SpeechNCT04497428
Sensory Basis of Speech Motor Learning
A study testing Adaptation and cTBS in people with Speech and Consolidation, run by Yale University at 1 site in Canada.
Trial summary
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning. Read more about this study
- Who is it for?
- Ages 21 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Speech, Consolidation
- What is being tested?
- Adaptation and cTBS
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteCanada
- Study dates
- 1 Aug 2019to 31 Jul 2025
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- right handed adults
- no known physical or neurological abnormalities
Who cannot join
- patients with:
- cardiac pacemaker
- surgical clips or values on the heart
- implants
- metal or metallic fragments in any part of the body
- pregnancy
Show all 12Show fewer
- claustrophobia
- a personal or family history of epilepsy
- currently taking antipsychotic drugs
- currently taking antidepressant drugs
- currently taking antianxiety drugs
- history of concussion.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Brain Structures in Speech Motor Memory Consolidation
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
Read the detailed description
Subjects will train using altered auditory feedback. Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds (first formant frequency) relative to baseline.
- Conditions
- Speech, Consolidation
- Being tested
- Adaptation, cTBS
- Medical subject headings
- Speech
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AdaptationBehavioural
Sensorimotor adaptation in speech
cTBSOther
continuous theta-burst stimulation
| Study group | Role | What they receive |
|---|---|---|
| Adaptation to Altered Auditory Feedback + cTBS to S1 | Experimental | Adaptation to Altered Auditory Feedback + cTBS to S1 Receives: Behavioral: Adaptation; Other: cTBS |
| Adaptation to Altered Auditory Feedback + cTBS to A1 | Experimental | Adaptation to Altered Auditory Feedback + cTBS to A1 Receives: Behavioral: Adaptation; Other: cTBS |
| Adaptation to Altered Auditory Feedback + cTBS to M1 | Experimental | Adaptation to Altered Auditory Feedback + cTBS to M1 Receives: Behavioral: Adaptation; Other: cTBS |
| Adaptation to Altered Auditory Feedback (Control) | Experimental | Adaptation to Altered Auditory Feedback (Control) Receives: Behavioral: Adaptation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean Percent Change in F1 to Assess Motor Learning
Learning is assessed as change in speech sounds (speech formant frequencies, F1) relative to baseline. The first formant frequency (F1) is the lowest resonant frequency of the vocal tract. Lower F1 Numbers Indicate a high or "closed" tongue position). Higher F1 Numbers indicate a low or "open" jaw position. Absolute numbers vary depending on a person's age and vocal tract size. Percent change calculated as ((F1 end of learning value minus F1 baseline value)/ F1 baseline value)*100).
Measured: Baseline and end of learning (30 minute session)
Mean Percent Change in F1 to Assess Retention of Learning
First formant frequency change (F1) relative to baseline is the dependent measure of retention. Percent change calculated as ((F1 end of retention value minus F1 baseline value)/ F1 baseline value)*100).
Measured: Baseline and 24 hours after learning (re-test lasts 30 minutes)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Aug 2020
- Study start1 Aug 2019
- Primary completion31 Jul 2025
- Study completion31 Jul 2025
Why it stopped: End of funding
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for SpeechStudies of the same condition, open and under way.
- More trials run by Yale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Yale University
- Sponsor type
- University, hospital or other
- Collaborators
- McGill University, National Institute on Deafness and Other Communication Disorders (NIDCD)
- Responsible party
- Sponsor
- Investigators
- David Ostry, Principal investigator, Haskins Laboratories
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04497428
- Sponsor's protocol ID
- 2000025475
- Other IDs
- R01DC017439
- Status last verified
- Sep 2026
- First submitted
- 30 Jul 2020
- Last updated
- 29 Sep 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Brain Structures in Speech Motor Memory Consolidation
- ClinicalTrials.gov ID
- NCT04497428
- Acronym / sponsor ID
- 2000025475
- Conditions
- Speech, Consolidation
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: End of funding
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Yale UniversityUniversity, hospital or other
- Collaborators
- McGill University, National Institute on Deafness and Other Communication Disorders (NIDCD)
- Study start
- 1 Aug 2019 (actual)
- Primary completion
- 31 Jul 2025 (actual)
- Study completion
- 31 Jul 2025 (actual)
- First posted
- 4 Aug 2020 (actual)
- Results
- Posted 29 Sep 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
Detailed description
Subjects will train using altered auditory feedback. Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds (first formant frequency) relative to baseline.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Adaptation to Altered Auditory Feedback + cTBS to S1 | Experimental | Behavioral: Adaptation, Other: cTBSAdaptation to Altered Auditory Feedback + cTBS to S1 |
| Adaptation to Altered Auditory Feedback + cTBS to A1 | Experimental | Behavioral: Adaptation, Other: cTBSAdaptation to Altered Auditory Feedback + cTBS to A1 |
| Adaptation to Altered Auditory Feedback + cTBS to M1 | Experimental | Behavioral: Adaptation, Other: cTBSAdaptation to Altered Auditory Feedback + cTBS to M1 |
| Adaptation to Altered Auditory Feedback (Control) | Experimental | Behavioral: AdaptationAdaptation to Altered Auditory Feedback (Control) |
Who may qualify
- Ages
- 21 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- right handed adults
- no known physical or neurological abnormalities
Key exclusion criteria (12 listed)
- patients with:
- cardiac pacemaker
- surgical clips or values on the heart
- implants
- metal or metallic fragments in any part of the body
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AdaptationSensorimotor adaptation in speech | Behavioural | Adaptation to Altered Auditory Feedback (Control), Adaptation to Altered Auditory Feedback + cTBS to A1, Adaptation to Altered Auditory Feedback + cTBS to M1, Adaptation to Altered Auditory Feedback + cTBS to S1 |
| cTBScontinuous theta-burst stimulation | Other | Adaptation to Altered Auditory Feedback + cTBS to A1, Adaptation to Altered Auditory Feedback + cTBS to M1, Adaptation to Altered Auditory Feedback + cTBS to S1 |
Primary outcome
Mean Percent Change in F1 to Assess Motor Learning
Time frame: Baseline and end of learning (30 minute session)
Learning is assessed as change in speech sounds (speech formant frequencies, F1) relative to baseline. The first formant frequency (F1) is the lowest resonant frequency of the vocal tract. Lower F1 Numbers Indicate a high or "closed" tongue position). Higher F1 Numbers indicate a low or "open" jaw position. Absolute numbers vary depending on a person's age and vocal tract size. Percent change calculated as ((F1 end of learning value minus F1 baseline value)/ F1 baseline value)*100).
Mean Percent Change in F1 to Assess Retention of Learning
Time frame: Baseline and 24 hours after learning (re-test lasts 30 minutes)
First formant frequency change (F1) relative to baseline is the dependent measure of retention. Percent change calculated as ((F1 end of retention value minus F1 baseline value)/ F1 baseline value)*100).
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
David Ostry principal investigator
Haskins Laboratories
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adaptation and cTBS in people with Speech and Consolidation, run by Yale University at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 29 Sep 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean Percent Change in F1 to Assess Motor Learning (time frame: Baseline and end of learning (30 minute session)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.