Clinical trials: sponsored by Karolinska Institutet
Myocardial Ischemia
Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance
The purpose of this study is to validate a full-automated post-processing software for quantitative perfusion of the myocardium with magnetic resonance imaging.
- Trial name
- NCT02723747
- Testing
- myocardial perfusion with magnetic resonance imaging
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Traumatic Brain Injury, Stroke
The Effect of Cognitive Reserve on Outcome After Stroke or Traumatic Brain Injury
A long-term follow-up study of patients who acquired a stroke or traumatic brain injury (TBI) 5-15 years ago. Primary objective is to describe the interaction between measures of cognitive reserve and neuropsychological…
- Trial name
- NCT05407948
- Where
- Sweden
- Volunteers
- 87 people
- Sponsor
- Natascha Ekdahl
Out-Of-Hospital Cardiac Arrest
AED-delivery Using Drones in Suspected OHCA
Time to defibrillation is the most important predictor of survival in cardiac arrest. Traditional emergency medical system response is often to slow.
- Trial name
- NCT04723368
- Testing
- Automated flying Drone carrying an Automated external defibrillator (AED)
- Where
- Sweden
- Volunteers
- 59 people
- Sponsor
- Karolinska Institutet
Adolescent Idiopathic Scoliosis
CLOSED SUCTION DRAIN VS. NO DRAIN IN ADOLESCENTS UNDERGOING PEDICLE SCREW INSTRUMENTATION FOR IDIOPATHIC SCOLIOSIS (DAISY 2018). A Randomized Clinical Trial
Abstract Background - Closed suction drain is typically used worldwide after instrumented posterior spinal fusion for adolescent idiopathic scoliosis (AIS).
- Trial name
- DAISY 2018 (NCT03729947)
- Testing
- Subfascial closed suction drain
- Where
- 3 sites in Finland, Sweden
- Volunteers
- 90 people
- Sponsor
- Turku University Hospital
Type 2 Diabetes Mellitus, Postprandial Hyperglycemia
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin.
- Trial name
- NCT00771693
- Testing
- Insulin aspart (Novorapid®)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes Mellitus
Evaluation of Antiplatelet Effects of Different Dosages of Aspirin in Type 2 Diabetic Patients
The efficacy of low dose aspirin appears to be substantially lower in diabetic patients, compared to patients without diabetes. The aim of the investigators study is to test the laboratory response to different dosing of aspirin…
- Trial name
- DM-ASA 001 (NCT00812032)
- Testing
- Aspirin
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Breast Cancer, Liver Metastases
BreCLIM-2 - A RCT Investigating Local Treatment for Breast Cancer Liver Metastases
Breast cancer is the second most common cancer in Sweden with an incidence of 8000 per year. The role of surgery for distant breast cancer metastasis beyond local lymph nodes remains controversial even though some reports suggest…
- Trial name
- BreCLIM-2 (NCT04079049)
- Testing
- Surgical intervention, Control
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Essential Tremor
The Swedish Essential Tremor (SWEET) Trial
To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial.
- Trial name
- SWEET (NCT03832712)
- Testing
- Deep Brain Stimulation, Best Medical Treatment
- Where
- 6 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes, Insulin Independent
Circadian High Intensity Interval Training Study
High intensity interval training (HIIT) is a promising intervention for treatment and prevention of type 2 diabetes. In spite of the interplay between circadian rhythms and exercise, the time of day in which the most robust…
- Trial name
- NCT03553524
- Testing
- morning HIIT --> afternoon HIIT, afternoon HIIT --> morning HIIT
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Muscle Pain
Cocoa Intake and Muscle Pain Sensation
This experimental randomized, double-blind, and controlled study included fifteen young, healthy, and pain-free men and 15 age-matched women. It lasted for three visits with at least one-week washout.
- Trial name
- NCT05378984
- Testing
- before - hypertonic saline 5%, after - hypertonic saline 5%
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Myocardial Infarction
Cognitive Behavioral Therapy Following Myocardial Infarction
Myocardial infarction (MI) is one of the leading cause s of health loss globally, representing a large proportion of general disability.
- Trial name
- MI-CBT (NCT04649307)
- Testing
- MI-CBT
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska Institutet
Alcohol Consumption
Feasibility Evaluation of a Self-guided Digital Tool for Problematic Alcohol Use
The purpose of the study is to evaluate the feasibility of a new monitored self-guided digital intervention based on an alcohol diary and techniques from cognitive behavioral therapy and relapse prevention.
- Trial name
- NCT05037630
- Testing
- Self-guided Digital Tool for Problematic Alcohol Use
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska Institutet
Candidiasis, Vulvovaginal
A Clinical Trial for Chlorhexidine as Treatment for Vulvovaginal Candidiasis
The overall aim of this study is to investigate if vaginally applied 1% chlorhexidine gluconate (CHG) could be an alternative treatment to oral fluconazole (FLZ), both during an acute episode and as prophylaxis, against recurrent…
- Trial name
- NCT05059145
- Testing
- Chlorhexidine Gluconate, Fluconazole
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Attention Deficit Disorder, Sleep Initiation and Maintenance Disorders
Better Sleep in Psychiatric Care - ADHD Pilot Study
Comorbidities, including sleep problems, are common in adult Attention Deficit Hyperactivity Disorder (ADHD). Treatment of choice for insomnia is cognitive behavioral therapy (CBT-i), but evidence is lacking for CBT-i in patients…
- Conditions
- Attention Deficit Disorder, Sleep Initiation and Maintenance Disorders, Sleep Wake Disorders
- Trial name
- BeSiP-ADHD (NCT03852966)
- Testing
- CBT-i/ADHD
- Where
- Sweden
- Volunteers
- 19 people
- Sponsor
- Karolinska Institutet
Nonsuicidal Self-injury
Internet Delivered ERITA for Nonsuicidal Self-Injury
To evaluate if Internet delivered emotion regulation individual therapy for adolescents is an efficacious treatment when delivered as adjunctive to treatment as usual compared to a control group consisting of treatment as usual.
- Trial name
- ERITA (NCT03353961)
- Testing
- Emotion regulation individual therapy, Treatment as usual
- Where
- 2 sites in Sweden
- Volunteers
- 166 people
- Sponsor
- Karolinska Institutet
Evaluate CBCT Protocols in Subjective Image Quality
Validation of X-ray Protocols in Cleft Children
Children born with an alveolar cleft receive bone grafts for improved function and aesthetics. The cleft area is radiologically examined before and post bone graft.
- Trial name
- NCT05351372
- Testing
- Ultra-low dose protocol, Standard dose protocol
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Karolinska Institutet
Incomplete Abortion, Intrauterine Contraception
Ideal Timing of Intrauterine Contraception Insertion After Medical Management of First Trimester Incomplete Abortion
Background: Unintended pregnancies continue to cause a public health threat in Low and Middle Income countries yet with restrictive abortion laws.
- Conditions
- Incomplete Abortion, Intrauterine Contraception, Misoprostol
- Trial name
- PAIC (NCT05343546)
- Testing
- Use of either copper T380A or Levonorgestrel LNG 52 IUS after medical management of first trimester incomplete abortion
- Where
- Uganda
- Volunteers
- 2,076 people
- Sponsor
- Makerere University
Obsessive-compulsive Disorder
Internet-based vs Face-to-face Cognitive Behavioural Therapy for Obsessive-compulsive Disorder
Randomized controlled non-inferiority trial comparing therapist-guided Internet-based Cognitive behavioral therapy (ICBT), self-guided ICBT, and individual face-to-face (f2f) CBT for Obsessive-Compulsive Disorder (OCD) in adults.
- Trial name
- NCT02541968
- Testing
- Cognitive-behavioral therapy (face-to-face), Internet-based Cognitive-behavioral therapy, Internet-based Cognitive-behavioral therapy without therapist support
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karolinska Institutet
Dysphagia, Oropharyngeal
Oral Screens in Post Stroke Training
Stroke is a common disease in older people, and often leads to various degrees of disability. Dysphagia is one such consequence which is associated with aspiration pneumonia and malnutrition.
- Trial name
- NCT03167892
- Testing
- Oral screen
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Irritable Bowel Syndrome
Internet-delivered Exposure-based Cognitive Behavior Therapy for Irritable Bowel Syndrome - a Cohort Effectiveness Study
The main purpose of the study is to investigate the clinical real-world effectiveness of a specific exposure based psychological treatment for irritable bowel syndrome (IBS).
- Trial name
- NCT05328245
- Volunteers
- 319 people
- Sponsor
- Karolinska Institutet
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.