Research institution
Milton S. Hershey Medical Center Clinical Trials
Studies where Milton S. Hershey Medical Center is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 59Diabetes Mellitus, Type 1
Closed Loop and Education for Hypoglycemia Awareness Restoration
The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1…
- Trial name
- CLEAR (NCT06325202)
- Testing
- Omnipod 5 or Medtronic 780G, My HypoCOMPaSS Education, HARPdoc Education
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 324 people
- Sponsor
- Milton S. Hershey Medical Center
Sleep, Autism Spectrum Disorder
Transdiagnostic Sleep and Circadian Treatment for Autistic Adolescents
Sleep and circadian problems are associated with deleterious social, emotional, and cognitive outcomes, yet are modifiable. This prospective study will adapt and optimize an empirically supported behavioral intervention that…
- Conditions
- Sleep, Autism Spectrum Disorder, Transdiagnostic
- Trial name
- NCT07612111
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Dependence
Use of Nicotine Pouches Among Daily Smokers
The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1.
- Trial name
- NCT06043362
- Testing
- 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Advance Care Planning, American Indian or Alaska Native
Using a Conversation Game to Engage Native American Washoe Tribe Members in Advance Care Planning: Preparation for a Clinical Trial
The goal of this study is to learn if a culturally adapted version of the Hello game, an advance care planning (ACP) conversation tool, is feasible and acceptable for use with members of the Washoe Tribe.
- Conditions
- Advance Care Planning, American Indian or Alaska Native, Gamification
- Trial name
- NCT07439393
- Testing
- Aim 1: Talking Circles, Aim 2: Play Modified Hello Game
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Anorexia Nervosa
Adapting Exposure for Adolescent AN
This pilot study is evaluating Exposure Therapy (Exp-AN) as a virtual treatment for adolescents (ages 14 - 17 years) with anorexia nervosa (AN) recruited from eating disorder clinic waitlists and clinician referrals at the Penn…
- Trial name
- NCT07188155
- Testing
- Exposure Therapy for Anorexia (Exp-AN)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Milton S. Hershey Medical Center
Depression, Anxiety
Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to…
- Conditions
- Depression, Anxiety, Stress
- Trial name
- NCT07240792
- Testing
- Student Delivered Cognitive Behavioral Therapy Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Meningitis, Bacteremia
THiamine for Recovery In Vulnerable Early-life Infections
To determine if the addition of thiamine to standard-of-care treatment will improve neurodevelopmental outcomes for infants with meningitis or bacteremia
- Trial name
- THRIVE (NCT07868679)
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Milton S. Hershey Medical Center
Endometriosis
The Impact of Yoga on Endometriosis-Related Pain
The central hypothesis of the investigators is that the practice of yoga will result in an improvement of endometriosis related pain symptoms for women with endometriosis.
- Trial name
- NCT06559852
- Testing
- Yoga
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Osteosarcoma, Ewing Sarcoma
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
Ewing sarcoma (EWS) and osteosarcoma primarily affect adolescents and young adults. Common treatments include chemotherapy, surgery and radiation, however, there have been few recent advancements in the standard of care.
- Trial name
- NCT07321912
- Testing
- Eflornithine, Topotecan, Cyclophosphamide
- Where
- 3 sites in United States
- Volunteers
- 406 people
- Sponsor
- Milton S. Hershey Medical Center
Neuroblastoma, Ewing Sarcoma
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors.
- Conditions
- Neuroblastoma, Ewing Sarcoma, Osteosarcoma, Rhabdomyosarcoma
- Trial name
- NCT06541262
- Testing
- Silmitasertib, Irinotecan, Temozolomide
- Where
- 24 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- Milton S. Hershey Medical Center
Completed, with results posted
All 112Polycystic Ovary Syndrome, Anovulation
Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance
- Trial name
- INSUPP-PCOS (NCT03864068)
- Testing
- Inositol
- Where
- 2 sites in United States
- Volunteers
- 154 people
- Sponsor
- Milton S. Hershey Medical Center
Prostate Cancer
Rectal Spacer for Prostate Cancer Radiation Image Guidance
The purpose of the study is to determine if a radiopaque hydrogel rectal spacer, SpaceOAR Vue®, can be used in place of fiducial markers when aligning patients for radiotherapy.
- Trial name
- NCT05650021
- Testing
- SpaceOAR Vue
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Milton S. Hershey Medical Center
Post-operative Nausea and Vomiting
Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion
The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.
- Trial name
- PONV (NCT05759481)
- Testing
- Hybrid anesthesia (propofol + sevoflurane), Propofol only TIVA
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Dependence
Testing the Effect of ENDS Flavors on Neurotransmission
The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.
- Trial name
- TEN (NCT05836051)
- Testing
- Flavor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Milton S. Hershey Medical Center
Endometriosis, Pelvic Pain
Use of TENS Unit in the Management of Endometriosis Pain
The purpose of this study is see if Transcutaneous Electrical Nerve Stimulator (TENS) units help decrease endometriosis flare pain.
- Trial name
- NCT05348005
- Testing
- Ovira Transcutaneous Electrical Nerve Stimulation Unit
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center