Clinical trials: Phase 2, completed
Obesity, Diet Therapy
Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting
This study will investigate how to better predict why some individuals gain or lose weight more easily than others. It will examine whether the increase in the amount of energy a body burns in 24 hours with overeating or the…
- Conditions
- Obesity, Diet Therapy, Weight Loss, Weight Gain
- Trial name
- NCT00687115
- Testing
- Weight Loss, Overfeeding, Overfeeding Low Pro
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Bipolar 1 Disorder
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder
This is a clinical research study for an investigational drug called RAP-219 in participants with bipolar I disorder. This study is being conducted to determine if RAP-219 is safe and effective in participants experiencing mania…
- Trial name
- NCT07046494
- Testing
- RAP-219
- Where
- 20 sites in United States
- Volunteers
- 253 people
- Sponsor
- Rapport Therapeutics Inc.
Diarrhoea
A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants
This study evaluates the immune response and safety of a multicomponent, 2-dose Shigella vaccine in preventing shigellosis in African infants.
- Trial name
- NCT06663436
- Testing
- altSonflex1-2-3 Dose A, altSonflex1-2-3 Dose B, altSonflex1-2-3 Dose C
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bronchiectasis
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis
The aim of this clinical trial is to assess the safety of: single doses of the study drug CHF6333 in Healthy Volunteers (HVs) and in subjects with Bronchiectasis (BE) - Part I repeated doses of the study drug CHF6333 in subjects…
- Trial name
- NCT06166056
- Testing
- CHF6333
- Where
- 8 sites in United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Refractory Plasma Cell Myeloma, Recurrent Plasma Cell Myeloma
Ixazomib Plus Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Relapsed/Refractory Multiple Myeloma
This phase I/II trial studies the side effects and best dose of ixazomib and to see how well it works when given together with pomalidomide and dexamethasone in treating patients with relapsed or relapsed/refractory multiple…
- Trial name
- NCT02119468
- Testing
- ixazomib citrate, dexamethasone, pomalidomide
- Where
- 5 sites in United States
- Volunteers
- 32 people
- Sponsor
- City of Hope Medical Center
Ischemia Reperfusion Injury, Myocardial Injury
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
- Conditions
- Ischemia Reperfusion Injury, Myocardial Injury, Acute Kidney Injury
- Trial name
- NACAM (NCT04750616)
- Testing
- Niacinamide
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Kaiser Permanente
Acute Heart Failure, Pulmonary Congestion
Oxygen Targets in Acute Heart Failure With Pulmonary Congestion
REDOX-AHF compared two oxygen saturation targets in adults admitted with acute heart failure and clinical or radiological signs of congestion.
- Conditions
- Acute Heart Failure, Pulmonary Congestion, Hypoxemia
- Trial name
- REDOX-AHF (NCT05613218)
- Testing
- Oxygen
- Where
- 2 sites in Denmark
- Volunteers
- 135 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Glucocorticoid Resistant ICIs-related Myocarditis
The Efficacy and Safety of Tofacitinib in Patients With Glucocorticoid Resistant ICIs-related Myocarditis
The efficacy and safety of Tofacitinib in patients with glucocorticoid resistant ICIs-related myocarditis: a single-arm, prospective, phase 2 trial
- Trial name
- NCT06393972
- Testing
- Tofacitinib 5 MG BID
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Zhongshan Hospital
T2DM (Type 2 Diabetes Mellitus)
A Study of RAY1225 in Participants With Type 2 Diabetes
The main purpose of this study is to learn more about the Tolerability of RAY1225 in participants with type 2 diabetes mellitus. The study will also explore the efficacy of RAY1225.
- Trial name
- NCT06254274
- Testing
- RAY1225
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Diabetic Macular Edema, Center-involved Diabetic Macular Edema
Randomized Clinical Trial to Evaluate the Effect of Dapagliflozin in Patients With Diabetic Macular Edema
The purpose of this clinical study is to explore the efficacy of dapagliflozin as an adjunct to intravitreal anti-vascular endothelial growth factor (anti-VEGF) for enhanced reduction of retinal thickness and vision improvement…
- Trial name
- DAPA-DME (NCT06845163)
- Testing
- Dapagliflozin, Anti-VEGF drug
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Alexandria University
Early Childhood Caries (ECC), Color Stability of Restoration
Evaluation of Silver Diamine Fluoride, Sodium Fluoride With Casein Phosphopeptide-Amorphous Calcium Phosphate(MI Varnish) and Dycal to Arrest Caries When Used in Indirect Pulp Capping Procedures in Children
Early childhood caries is a serious public health issue often neglected and goes untreated having detrimental effects on the child and their family. Hence, multiple teeth are affected with dental caries approaching close to pulp.
- Conditions
- Early Childhood Caries (ECC), Color Stability of Restoration, Caries Arrested, Caries,Dental
- Trial name
- SDF (NCT07893756)
- Testing
- Silver Diamine Fluoride (SDF, 38%) gel, Sodium Fluoride with CPP-ACP (MI varnish), Calcium Hydroxide (CH)
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- University of Jazan
Type2 Diabetes
Evaluation of the Efficacy and Safety of Curalin as Add-On Therapy in Adults With Type 2 Diabetes Mellitus
Evaluation of Efficacy and Safety of Curalin As Add-On Therapy in Adults With Type 2 Diabetes Mellitus
- Trial name
- NCT05439473
- Testing
- Curalin
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- CuraLife
Hematopoietic Stem Cell Transplantation, TP53
Venetoclax and Decitabin Based Conditioning Regimen Followed With Post-HSCT Decitabin Maintenance Therapy in TP53 Mutant AML/MDS Patients
This study aims to evaluate the effectiveness and safety of Venetoclax and Decitabin based conditioning regimen followed with post-HSCT Decitabin maintenance therapy in TP53 mutant AML/MDS Patients.
- Trial name
- NCT05528354
- Testing
- VEN and DEC based conditioning regimen, DEC
- Where
- 4 sites in China
- Volunteers
- 58 people
- Sponsor
- Zhejiang University
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism
11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours
10% of patients with hypertension potentially have the treatable condition - primary aldosteronism (PA). This is caused by either bilateral adrenal disease (~40%), managed with lifelong medications; or unilateral disease (~60%)…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism, Adrenal Tumors
- Trial name
- NCT06100367
- Testing
- 11C-Metomidate PET/CT imaging at Clinical Imaging Research Centre
- Where
- 7 sites in Singapore
- Volunteers
- 97 people
- Sponsor
- Changi General Hospital
Low Back Pain
Alberta Back Care Pathway (ABCp)
Every year, the pain, disability, addiction, and expense associated with LBP increase in Alberta. This escalation is largely because most people with LBP seek care from family physicians who are unable to provide effective…
- Trial name
- ABCp (NCT05452876)
- Testing
- ABCp, Usual Care
- Where
- Canada
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Gastrointestinal Tract Malignancies
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
The purpose of this study is to evaluate the safety and preliminary clinical activity of treatment combinations with and without chemotherapy in participants with locally advanced unresectable or metastatic gastric, GEJ, and…
- Trial name
- EDGE-Gastric (NCT05329766)
- Testing
- Domvanalimab, Quemliclustat, Zimberelimab
- Where
- 43 sites in United States, Canada and 4 more
- Volunteers
- 332 people
- Sponsor
- Arcus Biosciences, Inc.
Prostate Cancer
Detecting Metastases by PyL PET/CT in Subjects Starting Enzalutamide for Untreated Castration Resistant Prostate Cancer.
This study aimed to evaluate the diagnostic performance of 18F-DCFPyL (PyL) PET/CT in subjects presenting not previously treated for castration resistant prostate cancer and showing negative or equivocal findings per…
- Trial name
- PROSTEP-002 (NCT04655365)
- Testing
- Enzalutamide capsule
- Where
- 4 sites in Canada
- Volunteers
- 30 people
- Sponsor
- CHU de Quebec-Universite Laval
Brain Tumor
Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors
Background: More children with cancer are surviving into adulthood. Some side effects from treatment go away quickly. But some problems may not go away or may only show up months or years later.
- Trial name
- NCT02153957
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Type 2 Diabetes Mellitus
Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial
This study aims to provide essential mechanistic insights into natriuretic and hemodynamic effects of SGLT2i and GLP-1RA agents in T2D patients.
- Trial name
- NATRIURETIC (NCT04535960)
- Testing
- Empagliflozin 25 MG + Liraglutide 1.8 MG, Liraglutide 1.8 MG + Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Obesity, Diabetes
Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes
Quercetin is a compound naturally found in various foods. It may have some role in the treatment of obesity and diabetes. The purpose of this study is to investigate research volunteers with obesity or obesity with type 2…
- Trial name
- NCT00065676
- Testing
- Quercetin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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