efficacy of Core Stability in Non-Specific Chronic Low Back Pain. J Funct Morphol Kinesiol. 2021 Apr 22;6(2):37. doi: 10.3390/jfmk6020037.
- Background: PubMed 35003902Agnus Tom A, Rajkumar E, John R, Joshua George A. Determinants of quality of life in individuals with chronic low back pain: a systematic review. Health Psychol Behav Med. 2022 Jan 5;10(1):124-144. doi: 10.1080/21642850.2021.2022487. eCollection 2022.
- Background: PubMed 16550447van Tulder M, Becker A, Bekkering T, Breen A, del Real MT, Hutchinson A, Koes B, Laerum E, Malmivaara A; COST B13 Working Group on Guidelines for the Management of Acute Low Back Pain in Primary Care. Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J. 2006 Mar;15 Suppl 2(Suppl 2):S169-91. doi: 10.1007/s00586-006-1071-2. No abstract available.
- Background: PubMed 18439264Lamoth CJ, Stins JF, Pont M, Kerckhoff F, Beek PJ. Effects of attention on the control of locomotion in individuals with chronic low back pain. J Neuroeng Rehabil. 2008 Apr 25;5:13. doi: 10.1186/1743-0003-5-13.
- Background: PubMed 24532389Kanekar N, Aruin AS. Aging and balance control in response to external perturbations: role of anticipatory and compensatory postural mechanisms. Age (Dordr). 2014 Jun;36(3):9621. doi: 10.1007/s11357-014-9621-8. Epub 2014 Feb 16.
- Background: PubMed 8961451Hodges PW, Richardson CA. Inefficient muscular stabilization of the lumbar spine associated with low back pain. A motor control evaluation of transversus abdominis. Spine (Phila Pa 1976). 1996 Nov 15;21(22):2640-50. doi: 10.1097/00007632-199611150-00014.
- Background: PubMed 31726292Bussey MD, Aldabe D, Shemmell J, Jowett T. Anticipatory postural control differs between low back pain and pelvic girdle pain patients in the absence of visual feedback. Hum Mov Sci. 2020 Feb;69:102529. doi: 10.1016/j.humov.2019.102529. Epub 2019 Nov 11.
- Background: PubMed 11713638Hodges PW. Changes in motor planning of feedforward postural responses of the trunk muscles in low back pain. Exp Brain Res. 2001 Nov;141(2):261-6. doi: 10.1007/s002210100873.
- Background: PubMed 8552278Mitchell SL, Collins JJ, De Luca CJ, Burrows A, Lipsitz LA. Open-loop and closed-loop postural control mechanisms in Parkinson's disease: increased mediolateral activity during quiet standing. Neurosci Lett. 1995 Sep 8;197(2):133-6. doi: 10.1016/0304-3940(95)11924-l.
- Background: PubMed 8224055Collins JJ, De Luca CJ. Open-loop and closed-loop control of posture: a random-walk analysis of center-of-pressure trajectories. Exp Brain Res. 1993;95(2):308-18. doi: 10.1007/BF00229788.
- Background: PubMed 7589299Collins JJ, De Luca CJ, Burrows A, Lipsitz LA. Age-related changes in open-loop and closed-loop postural control mechanisms. Exp Brain Res. 1995;104(3):480-92. doi: 10.1007/BF00231982.
- Background: PubMed 27712027Wong JJ, Cote P, Sutton DA, Randhawa K, Yu H, Varatharajan S, Goldgrub R, Nordin M, Gross DP, Shearer HM, Carroll LJ, Stern PJ, Ameis A, Southerst D, Mior S, Stupar M, Varatharajan T, Taylor-Vaisey A. Clinical practice guidelines for the noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Eur J Pain. 2017 Feb;21(2):201-216. doi: 10.1002/ejp.931. Epub 2016 Oct 6.
- Efficacy of Core Stability in Non-Specific Chronic Low Back PainLink provided by the sponsor.
- Determinants of quality of life in individuals with chronic low back pain: a systematic reviewLink provided by the sponsor.
- Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary careLink provided by the sponsor.
- Effects of attention on the control of locomotion in individuals with chronic low back painLink provided by the sponsor.
- Compensatory but not anticipatory adjustments are altered in older adults during lateral postural perturbationsLink provided by the sponsor.
- Aging and balance control in response to external perturbations: role of anticipatory and compensatory postural mechanismsLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Zeinab Raoufi, PhD student principal investigator
Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences
Reza Salehi, PhD study director
Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing exercise therapy in people with Chronic Non-specific Low Back Pain, run by Iran University of Medical Sciences at 1 site in Iran.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Iran. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zeinab Raoufi (00982122222059, zraoofi93@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Oswestry Disability Index (time frame: "Baseline (pre-intervention)", "change from baseline immediately after the intervention at five weeks ", "change from baseline at three months "). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05832918, which also lists 35 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 May 2025.