Exercise TrainingNCT05427357
Evaluation of the Results of Closed Kinetic Chain Exercises in Patellofemoral Pain Syndrome
A study testing Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE) in people with Exercise Training, run by Taksim Egitim ve Arastirma Hastanesi.
Trial summary
Non-selective closed kinetic chain exercises and or selective closed kinetic chain exercises has been shown to increase Vastus medialis obliquus muscle power in patellofemoral pain syndrome. However, the superiority of the exercises to each other has not been shown. Read more about this study
- Who is it for?
- Ages 17 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise Training
- What is being tested?
- Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- Dec 2016to Feb 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 17 to 60 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Having peripatellar/retropatellar pain while sitting,going up and down the stairs
- Walking for a long time, crouching down, running, and kneeling down
- Having a VAS score of ≥3 during the evaluation and not developing these symptoms on a traumatic basis
Who cannot join
- Tendinitis
- Osgood-Schlatter Syndrome
- Traumatic hip or knee injuries
- Osteoarthritis
- Plica syndrome
- Sinding-Larsen-Johansson syndrome
Show all 11Show fewer
- Ligamentous instability
- Spinal pain
- Chondral lesion
- Patellar tendon pathology
- Distraction apophysitis of knee circumference
About this study
Official title: Evaluation of The Results of Closed Kinetic Chain Exercises Applied in The Conservative Treatment of Patellofemoral Pain Syndrome by Means of Shear Wave Elastography: A Randomized Controlled Trial
Non-selective closed kinetic chain exercises and or selective closed kinetic chain exercises has been shown to increase Vastus medialis obliquus muscle power in patellofemoral pain syndrome. However, the superiority of the exercises to each other has not been shown.
This study aimed to evaluating the effects of different exercises on the stiffness of the Vastus medialis obliquus and vastus lateralis muscles, pain management, functional scores, and thigh circumferences.
Read the detailed description
This randomized-controlled clinical trial included 40 patients (20 male and 20 female) who were admitted to hospital and who were clinically diagnosed with single-sided patellofemoral pain syndrome (PFPS) and 40 healthy controls (20 male and 20 female). Each group were randomized into subgroups according to diseased side of the PFPS group (40 knees), healthy side of the PFPS group (40 knees) and both side of the healthy control group (80 knees). Randomization was applied with random-number generator (Research Randomizer. Version 4.0). Only one of the authors was aware of randomization. Examiner and patient were blind to the relevant group. Non-selective closed kinetic chain and selective closed kinetic chain exercises were applied for 6 weeks in all groups. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee Score (LKS) score. Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy. Written informed consent was taken from each patient.This study is in line with the Declaration of Helsinki. Approval was obtained by the Local Ethics Committee (17/07/2016-258642).
- Conditions
- Exercise Training
- Being tested
- Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)
- Keywords
- Elastography, exercises, non-selective, pain, patellofemoral
- Medical subject headings
- Motor Activity, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)Other
Non-selective closed kinetic chain double-leg semi-squat exercise In this exercise, the standing patient leans his or her back against the wall and slides down the wall until the knees are about 45 degrees flexed. Daily program was determined as 5 sessions and 10 repeats. The knee stayed at flexion position for 10 seconds in each repeat, which aimed the contraction of quadriceps muscle. There is a relaxation period for 5 seconds between each repeat.
Selective closed kinetic chain double-leg semi-squat exercise with hip adduction In this exercise, the standing patient leans his or her back against the wall, forces the knees for adduction by squeezing the pillow placed between the knees and slides down the wall until the knees are about 45 degrees flexed. Daily program was determined as 5 sessions and 10 repeats.
| Study group | Role | What they receive |
|---|---|---|
| Diseased side of the patellofemoral pain syndrome (PFPS) group (40 knees) | Experimental | Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in diseased side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital. Receives: Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE) |
| Healthy side of the patellofemoral pain syndrome (PFPS) group (40 knees) | Experimental | Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in healthy side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital. Receives: Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE) |
| Both side of the healthy control group (80 knees) | Other | Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in side of the both side of the healthy control group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital. Receives: Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Shear Wave Elastography
Measurement of muscle strength before exercises
Measured: 1 day before exercise program
Shear Wave Elastography
Measurement of muscle strength after exercises
Measured: 6 weeks after exercise program
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jun 2022
- Study startDec 2016
- Primary completionDec 2016
- Study completionFeb 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Exercise TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Taksim Egitim ve Arastirma Hastanesi
- Sponsor type
- Other government
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05427357
- Sponsor's protocol ID
- Taksim eğitim
- Status last verified
- Jun 2022
- First submitted
- 7 Jun 2022
- Last updated
- 22 Jun 2022
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Kultur Y, Harbiyeli E, Botanlioglu H, Ozsahin MK, Ozturhalli S, Aydingoz O, Erginer MR. Evaluation of the results of closed kinetic chain exercises applied in the conservative treatment of patellofemoral pain syndrome by means of shear wave elastography: A randomized controlled trial. J Orthop Surg (Hong Kong). 2024 Sep-Dec;32(3):10225536241280384. doi: 10.1177/10225536241280384.
PubMed 39483049
Study at a glance
From the registry record, last updated by the sponsor on 22 Jun 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of The Results of Closed Kinetic Chain Exercises Applied in The Conservative Treatment of Patellofemoral Pain Syndrome by Means of Shear Wave Elastography: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT05427357
- Acronym / sponsor ID
- Taksim eğitim
- Conditions
- Exercise Training
- Keywords
- Elastography, exercises, non-selective, pain, patellofemoral
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Taksim Egitim ve Arastirma HastanesiOther government
- Study start
- Dec 2016 (actual)
- Primary completion
- Dec 2016 (actual)
- Study completion
- Feb 2018 (actual)
- First posted
- 22 Jun 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Non-selective closed kinetic chain exercises and or selective closed kinetic chain exercises has been shown to increase Vastus medialis obliquus muscle power in patellofemoral pain syndrome. However, the superiority of the exercises to each other has not been shown.
This study aimed to evaluating the effects of different exercises on the stiffness of the Vastus medialis obliquus and vastus lateralis muscles, pain management, functional scores, and thigh circumferences.
Detailed description
This randomized-controlled clinical trial included 40 patients (20 male and 20 female) who were admitted to hospital and who were clinically diagnosed with single-sided patellofemoral pain syndrome (PFPS) and 40 healthy controls (20 male and 20 female). Each group were randomized into subgroups according to diseased side of the PFPS group (40 knees), healthy side of the PFPS group (40 knees) and both side of the healthy control group (80 knees). Randomization was applied with random-number generator (Research Randomizer. Version 4.0). Only one of the authors was aware of randomization. Examiner and patient were blind to the relevant group. Non-selective closed kinetic chain and selective closed kinetic chain exercises were applied for 6 weeks in all groups. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee Score (LKS) score. Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy. Written informed consent was taken from each patient.This study is in line with the Declaration of Helsinki. Approval was obtained by the Local Ethics Committee (17/07/2016-258642).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Diseased side of the patellofemoral pain syndrome (PFPS) group (40 knees) | Experimental | Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in diseased side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital. |
| Healthy side of the patellofemoral pain syndrome (PFPS) group (40 knees) | Experimental | Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in healthy side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital. |
| Both side of the healthy control group (80 knees) | Other | Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in side of the both side of the healthy control group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital. |
Who may qualify
- Ages
- 17 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (3 listed)
- Having peripatellar/retropatellar pain while sitting,going up and down the stairs
- Walking for a long time, crouching down, running, and kneeling down
- Having a VAS score of ≥3 during the evaluation and not developing these symptoms on a traumatic basis
Key exclusion criteria (11 listed)
- Tendinitis
- Osgood-Schlatter Syndrome
- Traumatic hip or knee injuries
- Osteoarthritis
- Plica syndrome
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)Non-selective closed kinetic chain double-leg semi-squat exercise In this exercise, the standing patient leans his or her back against the wall and slides down the wall until the knees are about 45 degrees flexed. Daily program was determined as 5 sessions and 10 repeats. The knee stayed at flexion position for 10 seconds in each repeat, which aimed the contraction of quadriceps muscle. There is a relaxation period for 5 seconds between each repeat. Selective closed kinetic chain double-leg semi-squat exercise with hip adduction In this exercise, the standing patient leans his or her back against the wall, forces the knees for adduction by squeezing the pillow placed between the knees and slides down the wall until the knees are about 45 degrees flexed. Daily program was determined as 5 sessions and 10 repeats. | Other | Both side of the healthy control group (80 knees), Diseased side of the patellofemoral pain syndrome (PFPS) group (40 knees), Healthy side of the patellofemoral pain syndrome (PFPS) group (40 knees) |
Primary outcome
Shear Wave Elastography
Time frame: 1 day before exercise program
Measurement of muscle strength before exercises
Shear Wave Elastography
Time frame: 6 weeks after exercise program
Measurement of muscle strength after exercises
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jun 2022.
- Derived from this study: PubMed 39483049Kultur Y, Harbiyeli E, Botanlioglu H, Ozsahin MK, Ozturhalli S, Aydingoz O, Erginer MR. Evaluation of the results of closed kinetic chain exercises applied in the conservative treatment of patellofemoral pain syndrome by means of shear wave elastography: A randomized controlled trial. J Orthop Surg (Hong Kong). 2024 Sep-Dec;32(3):10225536241280384. doi: 10.1177/10225536241280384.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE) in people with Exercise Training, run by Taksim Egitim ve Arastirma Hastanesi.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jun 2022. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Shear Wave Elastography (time frame: 1 day before exercise program). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05427357, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2022.