Optimized MRI SequencesOPTIMNCT05326581
Optimization of Sequences to Improve the Quality and Comfort of the Magnetic Resonance Imaging Examination
An observational study of Optimized MRI Sequences, run by Fondation Ophtalmologique Adolphe de Rothschild at 1 site in France.
Trial summary
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. Read more about this study
- Who is it for?
- Ages 18 months and older
- Conditions the study is for
- Optimized MRI Sequences
- What is being tested?
- mri
- Type of treatment
- Medical device
- How many people
- 750 participants
- Where
- 1 siteFrance
- Study dates
- 23 May 2022to May 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 months and older
- All sexes
- Child, Adult, Older adult
Study population: Participation in the study will be offered to patients performing MRI imaging as part of the treatment as well as to healthy volunteers among the staff.
Who may be able to join
- Subject over 18 years old
- Consent to participate in the study
- Member of or beneficiary of a social security scheme
- For patients: benefiting from an MRI examination as part of their care
- For volunteers: Consent to be informed if an unexpected anomaly is revealed by the imaging.
Who cannot join
- Subject benefiting from a measure of legal protection
- Pregnant or breastfeeding women
- For volunteers: Contraindication to MRI (detailed contraindications questionnaire, THI score >28 questionnaire, hearing sensitivity questionnaire grade >1)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Julien Savatovsky, MD contact
France1 site, 1 recruiting
- Recruiting
Hôpital Fondation Adolphe de Rothschild
Paris, Paris, 75019
Amelie Yavchitz, MD, (0)148036454 ext. +33, ayavchitz@for.paris
Julien Savatovsky, MD, jsavatovsky@for.paris
About this study
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. The duration of the examination (or the extension of the examination planned as part of patient care) will be from a few minutes to an hour depending on the sequences to be optimized. Subjects who agree to research for more than 30 minutes in the MRI machine will be compensated with a multi-brand gift voucher worth 30 euros.
Read the detailed description
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. The duration of the examination (or the extension of the examination planned as part of patient care) will be from a few minutes to an hour depending on the sequences to be optimized. Subjects who agree to research for more than 30 minutes in the MRI machine will be compensated with a multi-brand gift voucher worth 30 euros
- Conditions
- Optimized MRI Sequences
- Being tested
- mri
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
mriDevice
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. The duration of the examination (or the extension of the examination planned as part of patient care) will be from a few minutes to an hour depending on the sequences to be optimized. Subjects who agree to research for more than 30 minutes in the MRI machine will be compensated with a multi-brand gift voucher worth 30 euros.
| Study group | Role | What they receive |
|---|---|---|
| PATIENTS | patients benefiting from an MRI examination as part of their care Receives: Device: mri | |
| VOLUNTEERS | healthy volunteers among staff. Receives: Device: mri |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quality of imagery
Quality of imagery evaluated on a likert-type scale (range from : "very bad quality" to "very good quality") by two experts
Measured: Baseline
Presence or absence of radiological image artifact
Presence/absence of radiological image artifact evaluated on a likert-type scale (range from : "major - impossible interpretation" to "none") by two experts
Measured: Baseline
Confidence in diagnosis
Confidence in diagnosis evaluated on a likert-type scale (range from : "not confident" to "very confident") by two experts
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2022
- Study start23 May 2022
- Primary completionMay 2027 (estimated)
- Study completionMay 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Optimized MRI SequencesStudies of the same condition, open and under way.
- More trials run by Fondation Ophtalmologique Adolphe de RothschildThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 750 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Sponsor type
- Research network
- Responsible party
- Sponsor
- Investigators
- Julien Savatovksy, MD, Principal investigator, Fondation A. de Rothschild
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05326581
- Sponsor's protocol ID
- JSY_2021_30
- Acronym
- OPTIM
- Status last verified
- Dec 2025
- First submitted
- 18 Mar 2022
- Last updated
- 5 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Optimization of Sequences to Improve the Quality and Comfort of the Magnetic Resonance Imaging Examination
- ClinicalTrials.gov ID
- NCT05326581
- Acronym / sponsor ID
- OPTIM / JSY_2021_30
- Conditions
- Optimized MRI Sequences
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 750 participants (estimated)
- Lead sponsor
- Fondation Ophtalmologique Adolphe de RothschildResearch network
- Study start
- 23 May 2022 (actual)
- Primary completion
- May 2027 (estimated)
- Study completion
- May 2027 (estimated)
- First posted
- 13 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. The duration of the examination (or the extension of the examination planned as part of patient care) will be from a few minutes to an hour depending on the sequences to be optimized. Subjects who agree to research for more than 30 minutes in the MRI machine will be compensated with a multi-brand gift voucher worth 30 euros.
Detailed description
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. The duration of the examination (or the extension of the examination planned as part of patient care) will be from a few minutes to an hour depending on the sequences to be optimized. Subjects who agree to research for more than 30 minutes in the MRI machine will be compensated with a multi-brand gift voucher worth 30 euros
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PATIENTS | – | Device: mripatients benefiting from an MRI examination as part of their care |
| VOLUNTEERS | – | Device: mrihealthy volunteers among staff. |
Who may qualify
- Ages
- 18 months and older
- Sex
- All
- Age groups
- Child, Adult, Older adult
- Study population
- Participation in the study will be offered to patients performing MRI imaging as part of the treatment as well as to healthy volunteers among the staff.
Key inclusion criteria (5 listed)
- Subject over 18 years old
- Consent to participate in the study
- Member of or beneficiary of a social security scheme
- For patients: benefiting from an MRI examination as part of their care
- For volunteers: Consent to be informed if an unexpected anomaly is revealed by the imaging.
Key exclusion criteria (3 listed)
- Subject benefiting from a measure of legal protection
- Pregnant or breastfeeding women
- For volunteers: Contraindication to MRI (detailed contraindications questionnaire, THI score >28 questionnaire, hearing sensitivity questionnaire grade >1)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| mriThe people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters. The duration of the examination (or the extension of the examination planned as part of patient care) will be from a few minutes to an hour depending on the sequences to be optimized. Subjects who agree to research for more than 30 minutes in the MRI machine will be compensated with a multi-brand gift voucher worth 30 euros. | Device | PATIENTS, VOLUNTEERS |
Primary outcome
Quality of imagery
Time frame: Baseline
Quality of imagery evaluated on a likert-type scale (range from : "very bad quality" to "very good quality") by two experts
Presence or absence of radiological image artifact
Time frame: Baseline
Presence/absence of radiological image artifact evaluated on a likert-type scale (range from : "major - impossible interpretation" to "none") by two experts
Confidence in diagnosis
Time frame: Baseline
Confidence in diagnosis evaluated on a likert-type scale (range from : "not confident" to "very confident") by two experts
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jan 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Julien Savatovsky, MD contact
Julien Savatovksy, MD principal investigator
Fondation A. de Rothschild
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Optimized MRI Sequences, run by Fondation Ophtalmologique Adolphe de Rothschild at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Amélie Yavchitz, MD ((0)148036454 ext. +33, ayavachitz@for.paris), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quality of imagery (time frame: Baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jan 2026.