Research institution
University of Illinois Chicago Clinical Trials
Studies where University of Illinois Chicago is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 130Breast Cancer
Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)
This is a post-marketing single arm, phase IV trial in which patients with high-risk early-stage HR+HER2- breast cancer will receive adjuvant abemaciclib in combination with endocrine therapy (ET) After study intervention…
- Trial name
- BRE-09 (NCT06169371)
- Testing
- Abemaciclib
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Illinois Chicago
Mobility Impairment, Frailty
Adapting an Evidence-Based Physical Activity Intervention to Prevent Frailty and Functional Decline in Older Women Living With HIV
This study will examine the effectiveness and implementation of a physical activity and health education intervention by comparing outcomes of participants in the intervention group to those in a control group.
- Trial name
- NCT07922499
- Testing
- Positively Fit and Strong!
- Volunteers
- 210 people
- Sponsor
- University of Illinois Chicago
Breast Cancer Invasive, Early-stage Breast Cancer
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer
To determine the effect of low dose azacitidine therapy on tumor infiltrating lymphocytes (TILs) in primary tumors from patients with high-risk early stage breast cancer, paired t-tests will be first used to compare TIL count in…
- Conditions
- Breast Cancer Invasive, Early-stage Breast Cancer, High Risk Breast Carcinoma
- Trial name
- BRE-04 (NCT04891068)
- Testing
- Azacitidine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Proliferative Sickle Cell Retinopathy
Anti-VEGF Versus Prompt Laser or Observation for Proliferative Sickle Cell Retinopathy (ALPS)
The purpose of the study is to determine if anti-VEGF/anti-Ang2 therapy results in prevention of vitreous hemorrhage or retinal detachment as compared to localized scatter laser photocoagulation in patients with stage 3…
- Trial name
- ALPS (NCT07922460)
- Testing
- Faricimab Injection for stage 3 or stage 4 Proliferative sickle cell eyes, Vitrectomy, Laser photocoagulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Nausea With Vomiting Chemotherapy-Induced
BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron
Patients undergoing either an autologous or allogeneic hematopoietic stem cell transplant (HSCT) and receiving preparative chemotherapy experience a considerable amount of chemotherapy-induced nausea and vomiting (CINV).
- Trial name
- NCT04150614
- Testing
- Granisetron Transdermal Patch, Intravenous Dexamethasone, Ondansetron
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Illinois Chicago
Hearing Impaired Children
Artificial Grammar Learning in Children Who Are Deaf or Hard-of-Hearing: Stimulus Length Effect
The goal of this basic experimental study involving humans (BESH) clinical trial is to examine how stimulus length affects grammar learning in children who are deaf or hard-of-hearing and who primarily use spoken language.
- Trial name
- NCT07782567
- Testing
- Short linguistic content, Long linguistic content
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Corneal Ulcer
Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells
The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow.
- Trial name
- NCT05705024
- Testing
- Mesenchymal Stromal Cells, Control Solution
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of Illinois Chicago
Iron Deficiency (ID), Pregnancy
Probiotic Supplementation in Optimizing Iron and Hematological Status Among Pregnant Females
Maternal iron deficiency (ID) and iron deficiency anemia (IDA) is associated with maternal and infant mortality, spontaneous preterm birth, maternal postpartum hemorrhage, and neurocognitive defects in the neonate.
- Trial name
- ProMoms (NCT07076849)
- Testing
- Lactiplantibacillus plantarum 299v
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Persistent Corneal Epithelial Defect, Corneal Epithelial Disorders
Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
In this phase II randomized double-masked clinical trials, subjects with non-resolving corneal epithelial disease/defect (i.e., refractory to standard treatments for at least two weeks) will receive 8 weeks treatment of topical…
- Trial name
- NCT06919081
- Testing
- Allogeneic Bone-Marrow Derived Mesenchymal Stromal Cells Secretome, Vehicle Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Illinois Chicago
Sleep, Physical Activity
On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial
This study will evaluate a program called On Track for Wellness (OTW) which is being adopted by the Illinois Department of Human Services' Division of Behavioral Health \& Recovery (DBHR) for use in all state-funded early…
- Conditions
- Sleep, Physical Activity, First Episode Psychosis
- Trial name
- OTW (NCT07387705)
- Testing
- On Track for Wellness
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- University of Illinois Chicago
Completed, with results posted
All 108Depression, Anxiety
Low Intensity Family Support for Refugees in an LMIC
The rapidly growing scale of humanitarian crises requires new response capabilities geared towards addressing populations with prolonged high vulnerability to mental health consequences and little to no access to mental health…
- Conditions
- Depression, Anxiety, PTSD, Family Dynamics
- Trial name
- NCT03978533
- Testing
- Family Support Group
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Behavioral Health
Feasibility Testing a Meditation App for Youth in the Legal System
This feasibility clinical trial aims to assess the feasibility of implementing a 1-month app-based meditation program with youth in the juvenile legal system. The primary questions it is designed to answer are: 1.
- Trial name
- NCT05146167
- Testing
- Bodhi AIM (intervention group), HIB (control group)
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Resilience, Psychological, Advance Care Planning
Facilitating Advance Care Planning Discussions for People With Advanced Cancer
The aims of this study are to (1) identify the advance care planning deliberation process among 20 dyads of patients with advanced cancer and family caregivers and (2) conduct usability testing among 9 dyads to refine the content…
- Trial name
- NCT06061965
- Testing
- Web-based resilience-building intervention
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Illinois Chicago
Mindfulness, Colon Cancer
Targeting Chronic Stress for Reducing Risk Factors for Colorectal Cancer
Many neighborhoods in Chicago experience daily exposure to stressors including economic inopportunity and violent crime in public spaces.
- Conditions
- Mindfulness, Colon Cancer, Females
- Trial name
- MindCRC (NCT06323421)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity, Hypertension
HealthMatters@24/7 eLearning for People Supporting Adults With Intellectual and Developmental Disabilities
The barriers faced by people with intellectual and developmental disabilities (IDD) begin in their mid to late 20s and often mirror the experiences of older adults (50+) living in the U.S.
- Conditions
- Obesity, Hypertension, Hypercholesterolemia, Hyperglycemia
- Trial name
- HM@24/7 (NCT03206164)
- Testing
- Asynchronous, eLearning Intervention
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago