Clinical trials: Early Phase 1, completed
Osteopenia
Melatonin and Osteogenic Loading on Osteopenia
This study will be assessing the efficacy of melatonin and/or osteogenic loading on modulating bone health in an osteopenic population.
- Trial name
- MelaOstrong (NCT04233112)
- Testing
- Melatonin 5 mg, Osteogenic loading, Mock for Osteogenic Loading
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Duquesne University
Interaction Drug Food
Assessing the Pharmacokinetics and Drug Interaction Liability of Kratom, an Opioid-like Natural Product
Kratom is a botanical natural product that has opioid-like effects. Kratom is commonly used to self-treat withdrawal symptoms associated with opioid addiction, as well as pain.
- Trial name
- NCT04392011
- Testing
- Midazolam HCl, Dextromethorphan HBr, Kratom
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington State University
Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Mesenchymal Stromal Cells, Cornea
Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops.
- Conditions
- Mesenchymal Stromal Cells, Cornea, Corneal Defect, Corneal Epithelium Defect
- Trial name
- MSC Secretome (NCT05204329)
- Testing
- MSC Secretome Eye Drops
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois at Chicago
Carcinoma of the Anal Canal
Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma
This research study is a Pilot Study. Pilot studies are conducted to see if it is practical to do this type of research ona larger scale in the future.
- Trial name
- NCT01858025
- Testing
- Pencil Beam scanning Radiation, 5-fluorouracil, Mitomycin-C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Dengue
Immunogenicity of an Intradermal Qdenga Vaccine Among Healthy Volunteers
Official title: Immunogenicity of an intradermal Qdenga vaccine among healthy volunteers: A pilot study
- Trial name
- NCT06837116
- Testing
- Vaccine
- Where
- 2 sites in Thailand
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Decompensated Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
This study is designed to investigate the quantitative effects of sodium-free chloride supplementation on electrolyte balance, volume status, and sodium avidity in stable heart failure patients in a highly controlled environment.
- Trial name
- NCT03440970
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Obesity, Childhood
Pharmacokinetics and Pharmacodynamics of Topiramate for Weight Loss in Youth: PHARMATOP
Pediatric severe obesity is the fastest growing obesity category in the United States, and anti-obesity pharmacotherapies are promising adjuncts to lifestyle modification (LSM) for the treatment of this disease.
- Trial name
- PHARMATOP (NCT04986631)
- Testing
- Topiramate Tablets
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Minnesota
Neurogenic Orthostatic Hypotension, Autonomic Failure
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
The purpose of this study is to learn more about the effects of abdominal compression and the medication midodrine, two interventions used for the treatment of orthostatic hypotension (low blood pressure on standing), on…
- Conditions
- Neurogenic Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT04620382
- Testing
- Midodrine, Abdominal compression
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
The purpose of this study is to understand the effects of chloride supplementation on volume-overloaded acute heart failure patients concomitantly treated with IV diuretics.
- Trial name
- NCT03446651
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Obesity, Childhood, Behavior, Health
Summer Youth Employment Programs for Health Promotion
The purpose of this proof-of-concept study is to assess the initial signal of effectiveness of summer youth employment programs (SYEP) on understudied obesity-related outcomes in adolescents.
- Conditions
- Obesity, Childhood, Behavior, Health, Healthy Lifestyle
- Trial name
- NCT07227220
- Testing
- Summer Youth Employment Program
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Houston
PTSD, Trauma
Neuroendocrine Risk for PTSD in Women
This study will test for effects of estradiol (E2) on PTSD symptoms and functional magnetic resonance imaging (fMRI) indicators of stress vulnerability, in naturally-cycling women who are not using hormonal birth control.
- Trial name
- NCT03973229
- Testing
- Estradiol patch
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Emory University
Critically Ill Patients
Esketamine Induction Intubation in ICU Patients.
Intubation in the intensive care unit (ICU) is usually an emergency. Pathophysiological changes such as shock, respiratory failure, and metabolic acidosis in critically ill patients can significantly increase the incidence of…
- Trial name
- NCT05464979
- Testing
- Esketamine Hydrochloride 28 Mg in 0.2 mL NASAL SOLUTION [Spravato], midazolam, fentanyl
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pathologic Stage IIA-IIIC Triple-Negative Breast Cancer, TNBC - Triple-Negative Breast Cancer
Adjuvant Therapy With an Alpha-lactalbumin Vaccine in Triple-Negative Breast Cancer
The purpose of this study is to determine the safety as well as the most effective dose of the alpha-lactalbumin vaccine (aLA breast cancer vaccine) to treat patients with non-metastatic triple negative breast cancer…
- Conditions
- Pathologic Stage IIA-IIIC Triple-Negative Breast Cancer, TNBC - Triple-Negative Breast Cancer, Residual Disease
- Trial name
- NCT04674306
- Testing
- α-lactalbumin vaccine, Zymosan
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- George T. Budd
Delta-9-tetrahydrocannabinol (THC), Stress
Effects of Drugs on Stress Memories
There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences.
- Trial name
- ETS (NCT06471647)
- Testing
- delta-9-tetrahydrocannabinol (THC) (5), delta-9-tetrahydrocannabinol (THC) (10)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Opioid Use Disorder
Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making…
- Trial name
- NCT03958474
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joshua A. Lile, Ph.D.
Healthy Participants
Washington University WU 409: Immune Responses to Rabies Vaccine.
This study will evaluate the immune response to rabies vaccination persons 18 years and older. We will evaluate thirty healthy participants across three cohorts: 1) standard rabies pre-exposure prophylaxis regimen (two doses of…
- Trial name
- NCT07399951
- Testing
- Imovax, RabAvert, HyperRAB
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bladder Cancer, Urothelial Carcinoma
18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy
This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of muscle invasive bladder cancer (as compared to regular CT…
- Trial name
- NCT04018053
- Testing
- 18F-fluciclovine, PET/CT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Keratoconus, Dry Eye
Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus
Drug delivery platforms are an innovative exciting advancement in ophthalmology. They allow patients to eliminate topical medications which are generally associated with lack of compliance, difficulty of use and requiring help…
- Conditions
- Keratoconus, Dry Eye, Allergy
- Trial name
- NCT04418999
- Testing
- dexamethasone ophthalmic insert 0.4 mg, for intracanalicular use, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Illinois College of Optometry
Social Anxiety Disorder
Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder
The purpose of this study is to examine the efficacy of 50 mg of d-cycloserine in comparison to placebo (a pill containing no medication) for improving the effectiveness of cognitive-behavioral therapy (CBT) in reducing symptoms…
- Trial name
- NCT02066792
- Testing
- D-Cycloserine, Cognitive Behavioral Therapy
- Where
- 3 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits