Cognitive DeclineNCT04534374
Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed
A study testing Resistance exercise in people with Cognitive Decline and Aging, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial. Read more about this study
- Who is it for?
- Ages 50 to 65 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Cognitive Decline, Aging
- What is being tested?
- Resistance exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 28 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Aug 2017to 1 Aug 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 65 years
- Men only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- male adults aged 50-65 years old
- exercise ≥ 150 minutes/week
- normal or corrected-to-normal vision
- right-handed
Who cannot join
- dementia (MMSE ≥ 24)
- any medical condition listed on PARQ
- depression (BDI-II score ≤ 13)
- any diagnostic cardiovascular, neurological and other chronic diseases
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed and Decreases Conflict-related Neural Activity in Older Adults: A Crossover, Sham Control, Randomized Control Trial With REP
This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial.
- Conditions
- Cognitive Decline, Aging
- Being tested
- Resistance exercise, Stretching exercise (sham exercise)
- Keywords
- exercise, resistance training, kinesiology, cognition, ERP, neuroimage
- Medical subject headings
- Cognitive Dysfunction, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance exerciseBehavioural
Barbell back squat, press, and deadlift for three sets of five repetitions with the weight closest to 75% of their estimated 1 repetition max. The participants were instructed to execute the movement with moderate speed (2s eccentric, 2s concentric, no pause in between). The rest period between sets and exercise movements was two to three minutes.
Stretching exercise (sham exercise)Behavioural
Participants completed a passive stretching exercise session for a similar duration of time as the resistance exercise (≈ 30 min) as sham intervention, which included 15-20 stretching movements twice, holding each for 30 seconds as recommended by ACSM.
| Study group | Role | What they receive |
|---|---|---|
| Resistance exercise | Experimental | The experimental intervention is a session of resistance exercise described in the intervention section. Receives: Behavioral: Resistance exercise |
| Stretching exercise | Active comparator | The active control intervention is a session of stretching exercise described in the intervention section. Receives: Behavioral: Stretching exercise (sham exercise) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change of Information processing speed between resistance and stretching exercises
Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.
Measured: 5-30 minutes before and 10-35 minutes after each intervention.
Change of Inhibitory control between resistance and stretching exercises
Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.
Measured: 5-30 minutes before and 10-35 minutes after each intervention.
Secondary outcomes (2)
Change of Conflict-related neural activity between resistance and stretching exercises
N2b (event-related potential)
Measured: 5-30 minutes before and 10-35 minutes after each intervention.
Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises
P3 (event-related potential)
Measured: 5-30 minutes before and 10-35 minutes after each intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Sep 2020
- Study start1 Aug 2017
- Primary completion1 Aug 2019
- Study completion1 Aug 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cognitive DeclineStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ting-Yu Lin, National Taiwan Normal University
- Investigators
- Tsung-Min Hung, Ph.D., Study chair, Department of Physical Education, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04534374
- Sponsor's protocol ID
- 201807HM004
- Status last verified
- Aug 2020
- First submitted
- 25 Aug 2020
- Last updated
- 1 Sep 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The participant-level data and statistical code are available on request and the data will be anonymized.
Publications
Lin TY, Hsieh SS, Chueh TY, Huang CJ, Hung TM. The effects of barbell resistance exercise on information processing speed and conflict-related ERP in older adults: a crossover randomized controlled trial. Sci Rep. 2021 Apr 28;11(1):9137. doi: 10.1038/s41598-021-88634-5.
PubMed 33911153
Study at a glance
From the registry record, last updated by the sponsor on 1 Sep 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed and Decreases Conflict-related Neural Activity in Older Adults: A Crossover, Sham Control, Randomized Control Trial With REP
- ClinicalTrials.gov ID
- NCT04534374
- Acronym / sponsor ID
- 201807HM004
- Conditions
- Cognitive Decline, Aging
- Keywords
- exercise, resistance training, kinesiology, cognition, ERP, neuroimage
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 1 Aug 2017 (actual)
- Primary completion
- 1 Aug 2019 (actual)
- Study completion
- 1 Aug 2019 (actual)
- First posted
- 1 Sep 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Resistance exercise | Experimental | Behavioral: Resistance exerciseThe experimental intervention is a session of resistance exercise described in the intervention section. |
| Stretching exercise | Active comparator | Behavioral: Stretching exercise (sham exercise)The active control intervention is a session of stretching exercise described in the intervention section. |
Who may qualify
- Ages
- 50 to 65 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- male adults aged 50-65 years old
- exercise ≥ 150 minutes/week
- normal or corrected-to-normal vision
- right-handed
Key exclusion criteria (4 listed)
- dementia (MMSE ≥ 24)
- any medical condition listed on PARQ
- depression (BDI-II score ≤ 13)
- any diagnostic cardiovascular, neurological and other chronic diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance exerciseBarbell back squat, press, and deadlift for three sets of five repetitions with the weight closest to 75% of their estimated 1 repetition max. The participants were instructed to execute the movement with moderate speed (2s eccentric, 2s concentric, no pause in between). The rest period between sets and exercise movements was two to three minutes. | Behavioural | Resistance exercise |
| Stretching exercise (sham exercise)Participants completed a passive stretching exercise session for a similar duration of time as the resistance exercise (≈ 30 min) as sham intervention, which included 15-20 stretching movements twice, holding each for 30 seconds as recommended by ACSM. | Behavioural | Stretching exercise |
Primary outcome
Change of Information processing speed between resistance and stretching exercises
Time frame: 5-30 minutes before and 10-35 minutes after each intervention.
Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.
Change of Inhibitory control between resistance and stretching exercises
Time frame: 5-30 minutes before and 10-35 minutes after each intervention.
Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.
2 secondary outcomes
Change of Conflict-related neural activity between resistance and stretching exercises
Time frame: 5-30 minutes before and 10-35 minutes after each intervention.
Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises
Time frame: 5-30 minutes before and 10-35 minutes after each intervention.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Sep 2020.
- Derived from this study: PubMed 33911153Lin TY, Hsieh SS, Chueh TY, Huang CJ, Hung TM. The effects of barbell resistance exercise on information processing speed and conflict-related ERP in older adults: a crossover randomized controlled trial. Sci Rep. 2021 Apr 28;11(1):9137. doi: 10.1038/s41598-021-88634-5.
- Individual participant dataSharing planned: Yes. The participant-level data and statistical code are available on request and the data will be anonymized.
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EFFECTS OF AN OUTDOOR MAT PILATES PROGRAM ON NEUROPHYSIOLOGICAL INDICATORS OF ELDERLY INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT
Cognition Disorders
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tsung-Min Hung, Ph.D. study chair
Department of Physical Education, National Taiwan Normal University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance exercise in people with Cognitive Decline and Aging, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Sep 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change of Information processing speed between resistance and stretching exercises (time frame: 5-30 minutes before and 10-35 minutes after each intervention.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04534374, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Sep 2020.