Drug or intervention
Ketamine Clinical Trials
Studies that test Ketamine, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 192Treatment Resistant Depression
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression
Depression is a common condition, with serious negative effects on the health and quality of life of those affected. While there are currently various medications which attempt to treat depression, they often take a long time to…
- Trial name
- TREASURE (NCT06781697)
- Testing
- Ketamine, Oculus VR headset
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Sunnybrook Health Sciences Centre
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
CPAP Ventilation, Sedation
Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit
Continuous positive airway pressure (CPAP) is a type of positive airway pressure, where the air flow is introduced into the airways to maintain a continuous pressure to constantly stent the airways open, in people who are…
- Conditions
- CPAP Ventilation, Sedation, Hemodynamics Instability
- Trial name
- CPAP (NCT07888192)
- Testing
- Group DK will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and ketamine (0.5 mg/kg/hr)., Group KP will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and propofol (2-4 mg/kg/hr).(
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Opioid Use Disorder
Ketamine for Opioid Use Disorder
The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults enrolled in methadone treatment for opioid use disorder.
- Trial name
- NCT06943859
- Testing
- Treatment with Ketamine, Treatment with Very Low Dose Ketamine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Healthy Volunteers, Depression
Neurobiology of Suicide
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies.
- Trial name
- NCT02543983
- Testing
- Magnetic Resonance Imaging scanner, 3T, NeurOptics PLRTM-3000 Pupillometer, Experimental Anxiety Devices
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anesthesia, Pain
Anesthetics and Analgesics in Children
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
- Trial name
- ANA01 (NCT03427736)
- Testing
- Ketorolac Tromethamine, Hydromorphone, Ketamine
- Where
- 13 sites in United States, Canada
- Volunteers
- 551 people
- Sponsor
- Chi Dang Hornik
Head and Neck Cancer
Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse
This 2-arm phase II study proposes to determine the efficacy of ketamine oral rinse in pain relief from mucositis in head and neck cancer patients undergoing radiation treatment.
- Trial name
- NCT06660017
- Testing
- Ketamine Topical
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Oklahoma
Completed, with results posted
All –Suicide, Attempted, Suicide and Depression
Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
This project aims to examine the signal of efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks.
- Conditions
- Suicide, Attempted, Suicide and Depression, Suicide Threat
- Trial name
- TASK (NCT04592809)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Post-traumatic Stress Disorder
Ketamine and Prolonged Exposure in PTSD
This study aims at investigating the effectiveness of the drug, Ketamine, in combination with Prolonged Exposure (PE) therapy for people suffering from PTSD.
- Trial name
- NCT03960658
- Testing
- ketamine-enhanced prolonged exposure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Major Depressive Disorder, Healthy Controls
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs.
- Trial name
- UNIKET (NCT05046184)
- Testing
- Ketamine Hydrochloride, Midazolam injection
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Depression
Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial
This protocol describes a feasibility trial that will evaluate the feasibility of conducting a full-scale phase 3 trial testing the hypothesis that a postoperative sustained, low-dose ketamine infusion can prevent postoperative…
- Trial name
- K-PASS (NCT05233566)
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Washington University School of Medicine
PTSD
Ketamine-enhanced Prolonged Exposure Therapy in PTSD
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo to reduce symptoms of Posttraumatic Stress Disorder (PTSD) among Veteran receiving Prolonged Exposure Therapy.
- Trial name
- NCT04560660
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development