Research institution
Wake Forest University Health Sciences Clinical Trials
Studies where Wake Forest University Health Sciences is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 201PrEP Use
Adapting the ESTEEM Intervention to Improve Mental Health and PrEP Uptake Among Men at Risk of HIV
The purpose of this research study is to adapt, implement, and evaluate a 10-session mental health intervention with men who have sex with men at the Regional AIDS Interfaith Network to find out if it will reduce anxiety and…
- Trial name
- ESTEEM (NCT07792148)
- Testing
- PrEPared Minds/ Mentes PrEParadas - Cognitive Behavioral Therapy, No Intervention
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus (T2D)
Culturally Tailored Program for Food-Insecure Adults: SPICE-D
The goal of this pilot intervention study is to learn if culturally appropriate food bundles and nutrition education can help people with diabetes who struggle to afford healthy food in patients with diabetes receiving care at…
- Trial name
- SPICE-D (NCT07361341)
- Testing
- Food Bundle Intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Hemianopia, Homonymous, Cortical Blindness, Unspecified Side of Brain
Ameliorating Stroke-induced Hemianopia Via Multisensory Training
This study seeks to determine the extent of the visual capabilities that can be restored in hemianopic stroke patients by a multisensory training technique and evaluate changes in the brain that the training induces.
- Trial name
- NCT05894434
- Testing
- Multisensory Training, Unisensory Training
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Wake Forest University Health Sciences
Tourette Syndrome, Tic Disorders
Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome
This study adapts and tests PRISM (Promoting Resilience in Stress Management), a short skills-based program that teaches resilience, for teens ages 12-18 with Tourette syndrome or persistent tic disorder.
- Conditions
- Tourette Syndrome, Tic Disorders, Persistent (Chronic) Motor or Vocal Tic Disorder
- Trial name
- PRISM-TS (NCT07905898)
- Testing
- PRISM Intervention, Usual care intervention
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Wake Forest University Health Sciences
Cortical Blindness
Multisensory Rehabilitation of Vision Loss After Cortical Damage
Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.
- Trial name
- NCT07659691
- Testing
- Multisensory Rehabilitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Philadelphia Positive Acute Lymphoblastic Leukemia
A Study of LP-118 In Combination With Ponatinib, Dexamethasone And Blinatumomab For Adults With Newly-Diagnosed, BCR::ABL1-Positive Acute Lymphoblastic Leukemia (ALL)
The purpose of this research study is to see if a drug called LP-118 is safe and effective for treating adults with Philadelphia chromosome-positive (Ph+) B cell acute lymphoblastic leukemia (ALL), when given with ponatinib…
- Trial name
- NCT07614022
- Testing
- LP-118
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Wake Forest University Health Sciences
Obesity
Vibegron for ENergy Thinking and Resilience in Aging
This 12-week randomized, double-blind, placebo-controlled trial will test the hypothesis that Vibegron (brand name GEMTESA) can improve energy metabolism, cardiometabolic risk factors, and physical and cognitive function in…
- Trial name
- VENTURA (NCT06987383)
- Testing
- Vibegron
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Bacterial Contamination
Bacterial Mask Contamination in Operating Room
The primary objective of this study is to determine whether surgical mask configuration policy-compliant (up or off ) versus mask dangling is associated with differences in bacterial contamination among unscrubbed operating room…
- Trial name
- NCT07900958
- Testing
- Mask up or off, Mask dangling
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypotension During Surgery, Cesarean Birth
OB VEGA-Phenylephrine vs Norepinephrine Outcomes
OB VEGA-Phenylephrine vs Norepinephrine Outcomes evaluation
- Trial name
- NCT07900919
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Wake Forest University Health Sciences
Opioid Use Disorder
Examining Analgesic Synergy and Efficacy in Trauma Care
Traumatic injury is responsible for over 25 million (16%) Emergency Department visits and over 225,000 deaths each year per 2021 Center for Disease Control data. This is the 3rd leading cause of death in the US.
- Trial name
- EASE (NCT07435077)
- Testing
- Buprenorphine, Oxycodone
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- Wake Forest University Health Sciences
Completed, with results posted
All 341Mild Cognitive Impairment, Cognitive Impairment
SNIFF - Combo INI+EMPA Trial
The proposed pilot study will provide safety and efficacy preliminary data regarding singular and combined effects of two therapeutic approaches, intranasal insulin and treatment with the sodium-glucose cotransporter type 2…
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05081219
- Testing
- Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
SNIFF Multi-Device Study 2
The SNIFF Device study will involve using one of three devices to administer insulin through each participant's nose or intra-nasally, accompanied by a lumbar puncture.
- Trial name
- NCT04199767
- Testing
- 20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Lipid Disorder
EMERALD (Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders)
The EMERALD intervention involves 1) ordering an Emergency Department (ED) lipid panel, 2) calculating 10-year Atherosclerotic cardiovascular disease (ASCVD) risk using the Pooled Cohort Equations, 3) prescribing a moderate- or…
- Trial name
- EMERALD (NCT05742841)
- Testing
- moderate- or high-intensity statin/ rosuvastatin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Gynecologic Cancer, Sexual Dysfunction
Pelvic Physical Therapy for Sexual Dysfunction in Gynecologic Oncology Survivors
The purpose of this research study is to investigate the use of pelvic physical therapy for gynecologic cancer survivors who report sexual dysfunction.
- Trial name
- NCT05242770
- Testing
- Control Arm, Physical Therapy Arm, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Stress, Anxiety
Cereset Research Long-Term Healthcare Worker Study
Randomized, controlled study of long-term maintenance Cereset Research after an initial 4-session intervention bolus versus usual care control following an initial 4-session intervention bolus.
- Conditions
- Stress, Anxiety, Autonomic Dysregulation, Acoustic Stimulation
- Trial name
- LT-HW (NCT05994261)
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences