AzTrials
AzTrials

Advanced Colorectal CancerPhase 3NCT04793958

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

A Phase 3 study testing MRTX849, Cetuximab and mFOLFOX6 Regimen in people with Advanced Colorectal Cancer and Metastatic Colorectal Cancer, run by Mirati Therapeutics Inc. at 419 sites in 32 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
MRTX849, Cetuximab and mFOLFOX6 Regimen
Could I receive a placebo?
No, everyone receives an active treatment
How many people
461 participants
Where
419 sitesin 32 countries
Study dates
24 Jun 2021to 23 Oct 2026
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
  • Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Who cannot join

  • Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
  • Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
  • Active brain metastasis

Trial locations and contacts

419 sites in 32 countries.

419 sites in 32 countries

United States185 sites

  • Local Institution - 010-855-E

    Alabaster, Alabama, 35007

  • Local Institution - 010-976-F

    American Fork, Utah, 84003

  • Local Institution - 010-956

    Atlanta, Georgia, 30322

  • Local Institution - 010-533 A

    Auburn, Washington, 98001

  • Local Institution - 010-872-H

    Aurora, Colorado, 80012

  • Local Institution - 010-810

    Aurora, Colorado, 80045

  • Local Institution - 010-535 - D

    Babylon, New York, 11702

  • Local Institution - 010-573

    Bakersfield, California, 93309

  • Local Institution - 010-534

    Baltimore, Maryland, 21201

  • Local Institution - 010-918 - B

    Basking Ridge, New Jersey, 07920

  • Local Institution - 010-920

    Baton Rouge, Louisiana, 70809

  • Local Institution - 010-993

    Belleville, New Jersey, 07109

  • Local Institution - 010-855-B

    Bessemer, Alabama, 35022

  • Local Institution - 010-855-D

    Birmingham, Alabama, 35209

  • Local Institution - 010-855-A

    Birmingham, Alabama, 35211

  • Local Institution - 010-855-F

    Birmingham, Alabama, 35235

  • Local Institution - 010-855-C

    Birmingham, Alabama, 35243

  • Local Institution - 010-855

    Birmingham, Alabama, 35243

  • Local Institution - 010-922-A

    Bonita Springs, Florida, 34135

  • Local Institution - 010-997

    Boston, Massachusetts, 02215

  • Local Institution - 010-872-A

    Boulder, Colorado, 80303

  • Local Institution - 010-976-C

    Bountiful, Utah, 84010

  • Local Institution - 010-922-D

    Bradenton, Florida, 34211

  • Local Institution - 010-531A

    Brownstown, Michigan, 48183

  • Local Institution - 010-922-E

    Cape Coral, Florida, 33909

  • Local Institution - 010-872-E

    Centennial, Colorado, 80112

  • Local Institution - 010-921

    Chattanooga, Tennessee, 37404

  • Local Institution - 010-979C

    Chula Vista, California, 91911

  • Local Institution - 010-893

    Cincinnati, Ohio, 45211

  • Local Institution - 010-585-B

    Clinton, North Carolina, 28328

  • Local Institution - 010-872-C

    Colorado Springs, Colorado, 80907

  • Local Institution - 010-918 - A

    Commack, New York, 11725

  • Local Institution - 010-572

    Dallas, Texas, 75216

  • Local Institution - 010-879

    Dallas, Texas, 75246

  • Local Institution - 010-531C

    Dearborn, Michigan, 48126

  • Local Institution - 010-872

    Denver, Colorado, 80218

  • Local Institution - 010-872-B

    Denver, Colorado, 80220

  • Local Institution - 010-531

    Detroit, Michigan, 48202

  • Local Institution - 010-975

    East Brunswick, New Jersey, 08816

  • Local Institution - 010-576

    Everett, Washington, 98201

  • Local Institution - 010-919

    Fairfax, Virginia, 22031-4630

  • Local Institution - 010-992

    Florham Park, New Jersey, 07932

  • Local Institution - 010-922

    Fort Myers, Florida, 33901

  • Local Institution - 010-922-B

    Fort Myers, Florida, 33905

  • Local Institution - 010-922-C

    Fort Myers, Florida, 33908

  • Local Institution - 010-597

    Fredericksburg, Virginia, 24408

  • Local Institution - 010-980

    Fresno, California, 93701

  • Local Institution - 010-851

    Fullerton, California, 92835

  • Local Institution - 010-533 B

    Gig Harbor, Washington, 98335

  • Local Institution - 010-996

    Gilbert, Arizona, 85234

  • Local Institution - 010-585

    Goldsboro, North Carolina, 27534

  • Local Institution - 010-566

    Goodyear, Arizona, 85338

  • Local Institution - 010-981

    Greenville, South Carolina, 29607

  • Local Institution - 010-918 - F

    Harrison, New York, 10604

  • Local Institution - 010-860 - A

    Henderson, Nevada, 89052

  • Local Institution - 010-860-F

    Henderson, Nevada, 89052

  • Local Institution - 010-860-B

    Henderson, Nevada, 89074

  • Local Institution - 010-984-B

    Holiday, Florida, 34691

  • Local Institution - 010-577-B

    Houston, Texas, 77008

  • Local Institution - 010-577-A

    Houston, Texas, 77024

  • Local Institution - 010-577

    Houston, Texas, 77030

  • Local Institution - 010-848

    Houston, Texas, 77030

  • Local Institution - 010-977

    Houston, Texas, 77090

  • Local Institution - 010-569-A

    Indianapolis, Indiana, 46237-8601

  • Local Institution - 010-569

    Indianapolis, Indiana, 46237-8601

  • Local Institution - 010-991

    Iowa City, Iowa, 52242

  • Local Institution - 010-999

    Irving, Texas, 75063

  • Local Institution - 010-829

    Jacksonville, Florida, 32224

  • Local Institution - 010-585-A

    Jacksonville, North Carolina, 28546

  • Local Institution - 010-979A

    La Mesa, California, 91942

  • Local Institution - 010-872-J

    Lakewood, Colorado, 80228

  • Local Institution - 010-923-A

    Largo, Florida, 33770

  • Local Institution - 010-923-B

    Largo, Florida, 33770

  • Local Institution - 010-923-C

    Largo, Florida, 33770

  • Local Institution - 010-923-D

    Largo, Florida, 33770

  • Local Institution - 010-923-E

    Largo, Florida, 33770

  • Local Institution - 010-923-F

    Largo, Florida, 33770

  • Local Institution - 010-923-G

    Largo, Florida, 33770

  • Local Institution - 010-923-H

    Largo, Florida, 33770

  • Local Institution - 010-923-I

    Largo, Florida, 33770

  • Local Institution - 010-923-J

    Largo, Florida, 33770

  • Local Institution - 010-923-K

    Largo, Florida, 33770

  • Local Institution - 010-923-L

    Largo, Florida, 33770

  • Local Institution - 010-923-M

    Largo, Florida, 33770

  • Local Institution - 010-923-N

    Largo, Florida, 33770

  • Local Institution - 010-923-O

    Largo, Florida, 33770

  • Local Institution - 010-923-P

    Largo, Florida, 33770

  • Local Institution - 010-860-D

    Las Vegas, Nevada, 89128

  • Local Institution - 010-860-C

    Las Vegas, Nevada, 89144

  • Local Institution - 010-860-E

    Las Vegas, Nevada, 89148

  • Local Institution - 010-860

    Las Vegas, Nevada, 89169

  • Local Institution - 010-976-D

    Layton, Utah, 84041

  • Local Institution - 010-564

    Lincoln, Nebraska, 68510

  • Local Institution - 010-872-F

    Littleton, Colorado, 80218

  • Local Institution - 010-872-G

    Longmont, Colorado, 80501

  • Local Institution - 010-878-B

    Longview, Texas, 75601

  • Local Institution - 010-958A

    Los Angeles, California, 90033

  • Local Institution - 010-958

    Los Angeles, California, 90033

  • Local Institution - 010-551

    Los Angeles, California, 90048

  • Local Institution - 010-990

    Miami, Florida, 33136

  • Local Institution - 010-918 - D

    Middletown, New Jersey, 07748

  • Local Institution - 010-947

    Milwaukee, Wisconsin, 53226

  • Local Institution - 010-875

    Minneapolis, Minnesota, 55404

  • Local Institution - 010-918 - C

    Montvale, New Jersey, 07645

  • Local Institution - 010-575

    Morgantown, West Virginia, 26506-9300

  • Local Institution - 010-976-A

    Murray, Utah, 84157

  • Local Institution - 010-963

    Naperville, Illinois, 60540

  • Local Institution - 010-922-F

    Naples, Florida, 34102

  • Local Institution - 010-922-G

    Naples, Florida, 34102

  • Local Institution - 010-801

    Nashville, Tennessee, 37203

  • Local Institution - 010-957

    New Brunswick, New Jersey, 08903-2681

  • Local Institution - 010-813

    New York, New York, 10016

  • Local Institution - 010-535 - G

    New York, New York, 10028

  • Local Institution - 010-998

    New York, New York, 10029

  • Local Institution - 010-918

    New York, New York, 10065

  • Local Institution - 010-986

    Newnan, Georgia, 30265

  • Local Institution - 010-847

    Newport Beach, California, 92663

  • Local Institution - 010-949

    Norwich, Connecticut, 06360

  • Local Institution - 010-531B

    Novi, Michigan, 48377

  • Local Institution - 010-538

    Ocala, Florida, 34474

  • Local Institution - 010-976-H

    Ogden, Utah, 84405

  • Local Institution - 010-532

    Oklahoma City, Oklahoma, 73104

  • Local Institution - 010-549

    Oklahoma City, Oklahoma, 73120

  • Local Institution - 010-590

    Omaha, Nebraska, 68130

  • Local Institution - 010-896

    Orlando, Florida, 32804

  • Local Institution - 010-988

    Orlando, Florida, 32806

  • Local Institution - 010-535 - C

    Patchogue, New York, 11772

  • Local Institution - 010-989

    Phoenix, Arizona, 85054

  • Local Institution - 010-596

    Pittsburgh, Pennsylvania, 15212

  • Local Institution - 010-922-H

    Port Charlotte, Florida, 33980

  • Local Institution - 010-535 - A

    Port Jefferson, New York, 11776

  • Local Institution - 010-535 - B

    Port Jefferson Station, New York, 11776

  • Local Institution - 010-976-G

    Provo, Utah, 84604

  • Local Institution - 010-872-I

    Pueblo, Colorado, 81008

  • Local Institution - 010-533 C

    Puyallup, Washington, 98372

  • Local Institution - 010-563

    Redlands, California, 92373

  • Local Institution - 010-539

    Richmond, Virginia, 23229

  • Local Institution - 010-536

    Richmond, Virginia, 23298

  • Local Institution - 010-535 - F

    Riverhead, New York, 11901

  • Local Institution - 010-830

    Rochester, Minnesota, 55905

  • Local Institution - 010-838

    Saint Louis Park, Minnesota, 55416

  • Local Institution - 010-838A

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838B

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838C

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838D

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838E

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838F

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838G

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838H

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838I

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838J

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838K

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838L

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-838M

    Saint Louis Park, Minnesota, 55426

  • Local Institution - 010-976-B

    Salt Lake City, Utah, 84102

  • Local Institution - 010-976

    Salt Lake City, Utah, 84106

  • Local Institution - 010-862

    San Antonio, Texas, 78240

  • Local Institution - 010-979B

    San Diego, California, 92123

  • Local Institution - 010-979D

    San Diego, California, 92123

  • Local Institution - 010-979

    San Diego, California, 92123

  • Local Institution - 010-982

    San Francisco, California, 94115

  • Local Institution - 010-561

    Santa Monica, California, 90404

  • Local Institution - 010-824

    Seattle, Washington, 98109--1023

  • Local Institution - 010-535

    Shirley, New York, 11967

  • Local Institution - 010-978

    Springdale, Arkansas, 72762

  • Local Institution - 010-541

    Springfield, Missouri, 65804

  • Local Institution - 010-923

    St. Petersburg, Florida, 33705

  • Local Institution - 010-984

    St. Petersburg, Florida, 33709-2236

  • Local Institution - 010-571

    Sylmar, California, 91342

  • Local Institution - 010-533

    Tacoma, Washington, 98405

  • Local Institution - 010-924

    Tallahassee, Florida, 32308

  • Local Institution - 010-964

    Temple, Texas, 76508

  • Local Institution - 010-535 - E

    The Bronx, New York, 10469

  • Local Institution - 010-872-D

    Thornton, Colorado, 80260

  • Local Institution - 010-574

    Torrance, California, 90505

  • Local Institution - 010-984-A

    Trinity, Florida, 34655

  • Local Institution - 010-584

    Tulsa, Oklahoma, 74146

  • Local Institution - 010-878

    Tyler, Texas, 75702

  • Local Institution - 010-918 - E

    Uniondale, New York, 11553

  • Local Institution - 010-885

    Vancouver, Washington, 98684

  • Local Institution - 010-976-E

    West Jordan, Utah, 84088

  • Local Institution - 010-926

    West Palm Beach, Florida, 33401

  • Local Institution - 010-537

    Weston, Florida, 33331

  • Local Institution - 010-570

    Whittier, California, 90602

  • Local Institution - 010-994

    Zion, Illinois, 60099

Other trials in United States

China33 sites

  • Local Institution - 010-717

    Beijing, Beijing Municipality, 100021

  • Local Institution - 010-712

    Bengbu, Anhui, 233004

  • Local Institution - 010-030

    Changchun, Jilin, 130012

  • Local Institution - 010-718

    Changchun, Jilin, 130021

  • Local Institution - 010-035

    Changsha, Hunan, 410008

  • Local Institution - 010-710

    Chengdu, Sichuan, 610044

  • Local Institution - 010-029

    Fuzhou, Fujian, 350014

  • Local Institution - 010-031

    Guangzhou, Guangdong, 510655

  • Local Institution - 010-707

    Hangzhou, Zhejiang, 310009

  • Local Institution - 010-034

    Hangzhou, Zhejiang, 310022

  • Local Institution - 010-032

    Hangzhou, 310016

  • Local Institution - 010-026

    Hefei, Anhui, 230001

  • Local Institution - 010-022

    Hefei, Anhui, 230022

  • Local Institution - 010-711

    Hefei, Anhui, 230031

  • Local Institution - 010-033

    Hongkou Qu, 200080

  • Local Institution - 010-714

    Jiangyin, Jiangsu, 214400

  • Local Institution - 010-036

    Jinan, Shandong, 250117

  • Local Institution - 010-706

    Nanchang, Jiangxi, 330006

  • Local Institution - 010-704

    Nanjing, Jiangsu, 210029

  • Local Institution - 010-715

    Nanning, Guangxi, 530021

  • Local Institution - 010-716

    Neijiang, Sichuan, 641199

  • Local Institution - 010-038

    Shanghai, Shanghai Municipality, 200080

  • Local Institution - 010-020

    Shanghai, Shanghai Municipality, 200120

  • Local Institution - 010-708

    Shanghai, Shanghai Municipality, 200240

  • Local Institution - 010-025

    Shanghai Shi, Shanghai Municipality, 200025

  • Local Institution - 010-024

    Shanghaishi, Shanghai Municipality, 200032

  • Local Institution - 010-709

    Shenyang, Liaoning, 110001

  • Local Institution - 010-705

    Shenyang, Liaoning, 110042

  • Local Institution - 010-713

    Shenzhen, Guangdong, 518036

  • Local Institution - 010-027

    Tianjin, Tianjin Municipality, 300060

  • Local Institution - 010-703

    Wuhan, Hubei, 430030

  • Local Institution - 010-701

    Wuhan, Hubei, 430079

  • Local Institution - 010-021

    Zhengzhou, Henan, 450008

Other trials in China

France18 sites

  • Local Institution - 010-668

    Avignon, 84918

  • Local Institution - 010-208

    Besançon, 25000

  • Local Institution - 010-669

    Bordeaux, 33000

  • Local Institution - 010-194

    Brest, 29200

  • Local Institution - 010-209-A

    Chambray-lès-Tours, Centre-Val de Loire, 37170

  • Local Institution - 010-192

    Dijon, 21079

  • Local Institution - 010-662

    Lille, 59037

  • Local Institution - 010-205

    Lyon, 69008

  • Local Institution - 010-682

    Marseille, 13005

  • Local Institution - 010-207

    Paris, 75010

  • Local Institution - 010-203

    Paris, 75012

  • Local Institution - 010-204

    Paris, 75013

  • Local Institution - 010-661

    Paris, 75015

  • Local Institution - 010-660

    Pessac, 33720

  • Local Institution - 010-667

    Suresnes, 92150

  • Local Institution - 010-680

    Toulouse, 31059

  • Local Institution - 010-209

    Tours, 37044

  • Local Institution - 010-202

    Villejuif, 94805

Other trials in France

South Korea15 sites

  • Local Institution - 010-116

    Anyang-si, 14068

  • Local Institution - 010-111

    Busan, 48108

  • Local Institution - 010-119

    Busan, 602-812

  • Local Institution - 010-525

    Daejeon, 35015

  • Local Institution - 010-117

    Goyang-si, 10408

  • Local Institution - 010-100

    Hwasun-gun, 58128

  • Local Institution - 010-520

    Seongnam-si, 13496

  • Local Institution - 010-105

    Seoul, 02841

  • Local Institution - 010-108

    Seoul, 03080

  • Local Institution - 010-118

    Seoul, 03722

  • Local Institution - 010-104

    Seoul, 05505

  • Local Institution - 010-114

    Seoul, 06351

  • Local Institution - 010-109

    Seoul, 06591

  • Local Institution - 010-115

    Suwon, 16247

  • Local Institution - 010-524

    Yangsan, 50612

Other trials in South Korea

Spain15 sites

  • Local Institution - 010-613

    A Coruña, 15006

  • Local Institution - 010-610

    Badalona, 08916

  • Local Institution - 010-612

    Barcelona, 08035

  • Local Institution - 010-600

    Barcelona, 08036

  • Local Institution - 010-621

    Córdoba, 14004

  • Local Institution - 010-620

    LHospitalet de Llobregat, 08908

  • Local Institution - 010-619

    Madrid, 28007

  • Local Institution - 010-601

    Madrid, 28040

  • Local Institution - 010-617

    Madrid, 28041

  • Local Institution - 010-624

    Madrid, 28046

  • Local Institution - 010-623

    Pamplona, 31008

  • Local Institution - 010-622

    Sabadell, 08208

  • Local Institution - 010-604

    Santander, 39008

  • Local Institution - 010-618

    Valencia, 46010

  • Local Institution - 010-625

    Valencia, 46014

Other trials in Spain

Italy14 sites

  • Local Institution - 010-292

    Avellino, 83100

  • Local Institution - 010-290

    Biella, 13875

  • Local Institution - 010-299

    Cagliari, 9042

  • Local Institution - 010-286

    Candiolo, 10060

  • Local Institution - 010-287

    Lido di Camaiore, 55041

  • Local Institution - 010-270

    Meldola, 47014

  • Local Institution - 010-278

    Milan, 20141

  • Local Institution - 010-293

    Milan, 20162

  • Local Institution - 010-271

    Naples, 80131

  • Local Institution - 010-297

    Padova, 35128

  • Local Institution - 010-294

    Pisa, 56126

  • Local Institution - 010-291

    Reggio Emilia, 42100

  • Local Institution - 010-295

    Roma, 00144

  • Local Institution - 010-289

    Torino, 10128

Other trials in Italy

Germany12 sites

  • Local Institution - 010-675

    Amberg, 92224

  • Local Institution - 010-657

    Berlin, 10117

  • Local Institution - 010-655

    Bochum, 44791

  • Local Institution - 010-227

    Dresden, 01307

  • Local Institution - 010-229

    Frankfurt am Main, 60488

  • Local Institution - 010-656

    Hamburg, D-20249

  • Local Institution - 010-658

    Herne, 44625

  • Local Institution - 010-228

    Mönchengladbach, 41063

  • Local Institution - 010-650

    München, 81377

  • Local Institution - 010-226

    München, 81737

  • Local Institution - 010-652

    Reutlingen, 72764

  • Local Institution - 010-676

    Ulm, 89081

Other trials in Germany

United Kingdom12 sites

  • Local Institution - 010-412

    Aberdeen, AB25 2ZN

  • Local Institution - 010-410

    Birmingham, B15 2WB

  • Local Institution - 010-413

    Cambridge, CB2 0QQ

  • Local Institution - 010-411

    Dorset, BH7 7DW

  • Local Institution - 010-400

    Glasgow, G12 0XH

  • Local Institution - 010-403

    Kent, ME16 9QQ

  • Local Institution - 010-414

    Leeds, LS9 7TF

  • Local Institution - 010-402

    London, NW1 2BU

  • Local Institution - 010-405

    London, SW3 6JJ

  • Local Institution - 010-406

    London, SW3 6JJ

  • Local Institution - 010-407

    Manchester, M20 4BX

  • Local Institution - 010-404

    Middlesex, HA6 2RN

Other trials in United Kingdom

Brazil10 sites

  • Local Institution - 010-450

    Blumenau, Santa Catarina, 89010-340

  • Local Institution - 010-442

    Curitiba, 80040-170

  • Local Institution - 010-446

    Ijuí, Rio Grande do Sul, 98700-000

  • Local Institution - 010-449

    Liberdade, 01509-010

  • Local Institution - 010-443

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Local Institution - 010-444

    Santo André, 09060-650

  • Local Institution - 010-440

    São José do Rio Preto, 15090-000

  • Local Institution - 010-441

    São Paulo, 01246-000

  • Local Institution - 010-445

    São Paulo, 01323-030

  • Local Institution - 010-447

    São Paulo, 04543-000

Other trials in Brazil

Romania8 sites

  • Local Institution - 010-347

    Baia Mare, 430031

  • Local Institution - 010-349

    Brasov, 500152

  • Local Institution - 010-512

    Bucharest, 022328

  • Local Institution - 010-344

    Cluj-Napoca, 400015

  • Local Institution - 010-340

    Cluj-Napoca, 400641

  • Local Institution - 010-343

    Craiova, 200746

  • Local Institution - 010-511

    Ovidiu, 905900

  • Local Institution - 010-510

    Timișoara, 300239

Other trials in Romania

Mexico7 sites

  • Local Institution - 010-471

    Colonia Centro Orizaba, Veracruz, 94300

  • Local Institution - 010-476

    Cuernavaca, Morelos, 62290

  • Local Institution - 010-472

    Guadalajara, Jalisco, 44280

  • Local Institution - 010-477

    Guadalajara, Jalisco, 44670

  • Local Institution - 010-473

    Mexico City, Mexico City, 14080

  • Local Institution - 010-475

    San Juan del Río, Querétaro, 76800

  • Local Institution - 010-474

    Tuxtla Gutiérrez, Chiapas, 29038

Other trials in Mexico

Taiwan7 sites

  • Local Institution - 010-129

    Changhua, 500

  • Local Institution - 010-121

    Kaohsiung City, 807

  • Local Institution - 010-124

    Taichung, 40705

  • Local Institution - 010-122

    Tainan, 704

  • Local Institution - 010-123

    Tainan, 73657

  • Local Institution - 010-120

    Taipei, 10002

  • Local Institution - 010-125

    Taoyuan, 333

Other trials in Taiwan

Argentina6 sites

  • Local Institution - 010-434

    Buenos Aires, C1426ANZ

  • Local Institution - 010-431

    Buenos Aires, CI264 AAA

  • Local Institution - 010-432

    CABA, 1061

  • Local Institution - 010-430

    La Rioja, F5300COE

  • Local Institution - 010-448

    Porto Alegre, 91350-200

  • Local Institution - 010-433

    Viedma, R8500ACE

Other trials in Argentina

Australia6 sites

  • Local Institution - 010-005

    Bedford Park, 5042

  • Local Institution - 010-004

    Clayton, 3168

  • Local Institution - 010-006

    Garran, 2065

  • Local Institution - 010-015

    Heidelberg, 3084

  • Local Institution - 010-012

    Melbourne, 3004

  • Local Institution - 010-002

    Waratah, 2298

Other trials in Australia

Greece6 sites

  • Local Institution - 010-501

    Athens, 11528

  • Local Institution - 010-232

    Cholargós, 155 62

  • Local Institution - 010-238

    Heraklion, 71110

  • Local Institution - 010-235

    Larissa, 41110

  • Local Institution - 010-231

    Thessaloniki, 54645

  • Local Institution - 010-230

    Thessaloniki, 57001

Other trials in Greece

Malaysia6 sites

  • Local Institution - 010-070

    Johor Bahru, Johor, 81100

  • Local Institution - 010-077

    Kota Kinabalu, Sabah, 88996

  • Local Institution - 010-073

    Kuala Lumpur, 50586

  • Local Institution - 010-074

    Kuala Lumpur, 50603

  • Local Institution - 010-071

    Petaling Jaya, Selangor, 46050

  • Local Institution - 010-072

    Putrajaya, 62250

Other trials in Malaysia

Ireland5 sites

  • Local Institution - 010-250

    Dublin, 4

  • Local Institution - 010-252

    Dublin, 9

  • Local Institution - 010-253

    Dublin, D07 R2WY

  • Local Institution - 010-254

    Dublin, D07 WKW8

  • Local Institution - 010-251

    Dublin, D24 NR0A

Other trials in Ireland

Portugal5 sites

  • Local Institution - 010-332

    Braga, 4710-243

  • Local Institution - 010-337

    Lisbon, 1400-038

  • Local Institution - 010-640

    Lisbon, 1649-035

  • Local Institution - 010-331

    Porto, 4099-001

  • Local Institution - 010-339

    Porto, 4200-072

Other trials in Portugal

Singapore5 sites

  • Local Institution - 010-090

    Singapore, 119074

  • Local Institution - 010-093

    Singapore, 168583

  • Local Institution - 010-095

    Singapore, 188770

  • Local Institution - 010-092

    Singapore, 217562

  • Local Institution - 010-091

    Singapore, 258499

Other trials in Singapore

Thailand5 sites

  • Local Institution - 010-132

    Bang Phlat, 10700

  • Local Institution - 010-134

    Bangkok, 10400

  • Local Institution - 010-131

    Chiang Mai, 50200

  • Local Institution - 010-130

    Hat Yai, 90110

  • Local Institution - 010-133

    Khlong Toey, 10110

Other trials in Thailand

Belgium4 sites

  • Local Institution - 010-154

    Brussels, 1090

  • Local Institution - 010-157

    Edegem, 2650

  • Local Institution - 010-156

    Ghent, 9000

  • Local Institution - 010-150

    Yvoir, B-5530

Other trials in Belgium

Canada4 sites

  • Local Institution - 010-487

    Montreal, Quebec, H1T 2M4

  • Local Institution - 010-481

    Ottawa, Ontario, K1H 8L6

  • Local Institution - 010-483

    Toronto, Ontario, M5B 1W8

  • Local Institution - 010-482

    Toronto, Ontario, M5G 2M9

Other trials in Canada

Colombia4 sites

  • Local Institution - 010-460

    Barranquilla, 080020

  • Local Institution - 010-462

    Bogotá, 0

  • Local Institution - 010-465

    Floridablanca, 0

  • Local Institution - 010-463

    Medellín, 050034

Other trials in Colombia

Czechia4 sites

  • Local Institution - 010-165

    Brno, 656 53

  • Local Institution - 010-160

    Brno, 656 91

  • Local Institution - 010-162

    Olomouc, 779 00

  • Local Institution - 010-161

    Prague, 150 06

Other trials in Czechia

Netherlands4 sites

  • Local Institution - 010-632

    Amsterdam, 1066 CX

  • Local Institution - 010-306

    Amsterdam, 1081 HV

  • Local Institution - 010-630

    Nijmegen, 6525 GA

  • Local Institution - 010-307

    Utrecht, 3543 AZ

Other trials in Netherlands

Poland4 sites

  • Local Institution - 010-328

    Gdansk, 80-219

  • Local Institution - 010-327

    Otwock, 05-400

  • Local Institution - 010-322

    Warsaw, 02-034

  • Local Institution - 010-787

    Warsaw, 02-507

Other trials in Poland

Austria3 sites

  • Local Institution - 010-145

    Innsbruck, 6020

  • Local Institution - 010-144

    Vienna, 1090

  • Local Institution - 010-143

    Wiener Neustadt, 2700

Other trials in Austria

Denmark3 sites

  • Local Institution - 010-171

    Copenhagen, 2100

  • Local Institution - 010-172

    Odense, 5000

  • Local Institution - 010-170

    Vejle, 7100

Other trials in Denmark

Finland3 sites

  • Local Institution - 010-180

    Helsinki, FI-00029

  • Local Institution - 010-182

    Tampere, 33520

  • Local Institution - 010-181

    Turku, 20521

Other trials in Finland

Puerto Rico3 sites

  • Local Institution - 010-902

    San Juan, 00919

  • Local Institution - 010-903

    San Juan, 00927

  • Local Institution - 010-900

    San Juan, 00935

Other trials in Puerto Rico

Hong Kong2 sites

  • Local Institution - 010-048

    Central, 0

  • Local Institution - 010-046

    Hong Kong, 0

Other trials in Hong Kong

Ukraine1 site

  • Local Institution - 010-424

    Sumy, 40022

Other trials in Ukraine

About this study

Official title: A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy

Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

Being tested
MRTX849, Cetuximab, mFOLFOX6 Regimen, FOLFIRI Regimen
Keywords
Colorectal Cancer, Colorectal Cancer Trial, Colorectal Carcinoma, Rectal Cancer, Colon Cancer, KRAS, KRAS G12C, RAS, Colorectal Adenocarcinoma
Medical subject headings
Colorectal Neoplasms, Rectal Neoplasms, Colonic Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • MRTX849Drug

    28 Day Cycle

  • CetuximabBiological

    Also called Erbitux

    28 Day Cycle

  • mFOLFOX6 RegimenDrug

    • Fluorouracil
    • Oxaliplatin
    • Folinic acid

  • FOLFIRI RegimenDrug

    • Fluorouracil
    • Irinotecan
    • Folinic acid
Study groups in NCT04793958
Study groupRoleWhat they receive
MRTX849 + CetuximabExperimentalNot described
Receives: Drug: MRTX849; Biological: Cetuximab
mFOLFOX6 or FOLFIRIActive comparatorNot described
Receives: Drug: mFOLFOX6 Regimen; Drug: FOLFIRI Regimen

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall Survival (OS)

    Defined as time from date of randomization to date of death due to any cause.

    Measured: 30 months

  2. Progression-free Survival (PFS)

    Defined as time from randomization until disease progression or death from any cause, whichever occurs first.

    Measured: 30 months

Secondary outcomes (5)

  1. Adverse Events

    Defined as number of patients with treatment emergent AEs.

    Measured: 30 months

  2. Objective Response Rate (ORR)

    Defined as the percent of patients documented to have a confirmed CR or PR.

    Measured: 30 months

  3. Duration of Response (DOR)

    Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.

    Measured: 30 months

  4. Patient Reported Outcomes (PROs)

    To be assessed by European Quality of Life Questionnaire for Cancer Patients (QLQ-C30).

    Measured: 30 months

  5. Quality of Life Assessment

    To be assessed by European Quality of Life Five Dimensions Questionnaire (EQ-5D-5L).

    Measured: 30 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Mar 2021
  2. Study start24 Jun 2021
  3. Primary completion16 Jan 2026
  4. Study completion23 Oct 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
461 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04793958
Sponsor's protocol ID
CA239-0006
Other IDs
KRYSTAL-10, CA239-0006, 849-010
Status last verified
Sep 2026
First submitted
2 Mar 2021
Last updated
28 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Expanded access
Available

Publications

  • Deming DA. Development of KRAS Inhibitors and Their Role for Metastatic Colorectal Cancer. J Natl Compr Canc Netw. 2025 Jan 3;23(1):e247067. doi: 10.6004/jnccn.2024.7067.

    PubMed 39752885

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing MRTX849, Cetuximab and mFOLFOX6 Regimen in people with Advanced Colorectal Cancer and Metastatic Colorectal Cancer, run by Mirati Therapeutics Inc. at 419 sites in 32 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 419 sites in United States, China, France, South Korea, Spain and 27 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Overall Survival (OS) (time frame: 30 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04793958, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026.

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