Strength TrainingExecutive-19NCT03946254
Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment
A study testing Effect of strength training on executive functions in elderly people with mild cognitive impairment. in people with Strength Training and Executive Function, run by University of Seville at 1 site in Spain.
Trial summary
Cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. To this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise. Read more about this study
- Who is it for?
- Ages 60 years and older
- Conditions the study is for
- Strength Training, Executive Function
- What is being tested?
- Effect of strength training on executive functions in elderly people with mild cognitive impairment.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteSpain
- Study dates
- 1 Sep 2019to 15 Jun 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- The sample is made up of people over 60 years of age, who are not active professionally, speak and understand the Spanish language.
- In addition, they should be diagnosed with mild cognitive impairment. This will be evaluated by specialists through the minimental test (score between 24 and 28).
- On the other hand, they should not suffer from other serious psychiatric or neurodegenerative neurological diseases.
- In relation to mental health, it will be a reason for exclusion to have had 3 episodes of depression in the last 5 years or 10 episodes that have required some psychiatric or medical treatment.In addition,
- The people included must be postmenopausal
Who cannot join
- Participate in other physical exercise programs in a systematic way or in individualized and systematic programs in cognitive programs.
- Dispose of cardiovascular diseases, heart diseases that involve an absolute contradiction of physical exercise (unstable angina, severe auroventricular block) and cerebrovascular or have suffered a heart attack in the last 6 years.
- Have had seizures (More than 2 in the last 12 months).
- Consumption of alcohol 20 grams / day or 2 beers or wine glasses daily.
- Functional limitations (According to Functional activities Questionnaire)
- Being a musician or bilingual.
Trial locations and contacts
1 site in 1 country.
Spain1 site
Education Faculty
Seville, 41013
manuel jesus j roldan, 650344644, jimenez.roldan.manueljesus@gmail.com
jimenez.roldan.manueljesus@gmail.com
About this study
Cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. To this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise.
In the existing scientific literature, you can find a lot of information about the effect of aerobic exercise on cognition, but little is known about the effect of force exercise and its effect on general cognition and executive functions.
Therefore, in this research the investigators will investigate the effect of strength training in people over 60 with a diagnosis of mild cognitive impairment in executive functions. For this, a controlled and randomized clinical trial will be developed in the city of Seville
Read the detailed description
The training program will last 20 weeks and a frequency of 3 times / week.
During the week 0 the initial evaluation will be developed. Between weeks 1-20, the training program will be addressed. In week 21, all the changes made in all the measured variables will be evaluated.
Finally, in week 33 the variables will be measured again to see if the possible improvements given in the training program last over time.
The experimental group will perform a planned and individualized training with guided machines and training loads will be adjusted at the beginning of each week.
The control group will perform breathing and relaxation exercises to avoid a sample death.
After the intervention, there will be a follow-up phase for 3 months.
- Conditions
- Strength Training, Executive Function
- Being tested
- Effect of strength training on executive functions in elderly people with mild cognitive impairment.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Effect of strength training on executive functions in elderly people with mild cognitive impairment.Other
Strength training sessions will have a frequency of 3 times per week (Monday, Tuesday and Wednesday) for 20 weeks. In addition, each subject is subject to an individualized training program according to the workload in order to progressively increase the intensity of work. The workload will be modified progressively by influencing both the total volume of repetitions and the intensity of the exercises. The exercises will be controlled movements and not harmful, as guided machines will be used to facilitate the execution of actions. In addition, the largest amount of muscle groups to be able to generate strength gains in all muscle groups. The control group will perform breathing exercises and low intensity stretching during the same days and with the same duration as the experimental group
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Experimental | THE EXPERIMENTAL GROUP WILL DEVELOP 20 WEEKS OF TRAINING TO IMPROVE THE MUSCLE CAPACITY. FOR THIS, FORCE EXERCISES WILL BE DEVELOPED IN GUIDED MACHINES. Receives: Other: Effect of strength training on executive functions in elderly people with mild cognitive impairment. |
| Control | Experimental | THE CONTROL GROUP WILL DEVELOP 20 WEEKS OF BALANCE AND BREATHING EXERCISES. Receives: Other: Effect of strength training on executive functions in elderly people with mild cognitive impairment. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Baseline of Inhibitory control
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors.
Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory control.
Measured: week 0
Mean Change from Baseline in Inhibitory control
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors.
Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
Measured: week 21
Inhibitory control in the follow-up phase
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors.
Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
Measured: week 33
Secondary outcomes (23)
Baseline of general cognition
Global cognition is evaluated through the mini-mental test (Folstein, Folstein, \& McHugh, 1975). It is a brief and quick test to apply and is frequently used to diagnose the degree of cognitive decline. It should be noted how various variables such as the socio-educational level, and age among others, can affect the result. In addition, the mini-mental test is low cost and can be applied by any professional with a minimum of knowledge and training towards their development. The diagnostic values for mild cognitive impairment are between 24 and 28.
Measured: Week 0
Mean Change from Baseline in General cognition
Global cognition is evaluated through the mini-mental test (Folstein, Folstein, \& McHugh, 1975). It is a brief and quick test to apply and is frequently used to diagnose the degree of cognitive decline. It should be noted how various variables such as the socio-educational level, and age among others, can affect the result. In addition, the mini-mental test is low cost and can be applied by any professional with a minimum of knowledge and training towards their development. The diagnostic values for mild cognitive impairment are between 24 and 28.
Measured: week 21
General cognition in the follow-up phase
Global cognition is evaluated through the mini-mental test (Folstein, Folstein, \& McHugh, 1975). It is a brief and quick test to apply and is frequently used to diagnose the degree of cognitive decline. It should be noted how various variables such as the socio-educational level, and age among others, can affect the result. In addition, the mini-mental test is low cost and can be applied by any professional with a minimum of knowledge and training towards their development. The diagnostic values for mild cognitive impairment are between 24 and 28.
Measured: week 33
Baseline of physical condition
Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli \& Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests: The tests described here are quantified by the distance achieved.
Test of flexibility of the lower extremities, Put your hands behind your back, Get up and walk and sit down again.
In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
Measured: week 0
Mean Change from Baseline in Physical condition
Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli \& Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests: The tests described here are quantified by the distance achieved.
Test of flexibility of the lower extremities, Put your hands behind your back, Get up and walk and sit down again.
In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
Measured: week 21
Physical condition in the follow-up phase
Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli \& Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests: The tests described here are quantified by the distance achieved.
Test of flexibility of the lower extremities, Put your hands behind your back, Get up and walk and sit down again.
In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
Measured: week 33
Baseline of physical condition variante
Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli \& Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests. The tests described here are quantified by the maximum number of repetitions performed.
Sit and get up from a chair for 30 seconds, push-ups for 30 seconds, In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
Measured: week 0
Mean Change from Baseline in Physical condition variante
Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli \& Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests. The tests described here are quantified by the maximum number of repetitions performed.
Sit and get up from a chair for 30 seconds, push-ups for 30 seconds, In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
Measured: week 21
Physical condition variante in the follow-up phase
Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli \& Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests. The tests described here are quantified by the maximum number of repetitions performed.
Sit and get up from a chair for 30 seconds, push-ups for 30 seconds, In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
Measured: week 33
Baseline of blood test
Only 15 ml of blood will be extracted from the antecubital vein to measure the concentrations of different biochemical parameters, such as the BDFN and IGF-1. To avoid interferences in the blood analysis, it is necessary that the patient goes on an empty stomach. It is also necessary that during the previous day the participant fulfills a normal sleep monitoring cycle and that he does not eat chocolate, cocoa, tea, coffee or any other stimulant.
Measured: week 0
Mean Change from Baseline in Blood test
Only 15 ml of blood will be extracted from the antecubital vein to measure the concentrations of different biochemical parameters, such as the BDFN and IGF-1. To avoid interferences in the blood analysis, it is necessary that the patient goes on an empty stomach. It is also necessary that during the previous day the participant fulfills a normal sleep monitoring cycle and that he does not eat chocolate, cocoa, tea, coffee or any other stimulant.
Measured: week 21
Baseline of strength
The point of maximum power is an elaborate and accurate assessment of muscle strength and is often evaluated at a speed of 60º per second. Therefore, the Biodex 4 system will be used to assess the capacity to generate the power peak of each subjectby knee extension.
Measured: week 0
Mean Change from Baseline in Strength
The point of maximum power is an elaborate and accurate assessment of muscle strength and is often evaluated at a speed of 60º per second. Therefore, the Biodex 4 system will be used to assess the capacity to generate the power peak of each subjectby knee extension.
Measured: week 21
Strength in the follow-up phase
The point of maximum power is an elaborate and accurate assessment of muscle strength and is often evaluated at a speed of 60º per second. Therefore, the Biodex 4 system will be used to assess the capacity to generate the power peak of each subjectby knee extension.
Measured: week 33
Baseline of cognitive flexibility
To evaluate the cognitive flexibility, will be used the WISCONSIN TEST. This test consists of two sets of 64 cards. The letters present various combinations according to 4 geometric shapes, 4 colors and 4 quantities.
Measured: week 0
Mean Change from Baseline in cognitive flexibility
To evaluate the cognitive flexibility, will be used the WISCONSIN TEST. This test consists of two sets of 64 cards. The letters present various combinations according to 4 geometric shapes, 4 colors and 4 quantities.
Measured: week 21
cognitive flexibility in the follow-up phase
To evaluate the cognitive flexibility, will be used the WISCONSIN TEST. This test consists of two sets of 64 cards. The letters present various combinations according to 4 geometric shapes, 4 colors and 4 quantities.
Measured: week 33
Baseline of cognitive flexibility variante
"Trail Making test part B" will be used to assess cognitive flexibility. This reliable test and valid consists of a page where you must surround numbers and letters. The numbers are they extend from 1 to 13 and the letters from A to L.
Measured: week 0
Mean Change from Baseline in cognitive flexibility variante
"Trail Making test part B" will be used to assess cognitive flexibility. This reliable test and valid consists of a page where you must surround numbers and letters. The numbers are they extend from 1 to 13 and the letters from A to L.
Measured: week 21
cognitive flexibility variante in the follow-up phase
"Trail Making test part B" will be used to assess cognitive flexibility. This reliable test and valid consists of a page where you must surround numbers and letters. The numbers are they extend from 1 to 13 and the letters from A to L.
Measured: week 33
Baseline of working memory
For that, wi will used the Verbal digit span forward and backward tests.This test is an excellent tool to evaluate working memory. The examiner reads a sequence of numbers and the participant must repeat it. It is composed of two parts, direct or indirect. In the first the subject must say the sequence of numbers in the order they appear. On the other hand, the indirect must name the numbers that appeared in reverse order. The length of the sequences of numbers increases progressively and two sequences with the same number are always administered. The task is suspended when the subject fails twice in the same sequence. This test gives us a measure of the attention capacity and working memory.
Measured: week 0
Mean Change from Baseline in working memory
For that, wi will used the Verbal digit span forward and backward tests.This test is an excellent tool to evaluate working memory. The examiner reads a sequence of numbers and the participant must repeat it. It is composed of two parts, direct or indirect. In the first the subject must say the sequence of numbers in the order they appear. On the other hand, the indirect must name the numbers that appeared in reverse order. The length of the sequences of numbers increases progressively and two sequences with the same number are always administered. The task is suspended when the subject fails twice in the same sequence. This test gives us a measure of the attention capacity and working memory.
Measured: week 21
Working memory in the follow-up phase
For that, wi will used the Verbal digit span forward and backward tests.This test is an excellent tool to evaluate working memory. The examiner reads a sequence of numbers and the participant must repeat it. It is composed of two parts, direct or indirect. In the first the subject must say the sequence of numbers in the order they appear. On the other hand, the indirect must name the numbers that appeared in reverse order. The length of the sequences of numbers increases progressively and two sequences with the same number are always administered. The task is suspended when the subject fails twice in the same sequence. This test gives us a measure of the attention capacity and working memory.
Measured: week 33
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 May 2019
- Study start1 Sep 2019 (estimated)
- Primary completion15 Mar 2020 (estimated)
- Study completion15 Jun 2020 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Strength TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Seville
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Manuel Jesús, University of Seville
- Investigators
- manuel jesus j roldan, Sports Sci, Principal investigator, University of Seville
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03946254
- Sponsor's protocol ID
- University of seville
- Acronym
- Executive-19
- Status last verified
- May 2019
- First submitted
- 3 May 2019
- Last updated
- 10 May 2019
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 May 2019. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment
- ClinicalTrials.gov ID
- NCT03946254
- Acronym / sponsor ID
- Executive-19 / University of seville
- Conditions
- Strength Training, Executive Function
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- University of SevilleUniversity, hospital or other
- Study start
- 1 Sep 2019 (estimated)
- Primary completion
- 15 Mar 2020 (estimated)
- Study completion
- 15 Jun 2020 (estimated)
- First posted
- 10 May 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. To this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise.
In the existing scientific literature, you can find a lot of information about the effect of aerobic exercise on cognition, but little is known about the effect of force exercise and its effect on general cognition and executive functions.
Therefore, in this research the investigators will investigate the effect of strength training in people over 60 with a diagnosis of mild cognitive impairment in executive functions. For this, a controlled and randomized clinical trial will be developed in the city of Seville
Detailed description
The training program will last 20 weeks and a frequency of 3 times / week.
During the week 0 the initial evaluation will be developed. Between weeks 1-20, the training program will be addressed. In week 21, all the changes made in all the measured variables will be evaluated.
Finally, in week 33 the variables will be measured again to see if the possible improvements given in the training program last over time.
The experimental group will perform a planned and individualized training with guided machines and training loads will be adjusted at the beginning of each week.
The control group will perform breathing and relaxation exercises to avoid a sample death.
After the intervention, there will be a follow-up phase for 3 months.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention | Experimental | Other: Effect of strength training on executive functions in elderly people with mild cognitive impairment.THE EXPERIMENTAL GROUP WILL DEVELOP 20 WEEKS OF TRAINING TO IMPROVE THE MUSCLE CAPACITY. FOR THIS, FORCE EXERCISES WILL BE DEVELOPED IN GUIDED MACHINES. |
| Control | Experimental | Other: Effect of strength training on executive functions in elderly people with mild cognitive impairment.THE CONTROL GROUP WILL DEVELOP 20 WEEKS OF BALANCE AND BREATHING EXERCISES. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- The sample is made up of people over 60 years of age, who are not active professionally, speak and understand the Spanish language.
- In addition, they should be diagnosed with mild cognitive impairment. This will be evaluated by specialists through the minimental test (score between 24 and 28).
- On the other hand, they should not suffer from other serious psychiatric or neurodegenerative neurological diseases.
- In relation to mental health, it will be a reason for exclusion to have had 3 episodes of depression in the last 5 years or 10 episodes that have required some psychiatric or medical treatment.In addition,
- The people included must be postmenopausal
Key exclusion criteria (6 listed)
- Participate in other physical exercise programs in a systematic way or in individualized and systematic programs in cognitive programs.
- Dispose of cardiovascular diseases, heart diseases that involve an absolute contradiction of physical exercise (unstable angina, severe auroventricular block) and cerebrovascular or have suffered a heart attack in the last 6 years.
- Have had seizures (More than 2 in the last 12 months).
- Consumption of alcohol 20 grams / day or 2 beers or wine glasses daily.
- Functional limitations (According to Functional activities Questionnaire)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Effect of strength training on executive functions in elderly people with mild cognitive impairment.Strength training sessions will have a frequency of 3 times per week (Monday, Tuesday and Wednesday) for 20 weeks. In addition, each subject is subject to an individualized training program according to the workload in order to progressively increase the intensity of work. The workload will be modified progressively by influencing both the total volume of repetitions and the intensity of the exercises. The exercises will be controlled movements and not harmful, as guided machines will be used to facilitate the execution of actions. In addition, the largest amount of muscle groups to be able to generate strength gains in all muscle groups. The control group will perform breathing exercises and low intensity stretching during the same days and with the same duration as the experimental group | Other | Control, Intervention |
Primary outcome
Baseline of Inhibitory control
Time frame: week 0
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors. Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory control.
Mean Change from Baseline in Inhibitory control
Time frame: week 21
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors. Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
Inhibitory control in the follow-up phase
Time frame: week 33
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors. Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
23 secondary outcomes
Baseline of general cognition
Time frame: Week 0
Mean Change from Baseline in General cognition
Time frame: week 21
General cognition in the follow-up phase
Time frame: week 33
Baseline of physical condition
Time frame: week 0
Mean Change from Baseline in Physical condition
Time frame: week 21
Physical condition in the follow-up phase
Time frame: week 33
Baseline of physical condition variante
Time frame: week 0
Mean Change from Baseline in Physical condition variante
Time frame: week 21
Physical condition variante in the follow-up phase
Time frame: week 33
Baseline of blood test
Time frame: week 0
Mean Change from Baseline in Blood test
Time frame: week 21
Baseline of strength
Time frame: week 0
Mean Change from Baseline in Strength
Time frame: week 21
Strength in the follow-up phase
Time frame: week 33
Baseline of cognitive flexibility
Time frame: week 0
Mean Change from Baseline in cognitive flexibility
Time frame: week 21
cognitive flexibility in the follow-up phase
Time frame: week 33
Baseline of cognitive flexibility variante
Time frame: week 0
Mean Change from Baseline in cognitive flexibility variante
Time frame: week 21
cognitive flexibility variante in the follow-up phase
Time frame: week 33
Baseline of working memory
Time frame: week 0
Mean Change from Baseline in working memory
Time frame: week 21
Working memory in the follow-up phase
Time frame: week 33
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 May 2019.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
manuel jesus j roldan, Sports Sci principal investigator
University of Seville
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Effect of strength training on executive functions in elderly people with mild cognitive impairment. in people with Strength Training and Executive Function, run by University of Seville at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 10 May 2019. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact manuel jesus j roldan, Sports Sci (650344644, jimenez.roldan.manueljesus@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Baseline of Inhibitory control (time frame: week 0). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 May 2019.