Knee Ligament InjuryNCT05364398
Comparison of ACL Reconstruction With Stump Preservation and Stump Resection
A study testing ACL reconstruction in people with Knee Ligament Injury, run by Cairo University at 1 site in Egypt.
Trial summary
To assess the clinical outcome in patients who had ACL reconstruction with preservation of the remnant and compare it with patients in whom the stump was resected Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Knee Ligament Injury
- What is being tested?
- ACL reconstruction
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Apr 2017to 1 Sep 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- patients with torn ACL within 6 months
Who cannot join
- Old ACL injury Multi-ligamentous knee injuries Mal-alignments
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Does Stump-Preserving Anterior Cruciate Ligament Reconstruction Provide Better Functional Outcomes?
To assess the clinical outcome in patients who had ACL reconstruction with preservation of the remnant and compare it with patients in whom the stump was resected
Read the detailed description
100 patients are subjected to ACL reconstruction. Half of them had ACL reconstruction with Stump preservation and the other half had ACL reconstruction with stump resection.
The clinical outcome in both groups is assessed and compared
- Conditions
- Knee Ligament Injury
- Being tested
- ACL reconstruction
- Keywords
- Anterior cruciate ligament reconstruction, tibial stump, stump preservation, knee proprioception.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ACL reconstructionProcedure or surgery
Use of hamstring tendons graft to replace the torn ACL and being passed and fixed through the femoral and tibial sides
| Study group | Role | What they receive |
|---|---|---|
| ACL reconstruction with stump preservation | Active comparator | Not described Receives: Procedure: ACL reconstruction |
| ACL reconstruction with stump resection | Active comparator | Not described Receives: Procedure: ACL reconstruction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Knee stability
KT-1000 Arthrometer
Measured: 2 years
Knee proprioception
Passive angle reproduction test
Measured: 2 years
Lysholm score
Measured: 2 years
Tegner activity score
Measured: 2 years
IKDC score
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2022
- Study start1 Apr 2017
- Primary completion30 Apr 2020
- Study completion1 Sep 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Knee Ligament InjuryStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Ahmed El-Desouky, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05364398
- Sponsor's protocol ID
- MD-09-2017
- Status last verified
- Nov 2025
- First submitted
- 3 May 2022
- Last updated
- 20 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
El-Desouky MA, Ezzat M, Abdelrazek BH. Clinical outcomes in stump-preserving versus stump-sacrificing anterior cruciate ligament reconstruction; a randomized controlled study. BMC Musculoskelet Disord. 2022 Jul 23;23(1):703. doi: 10.1186/s12891-022-05665-3.
PubMed 35870924
Study at a glance
From the registry record, last updated by the sponsor on 20 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does Stump-Preserving Anterior Cruciate Ligament Reconstruction Provide Better Functional Outcomes?
- ClinicalTrials.gov ID
- NCT05364398
- Acronym / sponsor ID
- MD-09-2017
- Conditions
- Knee Ligament Injury
- Keywords
- Anterior cruciate ligament reconstruction, tibial stump, stump preservation, knee proprioception.
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 120 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Apr 2017 (actual)
- Primary completion
- 30 Apr 2020 (actual)
- Study completion
- 1 Sep 2020 (actual)
- First posted
- 6 May 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To assess the clinical outcome in patients who had ACL reconstruction with preservation of the remnant and compare it with patients in whom the stump was resected
Detailed description
100 patients are subjected to ACL reconstruction. Half of them had ACL reconstruction with Stump preservation and the other half had ACL reconstruction with stump resection.
The clinical outcome in both groups is assessed and compared
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACL reconstruction with stump preservation | Active comparator | Procedure: ACL reconstruction |
| ACL reconstruction with stump resection | Active comparator | Procedure: ACL reconstruction |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- patients with torn ACL within 6 months
Key exclusion criteria (1 listed)
- Old ACL injury Multi-ligamentous knee injuries Mal-alignments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ACL reconstructionUse of hamstring tendons graft to replace the torn ACL and being passed and fixed through the femoral and tibial sides | Procedure or surgery | ACL reconstruction with stump preservation, ACL reconstruction with stump resection |
Primary outcome
Knee stability
Time frame: 2 years
KT-1000 Arthrometer
Knee proprioception
Time frame: 2 years
Passive angle reproduction test
Lysholm score
Time frame: 2 years
Tegner activity score
Time frame: 2 years
IKDC score
Time frame: 2 years
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Nov 2025.
- Derived from this study: PubMed 35870924El-Desouky MA, Ezzat M, Abdelrazek BH. Clinical outcomes in stump-preserving versus stump-sacrificing anterior cruciate ligament reconstruction; a randomized controlled study. BMC Musculoskelet Disord. 2022 Jul 23;23(1):703. doi: 10.1186/s12891-022-05665-3.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ACL reconstruction in people with Knee Ligament Injury, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Knee stability (time frame: 2 years). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05364398, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Nov 2025.