Total Hip Replacement SurgeryATHAQLuBNCT03666260
Analgesia in Total Hip Arthroplasty by Quadratus Lumborum Block
A study testing Quadratus Lumborum Block and femoral block in people with Total Hip Replacement Surgery, run by CHU de Reims at 1 site in France.
Trial summary
Patients are painful after total hip arthroplasty. These patients have significant co-morbidities. Analgesics cause significant side effects in this population. Locoregional analgesia is therefore an effective means of reducing the consumption of opioids in this surgery. Read more about this study
- Who is it for?
- Ages 18 to 95 years
- Conditions the study is for
- Total Hip Replacement Surgery
- What is being tested?
- Quadratus Lumborum Block and femoral block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 179 participants
- Where
- 1 siteFrance
- Study dates
- 8 Oct 2018to 9 Jul 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 95 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients eligible for total hip replacement surgery in Reims University Hospital
- Patients agreeing to participate in the research and having signed informed consent
- between 18 yo and 95 yo
- Patients affiliated to a social security system
Who cannot join
- Patients with allergy to local anesthetics
- Patients with neuropathy
- Patients with an ASA score of 4
- Patients undergoing revision surgery for total hip arthroplasty
- Patients receiving anterior hip total hip replacement surgery
- Patients with a contraindication to the realization of the quadratus lumborum block, femoral block or spinal anesthesia (clinical coagulopathy, infection at the point of puncture ...)
- Patients refusing the proposed techniques
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of the Clinical Effectiveness of the Quadratus Lumborum Block and Femoral Block in the Analgesia of Total Posterior Hip Arthroplasty
Patients are painful after total hip arthroplasty. These patients have significant co-morbidities. Analgesics cause significant side effects in this population. Locoregional analgesia is therefore an effective means of reducing the consumption of opioids in this surgery.
The "gold standard" of locoregional analgesia after Total Hip Arthroplasty is the femoral block. However, a new technique has recently been described: the Quadratus Lumborum Block.
The comparison of these two techniques is lacking in the literature. The comparison of the Quadratus Lumborum Block to the femoral block in Total Hip arthroplasty is important in the analgesic strategy of patients undergoing this surgery.
Read the detailed description
The aim of this study is to compare the clinical efficacy of two regional locoregional analgesia strategies in total hip replacement surgery: the ultrasound-guided Quadratus Lumborum Block and the ultrasound-guided femoral block.
This is a double-blind, randomized study in prospective inclusion with a superiority test. Two groups of patients will be compared: a group of patients with a quadratus lumborum block and a group of patients with a femoral block.
Management (quadratus lumborum block or femoral block) will be randomized. The randomization will be stratified on the type of anesthesia (spinal anesthesia and general anesthesia). Randomization will be done on the day of surgery to determine the patient's treatment group. The surgical procedure will not be modified by the participation of the patent in the study.
Patients who would benefit from total hip replacement surgery in the Reims University Hospital and who agreed to participate in the study were included.
- Conditions
- Total Hip Replacement Surgery
- Being tested
- Quadratus Lumborum Block, femoral block
- Keywords
- Total hip replacement surgery, post operative pain, quadratus lumborum block, femoral block
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Quadratus Lumborum BlockProcedure or surgery
Quadratus Lumborum Block with echography
femoral blockProcedure or surgery
femoral block with echography
| Study group | Role | What they receive |
|---|---|---|
| Quadratus Lumborum Block arm | Experimental | Not described Receives: Procedure: Quadratus Lumborum Block |
| Femoral block arm | Active comparator | Not described Receives: Procedure: femoral block |
What is being measured
The primary outcome is the main question the study is designed to answer.
morphine consumption
Morphine consumption during the 24 hours postoperative
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Sep 2018
- Study start8 Oct 2018
- Primary completion9 Jul 2020
- Study completion9 Jul 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Total Hip Replacement SurgeryStudies of the same condition, open and under way.
- More trials run by CHU de ReimsThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 179 participants (actual)
Sponsor and investigators
- Lead sponsor
- CHU de Reims
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03666260
- Sponsor's protocol ID
- PO18122
- Acronym
- ATHAQLuB
- Status last verified
- May 2024
- First submitted
- 10 Sep 2018
- Last updated
- 16 May 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Aissaoui S, Riffault M, Baene A, Smati MF, Siboni R, Houet C, Legros V, Thierry A, Michelet D, Malinovsky JM, Coffinet J, Fernandes O. Quadratus lumborum block versus femoral nerve block in total hip arthroplasty: a randomized clinical trial. BMC Anesthesiol. 2026 Feb 24;26(1):203. doi: 10.1186/s12871-025-03586-x.
PubMed 41731391
Study at a glance
From the registry record, last updated by the sponsor on 16 May 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Clinical Effectiveness of the Quadratus Lumborum Block and Femoral Block in the Analgesia of Total Posterior Hip Arthroplasty
- ClinicalTrials.gov ID
- NCT03666260
- Acronym / sponsor ID
- ATHAQLuB / PO18122
- Conditions
- Total Hip Replacement Surgery
- Keywords
- Total hip replacement surgery, post operative pain, quadratus lumborum block, femoral block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 179 participants (actual)
- Lead sponsor
- CHU de ReimsUniversity, hospital or other
- Study start
- 8 Oct 2018 (actual)
- Primary completion
- 9 Jul 2020 (actual)
- Study completion
- 9 Jul 2021 (actual)
- First posted
- 11 Sep 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Patients are painful after total hip arthroplasty. These patients have significant co-morbidities. Analgesics cause significant side effects in this population. Locoregional analgesia is therefore an effective means of reducing the consumption of opioids in this surgery.
The "gold standard" of locoregional analgesia after Total Hip Arthroplasty is the femoral block. However, a new technique has recently been described: the Quadratus Lumborum Block.
The comparison of these two techniques is lacking in the literature. The comparison of the Quadratus Lumborum Block to the femoral block in Total Hip arthroplasty is important in the analgesic strategy of patients undergoing this surgery.
Detailed description
The aim of this study is to compare the clinical efficacy of two regional locoregional analgesia strategies in total hip replacement surgery: the ultrasound-guided Quadratus Lumborum Block and the ultrasound-guided femoral block.
This is a double-blind, randomized study in prospective inclusion with a superiority test. Two groups of patients will be compared: a group of patients with a quadratus lumborum block and a group of patients with a femoral block.
Management (quadratus lumborum block or femoral block) will be randomized. The randomization will be stratified on the type of anesthesia (spinal anesthesia and general anesthesia). Randomization will be done on the day of surgery to determine the patient's treatment group. The surgical procedure will not be modified by the participation of the patent in the study.
Patients who would benefit from total hip replacement surgery in the Reims University Hospital and who agreed to participate in the study were included.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Quadratus Lumborum Block arm | Experimental | Procedure: Quadratus Lumborum Block |
| Femoral block arm | Active comparator | Procedure: femoral block |
Who may qualify
- Ages
- 18 to 95 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients eligible for total hip replacement surgery in Reims University Hospital
- Patients agreeing to participate in the research and having signed informed consent
- between 18 yo and 95 yo
- Patients affiliated to a social security system
Key exclusion criteria (7 listed)
- Patients with allergy to local anesthetics
- Patients with neuropathy
- Patients with an ASA score of 4
- Patients undergoing revision surgery for total hip arthroplasty
- Patients receiving anterior hip total hip replacement surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Quadratus Lumborum BlockQuadratus Lumborum Block with echography | Procedure or surgery | Quadratus Lumborum Block arm |
| femoral blockfemoral block with echography | Procedure or surgery | Femoral block arm |
Primary outcome
morphine consumption
Time frame: 24 hours
Morphine consumption during the 24 hours postoperative
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 May 2024.
- Derived from this study: PubMed 41731391Aissaoui S, Riffault M, Baene A, Smati MF, Siboni R, Houet C, Legros V, Thierry A, Michelet D, Malinovsky JM, Coffinet J, Fernandes O. Quadratus lumborum block versus femoral nerve block in total hip arthroplasty: a randomized clinical trial. BMC Anesthesiol. 2026 Feb 24;26(1):203. doi: 10.1186/s12871-025-03586-x.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Quadratus Lumborum Block and femoral block in people with Total Hip Replacement Surgery, run by CHU de Reims at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 May 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
morphine consumption (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03666260, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 May 2024.