Ideomotor ApraxiaNCT00063115
Using fMRI to Understand the Roles of Brain Areas for Fine Hand Movements
An observational study of Ideomotor Apraxia, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
Trial summary
Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements. This study will look at how different areas of the human brain control fine hand movements. Read more about this study
- Who is it for?
- Ages 21 years and olderHealthy volunteers can take part
- Conditions the study is for
- Ideomotor Apraxia
- How many people
- 35 participants
- Where
- 1 siteUnited States
- Study dates
- 16 Jun 2003to 2 Jul 2008
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy volunteers.
- Patients diagnosed with ideomotor apraxia with a single left hemisphere stroke will be included.
- The lesion will be located in any part of the frontal and parietal areas or both, as well as their connections.
Who cannot join
- Subjects with abnormal neurologic examinations, previous or current neurological and psychiatric disorders will be excluded.
- Subjects under age 21, pregnant or mentally impaired will also be excluded.
- Ideomotor apraxic patients with a second neurologic disorder including more than one brain lesion of the inability to cooperate fully will be excluded.
- Patients with a history of significant medical disorders such as cancers will be excluded.
- MRI experiments will not be performed in subjects or patients who have pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, insulin pumps, or shrapnel fragments.
- Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye of which they may be unaware. Subjects will be screened for these contraindications prior to the study.
- MRI experiments will not be performed on pregnant women.
Trial locations and contacts
1 site in 1 country.
United States1 site
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892
About this study
Official title: Event-Related fMRI Analysis of Patients With Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing
Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements. This study will look at how different areas of the human brain control fine hand movements.
Thirty-five participants 21 years and older will be enrolled in this study-25 healthy, right-handed people, and 10 stroke patients. They will undergo two outpatient sessions, each lasting up to 3 hours. The first visit for the stroke patients will occur between 2 weeks and 3 months after the stroke; the second visit will be at least 6 months after the stroke.
Participants will have a physical exam, give a medical history, and complete a questionnaire. Then they will undergo magnetic resonance imaging (MRI) scans. They will lie in the MRI scanner and will be asked to do a number of skilled hand movements using the right hand (such as pretending to use a hammer or waving goodbye) in response to directions that will appear on a screen mounted over their head. Their movements will be recorded on videotape during the procedures.
Read the detailed description
OBJECTIVE: The present study focuses on evaluating neural activation patterns underlying praxis movements in normal controls and in patients with ideomotor apraxia using event-related functional magnetic resonance imaging (fMRI). Ideomotor apraxia is a disorder affecting patients with stroke and a variety of other brain lesions. The disorder involves disturbed timing, sequence, and spatial organization of skilled movements, during the execution and probably also preparatory phases. As a consequence, patients suffer from incorrect temporal and spatial components to movements as evidenced during pantomime of transitive (object/tool related) and intransitive (independent of object/tool use) gestures. Thus far, damage to posterior parietal regions and parietofrontal circuits has been implicated in significantly contributing to this disorder. However, little is known about the mechanism of cortical reorganization following damage, notably during recovery process. We hypothesize that recruitment of parallel and contralateral motor pathways compensates for reduced communication within parietofrontal circuits which prevents accurate motor performance.
STUDY POPULATION: We will study two groups of participants: one group of patients with ideomotor apraxia and one group of healthy subjects.
DESIGN: We will measure fMRI activation on transitive and intransitive gestures in 10 patients with ideomotor apraxia during subacute and chronic stage compared to 25 normal controls. The design of the behavioral paradigm incorporates a distinct period of planning prior to each movement.
OUTCOME MEASURES: The design of this study allows evaluating any differences in the planning and execution phases between patients and controls. Further analysis will examine patterns of functional connectivity between activated brain areas, notably their altered interactions in ideomotor apraxia. Of special interest is the putative engagement of perilesional or even remote brain areas in a neuronal network during attempted recovery from motor deficit.
It is expected from the study that a better understanding of cortical plasticity compensating for motor deficits in ideomotor apraxia can be therapeutically exploited, notably in the rehabilitation process.
- Conditions
- Ideomotor Apraxia
- Keywords
- Praxis Movements, Pantomime, Statistical Parametric Mapping, Functional Connectivity, Path Analysis, Ideomotor Apraxia, Healthy Volunteer, HV
- Medical subject headings
- Apraxia, Ideomotor
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jun 2003 (estimated)
- Study start16 Jun 2003
- Study completion2 Jul 2008
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ideomotor ApraxiaStudies of the same condition, open and under way.
- More trials run by National Institute of Neurological Disorders and Stroke (NINDS)The sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Enrolment
- 35 participants
Sponsor and investigators
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00063115
- Sponsor's protocol ID
- 030230
- Other IDs
- 03-N-0230
- Status last verified
- 2 Jul 2008
- First submitted
- 19 Jun 2003
- Last updated
- 2 Jul 2017
- Results posted
- No
Publications
Haaland KY, Harrington DL, Knight RT. Neural representations of skilled movement. Brain. 2000 Nov;123 ( Pt 11):2306-13. doi: 10.1093/brain/123.11.2306.
PubMed 11050030
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Event-Related fMRI Analysis of Patients With Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing
- ClinicalTrials.gov ID
- NCT00063115
- Acronym / sponsor ID
- 030230
- Conditions
- Ideomotor Apraxia
- Keywords
- Praxis Movements, Pantomime, Statistical Parametric Mapping, Functional Connectivity, Path Analysis, Ideomotor Apraxia, Healthy Volunteer, HV
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 35 participants
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)US National Institutes of Health
- Study start
- 16 Jun 2003
- Study completion
- 2 Jul 2008
- First posted
- 20 Jun 2003 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements. This study will look at how different areas of the human brain control fine hand movements.
Thirty-five participants 21 years and older will be enrolled in this study-25 healthy, right-handed people, and 10 stroke patients. They will undergo two outpatient sessions, each lasting up to 3 hours. The first visit for the stroke patients will occur between 2 weeks and 3 months after the stroke; the second visit will be at least 6 months after the stroke.
Participants will have a physical exam, give a medical history, and complete a questionnaire. Then they will undergo magnetic resonance imaging (MRI) scans. They will lie in the MRI scanner and will be asked to do a number of skilled hand movements using the right hand (such as pretending to use a hammer or waving goodbye) in response to directions that will appear on a screen mounted over their head. Their movements will be recorded on videotape during the procedures.
Detailed description
OBJECTIVE: The present study focuses on evaluating neural activation patterns underlying praxis movements in normal controls and in patients with ideomotor apraxia using event-related functional magnetic resonance imaging (fMRI). Ideomotor apraxia is a disorder affecting patients with stroke and a variety of other brain lesions. The disorder involves disturbed timing, sequence, and spatial organization of skilled movements, during the execution and probably also preparatory phases. As a consequence, patients suffer from incorrect temporal and spatial components to movements as evidenced during pantomime of transitive (object/tool related) and intransitive (independent of object/tool use) gestures. Thus far, damage to posterior parietal regions and parietofrontal circuits has been implicated in significantly contributing to this disorder. However, little is known about the mechanism of cortical reorganization following damage, notably during recovery process. We hypothesize that recruitment of parallel and contralateral motor pathways compensates for reduced communication within parietofrontal circuits which prevents accurate motor performance.
STUDY POPULATION: We will study two groups of participants: one group of patients with ideomotor apraxia and one group of healthy subjects.
DESIGN: We will measure fMRI activation on transitive and intransitive gestures in 10 patients with ideomotor apraxia during subacute and chronic stage compared to 25 normal controls. The design of the behavioral paradigm incorporates a distinct period of planning prior to each movement.
OUTCOME MEASURES: The design of this study allows evaluating any differences in the planning and execution phases between patients and controls. Further analysis will examine patterns of functional connectivity between activated brain areas, notably their altered interactions in ideomotor apraxia. Of special interest is the putative engagement of perilesional or even remote brain areas in a neuronal network during attempted recovery from motor deficit.
It is expected from the study that a better understanding of cortical plasticity compensating for motor deficits in ideomotor apraxia can be therapeutically exploited, notably in the rehabilitation process.
Study design
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Healthy volunteers.
- Patients diagnosed with ideomotor apraxia with a single left hemisphere stroke will be included.
- The lesion will be located in any part of the frontal and parietal areas or both, as well as their connections.
Key exclusion criteria (7 listed)
- Subjects with abnormal neurologic examinations, previous or current neurological and psychiatric disorders will be excluded.
- Subjects under age 21, pregnant or mentally impaired will also be excluded.
- Ideomotor apraxic patients with a second neurologic disorder including more than one brain lesion of the inability to cooperate fully will be excluded.
- Patients with a history of significant medical disorders such as cancers will be excluded.
- MRI experiments will not be performed in subjects or patients who have pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, insulin pumps, or shrapnel fragments.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2017.
- Background: PubMed 11050030Haaland KY, Harrington DL, Knight RT. Neural representations of skilled movement. Brain. 2000 Nov;123 ( Pt 11):2306-13. doi: 10.1093/brain/123.11.2306.
Related trials for Ideomotor Apraxia
RecruitingObservational study
Post-Stroke Apraxia, Motor Function, Balance, and Gait
Stroke, Ideomotor Apraxia
RecruitingObservational study
Ideomotor Apraxia and Robotic Gait Rehabilitation Outcomes After Stroke
Stroke, Ideomotor Apraxia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ideomotor Apraxia, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00063115, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2017.