Chronic PeriodontitisNCT05275192
Utilization of a Videoscope in Periodontal Regeneration
A study testing Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery and Guided tissue regeneration surgery in people with Chronic Periodontitis, run by University of Illinois Chicago at 1 site in United States.
Trial summary
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS). Read more about this study
- Who is it for?
- Ages 18 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Chronic Periodontitis
- What is being tested?
- Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery and Guided tissue regeneration surgery
- Type of treatment
- Medical device, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteUnited States
- Study dates
- 1 May 2022to 31 Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- • Individual must be between the age of 18 and 70 years of age
- ASA I or II systemically healthy subjects
- Individuals presenting with at least 1 single or multirooted tooth with residual, isolated, interproximal bony defect with probing depths (PD) ≥ 6 mm, clinical attachment loss (CAL) ≥ 6mm, bleeding upon probing (BOP), and ≥ 2mm width of attached gingiva (WAG)
- Radiographic evidence of interproximal alveolar bone loss, on existing (< 2 years old) dental radiographs of diagnostic quality taken at the COD
- Vital tooth or previous root canal therapy with no signs/symptoms of pathology
- Individuals with plaque scores ≤ 20%
- English speaking subjects (Individual must be willing to follow all the study requirements and participate in the study procedures in its entirety and read, understand the informed consent form)
Who cannot join
- Individuals not referred from the Predoctoral Periodontics Student Clinics
- Uncontrolled systemic disorders such as hypertension, heart disease, bleeding disorders, metabolic bone diseases, autoimmune disorders, etc., that may influence cellular/healing status
- Diabetics
- Current smokers
- Individual less than 18 years of age
- Individuals with non-isolated, interproximal PD ≥ 4 mm extending to the facial/buccal and/or palatal/lingual tooth surfaces
Show all 14Show fewer
- Teeth with Grade 2 or 3 mobility
- Teeth with metal restorations such as a porcelain fused to metal crown (due to scattering of radiographic images)
- Intrabony defects on dental implants
- Individual who take medications known to affect host immunity or periodontal tissues (ex. steroids, antibiotics, phenytoin, etc.) in the previous 6 months
- Individuals on chronic anti-platelet/anti-coagulant therapy
- Oral pathologies other than periodontal disease (ex. periapical lesions of non-periodontal origin)
- Subjects who may be pregnant based on a positive pregnancy test
- Non-English speaking individuals
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Illinois, Chicago, College of Dentistry, Periodontics
Chicago, Illinois, 60612
About this study
Official title: Utilization of a Videoscope to Improve Clinical Outcomes of Periodontal Regeneration. A Pilot Study
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS). Although this therapeutic approach is well established in clinical settings and can rescue teeth with poor or questionable prognosis, MIS approaches often suffer from lack of predictability due to poor intraoral visibility of the bony lesion and inability to confirm thorough removal of etiological factors (plaque/calculus) on tooth surfaces. We seek to investigate whether improved visualization of the surgical field using an FDA approved videoscope (V) improves clinical outcomes. For this pilot study, N=50 (to attain 10/group) age, sex matched, systemically healthy subjects diagnosed with Stage III, Grade B periodontitis, formerly known as severe chronic periodontitis, will be randomly assigned to either the VMIS (Test), MIS (Control 1) or Guided Tissue Regeneration (GTR, Control 2) group. All periodontal therapy will be performed following the Standard of Care for periodontal regeneration to determine if utilization of the videoscope improves clinical and radiographic outcomes. We will examine bone fill using conventional digital periapical radiographs (PAR) and Cone Beam Computed Tomography (CBCT) imaging at 6 and 12 months compared to baseline and collect gingival crevicular fluid (GCF) to compare expression of growth factors and cytokines/chemokines during the healing period. This is a single center treatment study where subjects will be recruited from individuals seeking periodontal treatment at the Graduate Periodontics Clinic, UIC College of Dentistry (COD). Participation of all subjects will end after 12 months and will comprise 7 total visits.
- Conditions
- Chronic Periodontitis
- Being tested
- Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
- Keywords
- Periodontitis, Minimally invasive surgery, Videoscope, Guided tissue regeneration, Stage III, Grade B periodontitis
- Medical subject headings
- Chronic Periodontitis, Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Videoscope-assisted periodontal regeneration minimally invasive surgeryDevice
Use of a videoscope to improve visualization of periodontal defect during minimally invasive surgery
Periodontal regeneration minimally invasive surgeryProcedure or surgery
Conventional periodontal regeneration minimally invasive surgery without use of a videoscope
Guided tissue regeneration surgeryProcedure or surgery
Conventional guided tissue regeneration surgery for periodontal regeneration without use of a videoscope
| Study group | Role | What they receive |
|---|---|---|
| Videoscope-assisted periodontal regeneration minimally invasive surgery | Experimental | Videoscope-assisted periodontal regeneration minimally invasive surgery - Test group Receives: Device: Videoscope-assisted periodontal regeneration minimally invasive surgery |
| Periodontal regeneration minimally invasive surgery | Active comparator | Periodontal regeneration minimally invasive surgery - Control Group 1 Receives: Procedure: Periodontal regeneration minimally invasive surgery |
| Guided tissue regeneration surgery | Active comparator | Guided tissue regeneration - Control Group 2 Receives: Procedure: Guided tissue regeneration surgery |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical Attachment Level
Measured in mm as the periodontal probing depth (PD) plus gingival recession (GR).
Measured: 6 months
Probing Depth (PD)
Measured in mm as the distance from the gingival margin (GM) to the base of the gingival sulcus.
Measured: 6 months
Gingival Recession (GR)
Measured in mm as distance of the gingival margin (GM) to the cemento-enamel junction (CEJ).
Measured: 6 months
Radiographic Bone Height (RBH)
Measured in mm as the distance from the cemento-enamel junction (CEJ) to the base of the alveolar bone defect (ABD).
Measured: 6 months
Radiographic Bone Volume (RBV)
Measured in cubic mm as the volume of bone from the alveolar crest (AC) to the base of the alveolar bone defect (ABD).
Measured: 6 months
Clinical Attachment Level
Measured in mm as the periodontal probing depth (PD) plus gingival recession (GR).
Measured: 12 months
Probing Depth (PD)
Measured in mm as the distance from the gingival margin (GM) to the base of the gingival sulcus.
Measured: 12 months
Gingival Recession (GR)
Measured in mm as distance of the gingival margin (GM) to the cemento-enamel junction (CEJ).
Measured: 12 months
Radiographic Bone Height (RBH)
Measured in mm as the distance from the cemento-enamel junction (CEJ) to the base of the alveolar bone defect (ABD).
Measured: 12 months
Radiographic Bone Volume (RBV)
Measured in cubic mm as the volume of bone from the alveolar crest (AC) to the base of the alveolar bone defect (ABD).
Measured: 12 months
Secondary outcomes (2)
Gingival Crevicular Fluid (GCF) Growth Factor and Cytokine/Chemokine Levels
Concentration of 24 cytokines, chemokines, and growth factors in gingival crevicular fluid (GCF) measured in pg/mL.
Measured: 6 months
Gingival Crevicular Fluid (GCF) Growth Factor and Cytokine/Chemokine Levels
Concentration of 24 cytokines, chemokines, and growth factors in gingival crevicular fluid (GCF) measured in pg/mL.
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Mar 2022
- Study start1 May 2022
- Primary completion30 Apr 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic PeriodontitisStudies of the same condition, open and under way.
- More trials run by University of Illinois ChicagoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Illinois Chicago
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Salvador Nares, DDS, MS, PHD, MBA, University of Illinois Chicago
- Investigators
- Salvador Nares, DDS, PhD, Principal investigator, University of Illinois Chicago
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05275192
- Sponsor's protocol ID
- 2021-1311
- Status last verified
- Oct 2025
- First submitted
- 4 Feb 2022
- Last updated
- 17 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Utilization of a Videoscope to Improve Clinical Outcomes of Periodontal Regeneration. A Pilot Study
- ClinicalTrials.gov ID
- NCT05275192
- Acronym / sponsor ID
- 2021-1311
- Conditions
- Chronic Periodontitis
- Keywords
- Periodontitis, Minimally invasive surgery, Videoscope, Guided tissue regeneration, Stage III, Grade B periodontitis
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- University of Illinois ChicagoUniversity, hospital or other
- Study start
- 1 May 2022 (actual)
- Primary completion
- 30 Apr 2028 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 11 Mar 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS). Although this therapeutic approach is well established in clinical settings and can rescue teeth with poor or questionable prognosis, MIS approaches often suffer from lack of predictability due to poor intraoral visibility of the bony lesion and inability to confirm thorough removal of etiological factors (plaque/calculus) on tooth surfaces. We seek to investigate whether improved visualization of the surgical field using an FDA approved videoscope (V) improves clinical outcomes. For this pilot study, N=50 (to attain 10/group) age, sex matched, systemically healthy subjects diagnosed with Stage III, Grade B periodontitis, formerly known as severe chronic periodontitis, will be randomly assigned to either the VMIS (Test), MIS (Control 1) or Guided Tissue Regeneration (GTR, Control 2) group. All periodontal therapy will be performed following the Standard of Care for periodontal regeneration to determine if utilization of the videoscope improves clinical and radiographic outcomes. We will examine bone fill using conventional digital periapical radiographs (PAR) and Cone Beam Computed Tomography (CBCT) imaging at 6 and 12 months compared to baseline and collect gingival crevicular fluid (GCF) to compare expression of growth factors and cytokines/chemokines during the healing period. This is a single center treatment study where subjects will be recruited from individuals seeking periodontal treatment at the Graduate Periodontics Clinic, UIC College of Dentistry (COD). Participation of all subjects will end after 12 months and will comprise 7 total visits.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Videoscope-assisted periodontal regeneration minimally invasive surgery | Experimental | Device: Videoscope-assisted periodontal regeneration minimally invasive surgeryVideoscope-assisted periodontal regeneration minimally invasive surgery - Test group |
| Periodontal regeneration minimally invasive surgery | Active comparator | Procedure: Periodontal regeneration minimally invasive surgeryPeriodontal regeneration minimally invasive surgery - Control Group 1 |
| Guided tissue regeneration surgery | Active comparator | Procedure: Guided tissue regeneration surgeryGuided tissue regeneration - Control Group 2 |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- • Individual must be between the age of 18 and 70 years of age
Key exclusion criteria (14 listed)
- Individuals not referred from the Predoctoral Periodontics Student Clinics
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Videoscope-assisted periodontal regeneration minimally invasive surgeryUse of a videoscope to improve visualization of periodontal defect during minimally invasive surgery | Device | Videoscope-assisted periodontal regeneration minimally invasive surgery |
| Periodontal regeneration minimally invasive surgeryConventional periodontal regeneration minimally invasive surgery without use of a videoscope | Procedure or surgery | Periodontal regeneration minimally invasive surgery |
| Guided tissue regeneration surgeryConventional guided tissue regeneration surgery for periodontal regeneration without use of a videoscope | Procedure or surgery | Guided tissue regeneration surgery |
Primary outcome
Clinical Attachment Level
Time frame: 6 months
Measured in mm as the periodontal probing depth (PD) plus gingival recession (GR).
Probing Depth (PD)
Time frame: 6 months
Measured in mm as the distance from the gingival margin (GM) to the base of the gingival sulcus.
Gingival Recession (GR)
Time frame: 6 months
Measured in mm as distance of the gingival margin (GM) to the cemento-enamel junction (CEJ).
Radiographic Bone Height (RBH)
Time frame: 6 months
Measured in mm as the distance from the cemento-enamel junction (CEJ) to the base of the alveolar bone defect (ABD).
Radiographic Bone Volume (RBV)
Time frame: 6 months
Measured in cubic mm as the volume of bone from the alveolar crest (AC) to the base of the alveolar bone defect (ABD).
Clinical Attachment Level
Time frame: 12 months
Measured in mm as the periodontal probing depth (PD) plus gingival recession (GR).
Probing Depth (PD)
Time frame: 12 months
Measured in mm as the distance from the gingival margin (GM) to the base of the gingival sulcus.
Gingival Recession (GR)
Time frame: 12 months
Measured in mm as distance of the gingival margin (GM) to the cemento-enamel junction (CEJ).
Radiographic Bone Height (RBH)
Time frame: 12 months
Measured in mm as the distance from the cemento-enamel junction (CEJ) to the base of the alveolar bone defect (ABD).
Radiographic Bone Volume (RBV)
Time frame: 12 months
Measured in cubic mm as the volume of bone from the alveolar crest (AC) to the base of the alveolar bone defect (ABD).
2 secondary outcomes
Gingival Crevicular Fluid (GCF) Growth Factor and Cytokine/Chemokine Levels
Time frame: 6 months
Gingival Crevicular Fluid (GCF) Growth Factor and Cytokine/Chemokine Levels
Time frame: 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Salvador Nares, DDS, PhD principal investigator
University of Illinois Chicago
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery and Guided tissue regeneration surgery in people with Chronic Periodontitis, run by University of Illinois Chicago at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical Attachment Level (time frame: 6 months). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.