AzTrials
AzTrials

DyslipidemiaSANTORININCT04271280

Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events

An observational study of Dyslipidemia and Cardiovascular Diseases, run by Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company at 540 sites in 14 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

High and Very High Risk cardiovascular patient journeys seems to vary from country to country, and current understanding of the process is incomplete. This real-life observational study which documents meaningful patient journey-related parameters can be expected to provide meaningful insight into the care process… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
Non-interventional
How many people
9,559 participants
Where
540 sitesin 14 countries
Study dates
17 Mar 2020to 11 Apr 2022
Phase
Observational
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: High risk and very high-risk participants requiring lipid-modifying therapies

Who may be able to join

  • Very High Risk and High Risk dyslipidemic patients requiring LMTs
  • Not simultaneously participating in any interventional study
  • Providing written informed consent for participation in the study (Informed consent form)
  • Life expectancy > 1 year

Who cannot join

  • Not applicable; non-interventional study

Trial locations and contacts

540 sites in 14 countries.

540 sites in 14 countries

Germany139 sites

  • Downtown Clinic Aachen

    Aachen, 52062

  • Kardiologische Praxis Aachen

    Aachen, 52062

  • Praxis Delonge

    Aachen, 52078

  • Kliniken an der Paar - Krankenhaus Aichach

    Aichach, 86551

  • Oberpfalz Research GbR

    Amberg, 92224

  • MVZ Aue

    Aue, 08280

  • Kardiologische Praxis

    Bad Elster, 08645

  • Kardiologische Praxis

    Bad Homburg, 61348

  • Universitäts-Herz-Zentrum Freiburg-Bad Krozingen

    Bad Krozingen, 79189

  • Kerckhoff-Klinik Forschungsgesellschaft mbH

    Bad Nauheim, 61231

  • Herz - u. Diabeteszentrum NRW

    Bad Oeynhausen, 32545

  • Praxis am Landratspark

    Bad Segeberg, 23795

  • Gemeinschaftspraxis für Herz und Lunge

    Bamberg, 96049

  • Kardiologische Praxis

    Bechhofen, 66894

  • Diabetespraxis Prenzlauer Allee

    Berlin, 10409

  • Praxis Rankestraße

    Berlin, 10789

  • MVZ Dres. Ramdohr - Praxis für Cardiovascular und Ultraschalldiagnostik

    Berlin, 12034

  • Praxis Dr. Matthias Claus

    Berlin, 12559

  • Kardiologische Facharztpraxis Dr. Anne Winkelmann

    Berlin, 13053

  • Charité Campus Virchow

    Berlin, 13353

  • Vivantes Humboldt-Klinikum

    Berlin, 13509

  • Vivantes Klinikum Spandau

    Berlin, 13585

  • Marienhaus-Klinikum Eifel Bitburg

    Bitburg, 54634

  • Städtisches Klinikum Brandenburg

    Brandenburg an der Havel, 14770

  • Kardiologie an der Paulikirche

    Braunschweig, 38102

  • Kardiologie im Friedrichspalast Bruchsal

    Bruchsal, 76646

  • MediClin Reha-Zentrum Spreewald

    Burg, 03096

  • MVZ am Küchwald

    Chemnitz, 09113

  • Praxis Dipl.med Schermaul

    Chemnitz, 09122

  • Kardiologische Praxis

    Chemnitz, 09126

  • MVZ Polymed

    Chemnitz, 09130

  • St. Josefs-Hospital Cloppenburg

    Cloppenburg, 49661

  • Klinikum Coburg GmbH

    Coburg, 96450

  • MVZ Gesundes Herz

    Cologne, 51105

  • Praxis Dr. Menzel

    Dessau, 06846

  • Klinikum Lippe GmbH

    Detmold, 32756

  • Kardiologische Gemeinschaftspraxis

    Dortmund, 44137

  • Sankt-Johannes-Hospital

    Dortmund, 44137

  • Kardiologische Gemeinschaftspraxis Dres. Wetzel/Willgeroth

    Dortmund, 44141

  • Zentrum für klinische Prüfungen in der Facharztzentrum Dresden-Neustadt GbR

    Dresden, 01099

  • Praxis Dr. Methfessel

    Dresden, 01159

  • Hausärztlich-Kardiologisches MVZ "Am Felsenkeller" GmbH

    Dresden, 01277

  • Studienzentrum Dr. Faulmann

    Dresden, 01279

  • Dres. Günther/Kolschmann

    Dresden, 01307

  • Universitätsklinikum Carl Gustav Carus

    Dresden, 01307

  • Praxis Dres. Jänsch/Varnai

    Dresden, 01309

  • Praxis Dipl. - Med. Petra Herrmann - Fachärztin für Innere Medizin

    Eisenach, 99817

  • Kardiologische Praxis

    Elsterwerda, 04910

  • Elisabeth Krankenhaus Essen

    Essen, 45138

  • Universitätsklinikum Essen

    Essen, 45147

  • Medizentrum Essen Borbeck

    Essen, 45355

  • Klinikum Frankfurt Hoechst GmbH

    Frankfurt, 65929

  • MVZ Altstadt-Carree Fulda GmbH

    Fulda, 36037

  • Evangelisches Krankenhaus Gelsenkirchen

    Gelsenkirchen, 45879

  • Kardiologische Praxis

    Gera, 07551

  • Praxis für Gefäßmedizin

    Görlitz, 02827

  • Kardiologische Praxis

    Gotha, 99867

  • Universitätsmedizin Göttingen

    Göttingen, 37075

  • Praxis für Herzkreislauferkrankungen Greiz

    Greiz, 07973

  • Evangelisches Krankenhaus Hagen-Haspe

    Hagen, 58135

  • Gemeinschaftspraxis Dres. J. Hintze und M. Grundner

    Hainstadt, 63512

  • Cardiologicum Hamburg-Wandsbek

    Hamburg, 22041

  • Kardiologie am Tibarg

    Hamburg, 22459

  • MVZ Prof. Detlef Mathey, Prof. Schofer GmbH

    Hamburg, 22527

  • Kardiologische Praxis

    Hanover, 30559

  • Kardiologische Praxis

    Haßloch, 67454

  • Kardiologische Schwerpunktpraxis

    Heidelberg, 69115

  • Praxis für Angiologie und Hämatologie

    Heidelberg, 69120

  • Uniklinikum Heidelberg

    Heidelberg, 69120

  • Praxis

    Homburg, 66424

  • Kardiologie Oberschwaben - Bodensee Herz- und Gefäßpraxis

    Isny, 88316

  • Kardiologische Praxis

    Jena, 07743

  • Kardiopraxis Schirmer

    Kaiserslautern, 67655

  • Kardiologie/Internistenteam Kamen

    Kamen, 59174

  • SRH Klinikum Karlsbad-Langensteinbach

    Karlsbach, 76307

  • B. Braun Ambulantes Herzzentrum MVZ GmbH

    Kassel, 34121

  • CC Cleve-Studiencenter

    Kleve, 47533

  • Studienzentrum der Inneren Medizin I & II am Klinikum Konstanz

    Konstanz, 78464

  • Praxis für Innere Medizin / Kardiologie - Dr. med. E. Persicke / Dr. med. O. Scheuermann

    Kornwestheim, 70806

  • Kardiologische Gemeinschaftspraxis

    Leipzig, 04103

  • MediClin MVZ Leipzig

    Leipzig, 04109

  • Praxis für Gefäßerkrankungen und Gerinnungsstörungen Leipzig

    Leipzig, 04109

  • Gemeinschaftspraxis Dr. Täschner/Dr. Bonigut

    Leipzig, 04249

  • MVZ Stoffwechselmedizin Leipzig

    Leipzig, 04317

  • Universitätsklinikum Leipzig

    Leipzig, 4103

  • Kardiologische Fachpraxis

    Lengerich, 49525

  • Praxis Dr. med. Ilka Simon-Wagner

    Lichtenfels, 96215

  • St. Vincenz-Krankenhaus

    Limburg, 65549

  • Gemeinschaftspraxis Dr. Jens Biesenbaum und Dr. Uwe Gerbaulet

    Löhne, 32584

  • Kardiologische Praxis Lohne

    Löhne, 49393

  • Klinikum Lüdenscheid

    Lüdenscheid, 58515

  • Cardio Centrum Ludwigsburg-Bietigheim

    Ludwigsburg, 71634

  • Kardiologische Praxisklinik Ludwigshafen

    Ludwigshafen, 67071

  • Dres. Erdmann/Schütz/Sicken

    Lünen, 44534

  • St.Vincenz - u. Elisabeth-Hospital

    Mainz, 55131

  • Universitätsklinikum Mainz Site 6186

    Mainz, 55131

  • Universitätsklinikum Mainz Site 6187

    Mainz, 55131

  • zero Praxen Mannheim

    Mannheim, 68165

  • Universitätsklinikum Mannheim

    Mannheim, 68167

  • Kardiologische Praxis

    Markkleeberg, 04416

  • Praxis Dr. Ben-Chur

    Meiningen, 98617

  • Kardiologie-Praxis

    Moers, 47441

  • Gemeinschaftspraxis Dr. med. Martin Prohaska und Dr. med. Felix Schulte

    Mühldorf, 84453

  • Herzquartier Mühlheim, Kardiologische Gemeinschaftspraxis Dres. med. A. Krapivsky & P. Kekes

    Mühlheim, 45468

  • Zentrum für Diabetes und Gefäßerkrankungen Münster

    Münster, 48145

  • Praxis für Innere Medizin

    Münster, 48149

  • Universitätsklinikum Münster

    Münster, 48149

  • Praxis für Innere Medizin und Angiologie

    Nordhausen, 99734

  • Kardiologische Praxis Northeim

    Northeim, 37154

  • Gemeinschaftspraxis Drs. Haggenmiller/Jeserich Kardiologie-Angiologie-Innere Medizin

    Nuremberg, 90402

  • Kardiologie am Weißen Turm

    Nuremberg, 90402

  • St. Vincenz-Krankenhaus GmbH

    Paderborn, 33098

  • Kardiologische Praxis

    Panitzsch, 04451

  • Kardiologische Praxis Papenburg (Site 6097)

    Papenburg, 26871

  • Kardiologische Praxis Papenburg (Site 6098)

    Papenburg, 26871

  • Kardiologische Praxis

    Pirmasens, 66954

  • Cardiologicum Dresden/Pirna

    Pirna, 01796

  • Kardiologie Potsdam

    Potsdam, 14471

  • Kardiologische Gemeinschaftspraxis Potsdam

    Potsdam, 14471

  • Paracelsus-Harz-Klinik Bad Suderode

    Quedlinburg, 06485

  • Drs. Bauer/Buresch/Kösler

    Regensburg, 93059

  • Gemeinschaftspraxis Herz Riesa

    Riesa, 01587

  • Universitätsmedizin Rostock

    Rostock, 18057

  • Zentrum für Prävention und Rehabilitation

    Siegen, 57072

  • Kardiologische Praxis

    Stahnsdorf, 14532

  • Praxis Dr. Birkenhagen

    Stollberg, 09366

  • Drs. Knoebel @ Partner

    Straubing, 94315

  • Praxis Dr. Michael Rother

    Strausberg, 15344

  • Diabetologische Schwerpunktpraxis

    Trier, 54292

  • Krankenhaus der Barmherzigen Brüder Trier

    Trier, 54292

  • Studienzentrum der Herzklinik Ulm GbR

    Ulm, 89077

  • Praxis Dr. Sabine Hansen

    Unterwellenborn, 07333

  • Praxis für Prävention und Therapie

    Villingen-Schwenningen, 78048

  • SHG Klinik Völklingen

    Völklingen, 66333

  • GRN Klinik Weinheim

    Weinheim, 69469

  • Forschungszentrum-Ruhr KliFoCenter GmbH

    Witten, 58455

  • Klinikum Worms

    Worms, 67550

  • Praxis Dr. Woitek

    Wurzen, 04808

  • Praxis T. Schwarz

    Zwenkau, 04442

Other trials in Germany

Italy85 sites

  • INRCA -Ospedale U. Sestilli di Ancona

    Ancona, The Marches, 60124

  • Ospedali Riuniti "Umberto I - Lancisi - Salesi

    Ancona, The Marches, 60126

  • ASL Roma 6 - Ospedali Riuniti Anzio - Nettuno

    Anzio, Lazio, 00042

  • Ospedale di Arzignano

    Arzignano, Veneto, 36071

  • Presidio ospedaliero Cardinal Massaia - A.S.L. AT (SOC Diabetologia e Malattie Metaboliche)

    Asti, Piedmont, 14100

  • A.O. San Giuseppe Moscati (U.O.C. Cardiologia/UTIC)

    Avellino, Campania, 83100

  • A.O. San Giuseppe Moscati

    Avellino, Campania, 83100

  • Ente Ecclesiastico Ospedale Generale Regionale "F.Miulli"

    Bari, Apulia, 70021

  • A.O.U. Consorziale - Policlinico Bari (Dipartimento di Medicina Interna)

    Bari, Apulia, 70124

  • A.O.U. Consorziale - Policlinico Bari

    Bari, Apulia, 70124

  • A.O.R.N. San Pio - P.O. RUMMO

    Benevento, Campania, 82100

  • Ospedale di Bentivoglio

    Bentivoglio, Emilia-Romagna, 40010

  • Azienda Ospedaliera Papa Giovanni XXIII

    Bergamo, Lombardy, 24127

  • Ospedale Maggiore di Bologna

    Bologna, Emilia-Romagna, 40133

  • A.O.U di Bologna-Policlinico S.Orsola-Malpighi (U.O. Medicina Interna)

    Bologna, Emilia-Romagna, 40138

  • Policlinico Sant'Orsola-Malpighi (U.O. Cardiologia)

    Bologna, Emilia-Romagna, 40138

  • Ospedale di Bolzano (U.O. Cardiologia e Prove Funzionali)

    Bolzano, Trentino-Alto Adige, 39100

  • ASST Spedali Civili P.O di Brescia

    Brescia, Lombardy, 25123

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (U.O Medicina Generale 2)

    Brescia, Lombardy, 25123

  • Fondazione Poliambulanza Istituto Ospedaliero - Brescia

    Brescia, Lombardy, 25124

  • Ospedale di Carpi

    Carpi, Emilia-Romagna, 41012

  • Azienda Ospedaliera di Rilievo Nazionale(A.O.R.N.) "Sant'Anna e San Sebastiano" di Caserta

    Caserta, Campania, 81100

  • Ospedale Cannizzaro

    Catania, Sicily, 95126

  • Azienda Ospedaliera Universitaria Mater Domini - Site 8042

    Catanzaro, Calabria, 88100

  • Azienda Ospedaliera Universitaria Mater Domini - Site 8053

    Catanzaro, Calabria, 88100

  • Azienda Ospedaliera Universitaria Mater Domini - Site 8059

    Catanzaro, Calabria, 88100

  • Ospedale Civile Santa Maria Incoronata dell'Olmo

    Cava de' Tirreni, Campania, 84013

  • Ospedale Civile SS. Annunziata (MEDICINA INTERNA- DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO)

    Chieti, Abruzzo, 66013

  • Ospedale San Giuseppe

    Empoli, Tuscany, 50053

  • Arcispedale Sant'Anna Ferrara (U.O. Cardiologia)

    Ferrara, Emilia-Romagna, 44124

  • Azienda Ospedaliera-Universitaria S. Anna di Ferrara (Dipartimento medico)

    Ferrara, Emilia-Romagna, 44124

  • A.O.U. Careggi (S.O.D. Malattie Aterotrombotiche) - Site 8020

    Florence, Tuscany, 50134

  • A.O.U. Careggi - Site 8041

    Florence, Tuscany, 50134

  • A.O.U. Careggi - Site 8093

    Florence, Tuscany, 50134

  • A.O.U. Ospedali Riuniti

    Foggia, Apulia, 71122

  • Presidio Ospedaliero Vito Fazzi

    Lecce, Apulia, 73100

  • Ospedale Mater Salutis

    Legnago, Veneto, 37045

  • Ospedale S. Andrea - Usl Toscana Sud Est

    Massa Marittima, Tuscany, 58024

  • A.O.U. Policlinico "G. Martino" (U.O. Cardiologia)

    Messina, Sicily, 98125

  • IRCCS Multimedica

    Milan, Lombardy, 20099

  • Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122

  • Centro Cardiologico Monzino - IRCCS (Unità Prevenzione dell'Aterosclerosi)

    Milan, Lombardy, 20141

  • Centro Cardiologico Monzino - IRCCS

    Milan, Lombardy, 20141

  • Istituto Clinico Sant'Ambrogio

    Milan, Lombardy, 20149

  • IRCCS Istituto Ortopedico Galeazzi

    Milan, Lombardy, 20161

  • Grande Ospedale Metropolitano di Niguarda

    Milan, Lombardy, 20162

  • Presidio Ospedaliero di Mirano - ULSS 3 Serenissima

    Mirano, Veneto, 30035

  • A.O.U. Policlinico di Modena

    Modena, Emilia-Romagna, 41124

  • Ospedale Civile di Baggiovara- AOU di Modena

    Modena, Emilia-Romagna, 41126

  • Ospedale Regina Montis Regalis

    Mondovì, Piedmont, 12084

  • A.O.R.N. Cardarelli

    Naples, Campania, 80131

  • A.O.R.N. Ospedale dei Colli

    Naples, Campania, 80131

  • A.O.U. FEDERICO II (U.O.C. Diabetologia)

    Naples, Campania, 80131

  • A.O.U. Federico II

    Naples, Campania, 80131

  • Ospedale Buccheri La Ferla

    Palermo, Sicily, 90123

  • Triolo Zancle Hospital

    Palermo, Sicily, 90133

  • USL Umbria I

    Perugia, Umbria, 06126

  • A.O. Santa Maria della Misericordia

    Perugia, Umbria, 06129

  • Ospedale SS Cosma e Damiano di Pescia - Azienda Usl Toscana centro

    Pescia, Tuscany, 51017

  • Ospedale Unico della Valtidone

    Piacenza, Emilia-Romagna, 29015

  • Ospedale Guglielmo da Saliceto

    Piacenza, Emilia-Romagna, 29121

  • Università di Pisa

    Pisa, Tuscany, 56100

  • Fondazione Toscana Gabriele Monasterio

    Pisa, Tuscany, 56124

  • Ospedale Cisanello - A.U.O.P. Azienda Ospedaliera Universitaria Pisana

    Pisa, Tuscany, 56124

  • Ospedale di Santo Stefano di Prato - Azienda Usl Toscana centro (UO di Cardiologia)

    Prato, Tuscany, 59100

  • Ospedale Santo Stefano di Prato - Azienda Usl Toscana Centro

    Prato, Tuscany, 59100

  • Ospedale Macerata

    Province of Macerata, The Marches, 62100

  • Ospedale Giovanni Paolo II

    Ragusa, Sicily, 97100

  • Arcispedale Santa Maria Nuova - Azienda USL/IRCCS Reggio Emilia

    Reggio Emilia, Emilia-Romagna, 42123

  • Ospedale dei Castelli - ASL Roma 6

    Rome, Lazio, 00040

  • Policlinico Universitario Campus Bio-Medico

    Rome, Lazio, 00128

  • Policlinico Umberto I

    Rome, Lazio, 00161

  • Fondazione Policlinico Universitario A. Gemelli IRCCS

    Rome, Lazio, 00168

  • Ospedale Policlinico Casilino

    Rome, Lazio, 00169

  • Azienda Ospedaliera San Giovanni Addolorata

    Rome, Lazio, 00184

  • A.O.U. "San Giovanni di Dio e Ruggi d'Aragona"

    Salerno, Campania, 84131

  • Ospedale Civile SS Annunziata (Dipartimento di Medicina Clinica e Sperimentale)

    Sassari, Sardinia, 07100

  • Ospedale Civile San Rocco

    Sessa Aurunca, Campania, 81037

  • Azienda Ospedaliero-Universitaria Senese Dipartimento Delle Scienze Mediche U.O.C. Medicina Interna e della Complessità

    Siena, Tuscany, 53100

  • Ospedale Le Scotte

    Siena, Tuscany, 53100

  • Ospedale degli Infermi di Rivoli

    Turin, Piedmont, 10098

  • A.O.U. Città della Salute e della Scienza di Torino

    Turin, Piedmont, 10126

  • Presidio Ospedaliero "Santa Maria della Misericordia" di Udine

    Udine, Friuli, 33100

  • Ospedale dei Castelli

    Verbania, Piedmont, 28925

  • Ospedale G. Jazzolino

    Vibo Valentia, Calabria, 89900

Other trials in Italy

Spain72 sites

  • Complejo Hospitalario Universitario A Coruña

    A Coruña, Galicia, 15006

  • Hospital Principe de Asturias

    Alcalá de Henares, Madrid, 28805

  • Hospital Universitario Fundación Alcorcón

    Alcorcón, 28922

  • H. San Eloy

    Barakaldo, Basque Country, 48902

  • H. Clinic i Provincial de Barcelona

    Barcelona, Catalonia, 08036

  • H de la Santa Creu i Sant Pau

    Barcelona, Catalonia, 08041

  • H. del Mar Site 11041

    Barcelona, 08003

  • H. del Mar Site 11065

    Barcelona, 08003

  • H. Univ. Basurto

    Bilbao, Basque Country, 48013

  • H. Univ. de Basurto

    Bilbao, Basque Country, 48013

  • H. Univ. Basurto

    Bilbao, 48013

  • C S Colloto

    Colloto, Castille and León, 33010

  • Centro de Salud Colloto

    Colloto, 33010

  • Hospital de Alta Resolución de Sierra Norte

    Constantina, Andalusia, 41450

  • H. Reina Sofia

    Córdoba, Andalusia, 14004

  • Hospital de Alta Resolución de Ecija

    Écija, Andalusia, 41400

  • Complejo Hospitalario Univ. El Ferrol

    Ferrol, Galicia, 15405

  • H. Universitario Fuenlabrada

    Fuenlabrada, Madrid, 28942

  • Hospital Univ. Getafe

    Getafe, 28905

  • H Juan Ramón Jiménez de Huelva

    Huelva, Andalusia, 21005

  • H. Infanta Elena

    Huelva, Andalusia, 21080

  • Centro Médico Puerto

    Jerez de la Frontera, Andalusia, 11402

  • HG. Univ. De Jérez

    Jerez de la Frontera, Andalusia, 11407

  • Hospital de Jerez

    Jerez de la Frontera, 11407

  • H. Universitari Bellvitge

    L'Hospitalet de Llobregat, Catalonia, 08907

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, 08907

  • Clinica Privada Orotava

    La Orotava, Canary Islands, 38300

  • Hospital de Alta Resolución de Lebrija

    Lebrija, Andalusia, 41570

  • H Universitario De León

    León, Castille and León, 24008

  • H Clínico de Salamanca

    León, Castille and León, 37007

  • Hospital Universitario de la Princesa Site 11054

    Madrid, 28006

  • Hospital Universitario de la Princesa Site 11062

    Madrid, 28006

  • Hospital Universitario de la Princesa Site 11075

    Madrid, 28006

  • H Gregorio Marañon

    Madrid, 28007

  • Hospital Universitario Gregorio Marañon

    Madrid, 28007

  • Clinica Universitaria de Navarra

    Madrid, 28027

  • Clínica Universitaria de Navarra

    Madrid, 28027

  • Fundación Jiménez Díaz

    Madrid, 28029

  • H. Univ. Clínico San Carlos

    Madrid, 28029

  • H. Univ. La Paz-Carlos III

    Madrid, 28029

  • H. Universitario La Paz-Carlos III

    Madrid, 28029

  • Hospital La Paz-Carlos III

    Madrid, 28029

  • H. Univ. Ramón y Cajal

    Madrid, 28034

  • Fundación Jiménez Díaz

    Madrid, 28040

  • H. Universitario 12 de octubre

    Madrid, 28041

  • H Carlos Haya

    Málaga, Andalusia, 29010

  • H. Costa del Sol

    Marbella, Málaga, 29603

  • H. Clínico Virgen de la Arrixaca

    Murcia, 30120

  • Complejo Hospitalario de Ourense

    Ourense, Galicia, 32005

  • Complejo Hospitalario Universitario de Ourense (CHOU) Site 11003

    Ourense, 32005

  • Complejo Hospitalario Universitario de Ourense (CHOU) Site 11052

    Ourense, 32005

  • H Universitario Central de Asturias

    Oviedo, Principality of Asturias, 33011

  • H. San Joan de Reus

    Reus, 41009

  • Hospital Parc Tauli

    Sabadell, 08208

  • C S de la Alamedilla

    Salamanca, Castille and León, 37003

  • Hospital Clínico de Salamanca

    Salamanca, 37007

  • H. Univ. Infanta Sofía

    San Sebastián de los Reyes, Madrid, 28709

  • Hospital Universitario Infanta Sofía

    San Sebastián de los Reyes, 28709

  • Hospital de Sant Joan Despí Moisès Broggi

    Sant Joan Despí, 8970

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008

  • H. Clínico Univ. Santiago de Compostela

    Santiago de Compostela, Galicia, 15706

  • H. General de Segovia

    Segovia, Castille and León, 40002

  • Hospital General de Segovia

    Segovia, 40002

  • H. Univ. Virgen Macarena

    Seville, Andalusia, 41009

  • H. San Agustín

    Seville, Andalusia, 41700

  • Hospital Universitario Virgen de la Macarena

    Seville, 41009

  • Hospital Sant Pau i Santa Tecla

    Tarragona, 43003

  • Hospital HM de Torrelodones

    Torrelodones, 28250

  • H. Alta Resolución de Utrera

    Utrera, Andalusia, 41710

  • Hospital de Alta Resolución de La Janda

    Vejer de la Frontera, Andalusia, 11150

  • Complejo Asistencial de Zamora

    Zamora, Castille and León, 49022

  • Centro de Salud Fuentes Norte

    Zaragoza, 50002

Other trials in Spain

United Kingdom51 sites

  • The Atherstone Surgery

    Atherstone, CV9 1EU

  • Heart of Bath Medical Partnership

    Bath, Somerset, BA1 2SR

  • Ormeau Clinical Trials Ltd

    Belfast, Northern Ireland, BT7 2EB

  • Layton Medical Centre

    Blackpool, FY3 7EN

  • Waterloo Medical Care

    Blackpool, FY4 3AD

  • Glan Clwyd Hospital

    Bodelwyddan, Wales, LL18 5UJ

  • Brockwood Medical Practice

    Brockham, Surrey, RH3 7NJ

  • Llanedeyrn Health Centre

    Cardiff, CF23 9PN

  • Ely Bridge Surgery

    Cardiff, CF5 4AD

  • Carlisle Healthcare

    Carlisle, North Cumbria, CA2 7HY

  • Lakeside Surgery

    Corby, Northamptonshire, NN17 2UR

  • Craigavon Area Hospital

    Craigavon, Armagh, BT63 5QQ

  • Carmel Medical Practice

    Darlington, County Durham

  • Holderness Health Surgery

    Hedon

  • Burbage Surgery

    Hinckley, Leicestershire, LE10 2SE

  • Great Western Hospital Swindon

    Huddersfield, Wiltshire, SN3 6BB

  • Huddersfield Hospital

    Huddersfield, Yorkshire, HD3 3EA

  • Hull Royal Infirmary

    Hull, HU3 2JZ

  • Manor Park Medical Practice

    Leicester, East Midlands, LE4 8EA

  • Oak Tree Surgery

    Liskeard, Cornwall, PL14 3XA

  • Liverpool Heart & Chest Hospital NHS Trust

    Liverpool, Merseyside, L14 3PE

  • Barts Health NHS Trust

    London, Greater London, EC1M 6BQ

  • Church End Medical

    London, Greater London, NW10 9HP

  • Breckland Alliance

    London, Norfolk

  • Newquay Health Centre

    Newquay, Cornwall, TR7 1RU

  • North Tyneside General Hospital

    North Shields, Tyne and Wear, NE29 8NH

  • Danes Camp Medical Centre

    Northampton, Northamptonshire, NN4 0NY

  • Temple Sowerby Medical Practice

    Penrith, CA10 1RW

  • The Alverton Practice

    Penzance, Cornwall, TR18 4DX

  • Wansford and Kings Cliffe Practice

    Peterborough, PE8 6PL

  • Pickering Medical Practice

    Pickering, North Yorkshire, YO18 8BL

  • Knowle House Surgery

    Plymouth, Cornwall, PL5 3JB

  • The Adam Practice

    Poole, Dorset

  • Panthera Preston

    Preston, PR1 6YA

  • The Boathouse Sugery

    Reading, Berkshire, RG8 7DP

  • Clifton Medical Centre

    Rotherham, South Yorkshire, S65 1DA

  • Sherbourne Medical Centre

    Royal Leamington Spa, Warwickshire, CV32 4RA

  • Ecclesfield Group Practice

    Sheffield

  • Princess Royal Hospital

    Shrewsbury, Shropshire, SY3 8XQ

  • Staploe Medical Centre

    Soham, Surrey, CB7 5JD

  • Southend University Hospital

    Southend, Essex, SS0 0RY

  • Branch End Surgery

    Stocksfield, Northumberland, NE43 7LL

  • Sunderland Royal Hospital

    Sunderland, Tyne and Wear, SR4 7TP

  • Huddersfield Hospital

    Swindon, West Yorkshire, HD3 3EA

  • Great Western Hospital Swindon

    Swindon, Wiltshire, SN3 6BB

  • Princess Royal Hospital

    Telford, Shropshire, TF1 6TF

  • Royal Cornwall Hospital

    Truro, Cornwall, TR1 3LJ

  • Whitby Group Practice

    Whitby, North Yorkshire, YO21 1SD

  • Fellview Healthcare

    Whitehaven, Cumbria, CA28 7QE

  • Royal Albert Edward Infirmary

    Wigan, WN6 9EP

  • The Friarsgate Practice

    Winchester, Hampshire, SO22 6EL

Other trials in United Kingdom

France36 sites

  • 4 Rue Larrey

    Angers, 49900

  • Cabinet médical Louis Blanc

    Anzin, 59410

  • Clinique d'Argonay

    Argonay, 74370

  • Hôpital Henri Duffaut

    Avignon, 84902

  • Centre de Cardiologie et d'exploration de la Côte Basque

    Bayonne, 64100

  • 151 rue Georges Clémenceau

    Breteuil, 27160

  • 4 Rue du Capitaine Drillien

    Chalon-sur-Saône, 71100

  • Centre Hospitalier de Chateauroux

    Châteauroux, 36000

  • CH Compiègne

    Compiègne, 60200

  • Centre Hopsitalier Alpes Leman, 552 Route de Findrol

    Contamine-sur-Arve, 74130

  • 619 Rue de Saint Vaast

    Flesselles, 80260

  • CHU Grenoble

    Grenoble, 38000

  • 2 Boulevard Victor Hugo

    Istres, 13800

  • 2 Rue du Dr Schweitzer

    La Rochelle, 17000

  • Hôpital Louis Pasteur

    Le Coudray, 28630

  • 222 Avenue du Mont Gaillard

    Le Havre, 76620

  • Hôpital Marie Lannelongue

    Le Plessis-Robinson, 92350

  • Institut Cœur Poumons, Boulevard du Pr Leclercq

    Lille, 59000

  • Centre Hospitalier de Lisieux, 4 Rue Roger Aini

    Lisieux, 14100

  • Centre Hospitalier La Timone

    Marseille, 13005

  • Clinique de Meudon

    Meudon-la-Forêt, 92360

  • Clinique du Pont de Chaume

    Montauban, 82000

  • Clinique du Millénaire

    Montpellier, 34000

  • Centre Hospitalier Universitaire de Nantes

    Nantes, 44093

  • Hôpital Guillaume et René Laennec

    Nantes, 44093

  • Centre Hospitalier de Nice

    Nice, 06300

  • CHU Carémeau

    Nîmes, 30000

  • Cabinet médical du docteur Cohen

    Paris, 75012

  • Cabinet de cardiologie

    Paris, 75014

  • Hôpital Pitié Salpétrière

    Paris, 75651

  • Centre Hospitalier de Pau

    Pau, 64000

  • Clinique Sant Hilaire

    Rouen, 76000

  • 82 Avenue de Pontaillac

    Royan, 17200

  • Hôpital Sainte Musse

    Toulon, 83100

  • Centre Hospitalier Toulouse

    Toulouse, 31059

  • Hôpital Guy Chatillez

    Tourcoing, 59200

Other trials in France

Netherlands35 sites

  • Jeroen Bosch Hospital

    's-Hertogenbosch, 5223 GV

  • Ziekenhuis Groep Twente (ZGT)

    Almelo, 7609 PP

  • ZiekenhuisGroepTwente, Zilvermeeuw 1

    Almelo, 7609 PP

  • Meander Medical Center

    Amersfoort, 3813 TZ

  • Meander Medisch Centrum, Maatweg 3

    Amersfoort, 3813 TZ

  • Bovenij Zekenhuis

    Amsterdam, 1030 BD

  • Albert Schweitzerlaan 31

    Apeldoorn, 7334 DZ

  • Gelre Ziekenhuis

    Apeldoorn, 7334 DZ

  • Tergooi

    Blaricum, 1261 AN

  • Ijsselland Ziekenhuis, Prins Constanijnweg 2

    Capelle aan den IJssel, 2906 ZC

  • IJsselland Ziekenhuis

    Capelle aan den IJssel, 2906 ZC

  • Reinier de Graafweg 5

    Delft, 2625 AD

  • Nico Bolkesteinlaan 75

    Deventer, 7416 SE

  • Van Weel Bethesda

    Dirksland, 3247 BW

  • Slingeland

    Doetinchem, 7009 BL

  • Gelderse Vallei

    Ede, 6716 RP

  • Medisch Spectrum Twente

    Enschede, 7512 KZ

  • Admiraal de Ruijten Ziekenhuis

    Goes, 4462 RA

  • Groene Hart Gouda

    Gouda, 2800 BB

  • Boerhaavelaan 22

    Haarlem, 2035 RC

  • Ropcke Zweers hospital, Jan Weitkamplaan 4-a

    Hardenberg, 7772 SE

  • Saxenburgh Medisch Centrum

    Hardenberg, 7772 TS

  • Ziekenhuis St Jansdal

    Harderwijk, 3844 DG

  • Dr G.H. Amshoffweg 1

    Hoogeveen, 7909 AA

  • Treant Zorggroep

    Hoogeveen, 7909 AA

  • LUMC

    Leiden, 2333 ZA

  • Ikazai Ziekenhuis

    Rotterdam, 3083 AN

  • Els Borst

    The Hague, 2545 AA

  • Rivierenland ziekenhuis Tiel

    Tiel, 4002 WP

  • ETZ

    Tilburg, 5022 GC

  • Nistelrodeseweg 10

    Uden, 5406 PT

  • University Medical Center Utrecht

    Utrecht, 3584 CX

  • Diakonessenhuis Utrecht

    Utrecht, 3585 KE

  • Maxima Medisch Centrum

    Veldhoven, 5504 DB

  • Zaans Medisch Centrum

    Zaandam, 1502 DV

Other trials in Netherlands

Belgium27 sites

  • ASZ

    Aalst, 9300

  • Imeldaziekenhuis

    Bonheiden, 2820

  • Clinique Saint-Luc

    Bouge, 5004

  • AZ KLINA

    Brasschaat, 2930

  • CHU Saint Pierre

    Brussels, 1000

  • CHU Brugmann

    Brussels, 1020

  • CUB Hospital Erasme

    Brussels, 1070

  • UZ Brussel

    Brussels, 1090

  • Cliniques de l'Europe

    Brussels, 1180

  • Private practice

    De Haan, 8420

  • Private practice

    De Pinte, 9840

  • AZ Sint Blasius

    Dendermonde, 9200

  • AZ Sint Lucas

    Ghent, 9000

  • Universitair Ziekenhuis Gent

    Ghent, 9000

  • Cabinet de médecine générale

    Gribomont, 6887

  • CH Jolimont-Lobbes

    Haine-Saint-Paul, 7100

  • CHR de Huy

    Huy, 4500

  • Jan Yperman Hospital

    Ieper, 8900

  • AZ Groeninge VZW

    Kortrijk, 8500

  • CHC Liège

    Liège, 4000

  • AZ Delta

    Roeselare, 8800

  • AZ Glorieux

    Ronse, 9600

  • Sint Trudo

    Sint-Truiden, 3800

  • Private practice

    Tienen, 3300

  • BVBA Dr CAPIAU

    Wetteren, 9230

  • CHU UCL Namur

    Yvoir, 5530

  • Z Sint Elisabeth Zottegem

    Zottegem, 9620

Other trials in Belgium

Finland25 sites

  • Mehiläinen Leppävaara

    Espoo, 02600

  • Geri-Med Oy

    Helsinki, 00100

  • Pihlajalinna Dextra

    Helsinki, 00180

  • Pihlajalinna (Site 04-007)

    Joensuu, 80100

  • Pihlajalinna (Site 04-022)

    Joensuu, 80100

  • StudyCor Oy

    Jyväskylä, 40620

  • Terveystalo Kalajoki

    Kalajoki, 85100

  • Aava Kerava Medical Center

    Kerava, 04200

  • Terveystalo Kokkola

    Kokkola, 67100

  • Mehiläinen Kuopio

    Kuopio, 70400

  • Lappeenrannan Työterveys - Site 4024

    Lappeenranta, 53600

  • Lappeenrannan Työterveys - Site 4025

    Lappeenranta, 53600

  • Terveystalo

    Loimaa, 32200

  • Oulu University Hospital

    Oulu, 90220

  • Satasairaala

    Pori, 28500

  • Sastamalan seudun sosiaali- ja terveyspalvelut

    Sastamala, 38200

  • Seinäjoki Central Hospital

    Seinäjoki, 60220

  • Terveystalo Tampere

    Tampere, 33100

  • Tampere University Hospital

    Tampere, 33520

  • Mehiläinen Turku Kauppiaskatu

    Turku, 20100

  • Turku University Hospital

    Turku, 20520

  • Turku University Hospital

    Turku, 20521

  • Terveystalo Myyrmäki (Site 04015)

    Vantaa, 01600

  • Terveystalo Myyrmäki (Site 04017)

    Vantaa, 01600

  • Finla Työterveys Vantaa

    Vantaa, 1380

Other trials in Finland

Austria18 sites

  • Krankenhaus St. Josef Braunau GmbH

    Braunau am Inn, 5280

  • LKH-Univ. Klinikum Graz

    Graz, 8036

  • Medizinische Universität Graz

    Graz, 8036

  • Medizinische Universität Innsbruck

    Innsbruck, 6020

  • KABEG Klinikum Klagenfurt am Wörthersee

    Klagenfurt, 9020

  • Konventhospital der Barmherzigen Brüder Linz

    Linz, 4020

  • Privatklinik Wehrle-Diakonissen

    Salzburg, 5026

  • Ordination Universitätsdozent Dr. Alexander Kober

    Sankt Aegyd am Neuwalde, 3193

  • Ordination Dr. med. univ. Evelyn Fließer-Görzer

    Sankt Stefan, 8511

  • Ordination Dr. Thomas Maca / Evangelische KH Wien

    Vienna, 1010

  • Ordination Dr. Thomas Maca / Evangelisches KH Wien

    Vienna, 1010

  • Krankenhaus Rudolfstiftung

    Vienna, 1030

  • Zentrum für Klinische Studien Dr. Hanusch GmbH

    Vienna, 1060

  • Allgemeines Krankenhaus der Stadt Wien

    Vienna, 1090

  • Ordination Dr. Reinhard Sock

    Vienna, 1100

  • Krankenhaus Hietzing mit neurologischem Zentrum Rosenhügel

    Vienna, 1130

  • Krankenhaus Nord - Klinik Floridsdorf

    Vienna, 1210

  • Internistische Facharztpraxis Frau Dr. Carmen Gelsinger

    Zams, 6511

Other trials in Austria

Denmark12 sites

  • Hjerteklinik Osterbro

    Copenhagen, 2100

  • Amager Hospital

    Copenhagen, 2300

  • Bispebjerg-Frederiksberg Hospital

    Copenhagen, 2400

  • Bispebjerg/ Frederiksberg Hospital

    Copenhagen, 4200

  • Sydvestjysk Sygehus Esbjerg

    Esbjerg, 6700

  • Frederiksberg Hjerteklinik

    Frederiksberg, 2000

  • Frederiksberg Hjerteklinik

    Frederiksberg, 8009

  • Stroke center Rigshospitalet

    Glostrup Municipality, 232600

  • Rigshospitalet (Copenhagen University Hospital) - Glostrup (Glostrup Hospital)

    Glostrup Municipality, 2600

  • Gentofte Hospital

    Hellerup, 2900

  • Kobenhavns Universitet - Holbaek Sygehus

    Holbæk, 4300

  • Slagelse sygehus

    Slagelse, 4200

Other trials in Denmark

Portugal11 sites

  • Instituto do Coração

    Carnaxide, 2794-006

  • Centro Hospitalar Universitario do Algarve

    Faro, 8000-386

  • Associação Protetora de Diabéticos de Portugal

    Lisbon, 1250-189

  • Hospital Egas Moniz (CHLO)

    Lisbon, 1349-019

  • Hospital Lusíadas de Lisboa, Lisboa

    Lisbon, 1500-458

  • Centro Hospitalar Lisboa Norte - Site 10005

    Lisbon, 1649-028

  • Centro Hospitalar Lisboa Norte - Site 10006

    Lisbon, 1649-028

  • Clínica Cuida Mais

    Mangualde, 3530-191

  • Centro Hospitalar Universitário São João (CHUSJ)

    Porto, 4200-319

  • Instituto CUF Porto

    Porto, 4460-188

  • Centro Hospitalar de Entre Douro e Vouga

    Santa Maria da Feira, 4520-179

Other trials in Portugal

Sweden11 sites

  • Falu Lasarett, Diab/Endo-mottagning

    Falun, 79182

  • Sahlgrenska University Hospital

    Gothenburg, 41345

  • Östra Sahlgrenska Universitetssjukhuset - Ostra Sjukhuse

    Gothenburg, 41685

  • Värmdö Vårdcentral

    Gustavsberg, 13444

  • Öbackakliniken

    Härnösand, 87131

  • Länssjukhuset Ryhov

    Jönköping, 55305

  • Capio Citykliniken

    Lund, 22221

  • Skåne University Hospital

    Malmö, 20502

  • Cityheart

    Stockholm, 11157

  • Södersjukhuset Stockholm

    Stockholm, 11883

  • Karolinska University Hospital, Huddinge

    Stockholm, 14186

Other trials in Sweden

Switzerland11 sites

  • Kantonsspital Baden AG

    Baden, 5404

  • Universitätsspital Basel

    Basel, 4031

  • Hôpitaux Universitaires de Genève

    Geneva, 1205

  • University of Lausanne Unisanté

    Lausanne, 1010

  • Cardio Center Luzern

    Lucerne, 6003

  • Kardiolab

    Olten, 4600

  • Solothurner Spitäler AG

    Olten, 4600

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007

  • Cardiologue FMH

    Yverdon-les-Bains, 1400

  • Klinik Hirslanden

    Zurich, 8032

  • Universitätsspital Zürich

    Zurich, 8091

Other trials in Switzerland

Ireland7 sites

  • Beaumont Hospital

    Beaumont, Dublin

  • Cork University Hospital

    Cork, T23

  • Mater Private Hospital

    Dublin, D07 WKW8

  • St. James Hospital

    Dublin, D08 NHY1

  • Beacon Hospital

    Dublin, D18 AK68

  • Turloughmore Health Centre

    Galway

  • Tramore Medical Clinic

    Tramore, Waterford

Other trials in Ireland

About this study

Official title: Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events in Europe - a MultInatioNal ObservatIonal Study (SANTORINI)

High and Very High Risk cardiovascular patient journeys seems to vary from country to country, and current understanding of the process is incomplete. This real-life observational study which documents meaningful patient journey-related parameters can be expected to provide meaningful insight into the care process, country-by-country.

Read the detailed description

Suffering from hypercholesterolemia is a major health concern in Europe. Appropriate medical treatment lowers low density lipoprotein cholesterol and reduces the incidence of clinical cardiovascular events. Despite the multiple available treatments, many patients remain inadequately treated or even untreated and some lipid-lowering drugs may be associated with an increase in events like side effects or increase in diabetes. As this is a non-interventional study, only data from routine clinical practice will be documented.

Being tested
Non-interventional
Keywords
High-risk dyslipidemic, Low-density lipoprotein cholesterol, Cardiovascular disease, Lipid modifying therapies, Dyslipidemia, Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
Medical subject headings
Dyslipidemias, Cardiovascular Diseases, Hypercholesterolemia, Atherosclerosis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Non-interventionalOther

    This is a non-interventional study.

Study groups in NCT04271280
Study groupRoleWhat they receive
High Risk and Very High Risk Dyslipidemic ParticipantsParticipants are classified as High and Very High Risk (as assessed by the Framingham risk score for High Risk participants and the SMART score for Very High Risk participants) as well as if previously or newly diagnosed.
Receives: Other: Non-interventional

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Mean Low Density Lipid-Cholesterol (LDL-C) Levels in High and Very High Risk Cardiovascular Participants

    Blood plasma samples were used to assess LDL-C levels.

    Measured: Baseline up to 12 months post-enrollment

  2. Number of Participants Utilizing Any Treatment Modality to Manage Plasma Levels of Low Density Lipid-Cholesterol (LDL-C) in High and Very High Risk Participants Requiring Lipid Modifying Therapies (LMTs)

    Clinical events were assessed based on information captured in patient files/medical records.

    Measured: Baseline up to 12 months post-enrollment

Secondary outcomes (5)

  1. Mean Atherosclerotic Cardiovascular Disease (ASCVD)-Modifying Cholesterol Fragment Levels in High Risk and Very High Risk Dyslipidemic Participants

    Blood plasma samples were used to assess ASCVD-modifying cholesterol fragment levels.

    Measured: Baseline up to 12 months post-enrollment

  2. Mean Apolipoprotein B Levels in High Risk and Very High Risk Dyslipidemic Participants

    Blood plasma samples were used to assess Apolipoprotein B levels.

    Measured: Baseline up to 12 months post-enrollment

  3. Mean Lipid Protein A Levels in High Risk and Very High Risk Dyslipidemic Participants

    Blood plasma samples were used to assess lipid Protein A levels.

    Measured: Baseline up to 12 months post-enrollment

  4. Mean Inflammatory High-Sensitive C-Reactive Protein (hsCRP) in High Risk and Very High Risk Dyslipidemic Participants

    Blood plasma samples were used to assess hsCRP levels.

    Measured: Baseline up to 12 months post-enrollment

  5. Number of Participants With Clinical Events Associated With Treatment Modalities, For Any LMT

    The safety outcome measure reports clinical events based on information captured in patient files/medical records. Participants may have reported more than one clinical event associated with any LMT.

    Measured: Baseline up to 12 months post-enrollment

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted17 Feb 2020
  2. Study start17 Mar 2020
  3. Primary completion11 Apr 2022
  4. Study completion11 Apr 2022

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Other
Enrolment
9,559 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04271280
Sponsor's protocol ID
DSE-HCL-01-19-EU
Acronym
SANTORINI
Status last verified
Feb 2024
First submitted
7 Feb 2020
Last updated
20 Feb 2024
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Toplak H, Komen JJ, Bardet A, Catapano AL, Ray KK; SANTORINI Investigators. Low-density lipoprotein cholesterol management and goal attainment at 1 year in patients with diabetes, pre-diabetes and normoglycaemia: results from the European, prospective, observational SANTORINI study. BMJ Open. 2026 Jun 29;16(6):e108737. doi: 10.1136/bmjopen-2025-108737.

    PubMed 42373176

  • Ray KK, Aguiar C, Arca M, Connolly DL, Eriksson M, Ferrieres J, Laufs U, Mostaza JM, Nanchen D, Boachie C, Lee B, Soronen J, Becker C, Rietzschel E, Strandberg T, Toplak H, Visseren FLJ, Catapano AL; SANTORINI study investigators. Potential impact on cholesterol goal achievement and predicted cardiovascular risk by the addition of ezetimibe and bempedoic acid on top of statins: a simulation from the SANTORINI study. Am J Prev Cardiol. 2026 Mar 24;27:101577. doi: 10.1016/j.ajpc.2026.101577. eCollection 2026 Jun.

    PubMed 42291044

  • Connolly D, Fuat A, McCormack T, Mcnally D, Garstang J, Ryan J, Reed A, Robinson D, Catapano AL, Ray KK. Real-world changes in lipid-lowering therapy use and LDL-C goal attainment in high and very high cardiovascular risk patients in the UK: a secondary analysis of the European SANTORINI study 1-year follow-up. BMJ Open. 2026 Apr 24;16(4):e114031. doi: 10.1136/bmjopen-2025-114031.

    PubMed 42031497

  • Aguiar C, Aguiar P, Sequeira Duarte J, Gil V, Mimoso J, Monteiro P, Pinto FJ, Pinto F, Raposo J, von Hafe P, Ruivo JA, Teixeira C, Catapano AL, Ray KK. Lipid-lowering therapy and LDL cholesterol control among high- and very high-risk patients in Portugal: An analysis of the SANTORINI study. Rev Port Cardiol. 2026 Feb;45(2):51-64. doi: 10.1016/j.repc.2025.10.003. Epub 2025 Nov 28. English, Portuguese.

    PubMed 41319792

  • Arca M, Calabro P, Solini A, Pirillo A, Gambacurta R, Ray KK, Catapano AL; SANTORINI Italian Group. Challenges in achieving LDL-C goals: Insights from the Italian SANTORINI study cohort. Nutr Metab Cardiovasc Dis. 2026 Feb;36(2):104412. doi: 10.1016/j.numecd.2025.104412. Epub 2025 Oct 14.

    PubMed 41125511

  • Mostaza JM, Garcia-Ortiz L, Suarez Tembra MA, Talavera Calle P, Chimeno Garcia J, Escolar Perez V, Diaz-Diaz JL, Manzano-Espinosa L, Catapano AL, Ray KK, Diaz Moya G, Pedro-Botet Montoya J; en representacion del grupo de investigadores de SANTORINI Espana. Failure of LDL-C goals achievement and underuse of lipid-lowering therapies in patients at high and very high cardiovascular risk: Spanish subset from the European SANTORINI study. Rev Clin Esp (Barc). 2025 Feb;225(2):78-84. doi: 10.1016/j.rceng.2024.11.004. Epub 2024 Nov 28.

    PubMed 39613100

  • Ray KK, Haq I, Bilitou A, Manu MC, Burden A, Aguiar C, Arca M, Connolly DL, Eriksson M, Ferrieres J, Laufs U, Mostaza JM, Nanchen D, Rietzschel E, Strandberg T, Toplak H, Visseren FLJ, Catapano AL; SANTORINI Study Investigators. Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study. Lancet Reg Health Eur. 2023 Apr 5;29:100624. doi: 10.1016/j.lanepe.2023.100624. eCollection 2023 Jun.

    PubMed 37090089

Questions about this trial

What is this clinical trial studying?

An observational study of Dyslipidemia and Cardiovascular Diseases, run by Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company at 540 sites in 14 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 20 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 540 sites in Germany, Italy, Spain, United Kingdom, France and 9 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 20 Feb 2024). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Mean Low Density Lipid-Cholesterol (LDL-C) Levels in High and Very High Risk Cardiovascular Participants (time frame: Baseline up to 12 months post-enrollment). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04271280, which also lists 7 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2024.

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