Magnetic Resonance Imaging SequencesSEQ-IRMNCT03674645
Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research
A study testing MRI acquisitions in people with Magnetic Resonance Imaging Sequences, run by University Hospital, Bordeaux at 1 site in France.
Trial summary
Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Magnetic Resonance Imaging Sequences
- What is being tested?
- MRI acquisitions
- Type of treatment
- Injection or infusion, Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteFrance
- Study dates
- 19 Sep 2018to Sep 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy volunteers (over 18 yo),
- Male or female,
- Affiliated to social security,
- Without any contraindication to MRI exam and who will have signed a written inform consent.
Who cannot join
- Individuals deprived of liberty,
- Under guardianship or curatorship,
- Persons with known disease which could disturb MRI acquisition or with absolute or relative contraindication to an MRI examination
- Pregnant women,
- Breastfeeding women,
- Women without effective contraception,
- Participants who refused to be informed of the possible discovery of a significant anomaly,
- Persons involved in an interventional study with a drug or an implantable device.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHU de Bordeaux
Pessac, 33604
Hubert COCHET, MD, (0)557675613 ext. +33, hubert.cochet@chu-bordeaux.fr
Lorena SANCHEZ BLANCO, (0)557623091 ext. +33, lorena.sanchez-blanco@chu-bordeaux.fr
About this study
Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. These new sequences will allow better spatial resolution and specificity while reducing acquisition time.
Read the detailed description
The purpose of the present study is to test and optimize, on healthy subjects, specific MRI acquisition sequences firstly developed in a preclinical phase on phantoms (inert objects containing solutions or gels) and animal (Pig, sheep). This study will allow the investigators to define practical acquisition parameters that will allow reproducible results and precise definition of clinically relevant examination protocols for each new developed sequence.
- Conditions
- Magnetic Resonance Imaging Sequences
- Being tested
- MRI acquisitions
- Keywords
- Healthy volunteers, Test, Optimization
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRI acquisitionsDevice
Procedure of the study is an MRI exam without any injection or invasive procedure, that will be performed on the Siemens Magnetom Aera imager of Liryc institute (L'Institut de RYthmologie et modélisation Cardiaque) (Xavier Arnozan site - Bordeaux)
| Study group | Role | What they receive |
|---|---|---|
| MRI | Experimental | MRI exam performed on 200 healthy volunteers Receives: Device: MRI acquisitions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Image quality
Measured: Day 0
Signal to noise ratio
Measured: Day 0
Contrasts between structurally different regions
The values of the signal intensities will be measured in adjacent structures of interest. The difference between these values divided by the noise will be calculated to quantify the contrast-to-noise ratio between these structures. The higher this value is, the better is the sequence in its ability to differentiate these structures from one another.
Measured: Day 0
Total acquisition time
Measured: Day 0
Qualitative interpretation of image quality to respiratory and cardiac motions
In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The qualitative interpretation of image quality will be performed by visual image analysis.
Measured: Day 0
Quantitative interpretation of image quality to respiratory and cardiac motions
In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The quantitative interpretation of image quality will be performed by a measurement of sharpness of contours between adjacent structures of interest.
Measured: Day 0
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Sep 2018
- Study start19 Sep 2018
- Primary completionSep 2028 (estimated)
- Study completionSep 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Magnetic Resonance Imaging SequencesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Bordeaux
- Sponsor type
- University, hospital or other
- Collaborators
- L'Institut de RYthmologie et modélisation Cardiaque (IHU LIRYC)
- Responsible party
- Sponsor
- Investigators
- Hubert COCHET, MD, Principal investigator, University Hospital, Bordeaux
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03674645
- Sponsor's protocol ID
- CHUBX 2017/21
- Acronym
- SEQ-IRM
- Status last verified
- Mar 2026
- First submitted
- 20 Aug 2018
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research
- ClinicalTrials.gov ID
- NCT03674645
- Acronym / sponsor ID
- SEQ-IRM / CHUBX 2017/21
- Conditions
- Magnetic Resonance Imaging Sequences
- Keywords
- Healthy volunteers, Test, Optimization
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- University Hospital, BordeauxUniversity, hospital or other
- Collaborators
- L'Institut de RYthmologie et modélisation Cardiaque (IHU LIRYC)
- Study start
- 19 Sep 2018 (actual)
- Primary completion
- Sep 2028 (estimated)
- Study completion
- Sep 2028 (estimated)
- First posted
- 17 Sep 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. These new sequences will allow better spatial resolution and specificity while reducing acquisition time.
Detailed description
The purpose of the present study is to test and optimize, on healthy subjects, specific MRI acquisition sequences firstly developed in a preclinical phase on phantoms (inert objects containing solutions or gels) and animal (Pig, sheep). This study will allow the investigators to define practical acquisition parameters that will allow reproducible results and precise definition of clinically relevant examination protocols for each new developed sequence.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| MRI | Experimental | Device: MRI acquisitionsMRI exam performed on 200 healthy volunteers |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Healthy volunteers (over 18 yo),
- Male or female,
- Affiliated to social security,
- Without any contraindication to MRI exam and who will have signed a written inform consent.
Key exclusion criteria (8 listed)
- Individuals deprived of liberty,
- Under guardianship or curatorship,
- Persons with known disease which could disturb MRI acquisition or with absolute or relative contraindication to an MRI examination
- Pregnant women,
- Breastfeeding women,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRI acquisitionsProcedure of the study is an MRI exam without any injection or invasive procedure, that will be performed on the Siemens Magnetom Aera imager of Liryc institute (L'Institut de RYthmologie et modélisation Cardiaque) (Xavier Arnozan site - Bordeaux) | Device | MRI |
Primary outcome
Image quality
Time frame: Day 0
Signal to noise ratio
Time frame: Day 0
Contrasts between structurally different regions
Time frame: Day 0
The values of the signal intensities will be measured in adjacent structures of interest. The difference between these values divided by the noise will be calculated to quantify the contrast-to-noise ratio between these structures. The higher this value is, the better is the sequence in its ability to differentiate these structures from one another.
Total acquisition time
Time frame: Day 0
Qualitative interpretation of image quality to respiratory and cardiac motions
Time frame: Day 0
In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The qualitative interpretation of image quality will be performed by visual image analysis.
Quantitative interpretation of image quality to respiratory and cardiac motions
Time frame: Day 0
In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The quantitative interpretation of image quality will be performed by a measurement of sharpness of contours between adjacent structures of interest.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Hubert COCHET, MD principal investigator
University Hospital, Bordeaux
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MRI acquisitions in people with Magnetic Resonance Imaging Sequences, run by University Hospital, Bordeaux at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hubert COCHET, MD ((0)557675613 ext. +33, hubert.cochet@chu-bordeaux.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Image quality (time frame: Day 0). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.