Research institution
Brown University Clinical Trials
Studies where Brown University is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 38Problematic Phone Use Behavior, Depression
The Mindful Smartphone Use Study
The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention to address co-existing smartphone addiction and psychological distress among adolescents ages 13-19…
- Conditions
- Problematic Phone Use Behavior, Depression, Anxiety
- Trial name
- NCT07892807
- Testing
- Mindwire
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Alcohol Misuse
Using Virtual Reality to Augment Brief Interventions for Heavy Drinking Young Adults
The overarching goal of this research is to explore whether VR might be used to augment brief motivational interviewing (BMI) techniques among heavy drinking young adults (age 18-34) and to test the preliminary efficacy of the VR…
- Trial name
- VR for MI (NCT07902154)
- Testing
- Virtual Reality experience, Brief motivational intervention
- Volunteers
- 120 people
- Sponsor
- Brown University
HIV Prevention, HIV Infection Primary
Intervention to Enhance PrEP Persistence
The investigators will conduct a fully powered randomized controlled trial (RCT) to test the effect of a patient navigation intervention on PrEP initiation, adherence and retention in care.
- Trial name
- NCT06872307
- Testing
- RAMP-It-Up Initiation, Adherence, and Retention Intervention
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Brown University
Phase I
Pilot Study on the Effects of Psilocybin on Belief Updating and Insight Formation
The primary aim of this phase I mechanistic pilot study is to evaluate the effects of psilocybin on aspects of cognition in healthy adult volunteers.
- Trial name
- NCT07818564
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brown University
Unhealthy Alcohol Use
Supporting Health Through Alcohol Reduction and Relationship Enhancement Together
The aim of this project is to refine the couples-focused intervention with up to 24 adults with unhealthy alcohol use and their partners (N=12 couples) to obtain feedback on the intervention content and structure, as well as the…
- Trial name
- SHARE2Gether (NCT07854756)
- Testing
- SHARE2Gether
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Malignant Ascites, Colorectal Adenocarcinoma
TLR9 Immunotherapy for Peritoneal Carcinomatosis
The goal of this clinical trial is to determine the safety and efficacy of of ACM-CpG for inoperable peritoneal metastases or malignant ascites.
- Conditions
- Malignant Ascites, Colorectal Adenocarcinoma, Peritoneal (Metastatic) Cancer, Appendiceal Adenocarcinoma
- Trial name
- TIPC (NCT07658196)
- Testing
- ACM-CpG
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown University
Alcohol Use Disorder
Intranasal Insulin for Treatment of Alcohol Use Disorder
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo.
- Trial name
- ITA (NCT05988632)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Health Behavior, Wellness, Psychological
Teen Health Choices & Wellness
The goal of this observational study is to learn more about changes in health, wellness, and substance-use behaviors as teenagers get older.
- Conditions
- Health Behavior, Wellness, Psychological, Substance Use
- Trial name
- THC&W (NCT06822569)
- Testing
- Cue reactivity paradigm
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Brown University
Fall, Fall Injury Prevention
From Screening to Safety: Implementing the AL-STEADI Initiative in Assisted Living Communities
The goal of this trial is to test the real-world efficacy of AL-STEADI, a fall prevention program, in participating assisted living centers.
- Conditions
- Fall, Fall Injury Prevention, Fall Prevention
- Trial name
- AL-STEADI (NCT07531641)
- Testing
- AL-STEADI, Usual Care Group
- Volunteers
- 700 people
- Sponsor
- Brown University
Completed, with results posted
All 100Physical Inactivity
Early Phase Clinical Trial to Test the Feasibility of an ACT-based Physical Activity Promotion Program for Adults With Depressive Symptoms
The goal of the proposed project is to conduct a feasibility clinical trial comparing group-based acceptance and commitment therapy for physical activity, (ACT; ACTivity) to a time- and attention-matched standard PA intervention…
- Trial name
- NCT05407935
- Testing
- ACTivity, Relaxercise
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brown University
Inactivity
Web-based Physical Activity Intervention for Latinas
This renewal builds upon our successful culturally adapted PA intervention for Latinas (Pasos Hacia La Salud, R01CA159954) and expands its focus to the critical area of maintenance of behavior change.
- Trial name
- NCT03491592
- Testing
- Enhanced Physical Activity Intervention, Original Physical Activity Intervention
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Brown University
Acute Myeloid Leukemia
Fractionated Gemtuzumab Ozogamicin Followed by Non-engraftment Donor Leukocyte Infusions for Relapsed/Refractory Acute Myeloid Leukemia
This study includes patients with relapsed acute leukemia who have previously been treated with standard treatment that is still present and there is no curative treatment option available.
- Trial name
- NCT03374332
- Testing
- Gemtuzumab Ozogamicin (GO), Donor Leukocytes
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brown University
Youth Drinking, Alcohol Drinking
Alcohol Feedback, Reflection and Morning Evaluation
The investigators propose to examine mornings after drinking as an optimal time to provide repeated, personalized feedback, with the goal of reducing hazardous drinking.
- Trial name
- (A-FRAME) (NCT05509218)
- Testing
- Mobile-delivered personalized feedback
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Brown University
Alzheimer Disease or Associated Disorder
Coordinated Emergency Department Transitions
The goal of this observational study is to learn the feasibility, acceptability, appropriateness, and adherence to a case management intervention.
- Trial name
- NCT06933849
- Testing
- Structured case management
- Where
- United States
- Volunteers
- 1,376 people
- Sponsor
- Brown University