StrokePPCstimNCT03323255
rTMS Posterior Parietal Cortex Modulation and Upper Limb Movement After Stroke
A study testing repeated transcranial magnetic stimulation continuous theta-burst stimulation in people with Stroke and Hemiparesis, run by University Hospital, Lille at 1 site in France.
Trial summary
This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Stroke, Hemiparesis, Transcranial Magnetic Stimulation
- What is being tested?
- repeated transcranial magnetic stimulation continuous theta-burst stimulation
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 1 participants
- Where
- 1 siteFrance
- Study dates
- 10 Mar 2020to 1 Aug 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18 and 80y
- Right-handed
- Right hemispheric stroke confirmed by a 3D imaging technique
- at the chronic phase (>6months)
- subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk
- informed consent
- Social security affiliation
Who cannot join
- Severe comprehension troubles (language, cognitive or psychiatric disorders)
- History of neurological disorders in addition to the stroke
- Locomotor troubles affecting the paretic arm
- Contraindication to rTMS : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness
- pregnancy or breastfeeding
- adult subject to guardianship
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Influence of the Modulation of the Posterior Parietal Cortex (rTMS) on a Pointing Movement With the Paretic Upper Limb After Stroke
This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity.
To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.
- Being tested
- repeated transcranial magnetic stimulation continuous theta-burst stimulation, SHAM repeated transcranial magnetic stimulation
- Medical subject headings
- Stroke, Paresis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
repeated transcranial magnetic stimulation continuous theta-burst stimulationDevice
cTBS
SHAM repeated transcranial magnetic stimulationDevice
SHAM stimulation
| Study group | Role | What they receive |
|---|---|---|
| cTBS stimulation | Active comparator | continuous theta-burst TMS stimulation (1200 pulses, 50Hz, separated in two sequences of 600 pulses) Receives: Device: repeated transcranial magnetic stimulation continuous theta-burst stimulation |
| SHAM stimulation (placebo) | Sham comparator | SHAM stimulation Receives: Device: SHAM repeated transcranial magnetic stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time of movement during the pointing movement
Time between the initiation of the movement and the reaching of the target
Measured: 30 minutes
Secondary outcomes (9)
Reaction time (time between the go signal and th onset of the movement)
temporal parameters of pointing movements
Measured: 30 minutes
Response time (time between the go signal and the reaching of the target)
temporal parameters of pointing movements
Measured: 30 minutes
Peak velocity of the hand during the pointing movement
pak velocity in m/s
Measured: 30 minutes
smoothness (number of units of movement during the pointing movement),
Spatial parameters of pointing movements
Measured: 30 minutes
Linearity (ration between the length of the trajectory of the hand and the linear distance between the initial position of the hand and the target)
Spatial parameters of pointing movements
Measured: 30 minutes
Detection of mirror movements with the healthy upper limb
EMG detection
Measured: 30 minutes
Primary motor cortex excitability of both motor cortices
Resting motor threshold of lesioned and non-lesioned hemispheres
Measured: 30 minutes
Parietomotor connectivity in the contralesional hemisphere
Assessed by a paired-pulse TMS protocol (see Allart et al. 2017 for more details)
Measured: 30 minutes
Spatial bias
Line bisection test
Measured: 30 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2017
- Study start10 Mar 2020
- Primary completion1 Aug 2021
- Study completion1 Aug 2021
Why it stopped: COVID
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 1 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Lille
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Etienne Allart, MD, Principal investigator, University Hospital, Lille
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03323255
- Sponsor's protocol ID
- 2016_36
- Other IDs
- 2016-A01608-43
- Acronym
- PPCstim
- Status last verified
- May 2026
- First submitted
- 16 Oct 2017
- Last updated
- 15 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of the Modulation of the Posterior Parietal Cortex (rTMS) on a Pointing Movement With the Paretic Upper Limb After Stroke
- ClinicalTrials.gov ID
- NCT03323255
- Acronym / sponsor ID
- PPCstim / 2016_36
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: COVID
- Enrolment
- 1 participants (actual)
- Lead sponsor
- University Hospital, LilleUniversity, hospital or other
- Study start
- 10 Mar 2020 (actual)
- Primary completion
- 1 Aug 2021 (actual)
- Study completion
- 1 Aug 2021 (actual)
- First posted
- 26 Oct 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity.
To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| cTBS stimulation | Active comparator | Device: repeated transcranial magnetic stimulation continuous theta-burst stimulationcontinuous theta-burst TMS stimulation (1200 pulses, 50Hz, separated in two sequences of 600 pulses) |
| SHAM stimulation (placebo) | Sham comparator | Device: SHAM repeated transcranial magnetic stimulationSHAM stimulation |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Age between 18 and 80y
- Right-handed
- Right hemispheric stroke confirmed by a 3D imaging technique
- at the chronic phase (>6months)
- subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk
Key exclusion criteria (6 listed)
- Severe comprehension troubles (language, cognitive or psychiatric disorders)
- History of neurological disorders in addition to the stroke
- Locomotor troubles affecting the paretic arm
- Contraindication to rTMS : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness
- pregnancy or breastfeeding
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| repeated transcranial magnetic stimulation continuous theta-burst stimulationcTBS | Device | cTBS stimulation |
| SHAM repeated transcranial magnetic stimulationSHAM stimulation | Device | SHAM stimulation (placebo) |
Primary outcome
Time of movement during the pointing movement
Time frame: 30 minutes
Time between the initiation of the movement and the reaching of the target
9 secondary outcomes
Reaction time (time between the go signal and th onset of the movement)
Time frame: 30 minutes
Response time (time between the go signal and the reaching of the target)
Time frame: 30 minutes
Peak velocity of the hand during the pointing movement
Time frame: 30 minutes
smoothness (number of units of movement during the pointing movement),
Time frame: 30 minutes
Linearity (ration between the length of the trajectory of the hand and the linear distance between the initial position of the hand and the target)
Time frame: 30 minutes
Detection of mirror movements with the healthy upper limb
Time frame: 30 minutes
Primary motor cortex excitability of both motor cortices
Time frame: 30 minutes
Parietomotor connectivity in the contralesional hemisphere
Time frame: 30 minutes
Spatial bias
Time frame: 30 minutes
Results and safety
The study was stopped early (reason given: COVID). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Etienne Allart, MD principal investigator
University Hospital, Lille
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing repeated transcranial magnetic stimulation continuous theta-burst stimulation in people with Stroke and Hemiparesis, run by University Hospital, Lille at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 15 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: COVID). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time of movement during the pointing movement (time frame: 30 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 May 2026.