SuicideAUTOPSOMNCT05773898
Contribution of Psychological Autopsy to the Understanding of Suicidal Behaviors in French Overseas Territories
An observational study of Suicide and Mental Disorders, run by University Hospital Center of Martinique at 1 site in Martinique.
Trial summary
The mains objectives of our project are to coordinate the monitoring of suicides and to identify common or specific suicide risk factors in four overseas DROM-COM (French Polynesia, La Reunion, French Guiana and Martinique) by comparing to a site in mainland France (Amiens). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Suicide, Mental Disorders, Prognostic Factors
- What is being tested?
- other
- How many people
- 150 participants
- Where
- 1 siteMartinique
- Study dates
- 25 Jan 2024to Apr 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population corresponds to the relatives of a person who died by suicide. The deceased had been living for at least two years in one of the five study territories and information on cause of death information was obtained from potential sources on suicide victims.
Who may be able to join
- Persons close of the deceased
- Persons who knew about his/her childhood
- Age 18 or over
- Interviewed for the study between 2 and 11 months after the suicide
Who cannot join
- People with neuropsychiatric disorders that may affect the quality of the information collected, cognitive (memory and expression) and judgmental functions
- People who refuses to participate
- Persons referred to articles L.1121-6, L.1121-7, L. 1121-8 L.1121-1-2 of the French Public Health Code.
Trial locations and contacts
1 site in 1 country.
Martinique1 site, 1 recruiting
- Recruiting
Centre Hospitalier Universitaire de Martinique - Hôpital Pierre ZOBDA QUITMAN
Fort-de-France, France, 97261
SEBASTIEN CAVALINI, +596 596 592 696, sebastien.cavalini@chu-martinique.fr
About this study
The mains objectives of our project are to coordinate the monitoring of suicides and to identify common or specific suicide risk factors in four overseas DROM-COM (French Polynesia, La Reunion, French Guiana and Martinique) by comparing to a site in mainland France (Amiens). A mixed approach (quantitative and qualitative) will be used, based on semi-directed interviews of the psychological autopsy type.
Read the detailed description
Epidemiological studies on suicide are rare in Overseas France. Nevertheless, studies conducted independently in New Caledonia (NC) and French Guiana were able to highlight a high prevalence of suicides in minority indigenous populations (Kanaks and Amerindians). These data therefore suggest a socio-cultural variability of suicides within the different territories. Psychological autopsies (used in NC) are an innovative approach that has already proven worldwilde its effectiveness in researching socio-cultural factors and prevalence of mental disorders in suicide subjects (Inserm). However, the qualitative analysis of psychological autopsies, even if it is very complete, is limited to known factors of suicide risk. Given the ethnic specificities of suicidal behavior and the socio-cultural richness of each overseas territory, an exploratory anthropologic approach will make it possible to complete identification of risk factors for suicide or combinations of these specific factors (profiles).
Our project will improve the data collection of suicide cases with the implementation of a network in each site (Public Health Department, Emergency units, Coroner offices, GP, associations, families…). Then interview with proxies of subjects deceased by suicide will allow psychological autopsy (questionnaires SCID to detect mental disorders, Life Trajectories, to detect life events and their burden, Anthropologic for socio-cultural aspects and Psycholinguistic analysis).
The total duration of the project will be 24 months with the recruitment of a maximum of 30 cases per site. Duration of the inclusion period will be 23 months, duration of follow-up per participant 1 month. The follow-up interview will be carried out one month after the inclusion interview. It will make it possible to establish a post-vention of suicide among the bereaved and an evaluation of the impact of the psychological autopsy interviews and the life trajectories of the bereaved.
- Conditions
- Suicide, Mental Disorders, Prognostic Factors
- Being tested
- other
- Keywords
- Suicide, Psychological autopsies, epidemiology, risk factors, psycholinguistic approach, French overseas territories
- Medical subject headings
- Suicide, Mental Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
otherOther
The interviewers will collect data from relatives using questionnaires and evaluation grids based on an identification form, a Life Trajectory questionnaire, an anthropological evaluation grid, a retrospective psychiatric diagnosis questionnaire (SCID), a socio-demographic questionnaire, a questionnaire on suicide risks and a questionnaire on emotional state.
| Study group | Role | What they receive |
|---|---|---|
| person close to the deceased | Relatives will be invited to participate in two semi-structured research interviews in the form of a storytelling interview with an interviewer. All interviews will be conducted after obtaining the participants' non-objection. The interviews will be recorded and, once transcribed, will be analysed. Receives: Other: other |
What is being measured
The primary outcome is the main question the study is designed to answer.
Existence of risk factors and mental disorders evaluated by Structured Clinical Interview for Diagnostic (SCID)
Number and percentage of mental disorders presented by the deceased and identified on the basis of data collected during DSM 5 diagnostic interviews.
Measured: 1 month
Secondary outcomes (4)
Assessment and comparison of risk factors and mental disorders
The number of risk factors identified and the number of mental disorders detected will be compared between the overseas territories and the Somme department.
Measured: 1 month
Existence or not of violence in childhood or during life among suicide cases
The variables related to childhood violence will be presented with the number of subjects "n" expressed as a percentage.
Measured: 1 month
Score of adversity by the Life Trajectory Questionnaire
Once the interviews have been completed, the recordings will be transcribed semi-automatically via the HappyScribe® online platform. The resulting verbatim recordings will then be used as data for psycholinguistic and anthropological analyses.
The qualitative data will then be transformed into quantitative data following the methodology developed by Brown and Harris, in which a panel of experts (researchers from our team and clinicians) assigns an overall rating for each five-year period, according to the severity of the burden of adversity carried by the person. This rating, from 1 to 6, makes it possible to determine the burden of adversity in the development of the individual (detailed description Séguin et al, 2007). It is the ratings of adversity that will form the curve of these trajectories.
Measured: 6 month
Existence of language, social and anthropological elements associated with suicide risk factors
an audio-recording will record responses to semi-structured interview using anthropological approach. After transcription, the qualitative data gained from these questions will be analyzed using thematic analysis to understand the main themes (Representations of mental illness and suicidal commitment. Religious beliefs and cultural practices. Use of traditional methods to treat mental illness).
A part of the transcription will also be analyzed using psycholinguistic approach. The words will be defined according to their frequency of occurrence and the most frequent grouped according to several "reference universes" associated with central notions (e.g. feeling, sensation, behavior, time, family, crisis, suicide, etc.). The visualization of the reference universes will summarize the frequency and proximity of key words and will make it possible to obtain a cognitive and mental representation of the speech.
Measured: 6 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Mar 2023
- Study start25 Jan 2024
- Primary completionFeb 2025 (estimated)
- Study completionApr 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for SuicideStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 150 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Center of Martinique
- Sponsor type
- University, hospital or other
- Collaborators
- Department for Research, Studies, Evaluation and Statistics, French Health and Social Affairs Ministry, France, French National Institute for Health and Medical Research, MOODS Unit, Clinical research and Innovation Office, Martinique, SOS KRIZ, Martinique, Amiens University Hospital, France, Suicide Prevention Resource Center, French Guiana, Cayenne Hospital Center, French Guiana, University Hospital, La Réunion, Tahiti Hospital Center, French Polynesia, Regional Health Agency, Martinique, Regional Health Agency, French Guiana, Regional Health Agency, La Somme, Regional Health Agency, La Réunion
- Responsible party
- Sponsor
- Investigators
- STEPHANE AMADEO, Pr, Principal investigator, University hospital, Martinique
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05773898
- Sponsor's protocol ID
- 22_RIPH3_14
- Other IDs
- 2022-A02413-40
- Acronym
- AUTOPSOM
- Status last verified
- Sep 2024
- First submitted
- 7 Mar 2023
- Last updated
- 26 Sep 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Amiot M, Amadeo S, Merle S, Guidere M, Jehel L, Seguin M, Spodenkiewicz M. Identifying suicidal risk factors in the French Overseas Territories with multimethod psychological autopsy (AUTOPSOM): a mixed-methods study protocol. BMJ Open. 2024 Jul 16;14(7):e079405. doi: 10.1136/bmjopen-2023-079405.
PubMed 39013644
Study at a glance
From the registry record, last updated by the sponsor on 26 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Contribution of Psychological Autopsy to the Understanding of Suicidal Behaviors in French Overseas Territories
- ClinicalTrials.gov ID
- NCT05773898
- Acronym / sponsor ID
- AUTOPSOM / 22_RIPH3_14
- Conditions
- Suicide, Mental Disorders, Prognostic Factors
- Keywords
- Suicide, Psychological autopsies, epidemiology, risk factors, psycholinguistic approach, French overseas territories
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- University Hospital Center of MartiniqueUniversity, hospital or other
- Collaborators
- Department for Research, Studies, Evaluation and Statistics, French Health and Social Affairs Ministry, France, French National Institute for Health and Medical Research, MOODS Unit, Clinical research and Innovation Office, Martinique, SOS KRIZ, Martinique, Amiens University Hospital, France, Suicide Prevention Resource Center, French Guiana, Cayenne Hospital Center, French Guiana, University Hospital, La Réunion, Tahiti Hospital Center, French Polynesia, Regional Health Agency, Martinique, Regional Health Agency, French Guiana, Regional Health Agency, La Somme, Regional Health Agency, La Réunion
- Study start
- 25 Jan 2024 (actual)
- Primary completion
- Feb 2025 (estimated)
- Study completion
- Apr 2025 (estimated)
- First posted
- 17 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The mains objectives of our project are to coordinate the monitoring of suicides and to identify common or specific suicide risk factors in four overseas DROM-COM (French Polynesia, La Reunion, French Guiana and Martinique) by comparing to a site in mainland France (Amiens). A mixed approach (quantitative and qualitative) will be used, based on semi-directed interviews of the psychological autopsy type.
Detailed description
Epidemiological studies on suicide are rare in Overseas France. Nevertheless, studies conducted independently in New Caledonia (NC) and French Guiana were able to highlight a high prevalence of suicides in minority indigenous populations (Kanaks and Amerindians). These data therefore suggest a socio-cultural variability of suicides within the different territories. Psychological autopsies (used in NC) are an innovative approach that has already proven worldwilde its effectiveness in researching socio-cultural factors and prevalence of mental disorders in suicide subjects (Inserm). However, the qualitative analysis of psychological autopsies, even if it is very complete, is limited to known factors of suicide risk. Given the ethnic specificities of suicidal behavior and the socio-cultural richness of each overseas territory, an exploratory anthropologic approach will make it possible to complete identification of risk factors for suicide or combinations of these specific factors (profiles).
Our project will improve the data collection of suicide cases with the implementation of a network in each site (Public Health Department, Emergency units, Coroner offices, GP, associations, families…). Then interview with proxies of subjects deceased by suicide will allow psychological autopsy (questionnaires SCID to detect mental disorders, Life Trajectories, to detect life events and their burden, Anthropologic for socio-cultural aspects and Psycholinguistic analysis).
The total duration of the project will be 24 months with the recruitment of a maximum of 30 cases per site. Duration of the inclusion period will be 23 months, duration of follow-up per participant 1 month. The follow-up interview will be carried out one month after the inclusion interview. It will make it possible to establish a post-vention of suicide among the bereaved and an evaluation of the impact of the psychological autopsy interviews and the life trajectories of the bereaved.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| person close to the deceased | – | Other: otherRelatives will be invited to participate in two semi-structured research interviews in the form of a storytelling interview with an interviewer. All interviews will be conducted after obtaining the participants' non-objection. The interviews will be recorded and, once transcribed, will be analysed. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population corresponds to the relatives of a person who died by suicide. The deceased had been living for at least two years in one of the five study territories and information on cause of death information was obtained from potential sources on suicide victims.
Key inclusion criteria (4 listed)
- Persons close of the deceased
- Persons who knew about his/her childhood
- Age 18 or over
- Interviewed for the study between 2 and 11 months after the suicide
Key exclusion criteria (3 listed)
- People with neuropsychiatric disorders that may affect the quality of the information collected, cognitive (memory and expression) and judgmental functions
- People who refuses to participate
- Persons referred to articles L.1121-6, L.1121-7, L. 1121-8 L.1121-1-2 of the French Public Health Code.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| otherThe interviewers will collect data from relatives using questionnaires and evaluation grids based on an identification form, a Life Trajectory questionnaire, an anthropological evaluation grid, a retrospective psychiatric diagnosis questionnaire (SCID), a socio-demographic questionnaire, a questionnaire on suicide risks and a questionnaire on emotional state. | Other | person close to the deceased |
Primary outcome
Existence of risk factors and mental disorders evaluated by Structured Clinical Interview for Diagnostic (SCID)
Time frame: 1 month
Number and percentage of mental disorders presented by the deceased and identified on the basis of data collected during DSM 5 diagnostic interviews.
4 secondary outcomes
Assessment and comparison of risk factors and mental disorders
Time frame: 1 month
Existence or not of violence in childhood or during life among suicide cases
Time frame: 1 month
Score of adversity by the Life Trajectory Questionnaire
Time frame: 6 month
Existence of language, social and anthropological elements associated with suicide risk factors
Time frame: 6 month
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Sep 2024.
- Derived from this study: PubMed 39013644Amiot M, Amadeo S, Merle S, Guidere M, Jehel L, Seguin M, Spodenkiewicz M. Identifying suicidal risk factors in the French Overseas Territories with multimethod psychological autopsy (AUTOPSOM): a mixed-methods study protocol. BMJ Open. 2024 Jul 16;14(7):e079405. doi: 10.1136/bmjopen-2023-079405.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
STEPHANE AMADEO, Pr principal investigator
University hospital, Martinique
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Suicide and Mental Disorders, run by University Hospital Center of Martinique at 1 site in Martinique.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 26 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Martinique. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact SEBASTIEN CAVALINI (+596 596 592 696, sebastien.cavalini@chu-martinique.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Existence of risk factors and mental disorders evaluated by Structured Clinical Interview for Diagnostic (SCID) (time frame: 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05773898, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Sep 2024.