Blood PressureOHNCT03496792
The Venous Distension Reflex and Orthostatic Hypertension
A study testing Tilt + external pressure, Tilt + no external pressure. and Limb occlusion + negative pressure in people with Blood Pressure, run by Milton S. Hershey Medical Center at 1 site in United States.
Trial summary
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Blood Pressure
- What is being tested?
- Tilt + external pressure, Tilt + no external pressure. and Limb occlusion + negative pressure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 10 Mar 2020to 1 Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Are capable of giving informed consent
- Are of any race or ethnicity
- Are fluent in written and spoken English
- Whose history and physical exam did not uncover any exclusion criteria
- Are 18 years of age
- For subjects with elevated standing BP
Show all 12Show fewer
- Systolic BP (SBP) during standing is at least 10 mmHg > the supine SBP
- Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED
- For normal subjects without elevated standing BP
- The change in SBP by standing is within ± 5 mmHg from the supine SBP
- Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP
- Free of acute or chronic medical conditions
Who cannot join
- Age < 18 years of age
- Are a pregnant or nursing woman
- Are a prisoner or institutionalized individual or unable to consent
- Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
- Have orthostatic hypotension or a history of syncope
- Current smoker
- History of blood clots
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033
Kristen Gray, 7175314589, kgray1@pennstatehealth.psu.edu
Jian Cui, 717-531-1799, jcui@pennstatehealth.psu.edu
About this study
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
Read the detailed description
In humans, two-thirds of the blood volume is contained within the venous vasculature. Because of this, changes in peripheral blood volume and alterations in the mechanical properties of peripheral veins can greatly impact cardiac filling, cardiac output and blood pressure (BP) responses to physiologic stress. Work from our laboratory over the past seven years has shown that local upper limb venous distension via volume infusion into an occluded arm (i.e. volume infusion model) or applying negative pressure to an occluded leg (limb suction experimental model) leads to an acute and dramatic increase in Muscle Sympathetic Nerve Activity (MSNA; an index of sympathetic activity directed to skeletal muscle) and BP in humans. Since this venous distension reflex (VDR) differs physiologically from the other reflex systems, and since this system may play a critical role in orthostatic BP control, we believe that it is a significant area of study.
The investigators speculate that VDR from lower limbs contributes to the autonomic adjustment to orthostatic stress. To examine the VDR in lower limbs, an arterial occlusion cuff on the mid-thigh was inflated (250 mm mercury; Hg). Then, limb suction (-100 mmHg) was applied ~10-15 cm below the level of arterial occlusion (i.e. below the knee). MSNA was measured in the opposite control limb. When suction was applied below the level of arterial occlusion (i.e. occlusion + suction), both MSNA and mean arterial BP (MAP) increased. In control trials, arterial occlusion without limb suction (i.e. occlusion alone) did not increase MSNA. Plethysmographic data showed calf circumference increased without detectable arterial pulsations. Pilot data suggest that the fluid shifts from the occluded but non-depressurized zone of the limb (i.e. between the cuff and knee) into the occluded and depressurized region of the limb within the tank. Thus, the results suggest that the VDR was engaged with this limb suction experimental model.
These experimental models "selectively" alter peripheral venous volume as the investigators measure sympathetic reflex responses. This approach is innovative and allows examination of a previously overlooked autonomic reflex in conscious humans. If these studies confirm the hypotheses, the obtained data would challenge the present teaching regarding how the sympathetic nervous system is engaged in humans during postural stress.
In ~2.5-10% of the population, BP rises as the person stands. This has been termed orthostatic hypertension, and is different from the "normal" sustained BP response when a person stands. The incidence of orthostatic hypertension may increase with aging (~2.4% for 45-64 years old and ~8.7% for >70 years old). Orthostatic hypertension is a risk factor for the development of stroke, left ventricular hypertrophy, and chronic kidney disease. It is unclear why BP rises with standing in some individuals. Some investigators have speculated that orthostatic hypertension is due to exaggerated baroreceptor withdrawal with standing. Others have speculated that this response is due to an increase in sympathetic output. It has been noted that some patients with orthostatic hypertension have increased venous pooling in their lower legs. Based these data, the investigators postulate that heightened engagement of the VDR reflexly increases MSNA and also serves to reset the aortic baroreflex. In this protocol, the investigators will determine if the MSNA response to leg suction is heightened in the individuals with elevated standing BP, and examine if the baroreflex is altered in these individuals. The investigators will also examine if external pressure on lower limbs, which limits the venous pooling in the lower limbs, will attenuate the increase in BP during standing in those individuals.
- Conditions
- Blood Pressure
- Being tested
- Tilt + external pressure, Tilt + no external pressure., Limb occlusion + negative pressure, Limb occlusion + no negative pressure
- Keywords
- venous distension reflex
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tilt + external pressureOther
In Visit 1, the anti-shock trousers will be inflated to 20, 40, or 60 mmHg. BP will be measured 3 times from the brachial artery. Then the table will be tilted head up to a maximum of 70o for up to 10 min, while BP will be measured from the brachial artery at 1 min intervals. The tilt table is returned to 0o and the resting supine baseline BP will be collected. Then, the anti-shock trousers will be inflated to a different pressure (20, 40, or 60 mmHg) and the head up tilt will be repeated. Repetitions at the various pressures will be performed in a random order with suitable resting intervals in between the tilting bouts.
Tilt + no external pressure.Other
In Visit 1, the anti-shock trousers will NOT be inflated. Auscultatory BP will be measured 3 times from the brachial artery. Thereafter, the table will be tilted head up to a maximum of 70o for up to 10 min, while BP will be measured from the brachial artery at 1 min intervals.
Limb occlusion + negative pressureOther
In Visit 2, a cuff will be placed on the thigh of a leg that is sealed in an airtight pressure tank. After the cuff is inflated to 250 mmHg, the pressure in the tank will be reduced to -100mmHg for 2 minutes. The application of negative pressure creates a suction effect on the leg, and leads to an overall increase in pressure gradient across the blood vessel wall and induces vascular distension.
Limb occlusion + no negative pressureOther
In Visit 2, a cuff will be placed on the thigh of a leg that is sealed in an airtight pressure tank. The cuff is inflated to 250 mmHg for 2 minutes, but the pressure in the tank is not changed.
| Study group | Role | What they receive |
|---|---|---|
| Tilt + external pressure | Experimental | Tilt + external pressure on legs performed in both "BP elevated with standing" and "BP maintained with standing" groups. Receives: Other: Tilt + external pressure |
| Tilt + no external pressure | Placebo comparator | Tilt + no external pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups. Receives: Other: Tilt + no external pressure. |
| Limb occlusion + negative pressure | Experimental | Limb occlusion + negative pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups. Receives: Other: Limb occlusion + negative pressure |
| Limb occlusion + no negative pressure | Placebo comparator | Limb occlusion + no negative pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups. Receives: Other: Limb occlusion + no negative pressure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Sympathetic Nerve Activity (MSNA) in bursts/min or arbitrary units/min
MSNA provides direct recordings of sympathetic nerve activity directed to blood vessels in skeletal muscle.
Measured: Recorded continuously during Visit 2, the 4-5 hr Negative Pressure study visit.
Secondary outcomes (2)
Blood pressure in mmHg
Cuffs placed on a finger and arm will monitor blood pressure.
Measured: Recorded continuously during the 4-5 hr visit.
Heart rate in beats per minute
Electrocardiogram (ECG) patches attached to a Cardiocap will monitor heart rate.
Measured: Recorded continuously during the 4-5 hr visit.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Apr 2018
- Study start10 Mar 2020
- Primary completion1 Nov 2026 (estimated)
- Study completion1 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Blood PressureStudies of the same condition, open and under way.
- More trials run by Milton S. Hershey Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- The investigators will examine if individuals with elevated standing blood pressure have a heightened VDR. Two groups of subjects, "BP elevated with standing" group and "BP maintained with standing" group will be examined for this experiment. The tilt + external pressure and tilt + no external pressure, or the limb occlusion + negative pressure and limb occlusion + no negative pressure trials will be performed in random order using a Latin Square design. Because the nature of the interventions, neither the subjects nor the investigators can be blinded to the interventions
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Milton S. Hershey Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jian Cui, Milton S. Hershey Medical Center
- Investigators
- Jian Cui, Principal investigator, Penn State College of Medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03496792
- Sponsor's protocol ID
- STUDY00007397
- Acronym
- OH
- Status last verified
- Jul 2026
- First submitted
- 15 Feb 2018
- Last updated
- 9 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Cui J, Blaha C, Herr MD, Drew RC, Muller MD, Sinoway LI. Limb suction evoked during arterial occlusion causes systemic sympathetic activity in humans. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R482-8. doi: 10.1152/ajpregu.00117.2015. Epub 2015 Jul 1.
PubMed 26136530Cui J, Gao Z, Blaha C, Herr MD, Mast J, Sinoway LI. Distension of central great vein decreases sympathetic outflow in humans. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H378-85. doi: 10.1152/ajpheart.00019.2013. Epub 2013 May 31.
PubMed 23729210Cui J, Leuenberger UA, Gao Z, Sinoway LI. Sympathetic and cardiovascular responses to venous distension in an occluded limb. Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1831-7. doi: 10.1152/ajpregu.00170.2011. Epub 2011 Sep 21.
PubMed 21940404Cui J, McQuillan PM, Blaha C, Kunselman AR, Sinoway LI. Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans. Am J Physiol Heart Circ Physiol. 2012 Aug 15;303(4):H457-63. doi: 10.1152/ajpheart.00236.2012. Epub 2012 Jun 15.
PubMed 22707559Cui J, McQuillan P, Moradkhan R, Pagana C, Sinoway LI. Sympathetic responses during saline infusion into the veins of an occluded limb. J Physiol. 2009 Jul 15;587(Pt 14):3619-28. doi: 10.1113/jphysiol.2009.173237. Epub 2009 May 26.
PubMed 19470776Kario K. Orthostatic hypertension-a new haemodynamic cardiovascular risk factor. Nat Rev Nephrol. 2013 Dec;9(12):726-38. doi: 10.1038/nrneph.2013.224. Epub 2013 Nov 5.
PubMed 24189649
Study at a glance
From the registry record, last updated by the sponsor on 9 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Venous Distension Reflex and Orthostatic Hypertension
- ClinicalTrials.gov ID
- NCT03496792
- Acronym / sponsor ID
- OH / STUDY00007397
- Conditions
- Blood Pressure
- Keywords
- venous distension reflex
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Milton S. Hershey Medical CenterUniversity, hospital or other
- Study start
- 10 Mar 2020 (actual)
- Primary completion
- 1 Nov 2026 (estimated)
- Study completion
- 1 Nov 2027 (estimated)
- First posted
- 12 Apr 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
Detailed description
In humans, two-thirds of the blood volume is contained within the venous vasculature. Because of this, changes in peripheral blood volume and alterations in the mechanical properties of peripheral veins can greatly impact cardiac filling, cardiac output and blood pressure (BP) responses to physiologic stress. Work from our laboratory over the past seven years has shown that local upper limb venous distension via volume infusion into an occluded arm (i.e. volume infusion model) or applying negative pressure to an occluded leg (limb suction experimental model) leads to an acute and dramatic increase in Muscle Sympathetic Nerve Activity (MSNA; an index of sympathetic activity directed to skeletal muscle) and BP in humans. Since this venous distension reflex (VDR) differs physiologically from the other reflex systems, and since this system may play a critical role in orthostatic BP control, we believe that it is a significant area of study.
The investigators speculate that VDR from lower limbs contributes to the autonomic adjustment to orthostatic stress. To examine the VDR in lower limbs, an arterial occlusion cuff on the mid-thigh was inflated (250 mm mercury; Hg). Then, limb suction (-100 mmHg) was applied ~10-15 cm below the level of arterial occlusion (i.e. below the knee). MSNA was measured in the opposite control limb. When suction was applied below the level of arterial occlusion (i.e. occlusion + suction), both MSNA and mean arterial BP (MAP) increased. In control trials, arterial occlusion without limb suction (i.e. occlusion alone) did not increase MSNA. Plethysmographic data showed calf circumference increased without detectable arterial pulsations. Pilot data suggest that the fluid shifts from the occluded but non-depressurized zone of the limb (i.e. between the cuff and knee) into the occluded and depressurized region of the limb within the tank. Thus, the results suggest that the VDR was engaged with this limb suction experimental model.
These experimental models "selectively" alter peripheral venous volume as the investigators measure sympathetic reflex responses. This approach is innovative and allows examination of a previously overlooked autonomic reflex in conscious humans. If these studies confirm the hypotheses, the obtained data would challenge the present teaching regarding how the sympathetic nervous system is engaged in humans during postural stress.
In ~2.5-10% of the population, BP rises as the person stands. This has been termed orthostatic hypertension, and is different from the "normal" sustained BP response when a person stands. The incidence of orthostatic hypertension may increase with aging (~2.4% for 45-64 years old and ~8.7% for >70 years old). Orthostatic hypertension is a risk factor for the development of stroke, left ventricular hypertrophy, and chronic kidney disease. It is unclear why BP rises with standing in some individuals. Some investigators have speculated that orthostatic hypertension is due to exaggerated baroreceptor withdrawal with standing. Others have speculated that this response is due to an increase in sympathetic output. It has been noted that some patients with orthostatic hypertension have increased venous pooling in their lower legs. Based these data, the investigators postulate that heightened engagement of the VDR reflexly increases MSNA and also serves to reset the aortic baroreflex. In this protocol, the investigators will determine if the MSNA response to leg suction is heightened in the individuals with elevated standing BP, and examine if the baroreflex is altered in these individuals. The investigators will also examine if external pressure on lower limbs, which limits the venous pooling in the lower limbs, will attenuate the increase in BP during standing in those individuals.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 4
- Model description
- The investigators will examine if individuals with elevated standing blood pressure have a heightened VDR. Two groups of subjects, "BP elevated with standing" group and "BP maintained with standing" group will be examined for this experiment. The tilt + external pressure and tilt + no external pressure, or the limb occlusion + negative pressure and limb occlusion + no negative pressure trials will be performed in random order using a Latin Square design. Because the nature of the interventions, neither the subjects nor the investigators can be blinded to the interventions
| Arm | Type | Receives |
|---|---|---|
| Tilt + external pressure | Experimental | Other: Tilt + external pressureTilt + external pressure on legs performed in both "BP elevated with standing" and "BP maintained with standing" groups. |
| Tilt + no external pressure | Placebo comparator | Other: Tilt + no external pressure.Tilt + no external pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups. |
| Limb occlusion + negative pressure | Experimental | Other: Limb occlusion + negative pressureLimb occlusion + negative pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups. |
| Limb occlusion + no negative pressure | Placebo comparator | Other: Limb occlusion + no negative pressureLimb occlusion + no negative pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (12 listed)
- Are capable of giving informed consent
- Are of any race or ethnicity
- Are fluent in written and spoken English
- Whose history and physical exam did not uncover any exclusion criteria
- Are 18 years of age
Key exclusion criteria (7 listed)
- Age < 18 years of age
- Are a pregnant or nursing woman
- Are a prisoner or institutionalized individual or unable to consent
- Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
- Have orthostatic hypotension or a history of syncope
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tilt + external pressureIn Visit 1, the anti-shock trousers will be inflated to 20, 40, or 60 mmHg. BP will be measured 3 times from the brachial artery. Then the table will be tilted head up to a maximum of 70o for up to 10 min, while BP will be measured from the brachial artery at 1 min intervals. The tilt table is returned to 0o and the resting supine baseline BP will be collected. Then, the anti-shock trousers will be inflated to a different pressure (20, 40, or 60 mmHg) and the head up tilt will be repeated. Repetitions at the various pressures will be performed in a random order with suitable resting intervals in between the tilting bouts. | Other | Tilt + external pressure |
| Tilt + no external pressure.In Visit 1, the anti-shock trousers will NOT be inflated. Auscultatory BP will be measured 3 times from the brachial artery. Thereafter, the table will be tilted head up to a maximum of 70o for up to 10 min, while BP will be measured from the brachial artery at 1 min intervals. | Other | Tilt + no external pressure |
| Limb occlusion + negative pressureIn Visit 2, a cuff will be placed on the thigh of a leg that is sealed in an airtight pressure tank. After the cuff is inflated to 250 mmHg, the pressure in the tank will be reduced to -100mmHg for 2 minutes. The application of negative pressure creates a suction effect on the leg, and leads to an overall increase in pressure gradient across the blood vessel wall and induces vascular distension. | Other | Limb occlusion + negative pressure |
| Limb occlusion + no negative pressureIn Visit 2, a cuff will be placed on the thigh of a leg that is sealed in an airtight pressure tank. The cuff is inflated to 250 mmHg for 2 minutes, but the pressure in the tank is not changed. | Other | Limb occlusion + no negative pressure |
Primary outcome
Muscle Sympathetic Nerve Activity (MSNA) in bursts/min or arbitrary units/min
Time frame: Recorded continuously during Visit 2, the 4-5 hr Negative Pressure study visit.
MSNA provides direct recordings of sympathetic nerve activity directed to blood vessels in skeletal muscle.
2 secondary outcomes
Blood pressure in mmHg
Time frame: Recorded continuously during the 4-5 hr visit.
Heart rate in beats per minute
Time frame: Recorded continuously during the 4-5 hr visit.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jul 2026.
- Background: PubMed 26136530Cui J, Blaha C, Herr MD, Drew RC, Muller MD, Sinoway LI. Limb suction evoked during arterial occlusion causes systemic sympathetic activity in humans. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R482-8. doi: 10.1152/ajpregu.00117.2015. Epub 2015 Jul 1.
- Background: PubMed 23729210Cui J, Gao Z, Blaha C, Herr MD, Mast J, Sinoway LI. Distension of central great vein decreases sympathetic outflow in humans. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H378-85. doi: 10.1152/ajpheart.00019.2013. Epub 2013 May 31.
- Background: PubMed 21940404Cui J, Leuenberger UA, Gao Z, Sinoway LI. Sympathetic and cardiovascular responses to venous distension in an occluded limb. Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1831-7. doi: 10.1152/ajpregu.00170.2011. Epub 2011 Sep 21.
- Background: PubMed 22707559Cui J, McQuillan PM, Blaha C, Kunselman AR, Sinoway LI. Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans. Am J Physiol Heart Circ Physiol. 2012 Aug 15;303(4):H457-63. doi: 10.1152/ajpheart.00236.2012. Epub 2012 Jun 15.
- Background: PubMed 19470776Cui J, McQuillan P, Moradkhan R, Pagana C, Sinoway LI. Sympathetic responses during saline infusion into the veins of an occluded limb. J Physiol. 2009 Jul 15;587(Pt 14):3619-28. doi: 10.1113/jphysiol.2009.173237. Epub 2009 May 26.
- Background: PubMed 24189649Kario K. Orthostatic hypertension-a new haemodynamic cardiovascular risk factor. Nat Rev Nephrol. 2013 Dec;9(12):726-38. doi: 10.1038/nrneph.2013.224. Epub 2013 Nov 5.
Related trials for Blood Pressure
Active, not recruiting
Digital Reinforcement of Motivational Interviewing Micro-Skills Among Primary Care Healthcare Professionals
Hypertension (Without Type 2 Diabetes Mellitus)
RecruitingPhase 3
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
Chronic Kidney Disease and Hypertension
Recruiting
Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot Trial
End Stage Kidney Disease (ESKD), Hypertension (HTN)
RecruitingPhase 4
Hematological Safety of Dipyrone Versus Paracetamol After Dental Extractions
Hematologic Test, Agranulocytosis
Not yet recruiting
Acute Effects of Mat Pilates on Blood Pressure Response to Mental Stress in Higher Education Teachers
Behavior
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jian Cui principal investigator
Penn State College of Medicine
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tilt + external pressure, Tilt + no external pressure. and Limb occlusion + negative pressure in people with Blood Pressure, run by Milton S. Hershey Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jian Cui, PhD (717-531-1799, jcui@pennstatehealth.psu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Sympathetic Nerve Activity (MSNA) in bursts/min or arbitrary units/min (time frame: Recorded continuously during Visit 2, the 4-5 hr Negative Pressure study visit.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03496792, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2026.