Tooth ExtractionNCT03943680
Plasma Rich in Growth Factors in Post-extraction Sockets
A study testing PRGF and ABB in people with Tooth Extraction and Dental Implants, run by Universidad de Granada at 1 site in Spain.
Trial summary
The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Tooth Extraction, Dental Implants
- What is being tested?
- PRGF and ABB
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteSpain
- Study dates
- 4 Mar 2019to 30 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
- Adjacent and opposing natural teeth present and healthy.
- At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.
Who cannot join
- Active local infection.
- Uncontrolled diabetes mellitus.
- Long term (>10 years) use of oral bisphosphonates.
- Use of intravenous bisphosphonates.
- Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
- Pregnancy.
- Smokers of more than 10 cigarettes per day.
- Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Clinical Behavior and Molecular Pathways of PRGF in Post-extraction Sockets
The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.
- Conditions
- Tooth Extraction, Dental Implants
- Being tested
- PRGF, ABB
- Keywords
- Tooth extraction, Socket regeneration, Dental Implants
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PRGFDevice
Also called PRGF-Endoret
After tooth extraction, the socket will be grafted with PRGF-Endoret
ABBDevice
Also called Geistlich Bio-Oss® Collagen
After tooth extraction, the socket will be grafted with Geistlich Bio-Oss® Collagen
| Study group | Role | What they receive |
|---|---|---|
| PRGF | Experimental | Post-extraction socket grafted with PRGF-Endoret Receives: Device: PRGF |
| ABB | Active comparator | Post-extraction socket grafted with anorganic bovine bone (ABB) Receives: Device: ABB |
What is being measured
The primary outcome is the main question the study is designed to answer.
Alveolar bone change in Cone Beam Computerized Tomography
Volumetric change in the alveolar bone from immediately after tooth extraction to immediately before implant placement (4 months after the extraction and grafting of the socket)
Measured: Baseline and 4 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 May 2019
- Study start4 Mar 2019
- Primary completion18 Nov 2024
- Study completion30 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Tooth ExtractionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidad de Granada
- Sponsor type
- University, hospital or other
- Collaborators
- BTI Biotechnology Institute
- Responsible party
- Principal investigator, Pablo Galindo-Moreno, Universidad de Granada
- Investigators
- Pablo Galindo-Moreno, DDS, PhD, Principal investigator, Universidad de Granada
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03943680
- Sponsor's protocol ID
- 1962-N-18
- Status last verified
- May 2026
- First submitted
- 7 May 2019
- Last updated
- 12 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Anitua E, Murias-Freijo A, Alkhraisat MH, Orive G. Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig. 2015 Apr;19(3):589-600. doi: 10.1007/s00784-014-1278-2. Epub 2014 Jul 8.
PubMed 24998770
Study at a glance
From the registry record, last updated by the sponsor on 12 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Behavior and Molecular Pathways of PRGF in Post-extraction Sockets
- ClinicalTrials.gov ID
- NCT03943680
- Acronym / sponsor ID
- 1962-N-18
- Conditions
- Tooth Extraction, Dental Implants
- Keywords
- Tooth extraction, Socket regeneration, Dental Implants
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Universidad de GranadaUniversity, hospital or other
- Collaborators
- BTI Biotechnology Institute
- Study start
- 4 Mar 2019 (actual)
- Primary completion
- 18 Nov 2024 (actual)
- Study completion
- 30 Oct 2025 (actual)
- First posted
- 9 May 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PRGF | Experimental | Device: PRGFPost-extraction socket grafted with PRGF-Endoret |
| ABB | Active comparator | Device: ABBPost-extraction socket grafted with anorganic bovine bone (ABB) |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
- Adjacent and opposing natural teeth present and healthy.
- At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.
Key exclusion criteria (8 listed)
- Active local infection.
- Uncontrolled diabetes mellitus.
- Long term (>10 years) use of oral bisphosphonates.
- Use of intravenous bisphosphonates.
- Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PRGFAlso: PRGF-EndoretAfter tooth extraction, the socket will be grafted with PRGF-Endoret | Device | PRGF |
| ABBAlso: Geistlich Bio-Oss® CollagenAfter tooth extraction, the socket will be grafted with Geistlich Bio-Oss® Collagen | Device | ABB |
Primary outcome
Alveolar bone change in Cone Beam Computerized Tomography
Time frame: Baseline and 4 months
Volumetric change in the alveolar bone from immediately after tooth extraction to immediately before implant placement (4 months after the extraction and grafting of the socket)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 May 2026.
- Background: PubMed 24998770Anitua E, Murias-Freijo A, Alkhraisat MH, Orive G. Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig. 2015 Apr;19(3):589-600. doi: 10.1007/s00784-014-1278-2. Epub 2014 Jul 8.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Pablo Galindo-Moreno, DDS, PhD principal investigator
Universidad de Granada
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing PRGF and ABB in people with Tooth Extraction and Dental Implants, run by Universidad de Granada at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Alveolar bone change in Cone Beam Computerized Tomography (time frame: Baseline and 4 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03943680, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 May 2026.