Treatment Adherence and ComplianceApp-etiteNCT07885254
Testing a Smartphone App to Support a Mediterranean Diet and Strength Exercise
A study testing MedEx Tracker and Printed dietary and resistance exercise programme in people with Treatment Adherence and Compliance and Resistance Exercise, run by Liverpool John Moores University at 1 site in United Kingdom.
Trial summary
Eating a Mediterranean-style diet and doing regular resistance training are both known to lower the risk of heart disease. However, most people find it hard to stick to these habits over time, and few smartphone apps support both diet and strength training together. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Treatment Adherence and Compliance, Resistance Exercise, Mediterranean Diet
- What is being tested?
- MedEx Tracker and Printed dietary and resistance exercise programme
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- Nov 2026to Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- own and use a smartphone
- no contraindication to exercise on a pre-activity readiness questionnaire (PARQ)
Who cannot join
- pregnant or nursing
- presence of a dietary allergy or food intolerance
- adherence to a restrictive diet (keto, carnivore, vegan, vegetarian etc)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site
Liverpool John Moores University
Liverpool, Merseyside, L3 3AF
Dave Harriss, PhD, +447929999021, D.Harriss@ljmu.ac.uk
About this study
Official title: App-etite for Change: A Four-Week Feasibility Randomised Controlled Trial of a Smartphone Application to Support Adherence to a Mediterranean-Style Diet and Resistance Exercise
Eating a Mediterranean-style diet and doing regular resistance training are both known to lower the risk of heart disease. However, most people find it hard to stick to these habits over time, and few smartphone apps support both diet and strength training together. This study tests a smartphone app called MedEx Tracker, which was developed by the research team. The app lets people record what they have eaten against a set of Mediterranean diet targets, record the weight and repetitions for each set of their resistance training, and see how they are doing through a progress screen. It also sends reminders during the day and suggests when to increase training weight. Healthy adults aged 18 to 55 will be randomly assigned to one of two groups. Both groups will be given the same Mediterranean diet targets and the same strength training programme. One group will receive this through the app; the other will receive it as a printed booklet. This means any difference between the groups should be due to the app itself rather than to different advice. Everyone will attend the laboratory before and after the four weeks for measurements and questionnaires. The main aim is to find out whether the app is usable and acceptable to participants, and whether it helps people stick to a Mediterranean-style diet and a resistance training programme. The findings will be used to decide whether the app is suitable for a larger future study.
Read the detailed description
This is a four-week, two-arm, parallel-group feasibility randomised controlled trial conducted at Liverpool John Moores University. Healthy adults aged 18 to 55 years who own a smartphone will be randomised in a 1:1 ratio to an application-supported intervention arm (APP) or a control arm (CON). Allocation will be generated by a staff member independent of the project using a computerised random number generator. Blinding of participants is not feasible given the nature of the intervention; statistical analysis will be performed by a blinded statistician.
All participants, irrespective of allocation, will receive the same printed booklet containing Mediterranean-style dietary serving targets with serving size definitions and a structured resistance exercise programme with written technique guidance and load progression criteria, and will be asked to follow these to the best of their ability throughout the four-week intervention period. Participants in the APP arm will additionally receive access to MedEx Tracker, a purpose-built cross-platform mobile application. The application supports structured daily and weekly dietary logging against the prescribed serving targets, set-level recording of resistance exercise including load and repetitions, automated load progression prompts, an inter-set rest timer, embedded exercise demonstration videos, a library of Mediterranean recipes, and a progress dashboard displaying computed daily and weekly dietary compliance. Automated reminders are delivered three times daily for diet and every alternate day for exercise. Both arms therefore receive an identical prescription, with access to the application, and the self-monitoring, progress feedback and automated reminders it provides, representing the only difference between groups.
All participants will attend the laboratory before and after the intervention period. Primary outcomes are adherence to a Mediterranean-style diet and a resistance exercise programme, and the usability, acceptability and engagement with the application. Dietary adherence will be assessed using the 14-item Mediterranean Diet Adherence Screener and resistance exercise adherence as weekly muscle-strengthening frequency using the long form of the Muscle-Strengthening Exercise Questionnaire. Usability and acceptability will be assessed using the Mobile App Usability Questionnaire and the user version of the Mobile Application Rating Scale, supplemented by a focus group at follow-up. Engagement will be derived from application-generated data, including frequency of access and completeness of dietary and resistance exercise records. Secondary outcomes include recruitment and retention rates, dietary intake derived from three-day food records, body mass and body composition.
The study is not powered to detect definitive between-group differences. Its purpose is to establish whether the application functions as an adherence support and tracking tool of sufficient quality to be used within a subsequent fully powered trial examining LDL aggregation susceptibility.
- Conditions
- Treatment Adherence and Compliance, Resistance Exercise, Mediterranean Diet, Healthy Volunteers
- Being tested
- MedEx Tracker, Printed dietary and resistance exercise programme
- Keywords
- mHealth, mobile application, mediterranean diet, resistance training, dietary adherence, exercise adherence, behaviour change, self-monitoring, feasibility study
- Medical subject headings
- Treatment Adherence and Compliance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MedEx TrackerBehavioural
MedEx Tracker is a purpose-built cross-platform smartphone application developed by the research team to support adherence to a Mediterranean-style diet and a resistance training programme. Participants record daily servings of six food groups and weekly servings of five further food groups against defined targets, with serving definitions available within the application. Resistance training is recorded at the level of individual sets, capturing the load lifted and repetitions completed, with demonstration videos, automated prompts to increase or reduce load based on previous performance, and an inter-set rest timer. A progress dashboard displays a computed daily and weekly dietary compliance percentage, sessions completed, and seven-day activity calendars. The application also provides a library of Mediterranean diet-aligned recipes and delivers automated reminders three times daily for diet and every alternate day for exercise.
Printed dietary and resistance exercise programmeBehavioural
A printed booklet containing Mediterranean-style dietary serving targets with accompanying serving size definitions, and the prescribed resistance exercises with written technique guidance and load progression criteria. Participants are asked to follow the programme to the best of their ability over the four-week study period.
| Study group | Role | What they receive |
|---|---|---|
| Application-supported | Experimental | Participants receive Mediterranean-style dietary serving targets and a structured resistance exercise programme as a printed booklet, together with access to the MedEx Tracker mobile application, which provides self-monitoring, progress feedback, automated reminders and load progression prompts over four weeks. Receives: Behavioral: MedEx Tracker; Behavioral: Printed dietary and resistance exercise programme |
| Printed booklet | Active comparator | Participants receive the same printed booklet containing Mediterranean-style dietary serving targets and a structured resistance exercise programme over four weeks. No application access, progress feedback or automated reminders are provided. Receives: Behavioral: Printed dietary and resistance exercise programme |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mediterranean diet adherence
Adherence measured using the 14-item Mediterranean Diet Adherence Screener (MEDAS). Total score ranges from 0 to 14, with higher scores indicating greater adherence
Measured: Baseline and week 4
Resistance exercise adherence
Weekly muscle-strengthening exercise frequency, self-reported using the long form of the Muscle-Strengthening Exercise Questionnaire (MSEQ). Reported in days per week (minimum 0, maximum 7); higher values indicate more frequent muscle-strengthening exercise, i.e. greater adherence. This is a frequency count rather than a scale score; the MSEQ has no composite total score. Total weekly frequency is taken as the highest frequency reported across the four MSEQ exercise types.
Measured: Baseline and week 4
Application usability
Usability assessed in the intervention group using the Mobile App Usability Questionnaire (MAUQ). Higher scores indicate better usability.
Measured: Week 4 (end of intervention)
Application quality and acceptability
Assessed in the intervention group using the user version of the Mobile Application Rating Scale (uMARS), scored across engagement, functionality, aesthetics and information quality. Scoring is 1-5 (higher= better).
Measured: Week 4 (end of intervention)
Engagement with the application
Frequency of application access and completeness of dietary and resistance training records, derived from application-generated data in the intervention group.
Measured: Weeks 1-4, recorded continuously by the application
Secondary outcomes (5)
Dietary intake
Energy and macronutrient intake derived from three-day food records.
Measured: Baseline and week 4
Body mass
In kg using calibrated scales
Measured: Baseline and week 4
Body composition
Fat mass and fat-free mass assessed by bioelectrical impedance analysis
Measured: Baseline and week 4
Recruitment rate
Number of participants randomised per month of recruitment. Also reported:
- number screened
- proportion of those screened who are eligible
- proportion of eligible people who consent and are randomised
Measured: From the start of recruitment to randomisation of the final participant (up to approximately 4 months)
Retention rate
Proportion of randomised participants who attend the week-4 follow-up visit, reported overall and by arm, with reasons for withdrawal where given.
Measured: Baseline to week 4 (end of intervention)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study startNov 2026 (estimated)
- Primary completionFeb 2027 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Treatment Adherence and ComplianceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Liverpool John Moores University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Richard P Kirwan, PhD, Study director, Liverpool John Moores University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07885254
- Sponsor's protocol ID
- 260108LJMUREC272
- Acronym
- App-etite
- Status last verified
- Oct 2026
- First submitted
- 9 Oct 2026
- Last updated
- 6 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be made publicly available. The small sample size and single-site recruitment mean that participants could potentially be identified from combinations of demographic and anthropometric variables. Requests for data access will be considered on an individual basis by the corresponding author, subject to approval by the Liverpool John Moores University Research Ethics Committee and completion of a data sharing agreement.
Study at a glance
From the registry record, last updated by the sponsor on 6 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- App-etite for Change: A Four-Week Feasibility Randomised Controlled Trial of a Smartphone Application to Support Adherence to a Mediterranean-Style Diet and Resistance Exercise
- ClinicalTrials.gov ID
- NCT07885254
- Acronym / sponsor ID
- App-etite / 260108LJMUREC272
- Conditions
- Treatment Adherence and Compliance, Resistance Exercise, Mediterranean Diet, Healthy Volunteers
- Keywords
- mHealth, mobile application, mediterranean diet, resistance training, dietary adherence, exercise adherence, behaviour change, self-monitoring
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Liverpool John Moores UniversityUniversity, hospital or other
- Study start
- Nov 2026 (estimated)
- Primary completion
- Feb 2027 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 21 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eating a Mediterranean-style diet and doing regular resistance training are both known to lower the risk of heart disease. However, most people find it hard to stick to these habits over time, and few smartphone apps support both diet and strength training together. This study tests a smartphone app called MedEx Tracker, which was developed by the research team. The app lets people record what they have eaten against a set of Mediterranean diet targets, record the weight and repetitions for each set of their resistance training, and see how they are doing through a progress screen. It also sends reminders during the day and suggests when to increase training weight. Healthy adults aged 18 to 55 will be randomly assigned to one of two groups. Both groups will be given the same Mediterranean diet targets and the same strength training programme. One group will receive this through the app; the other will receive it as a printed booklet. This means any difference between the groups should be due to the app itself rather than to different advice. Everyone will attend the laboratory before and after the four weeks for measurements and questionnaires. The main aim is to find out whether the app is usable and acceptable to participants, and whether it helps people stick to a Mediterranean-style diet and a resistance training programme. The findings will be used to decide whether the app is suitable for a larger future study.
Detailed description
This is a four-week, two-arm, parallel-group feasibility randomised controlled trial conducted at Liverpool John Moores University. Healthy adults aged 18 to 55 years who own a smartphone will be randomised in a 1:1 ratio to an application-supported intervention arm (APP) or a control arm (CON). Allocation will be generated by a staff member independent of the project using a computerised random number generator. Blinding of participants is not feasible given the nature of the intervention; statistical analysis will be performed by a blinded statistician.
All participants, irrespective of allocation, will receive the same printed booklet containing Mediterranean-style dietary serving targets with serving size definitions and a structured resistance exercise programme with written technique guidance and load progression criteria, and will be asked to follow these to the best of their ability throughout the four-week intervention period. Participants in the APP arm will additionally receive access to MedEx Tracker, a purpose-built cross-platform mobile application. The application supports structured daily and weekly dietary logging against the prescribed serving targets, set-level recording of resistance exercise including load and repetitions, automated load progression prompts, an inter-set rest timer, embedded exercise demonstration videos, a library of Mediterranean recipes, and a progress dashboard displaying computed daily and weekly dietary compliance. Automated reminders are delivered three times daily for diet and every alternate day for exercise. Both arms therefore receive an identical prescription, with access to the application, and the self-monitoring, progress feedback and automated reminders it provides, representing the only difference between groups.
All participants will attend the laboratory before and after the intervention period. Primary outcomes are adherence to a Mediterranean-style diet and a resistance exercise programme, and the usability, acceptability and engagement with the application. Dietary adherence will be assessed using the 14-item Mediterranean Diet Adherence Screener and resistance exercise adherence as weekly muscle-strengthening frequency using the long form of the Muscle-Strengthening Exercise Questionnaire. Usability and acceptability will be assessed using the Mobile App Usability Questionnaire and the user version of the Mobile Application Rating Scale, supplemented by a focus group at follow-up. Engagement will be derived from application-generated data, including frequency of access and completeness of dietary and resistance exercise records. Secondary outcomes include recruitment and retention rates, dietary intake derived from three-day food records, body mass and body composition.
The study is not powered to detect definitive between-group differences. Its purpose is to establish whether the application functions as an adherence support and tracking tool of sufficient quality to be used within a subsequent fully powered trial examining LDL aggregation susceptibility.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Application-supported | Experimental | Behavioral: MedEx Tracker, Behavioral: Printed dietary and resistance exercise programmeParticipants receive Mediterranean-style dietary serving targets and a structured resistance exercise programme as a printed booklet, together with access to the MedEx Tracker mobile application, which provides self-monitoring, progress feedback, automated reminders and load progression prompts over four weeks. |
| Printed booklet | Active comparator | Behavioral: Printed dietary and resistance exercise programmeParticipants receive the same printed booklet containing Mediterranean-style dietary serving targets and a structured resistance exercise programme over four weeks. No application access, progress feedback or automated reminders are provided. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- own and use a smartphone
- no contraindication to exercise on a pre-activity readiness questionnaire (PARQ)
Key exclusion criteria (3 listed)
- pregnant or nursing
- presence of a dietary allergy or food intolerance
- adherence to a restrictive diet (keto, carnivore, vegan, vegetarian etc)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MedEx TrackerMedEx Tracker is a purpose-built cross-platform smartphone application developed by the research team to support adherence to a Mediterranean-style diet and a resistance training programme. Participants record daily servings of six food groups and weekly servings of five further food groups against defined targets, with serving definitions available within the application. Resistance training is recorded at the level of individual sets, capturing the load lifted and repetitions completed, with demonstration videos, automated prompts to increase or reduce load based on previous performance, and an inter-set rest timer. A progress dashboard displays a computed daily and weekly dietary compliance percentage, sessions completed, and seven-day activity calendars. The application also provides a library of Mediterranean diet-aligned recipes and delivers automated reminders three times daily for diet and every alternate day for exercise. | Behavioural | Application-supported |
| Printed dietary and resistance exercise programmeA printed booklet containing Mediterranean-style dietary serving targets with accompanying serving size definitions, and the prescribed resistance exercises with written technique guidance and load progression criteria. Participants are asked to follow the programme to the best of their ability over the four-week study period. | Behavioural | Application-supported, Printed booklet |
Primary outcome
Mediterranean diet adherence
Time frame: Baseline and week 4
Adherence measured using the 14-item Mediterranean Diet Adherence Screener (MEDAS). Total score ranges from 0 to 14, with higher scores indicating greater adherence
Resistance exercise adherence
Time frame: Baseline and week 4
Weekly muscle-strengthening exercise frequency, self-reported using the long form of the Muscle-Strengthening Exercise Questionnaire (MSEQ). Reported in days per week (minimum 0, maximum 7); higher values indicate more frequent muscle-strengthening exercise, i.e. greater adherence. This is a frequency count rather than a scale score; the MSEQ has no composite total score. Total weekly frequency is taken as the highest frequency reported across the four MSEQ exercise types.
Application usability
Time frame: Week 4 (end of intervention)
Usability assessed in the intervention group using the Mobile App Usability Questionnaire (MAUQ). Higher scores indicate better usability.
Application quality and acceptability
Time frame: Week 4 (end of intervention)
Assessed in the intervention group using the user version of the Mobile Application Rating Scale (uMARS), scored across engagement, functionality, aesthetics and information quality. Scoring is 1-5 (higher= better).
Engagement with the application
Time frame: Weeks 1-4, recorded continuously by the application
Frequency of application access and completeness of dietary and resistance training records, derived from application-generated data in the intervention group.
5 secondary outcomes
Dietary intake
Time frame: Baseline and week 4
Body mass
Time frame: Baseline and week 4
Body composition
Time frame: Baseline and week 4
Recruitment rate
Time frame: From the start of recruitment to randomisation of the final participant (up to approximately 4 months)
Retention rate
Time frame: Baseline to week 4 (end of intervention)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Nov 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be made publicly available. The small sample size and single-site recruitment mean that participants could potentially be identified from combinations of demographic and anthropometric variables. Requests for data access will be considered on an individual basis by the corresponding author, subject to approval by the Liverpool John Moores University Research Ethics Committee and completion of a data sharing agreement.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Richard P Kirwan, PhD study director
Liverpool John Moores University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MedEx Tracker and Printed dietary and resistance exercise programme in people with Treatment Adherence and Compliance and Resistance Exercise, run by Liverpool John Moores University at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alexandros M Amorginos, MSc (+447713180851, spsaamor@ljmu.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mediterranean diet adherence (time frame: Baseline and week 4). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Nov 2026.