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AzTrials

Vascular DiseasesOPTIMEVNCT00670540

Epidemiology of Thromboembolism Disease: A Cohort Study

An observational study of Vascular Diseases and Embolism and Thrombosis, run by University Hospital, Grenoble at 231 sites in 3 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The purpose of this study is to determine different risk factors of thromboembolic disease. Different points will be studied 1. do different types of thromboembolic disease (distal Deep Vein Thrombosis (DVT), proximal DVT, Pulmonary Embolism (PE) and DVT, PE without DVT) have the same clinical significance (risk… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosis
How many people
8,256 participants
Where
231 sitesin 3 countries
Study dates
Nov 2004to Feb 2010
Phase
Observational

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: All male or female inpatients and outpatients hospital and office-based. 18 years old with clinical suspicion of deep vein thrombosis (DVT) or pulmonary embolism (PE). Patients with cognitive disorders or language impairment preventing collection of risk factor data by history-taking were excluded.

Who may be able to join

  • patient aged more than 18
  • male or female
  • patients with clinical thromboembolic signs (deep vein thrombosis or pulmonary embolism)

Who cannot join

  • patient less than 18 years old
  • patient unable to understand
  • patient who refused to participate

Trial locations and contacts

231 sites in 3 countries.

231 sites in 3 countries

France229 sites

  • General Hospital

    Abbeville

  • Office-based Specialist in vascular medecine

    Albertville, 73200

  • Office-based Specialist in vascular medecine

    Albi, 81000

  • Office-based Specialist in vascular medecine

    Alençon, 61000

  • Office-based Specialist in vascular medecine

    Alès, 30100

  • Office-based Specialist in vascular medecine

    Ambares, 33440

  • Office-based Specialist in vascular medecine

    Amberieu En Buget, 01500

  • Office-based Specialist in vascular medecine

    Amiens, 80000

  • University Hospital

    Amiens

  • Office-based Specialist in vascular medecine

    Ancenis, 44150

  • Office-based Specialist in vascular medecine

    Angers, 49000

  • University Hospital

    Angers

  • Office-based Specialist in vascular medecine

    Annecy, 74000

  • Hospital

    Annecy

  • Hospital

    Armentières

  • Office-based Specialist in vascular medecine

    Arnouville, 95400

  • Office-based Specialist in vascular medecine

    Arpajon, 91290

  • Office-based Specialist in vascular medecine

    Arras, 62000

  • Office-based Specialist in vascular medecine

    Aubenas, 07200

  • Hospital

    Auch

  • Office-based Specialist in vascular medecine

    Auxerre, 89000

  • Office-based Specialist in vascular medecine

    Bagnoles-de-l'orme, 61140

  • Office-based Specialist in vascular medecine

    Beauvais, 60000

  • University Hospital

    Belfort

  • Office-based Specialist in vascular medecine

    Bergerac, 24100

  • Office-based Specialist in vascular medecine

    Besançon, 25000

  • Office-based Specialist in vascular medecine

    Béziers, 35500

  • Office-based Specialist in vascular medecine

    Blagnac, 31700

  • Office-based Specialist in vascular medecine

    Bordeaux, 33000

  • Hospital St ANDRE

    Bordeaux

  • Office-based Specialist in vascular medecine

    Boulogne-sur-Mer, 62200

  • Office-based Specialist in vascular medecine

    Bourg-en-Bresse, 01000

  • Office-based Specialist in vascular medecine

    Bourgoin, 38300

  • Office-based Specialist in vascular medecine

    Brest, 29200

  • University Hospital La Cavale Blanche

    Brest

  • Office-based Specialist in vascular medecine

    Bretenoux, 46130

  • Office-based Specialist in vascular medecine

    Brétigny-sur-Orge, 91220

  • Office-based Specialist in vascular medecine

    Bron, 69500

  • Office-based Specialist in vascular medecine

    Cabestany, 66330

  • University Hospital

    Caen

  • Office-based Specialist in vascular medecine

    Caluire-et-Cuire, 69300

  • Office-based Specialist in vascular medecine

    Cambrai, 59400

  • Office-based Specialist in vascular medecine

    Cannes, 06400

  • Office-based Specialist in vascular medecine

    Carcassonne, 11000

  • Hospital Antoine Gayraud

    Carcassonne

  • Office-based Specialist in vascular medecine

    Castanet-Tolosan, 31320

  • Office-based Specialist in vascular medecine

    Castres, 81100

  • Office-based Specialist in vascular medecine

    Cenon, 33150

  • Office-based Specialist in vascular medecine

    Chalon En Champagne, 51000

  • Office-based Specialist in vascular medecine

    Chalon-sur-Saône, 71100

  • Office-based Specialist in vascular medecine

    Chambéry, 73000

  • Hospital

    Chambéry

  • Office-based Specialist in vascular medecine

    Champagnole, 39300

  • Office-based Specialist in vascular medecine

    Chantilly, 60500

  • Office-based Specialist in vascular medecine

    Charleville-Mézières, 08000

  • Office-based Specialist in vascular medecine

    Chartres, 28000

  • Office-based Specialist in vascular medecine

    Châteaubriant, 44110

  • Office-based Specialist in vascular medecine

    Cholet, 49300

  • Office-based Specialist in vascular medecine

    Clamart, 92140

  • Office-based Specialist in vascular medecine

    Clapiers, 34830

  • Office-based Specialist in vascular medecine

    Clermont-Ferrand, 63000

  • Hospital Hotel Dieu

    Clermont-Ferrand

  • Office-based Specialist in vascular medecine

    Clermont-l'Hérault, 34800

  • Office-based Specialist in vascular medecine

    Clisson, 44190

  • Office-based Specialist in vascular medecine

    Cluses, 74300

  • Office-based Specialist in vascular medecine

    Colomiers, 31770

  • General Hospital

    Compiègne

  • Office-based Specialist in vascular medecine

    Coulommiers, 77120

  • Office-based Specialist in vascular medecine

    Crolles, 38920

  • Office-based Specialist in vascular medecine

    Denain, 59220

  • Office-based Specialist in vascular medecine

    Dieppe, 76200

  • Office-based Specialist in vascular medecine

    Dijon, 21000

  • Hospital Bocage

    Dijon

  • University Hospital

    Dijon

  • Office-based Specialist in vascular medecine

    Draguignan, 83300

  • Office-based Specialist in vascular medecine

    Échirolles, 38130

  • Office-based Specialist in vascular medecine

    Ermont, 95120

  • Office-based Specialist in vascular medecine

    Évreux, 27000

  • Office-based Specialist in vascular medecine

    Fécamp, 76400

  • Office-based Specialist in vascular medecine

    Feytiat, 87220

  • Office-based Specialist in vascular medecine

    Figeac, 46100

  • Hospital

    Flers

  • Office-based Specialist in vascular medecine

    Foix, 09000

  • Hospital Val d'Ariege

    Foix

  • Office-based Specialist in vascular medecine

    Fontenay-le-Comte, 85200

  • Office-based Specialist in vascular medecine

    Glanes, 46130

  • Office-based Specialist in vascular medecine

    Grenoble, 38000

  • University Hospital Grenoble

    Grenoble, 38043

  • Office-based Specialist in vascular medecine

    Gruchet-le-Valasse, 76210

  • Office-based Specialist in vascular medecine

    Hœnheim, 67800

  • Office-based Specialist in vascular medecine

    Issy-les-Moulineaux, 92130

  • Office-based Specialist in vascular medecine

    Istres, 13800

  • Office-based Specialist in vascular medecine

    L'Île-Rousse, 20220

  • Office-based Specialist in vascular medecine

    La Roche-sur-Yon, 85000

  • Departemental Hospital

    La Roche-sur-Yon

  • Office-based Specialist in vascular medecine

    La Rochelle, 17000

  • Office-based Specialist in vascular medecine

    Lannion, 22300

  • Office-based Specialist in vascular medecine

    Lattes, 34970

  • Office-based Specialist in vascular medecine

    Laval, 53000

  • Office-based Specialist in vascular medecine

    Laxou, 54520

  • Hospital Versailles

    Le Chesnay

  • Office-based Specialist in vascular medecine

    Le Mans, 72000

  • Office-based Specialist in vascular medecine

    Le Quesnoy, 59530

  • Office-based Specialist in vascular medecine

    Levallois-Perret, 92300

  • Office-based Specialist in vascular medecine

    Limoges, 87000

  • Office-based Specialist in vascular medecine

    Lisieux, 14100

  • Hospital Saint Philibert

    Lomme

  • Office-based Specialist in vascular medecine

    Longjumeau, 91160

  • Office-based Specialist in vascular medecine

    Longwy, 54440

  • Office-based Specialist in vascular medecine

    Lons-le-Saunier, 39000

  • Office-based Specialist in vascular medecine

    Lorient, 56100

  • Office-based Specialist in vascular medecine

    Louviers, 27400

  • Hospital Edouard Herriot

    Lyon

  • University Hospital

    Lyon

  • Office-based Specialist in vascular medecine

    Malemort-sur-Corrèze, 19360

  • Office-based Specialist in vascular medecine

    Manosque, 04100

  • Office-based Specialist in vascular medecine

    Mantes-la-Jolie, 78200

  • Office-based Specialist in vascular medecine

    Marcq-en-Barœul, 59700

  • Office-based Specialist in vascular medecine

    Marseille, 13000

  • Office-based Specialist in vascular medecine

    Martinique, 97000

  • Office-based Specialist in vascular medecine

    Maurepas, 78310

  • Office-based Specialist in vascular medecine

    Meaux, 77100

  • Office-based Specialist in vascular medecine

    Metz, 57000

  • Office-based Specialist in vascular medecine

    Meudon, 92190

  • Office-based Specialist in vascular medecine

    Moissac, 82200

  • Office-based Specialist in vascular medecine

    Montaigu, 85600

  • Office-based Specialist in vascular medecine

    Montbéliard, 25200

  • General Hospital

    Montbéliard

  • Hospital Jacques Monod

    Montivilliers

  • Office-based Specialist in vascular medecine

    Montluçon, 03100

  • Hospital

    Montluçon

  • Hospital

    Montmorillon

  • Office-based Specialist in vascular medecine

    Montpellier, 34000

  • Hospital St Eloi

    Montpellier

  • Office-based Specialist in vascular medecine

    Mulhouse, 68100

  • Office-based Specialist in vascular medecine

    Nancy, 54000

  • Office-based Specialist in vascular medecine

    Nantes, 44000

  • Office-based Specialist in vascular medecine

    Narbonne, 11100

  • Office-based Specialist in vascular medecine

    Nice, 06000

  • Office-based Specialist in vascular medecine

    Nîmes, 30000

  • Office-based Specialist in vascular medecine

    Niort, 79000

  • Office-based Specialist in vascular medecine

    Noumea (Nouvelle Calédonie), 98800

  • Office-based Specialist in vascular medecine

    Noyal-Pontivy, 56920

  • Office-based Specialist in vascular medecine

    Noyon, 60400

  • Office-based Specialist in vascular medecine

    Orange, 84100

  • Office-based Specialist in vascular medecine

    Orléans, 45000

  • Regional Hospital

    Orleans La Source

  • Office-based Specialist in vascular medecine

    Paris, 75000

  • Hospital Croix Saint Simon

    Paris

  • Hospital

    Périgueux

  • Office-based Specialist in vascular medecine

    Péronne, 80200

  • Office-based Specialist in vascular medecine

    Pessac, 33600

  • Office-based Specialist in vascular medecine

    Poissy, 78300

  • Office-based Specialist in vascular medecine

    Poitiers, 86000

  • Office-based Specialist in vascular medecine

    Pontarlier, 25300

  • Office-based Specialist in vascular medecine

    Pornic, 44210

  • Office-based Specialist in vascular medecine

    Puilboreau, 17000

  • Office-based Specialist in vascular medecine

    Quimper, 29000

  • Office-based Specialist in vascular medecine

    Rambouillet, 78120

  • Office-based Specialist in vascular medecine

    Redon, 35600

  • Office-based Specialist in vascular medecine

    Reims, 51200

  • University Hospital

    Reims

  • Office-based Specialist in vascular medecine

    Riom, 63200

  • Office-based Specialist in vascular medecine

    Rivesaltes, 66600

  • Office-based Specialist in vascular medecine

    Rochefort, 17300

  • Office-based Specialist in vascular medecine

    Rodez, 12000

  • Hospital

    Rodez, MD

  • Office-based Specialist in vascular medecine

    Romans-sur-Isère, 26000

  • Office-based Specialist in vascular medecine

    Rouen, 76000

  • Office-based Specialist in vascular medecine

    Sablé-sur-Sarthe, 72300

  • Office-based Specialist in vascular medecine

    Saint Genevieve Des Bois, 91700

  • Cmc Les Petites Roches

    Saint Hilaire Du Touvert

  • Office-based Specialist in vascular medecine

    Saint Pierre (ile de La Reunion), 97410

  • Office-based Specialist in vascular medecine

    Saint-Aubin-de-Médoc, 33160

  • Office-based Specialist in vascular medecine

    Saint-Benoît, 86200

  • Office-based Specialist in vascular medecine

    Saint-Brieuc, 22000

  • Office-based Specialist in vascular medecine

    Saint-Chamond, 42400

  • Office-based Specialist in vascular medecine

    Saint-Cloud, 92210

  • Office-based Specialist in vascular medecine

    Saint-Cyr-l'École, 78210

  • Office-based Specialist in vascular medecine

    Saint-Égrève, 38120

  • Office-based Specialist in vascular medecine

    Saint-Etienne, 42000

  • University Hospital

    Saint-Etienne

  • Office-based Specialist in vascular medecine

    Saint-Gaudens, 31800

  • Office-based Specialist in vascular medecine

    Saint-Germain-en-Laye, 78100

  • Office-based Specialist in vascular medecine

    Saint-Lô, 50000

  • Memorial Hospital

    Saint-Lô

  • Office-based Specialist in vascular medecine

    Saint-Martin-Boulogne, 62280

  • Office-based Specialist in vascular medecine

    Saint-Priest, 69800

  • Hospital

    Saint-Quentin

  • Office-based Specialist in vascular medecine

    Sallanches, 74700

  • Office-based Specialist in vascular medecine

    Salon-de-Provence, 13300

  • Office-based Specialist in vascular medecine

    Sarcelles, 95200

  • Office-based Specialist in vascular medecine

    Sarrebourg, 57400

  • Office-based Specialist in vascular medecine

    Sarreguemines, 57200

  • Office-based Specialist in vascular medecine

    Saverne, 67700

  • Office-based Specialist in vascular medecine

    Savigny-sur-Orge, 91600

  • Office-based Specialist in vascular medecine

    Sceaux, 92330

  • Office-based Specialist in vascular medecine

    Sélestat, 67600

  • Office-based Specialist in vascular medecine

    Sèvres, 92310

  • Office-based Specialist in vascular medecine

    Strasbourg, 67000

  • Regional University Hospital

    Strasbourg

  • Office-based Specialist in vascular medecine

    Talant, 21000

  • Office-based Specialist in vascular medecine

    Tarare, 69170

  • Office-based Specialist in vascular medecine

    Toulouse, 31000

  • University Hospital Rangueil Larrey

    Toulouse

  • University Hospital Rangueil

    Toulouse

  • University Hospital

    Toulouse

  • Office-based Specialist in vascular medecine

    Tours, 37000

  • Office-based Specialist in vascular medecine

    Trois Rivieres (guadeloupe), 97114

  • Office-based Specialist in vascular medecine

    Troyes, 10000

  • Office-based Specialist in vascular medecine

    Valence, 26000

  • Office-based Specialist in vascular medecine

    Vannes, 56000

  • Office-based Specialist in vascular medecine

    Vendôme, 41100

  • Office-based Specialist in vascular medecine

    Vénissieux, 69200

  • Office-based Specialist in vascular medecine

    Verrières-le-Buisson, 91370

  • Office-based Specialist in vascular medecine

    Versailles, 78000

  • Office-based Specialist in vascular medecine

    Vesoul, 70000

  • Office-based Specialist in vascular medecine

    Vichy, 03200

  • Office-based Specialist in vascular medecine

    Vienne, 38200

  • Office-based Specialist in vascular medecine

    Villebon-sur-Yvette, 91140

  • Office-based Specialist in vascular medecine

    Villefranche-sur-Saône, 69400

  • Office-based Specialist in vascular medecine

    Villemoisson-sur-Orge, 91360

  • Office-based Specialist in vascular medecine

    Villeurbanne, 69100

  • Office-based Specialist in vascular medecine

    Vincennes, 94300

  • Office-based Specialist in vascular medecine

    Viroflay, 78220

  • Office-based Specialist in vascular medecine

    Vizille, 38220

  • Office-based Specialist in vascular medecine

    Voiron, 38500

  • Office-based Specialist in vascular medecine

    Wissembourg, 67160

  • Office-based Specialist in vascular medecine

    Wizernes, 62570

Other trials in France

Belgium1 site

  • University Hospital ND des Bruyeres Liege

    Chênée

Other trials in Belgium

Guadeloupe1 site

  • Office-based Specialist in vascular medecine

    Basse-Terre, 97100

Other trials in Guadeloupe

About this study

Official title: A Prospective Epidemiological Multicenter Cohort Study on Patients Clinically Suspected of Deep Vein Thrombosis or Pulmonary Embolism

The purpose of this study is to determine different risk factors of thromboembolic disease. Different points will be studied

  1. do different types of thromboembolic disease (distal Deep Vein Thrombosis (DVT), proximal DVT, Pulmonary Embolism (PE) and DVT, PE without DVT) have the same clinical significance (risk factors and prognosis) ?
  2. Is it necessary to obtain a detailed history of thromboembolic disease ?
  3. Do older patients have particular risk factors ?
  4. Do preventive treatments modify the level of risk factors and the clinical signs of thromboembolic disease ?
  5. Do predictive clinical scores have the same performance for both in and outpatients ?
  6. Can patients with a potential high level of thromboembolic risk (surgery, pregnancy) but no clinical thromboembolic symptoms, develop a low risk ?
  7. The evolution of the disease in patients with negative or positive Venous ThromboEmbolism (VTE) exploratory tests.
Read the detailed description

The OPTIMEV study is a prospective epidemiological multicenter cohort study, including in-and outpatients clinically suspected of thromboembolic disease. Deep vein thrombosis is diagnosed using a duplex ultrasound examination, whereas pulmonary embolism is investigated by lung scan scintigraphy or computed helical tomodensitometry and/or duplex ultrasound examination. Initial data on medical history, clinical symptoms, presence of transient and chronic risk factors, diagnosis at the end of the medical examination, diagnostic tests results, treatment (type and duration) are collected by the physician into an electronic medical record. Other general medical considerations are collected (particularly on cardiovascular diseases). A phone follow up at 3 months, 1, 2 and 3 years is realised by the Centre for Clinical Research of Grenoble. All Venous ThromboEmbolism (VTE) positive patients (including superficial vein thrombosis) are contacted. For each VTE positive a negative one is selected (same site, same season). Data on mortality, development or recurrence of VTE, treatments prescribed (type + duration), major bleeding, cancer onset, cardiovascular events and venous insufficiency (leg ulcer) are collected. All these serious adverse events are documented and reviewed by an independent critical events committee.

Being tested
procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosis
Keywords
pulmonary embolism, duplex ultrasound examination, recurrence
Medical subject headings
Vascular Diseases, Embolism and Thrombosis, Phlebitis, Venous Insufficiency, Pulmonary Embolism, Recurrence

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosisOther

    Also called VTE (venous thromboembolism), DVT (deep vein thrombosis), PE (pulmonary embolism)

    patients with a clinical suspicion of Venous ThromboEmbolism (VTE = Deep Vein Thrombosis or Pulmonary Embolism) were eligible

Study groups in NCT00670540
Study groupRoleWhat they receive
1patients with suspected Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE)
Receives: Other: procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosis

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percentage of Participants Who Developed a New or Recurrence of Venous Thromboembolism (VTE)

    new VTE which can occur during follow up for no VTE patients at inclusion. Or VTE recurrence for VTE patients at inclusion.

    Measured: at 3 years

Secondary outcomes (6)

  1. Percentage of Participants Who Developed Major Bleeding Events

    Measured: at 3 years

  2. Percentage of Participants With Treatment Anticoagulant Prescribed

    Measured: after inclusion

  3. Percentage of Participants Who Developed Cardiovascular Events

    Measured: at 3 years

  4. Percentage of Participants Who Died From Any Cause

    Measured: at 3 years

  5. Percentage of Participants Who Developed Cancer Onset

    Measured: at 3 years

  6. Percentage of Participants Who Developed Venous Insufficiency (Leg Ulcer)

    Measured: at 3 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 May 2008 (estimated)
  2. Study startNov 2004
  3. Primary completionJan 2009
  4. Study completionFeb 2010

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
8,256 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00670540
Sponsor's protocol ID
DCIC-04-02
Acronym
OPTIMEV
Status last verified
May 2012
First submitted
30 Apr 2008
Last updated
8 May 2012
Data monitoring committee
No

Publications

  • Bosson JL, Labarere J, Sevestre MA, Belmin J, Beyssier L, Elias A, Franco A, Le Roux P. Deep vein thrombosis in elderly patients hospitalized in subacute care facilities: a multicenter cross-sectional study of risk factors, prophylaxis, and prevalence. Arch Intern Med. 2003 Nov 24;163(21):2613-8. doi: 10.1001/archinte.163.21.2613.

    PubMed 14638561

  • Samama MM. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med. 2000 Dec 11-25;160(22):3415-20. doi: 10.1001/archinte.160.22.3415.

    PubMed 11112234

  • Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet. 1999 Apr 24;353(9162):1386-9. doi: 10.1016/s0140-6736(98)07534-5.

    PubMed 10227218

  • Stein PD, Hull RD, Ghali WA, Patel KC, Olson RE, Meyers FA, Kalra NK. Tracking the uptake of evidence: two decades of hospital practice trends for diagnosing deep vein thrombosis and pulmonary embolism. Arch Intern Med. 2003 May 26;163(10):1213-9. doi: 10.1001/archinte.163.10.1213.

    PubMed 12767959

  • Sevestre MA, Labarere J, Brin S, Carpentier P, Constans J, Degeilh M, Deslandes B, Elgrishi I, Lanoye P, Laroche JP, Le Roux P, Pichot O, Quere I, Bosson JL; OPTIMEV study. [Optimizing history taking for evaluating the risk of venous thromboembolism: the OPTIMEV study]. J Mal Vasc. 2005 Sep;30(4 Pt 1):217-27. doi: 10.1016/s0398-0499(05)88206-x. French.

    PubMed 16292199

  • Galanaud JP, Arnoult AC, Sevestre MA, Genty C, Bonaldi M, Guyard A, Giordana P, Pichot O, Colonna M, Quere I, Bosson JL; OPTIMEV-SFMV Investigators. Impact of anatomical location of lower limb venous thrombus on the risk of subsequent cancer. Thromb Haemost. 2014 Dec;112(6):1129-36. doi: 10.1160/TH14-04-0351. Epub 2014 Aug 7.

    PubMed 25104514

  • Le Moigne E, Genty C, Meunier J, Arnoult AC, Righini M, Bressollette L, Bosson JL, Le Gal G; OPTIMEV Investigators. Validation of the LEFt score, a newly proposed diagnostic tool for deep vein thrombosis in pregnant women. Thromb Res. 2014 Sep;134(3):664-7. doi: 10.1016/j.thromres.2014.07.009. Epub 2014 Jul 17.

    PubMed 25087889

  • Galanaud JP, Bosson JL, Genty C, Presles E, Cucherat M, Sevestre MA, Quere I, Decousus H, Leizorovicz A. Superficial vein thrombosis and recurrent venous thromboembolism: a pooled analysis of two observational studies. J Thromb Haemost. 2012 Jun;10(6):1004-11. doi: 10.1111/j.1538-7836.2012.04704.x.

    PubMed 22429908

  • Galanaud JP, Sevestre MA, Genty C, Laroche JP, Zizka V, Quere I, Bosson JL; OPTIMEV SFMV investigators. Comparison of the clinical history of symptomatic isolated muscular calf vein thrombosis versus deep calf vein thrombosis. J Vasc Surg. 2010 Oct;52(4):932-8, 938.e1-2. doi: 10.1016/j.jvs.2010.05.019. Epub 2010 Jul 13.

    PubMed 20630688

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