Cardiac ArrestNCT03230461
Estimation of CPR Chest Compression Depth
A study testing Compression depth in people with Cardiac Arrest, run by University Hospital Southampton NHS Foundation Trust at 1 site in United Kingdom.
Trial summary
Optimal chest compression depth during CPR is 4.56cm which is at variance with the current guidelines of 5.0-6.0cm. A change in guidelines is only worthwhile if healthcare professionals can accurately judge a subtle reduction in chest compression depth during CPR by a relatively small amount. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cardiac Arrest
- What is being tested?
- Compression depth
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- Oct 2016to 7 Aug 2017
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- NHS professionals (staff or students), who have successfully completed a hospital-accredited basic life support (BLS) course, including a practical CPR component.
Who cannot join
- Pregnancy, significant medical illness or injury that would impair delivery of chest compressions
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
University Hospital Southampton
Southampton, Hampshire, SO16 6YD
About this study
Official title: Can Rescuers Accurately Deliver Subtle Changes to Chest Compression Depth if Recommended by Future Guidelines?
Optimal chest compression depth during CPR is 4.56cm which is at variance with the current guidelines of 5.0-6.0cm. A change in guidelines is only worthwhile if healthcare professionals can accurately judge a subtle reduction in chest compression depth during CPR by a relatively small amount.
Read the detailed description
Chest compression depth and rate during cardiopulmonary resuscitation (CPR) are important predictors of return of spontaneous circulation and survival following cardiac arrest. Stiell et al (2014) found optimal survival at a compression depth of 4.56cm, which is at variance with the current guidelines of 5.0-6.0cm. A change in guidelines is only likely to improve survival rates if healthcare professionals can accurately implement these subtle depth modifications into the basic life support (BLS) algorithm. This study aims to determine if healthcare professionals can accurately judge compression depth without real-time feedback.
- Conditions
- Cardiac Arrest
- Being tested
- Compression depth
- Keywords
- CPR, Basic life support
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Compression depthBehavioural
| Study group | Role | What they receive |
|---|---|---|
| Target compression depth 4.0-5.0 cm | Experimental | The rescuer is asked to perform two minutes of chest compressions on a manikin, aiming to compress to the target depth at a rate of 100-120/min Receives: Behavioral: Compression depth |
| Target compression depth 4.5-5.5 cm | Experimental | The rescuer is asked to perform two minutes of chest compressions on a manikin, aiming to compress to the target depth at a rate of 100-120/min Receives: Behavioral: Compression depth |
| Target compression depth 5.0-6.0 cm | Experimental | The rescuer is asked to perform two minutes of chest compressions on a manikin, aiming to compress to the target depth at a rate of 100-120/min Receives: Behavioral: Compression depth |
What is being measured
The primary outcome is the main question the study is designed to answer.
Compression to target window depth
Mean compression depth
Measured: Two minutes
Secondary outcomes (1)
Compression to target rate
Mean compression rate
Measured: Two minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jul 2017
- Study startOct 2016
- Primary completion7 Aug 2017
- Study completion7 Aug 2017
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Model description
- Prospective, randomised.
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital Southampton NHS Foundation Trust
- Sponsor type
- University, hospital or other
- Collaborators
- University of Southampton
- Responsible party
- Sponsor
- Investigators
- Charles Deakin, MD, Principal investigator, University Hospital Southampton NHS Foundation Trust
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03230461
- Sponsor's protocol ID
- 19575
- Status last verified
- Aug 2017
- First submitted
- 21 Jul 2017
- Last updated
- 9 Aug 2017
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Available on request
Study at a glance
From the registry record, last updated by the sponsor on 9 Aug 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Can Rescuers Accurately Deliver Subtle Changes to Chest Compression Depth if Recommended by Future Guidelines?
- ClinicalTrials.gov ID
- NCT03230461
- Acronym / sponsor ID
- 19575
- Conditions
- Cardiac Arrest
- Keywords
- CPR, Basic life support
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- University Hospital Southampton NHS Foundation TrustUniversity, hospital or other
- Collaborators
- University of Southampton
- Study start
- Oct 2016 (actual)
- Primary completion
- 7 Aug 2017 (actual)
- Study completion
- 7 Aug 2017 (actual)
- First posted
- 26 Jul 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Optimal chest compression depth during CPR is 4.56cm which is at variance with the current guidelines of 5.0-6.0cm. A change in guidelines is only worthwhile if healthcare professionals can accurately judge a subtle reduction in chest compression depth during CPR by a relatively small amount.
Detailed description
Chest compression depth and rate during cardiopulmonary resuscitation (CPR) are important predictors of return of spontaneous circulation and survival following cardiac arrest. Stiell et al (2014) found optimal survival at a compression depth of 4.56cm, which is at variance with the current guidelines of 5.0-6.0cm. A change in guidelines is only likely to improve survival rates if healthcare professionals can accurately implement these subtle depth modifications into the basic life support (BLS) algorithm. This study aims to determine if healthcare professionals can accurately judge compression depth without real-time feedback.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
- Model description
- Prospective, randomised.
| Arm | Type | Receives |
|---|---|---|
| Target compression depth 4.0-5.0 cm | Experimental | Behavioral: Compression depthThe rescuer is asked to perform two minutes of chest compressions on a manikin, aiming to compress to the target depth at a rate of 100-120/min |
| Target compression depth 4.5-5.5 cm | Experimental | Behavioral: Compression depthThe rescuer is asked to perform two minutes of chest compressions on a manikin, aiming to compress to the target depth at a rate of 100-120/min |
| Target compression depth 5.0-6.0 cm | Experimental | Behavioral: Compression depthThe rescuer is asked to perform two minutes of chest compressions on a manikin, aiming to compress to the target depth at a rate of 100-120/min |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- NHS professionals (staff or students), who have successfully completed a hospital-accredited basic life support (BLS) course, including a practical CPR component.
Key exclusion criteria (1 listed)
- Pregnancy, significant medical illness or injury that would impair delivery of chest compressions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Compression depth | Behavioural | Target compression depth 4.0-5.0 cm, Target compression depth 4.5-5.5 cm, Target compression depth 5.0-6.0 cm |
Primary outcome
Compression to target window depth
Time frame: Two minutes
Mean compression depth
1 secondary outcome
Compression to target rate
Time frame: Two minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Aug 2017.
- Individual participant dataSharing planned: Undecided. Available on request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Charles Deakin, MD principal investigator
University Hospital Southampton NHS Foundation Trust
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Compression depth in people with Cardiac Arrest, run by University Hospital Southampton NHS Foundation Trust at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Aug 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Compression to target window depth (time frame: Two minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Aug 2017.