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Chronic Non-Specific Low Back PainNCT07920991

Effects of 3-dimensional Versus Dynamic Myofascial Release Techniques With Lumbar Mobilization and Exercise Therapy Program in Chronic Non-specific Low Back Pain.

A study testing 3 Dimensional Myofascial Release, Dynamic Myofascial Release and Lumbar Mobilization in people with Chronic Non-Specific Low Back Pain and Myofascial Release, run by Riphah International University at 1 site in Pakistan.

Enrolling by invitation

Enrolling by invitation. The study team selects and invites participants, usually from an existing group of patients.

Sites and contacts
Official record
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Trial summary

Ninety percent of cases of LBP are nonspecific, which means they do not have an obvious reason like an infection or tumor. Pain that spreads from the thoracic spine to the gluteal area and upper leg is a common sign. Pain that lasts 12 weeks or more is classified as chronic. Read more about this study

Who is it for?
Ages 20 to 40 years
What is being tested?
3 Dimensional Myofascial Release, Dynamic Myofascial Release and Lumbar Mobilization
Could I receive a placebo?
No, everyone receives an active treatment
How many people
52 participants
Where
1 sitePakistan
Study dates
10 Sep 2026to 10 Nov 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 40 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age 20 - 40 years
  • Both genders
  • LBP onset from > 12 weeks
  • Back pain localized between T12 and the gluteal fold
  • Pain provoked by movement or prolonged posture
  • SLR and slump tests: Negative; manual lumbar distraction: Positive
Show all 9Show fewer
  • Pain intensity ≥ 3 on the Numerical Pain Rating Scale
  • Lumbar flexion < 65°, lumbar extension < 31°, lateral flexion < 30°, and rotation < 15.3°
  • The patient must have >40% ODI score.

Who cannot join

  • Cognitive impairment
  • Individuals with recent fractures or surgeries in the spine or lower limbs
  • Limb length discrepancy
  • Long-term medications like corticosteroids and painkillers affecting musculoskeletal symptoms
  • Ongoing physiotherapy or chiropractic treatment
  • Participants with lumbar or lower limb neurological defects
Show all 10Show fewer
  • Patients with specific low back pain
  • Pregnant women
  • Systemic inflammatory disease
  • Those with severe cardiovascular conditions

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Pakistan1 site
  • Multazam Health Care

    Lahore, Punjab Province, 54000

Other trials in Pakistan

About this study

Official title: Effects of 3-Dimensional Versus Dynamic Myofascial Release Techniques With Lumbar Mobilization and Exercise Therapy Program in Chronic Non-Specific Low Back Pain.

Ninety percent of cases of LBP are nonspecific, which means they do not have an obvious reason like an infection or tumor. Pain that spreads from the thoracic spine to the gluteal area and upper leg is a common sign. Pain that lasts 12 weeks or more is classified as chronic. Non-specific low back pain (NSLBP) is marked by limits in facet joints, increased myofascial thickness, and lower lumbar flexibility, which can lead to further dysfunction. 3D-MFR works on fascia in three planes (sagittal, frontal, and transverse) to remove multidirectional limitations, mostly guided by the therapist. In contrast, DMFR is an active method that combines fascial release and joint mobilization, requiring the therapist to perform movements while the patient continually breathes in a synchronized pattern throughout therapy. While the therapeutic effects of MFR have been extensively studied, but dynamic technique - that is MFR in conjunction with joint mobilization and 3 dimensional myofascial release - that is fascia movements in three plane (sagittal, frontal and transverse) have received less attention. This two-arm randomized controlled trial will compare 3 dimensional and dynamic myofascial release in adults aged 20 to 40 years with CNSLBP. Participants will randomly allocated into two groups. Group A will receive 3 Dimensional myofascial release while group B will receive Dynamic myofascial release. Both groups also receive lumbar mobilization and exercise therapy program as the standard protocol for three sessions/week over four weeks. Outcomes will include pain intensity (NPRS), range of motion (Goniometer) and functional disability (ODI).

Read the detailed description

Low back, lumbosacral, sacroiliac, and hip areas are the primary expression of low back pain (LBP), a set of pain disorders that commonly accompany leg discomfort, numbness, and weakness. The primary areas impacted are the lumbosacral joints, muscles, tendons, ligaments, fascia, and intervertebral discs. It is becoming a common condition in orthopedics and rehabilitation and a major public health concern. The likelihood of an ongoing disability course is increased by psychosocial distress, inadequate coping mechanisms, and a significant baseline disability. Ninety percent of cases of LBP are nonspecific, which means they do not have an obvious reason like an infection or tumor. Pain that spreads from the thoracic spine to the gluteal area and upper leg is a common sign. Pain that lasts 12 weeks or more is classified as chronic. Findings from a study that 79% of men and 89% of women with CLBP could not be diagnosed in a general practice setting led to the term ''nonspecific low back pain.'' Non-specific low back pain (NSLBP) is marked by limits in facet joints, increased myofascial thickness, and lower lumbar flexibility, which can lead to further dysfunction. People with either sudden or prolonged lower back pain need to be informed and supervised to sustain an active lifestyle. Pharmaceuticals (such as NSAIDs, Muscle Relaxant and Opioids) are indicated as second-line therapies for chronic LBP, following education, exercise (Pilates and Mckenze) and behavioral therapy. Long periods of standing or walking, heavy lifting, an unhealthy lifestyle, psychological variables and a history of LBP are all risk factors for nonspecific episodes. Physiotherapy provides a variety of back pain treatments including manual therapy, posture instruction and exercises. Movements that promote balanced activation and develop lumbar-supporting muscles include core stabilization exercises such as abdominal bracing, bridging and pelvic tilts. Tight hip flexors, lower back muscles and chest are the focus of stretching exercises. Manual therapy techniques such as myofascial release, joint mobilization and soft tissue massage relieve tension, remove limitations and enhance alignment. In everyday tasks, postural education emphasizes body mechanics and ergonomics concepts. Biomechanics, exercises, manual approaches and increased postural awareness are the cornerstones of holistic approach. Mobilization is a passive and slow rhythmic movement performed on symptomatic or hypomobile vertebrae. Posterior-anterior vertebral mobilization (PAVM), an important manual treatment technique, corrects misalignment, increases muscle strength, mobility, and flexibility, and aids in pain management via neural pathways. Manual passive stretching to increase muscular flexibility, strengthening exercises to boost core and spinal support, and lumbar stabilization activities to improve spinal stability and lower the likelihood of repeated discomfort are all potential components of a workout regimen for low back pain. The body's essential tissue network fascia is made up of both superficial and deep layers. Fascia, extensive layers of fibrous tissue, interconnects all body connective tissues, both contractile and non-contractile, supporting structural stability while allowing essential movement under normal conditions. Any restriction in the fascia can cause pain, stiffness, and limited ROM. The TLF is a multilayered aponeurotic structure with a diamond shape that divides the posterior abdominal wall muscles from the paraspinal muscles. The erector spinae muscles are covered by its posterior layer, which is controlled by the latissimus dorsi muscle insertion. Studies have highlighted TLF's nociceptive potential, which is caused by a sizable percentage of nociceptors and is consistent with innervation by both A and C fibers. Shearing action between TLF and erector spinae muscle's epimysium is reduced in LBP patient that are linked by decrease in TLF's elasticity, stiffening and sliding mobility which might lead to inflammation, proprioceptor dysfunction, micro-injuries and nociceptor sensitization. It is essential to understand the connection between back muscle function and TLF deformation during shoulder, scapula, thoracic spine, lumber spine, pelvic, and hip movements. Due to the abundance of free and capsulate nerve terminals, including Pacini's and Ruffini's corpuscles, TLF is one of the primary causes of the rise in non-specific LBP. The lumbopelvic fascia plays a significant role in NSLBP via mechanisms such as fibrosis and inflammation. Effective treatments may include resolving fascial dysfunctions, strengthening local stabilizers such as the transversus abdominis and multifidus, and controlling global mobilizers such as the erector spinae, in addition to pharmaceutical, alternative, and traditional therapy. Since the early days of osteopathy, myofascial release has been used as an osteopathic soft tissue stretching technique. It is defined as 'the facilitation of mechanical, neural and psychophysiological adaptive potential as interfaced via the myofascial system'. Persistent low back pain is mostly produced by myofascial discomfort . MFR techniques reduce pain, increase lumbar ROM, improve shortness of the lumbar myofascial tissue and posture, regain connective tissue elasticity and mechanical characteristics while minimizing muscle knots, boost flexibility along with fascial glide, speed up recovery, and ease symptoms in people with CNSLBP. The MFR Manual by Manheim lays out the fundamental ideas of 3 Dimensional Myofascial Release (3D-MFR) of John F. Barnes (PT) who was the first to widely educate that fascia is not a series of isolated linear bands and emphasizes the significance of seeing the fascia as a continuous, 3D network stretching from head to toe. Fascial limitations that span many planes of motion are the focus of 3D-MFR. It is especially helpful for myofascial pain syndrome, postural abnormalities, movement limitation after surgery, accident or immobilization, chronic neck and back pain. Its absolute contraindications are acute/active infection, fracture, cancer, deep vein thrombosis and open wounds. Relative contraindications that require precautions are osteoporosis, bleeding disorders, severe cardiopulmonary conditions and psychological distress. The therapist thoroughly assesses the patient to ensure technique's application safety and effectiveness. 3D-MFR improves traditional myofascial release. Unlike standard MFR, which focuses on elongation along a single line, 3D-MFR considers fascial restrictions in three planes: sagittal (vertical) fascia align with direction of gravity to stretch the tissue in response restriction release, frontal (horizontal) fascia align in front to back direction to restore tissue flexibility and alignment, and transverse (rotational) targets twisting or rotational movements of fascia. This multidimensional approach promotes pain relief, mobility, and overall function by addressing deeper tissue layers and correcting early soft tissue damage using the three-dimensional Release Technique (3-DRT), which includes passive muscle release approaches. Dynamic myofascial release (DMFR) is described by Dong-Woo Lee in 2019 research article. It is comparable to MFR for fascia release and joint movement for increase of ROM. In DMFR, patients are performing breathing in a synchronised pattern while the therapist is performing movement actively, whereas in MFR is passive approach by therapists in a static position. As a result, DMFR could be more successful in generating non-local systemic effects and increasing proprioception. DMFR manually applying a long duration, low amplitude stretch to the muscle and fascia between T6 and T12. The therapist smoothly moved the joints in a diagonal or horizontal direction at a leisurely pace within the ROM after instructing participants to relax as much as possible. At the end of ROM, the therapist shaken, pulled or pushed the joint region three to five times for three seconds. The patient continues to move during therapy. DMFR improves ROM and reduces pain. Musculoskeletal disorders, particularly CNSLBP, are prevalent conditions that can be treated by physical therapy. In a clinical setting, patients with low back pain are easily accessible. Changes in low back discomfort are linked to lumbar biomechanics, like increased fascial stiffness and limited motion. Restoring normal fascial gliding improves spinal mobility and reduces disability. This study has an objective to compare the effectiveness of dynamic myofascial release or three-dimensional myofascial release combined with lumbar mobilization and exercise therapy. After determining which intervention is more effective in reducing disability, improving range of motion, and relieving pain, physiotherapists can expect to benefit. Myofascial release therapies are gaining popularity for treating chronic non-specific low back pain, yet literature reveals significant gaps. Research primarily focuses on solitary treatments, with deficient exploration of myofascial release combined with lumbar mobilization and structured exercise. Furthermore, comparative studies on various myofascial techniques, including three-dimensional and dynamic release, are scarce, highlighting the need for well-structured randomized controlled trials in this area.

Being tested
3 Dimensional Myofascial Release, Dynamic Myofascial Release, Lumbar Mobilization, Exercise Therapy Program
Keywords
Dynamic Myofascial Release, Disability, Pain, 3 Dimensional Myofascial Release, Lumbar Range of Motion, Exercise Therapy
Medical subject headings
Pain

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • 3 Dimensional Myofascial ReleaseOther

    Also called 3-D MFR

    Three sets of 90-second holds were used for 3DMFR. While the patient was seated for 3D-MFR, the therapist stood behind them. The 3D-MFR technique was performed from four separate positions. With one hand on the back of the shoulder and the other on the PSIS of the opposite side, the therapist started with a diagonal stretch. When one hand griped the posterior shoulder and the other griped the lateral aspect of the opposing shoulder, the trunk rotated. To keep a balanced fascial tension during these stretches, one hand gave force downward diagonally while the other extended upward and slightly forward. The end range was increased in each position by applying compression or additional stretch. The therapist gently twisted the patient's trunk while guided them into hyperextension and applied mild counter-pressure across the upper back to deepen the release. The therapist placed one hand on the patient's head and the other on their back to aid the extension movement

  • Dynamic Myofascial ReleaseOther

    Also called DMFR

    DMFR was given for 15 minutes per session as a manual, low-amplitude, long-duration stretch targeting fascia and muscles. Participants remained relaxed while the therapist performed slow diagonal or horizontal joint motions within available ROM, using gentle pushing, pulling or shaking for 3-5 repetitions of about 3 s, ending with some mobilization. Step 1: the therapist supported one arm and pulled the shoulder with breathing. Step 2: the participant's elbows rested on the therapist's lap, hands behind neck, synchronized with breathing. Step 3: the upper flexed knee was supported while pelvis and lower limb were led through gait-cycle motions. Step 4: the iliac crest was moved in all four directions. Finally, in prone, shoulder and pelvic girdles were gently counter-rotated.

  • Lumbar MobilizationOther

    Also called PA glide

    Standard physiotherapy treatment: Participants' positions should be in prone lying while the therapist stood on their side. The hypomobile spinous process of the lumbar vertebra was covered by the hand's ulnar surface. Another hand should be placed on the first one to generate force. With the therapist's shoulders precisely above the spinous process and elbows slightly bent, they executed rhythmic vertebral movements by giving the spinous process a central PA glide. Four applications of Grade III mobilization were made, each lasting 60 seconds of oscillation and 20 seconds of rest (two or three oscillations per second).

  • Exercise Therapy ProgramOther

    Standard PT: The exercise therapy program began with a hot pack on the lumbar region for 15 minutes before treatment to prepare the soft tissue. TENS was applied for 15 minutes via 2 channels, four 5 x 5 cm electrodes placed paraspinally at T12-S1, at 60-120 Hz and a pulse width of 50-100 µs. Three times per session, the lower back extensors, hamstrings and iliopsoas were manually and passively stretched in prone, supine, and supine with knee to chest positions, respectively, holding each for 30 seconds. Strengthening comprised abdominal curls in supine and prone cobra pose for the back extensors, 10 reps, 2 sets. Lumbar stabilization included abdominal bracing in crook lying, side support (hips lifted, resting on one elbow and foot), and quadruped exercise with one leg raised and the hip extended to 30 degrees, each for 10 reps with an 8-second hold. Patient education covered staying active, avoiding prolonged bed rest, safe movements, correct lifting form, and gradual progression.

Study groups in NCT07920991
Study groupRoleWhat they receive
3 Dimensional Myofascial Release with lumbar mobilization and exercise therapy programExperimentalParticipants with chronic non specific low back pain will receive 3 Dimensional Myofascial Release with lumbar mobilization and exercise therapy program.
Receives: Other: 3 Dimensional Myofascial Release; Other: Lumbar Mobilization; Other: Exercise Therapy Program
Dynamic Myofascial Release with lumbar mobilization and exercise therapy programActive comparatorParticipants with chronic non specific low back pain will receive Dynamic Myofascial Release with lumbar mobilization and exercise therapy program.
Receives: Other: Dynamic Myofascial Release; Other: Lumbar Mobilization; Other: Exercise Therapy Program

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Pain intensity on Numeric Pain Rating Scale (NPRS)

    Pain intensity will be measured using a numeric rating scale (NRS). Participants will rate their current pain severity using an 11-point pain numerical rating scale ranging from 0 (no pain at all) to 10 (the worst imagined pain). It interpret as 0: No Pain, 1-3: Mild Pain, 4-6: Moderate Pain and 7-10: Severe Pain.

    Measured: Baseline (pre) and at the 4th Week of Study (post)

Secondary outcomes (2)
  1. Lumbar Range of Motions by Goniometer

    Lumbar ROM will be assessed using a manual goniometer according to standard clinical protocols. Common movements include lumbar flexion (forward bending), extension (backward bending), lateral flexion (side bending), and rotation. The participant should remain in a neutral position for 5 s, then the ROM assessment will be conducted: lumbar flexion, lumbar extension, lumbar lateral flexion, and lumbar rotation. Scientific evidence of normal lumbar flexion (65°), lumbar extension (31°), lateral flexion (30°), and rotation (15.3°).

    Measured: Baseline (pre) and at the 4th Week of Study (post)

  2. Functional Disability in Oswestry Disability Index (ODI)

    Functional impairment will be measured using the Oswestry Disability Index (ODI). Participants will mark replies in ten categories on a 0-5 scale using the original English ODI version. Scores will be computed as (counted marks/50 × 100%). Mild disability is classified as 0-20%, moderate disability as 21-40%, severe disability as 41-60%, crippled handicap as 61-80%, and total disability as 81-100%.

    Measured: Baseline (pre) and at the 4th Week of Study (post)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Nov 2026
  2. Study start10 Sep 2026
  3. Primary completion30 Oct 2026 (estimated)
  4. Study completion10 Nov 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
52 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07920991
Sponsor's protocol ID
REC/RCR & AHS/25/0154
Status last verified
Nov 2026
First submitted
2 Nov 2026
Last updated
6 Nov 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Mavajian M, Fakhari Z, Naghdi S, Bagheri H, Jalaie S. A pilot study on the short-term effects of myofascial release and core stability exercises on balance in chronic low back pain. Auditory and Vestibular Research. 2020.

  • Gauns B, Welling A, Kage V, Gurudut P, Hulamani S. Three-dimensional Myofascial Release and Neck Strengthening in the Management of Cervical Spondylosis-A Case Report. Int J Ther Massage Bodywork. 2026 Mar 12;19(1):71-79. doi: 10.3822/ijtmb.v19i1.1257. eCollection 2026 Mar.

    PubMed 41778085
  • Manisha J, Pulimi R, Angeline R, Mohan Doss SR, Antony Leo Aseer P, Subbiah K. Efficacy of Myofascial Release in Improving the Flexibility of Erector Spinae and Thoracolumbar Fascia in Subjects with Chronic Low Back Pain-A Sonoelastographic Analysis. Int J Ther Massage Bodywork. 2026 Sep 10;19(3):39-49. doi: 10.3822/ijtmb.v19i3.1329. eCollection 2026 Sep.

    PubMed 42688892
  • Lee D-W, Shin H-K, Kim K-S. Effects of dynamic myofascial release on trunk mobility and standing balance in persons with chronic nonspecific low back pain. Physical therapy rehabilitation science. 2019;8(2):74-8.

  • Gauns B, Welling A, Gurudut P, Kage V, Hulamani S. Three-dimensional Myofascial Release for Musculoskeletal Conditions: An Educational Perspective. Indian journal of physical therapy and research. 2025;7(1):105-8.

  • Welling A, Patil A, Gunjal P, Naik P, Hubli R. Effectiveness of Three-Dimensional Myofascial Release on Lumbar Lordosis in Individuals with Asymptomatic Hyperlordosis: A Placebo Randomized Controlled Trial. Int J Ther Massage Bodywork. 2024 Jun 13;17(2):20-31. doi: 10.3822/ijtmb.v17i2.957. eCollection 2024 Jun.

    PubMed 38873188
  • Javaid HMW, Rehman SSU, Kashif M, Bashir MS, Zia W. The Effects of Joint Mobilization and Myofascial Release on Muscle Thickness in Non-Specific Low Back Pain: A Randomized Clinical Trial. J Clin Med. 2025 Apr 19;14(8):2830. doi: 10.3390/jcm14082830.

    PubMed 40283659
  • Farley T, Stokke J, Goyal K, DeMicco R. Chronic Low Back Pain: History, Symptoms, Pain Mechanisms, and Treatment. Life (Basel). 2024 Jun 27;14(7):812. doi: 10.3390/life14070812.

    PubMed 39063567

Questions about this trial

What is this clinical trial studying?

A study testing 3 Dimensional Myofascial Release, Dynamic Myofascial Release and Lumbar Mobilization in people with Chronic Non-Specific Low Back Pain and Myofascial Release, run by Riphah International University at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: enrolling by invitation, as of the sponsor's last update on 6 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Pain intensity on Numeric Pain Rating Scale (NPRS) (time frame: Baseline (pre) and at the 4th Week of Study (post)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07920991, which also lists 8 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Nov 2026.

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