Clinical trials: sponsored by University of Oxford
Renal Cancer
Vascular Targeted Photodynamic Therapy T1a Renal Tumours
Vascular Targeted Photodynamic therapy (VTP) with the Vascular Occluding Agent (VOA) WST11, may offer an alternative, providing tumour destruction via a minimally invasive approach.
- Trial name
- KCM201 (NCT01573156)
- Testing
- Light activated WST11
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Oxford
Pleural Effusion
Using Ultrasound to Predict the Results of Draining Pleural Effusions
Pleural effusion is an extremely common problem with multiple causes; its subsequent investigation with thoracocentesis and treatment with drainage represent two of the most frequently performed diagnostic and therapeutic medical…
- Trial name
- NCT01973985
- Testing
- Pleural Manometry, Thoracic ultrasonography, Pleural aspiration catheter OR chest drain (standard care)
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- University of Oxford
Malignant Pleural Effusion
Using Thoracic Ultrasound to Predict Pleurodesis Success in Malignant Pleural Effusions: a Pilot Study
The observational pilot study at the Churchill Hospital, funded by Oxford Respiratory Trials Unit, will assess the feasibility and efficacy of thoracic ultrasound (TUS) assessment in patients undergoing talc pleurodesis via…
- Trial name
- NCT02625675
- Testing
- Ultrasound scan
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Oxford
Bile Duct Injury
FLuorescence Cholangiography Using Methylene Blue
Open label prospective, non-randomised proof of principle study assessing the use of methylene blue fluorescence cholangiography.
- Trial name
- FLoCaMB (NCT03386201)
- Testing
- Intravenous Methylene blue
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Healthy
Observational Study of Immune Response to Hepatitis B Childhood Booster
The UK immunisation guidelines recommend that children immunised with an accelerated course of hepatitis B vaccine (i.e. vaccination at 0, 1, 2 and 12 months) receive an additional booster dose of vaccine in later childhood…
- Trial name
- NCT00873652
- Testing
- Engerix B®, a recombinant hepatitis B vaccine
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Influenza
Swine Flu (Influenza A H1N1) Follow on Vaccine Study
In 2009 the World Health Organization (WHO) declared the Influenza A H1N1 (swine 'flu) outbreak the first global pandemic of this century.
- Trial name
- NCT01239537
- Testing
- Seasonal Flu vaccine
- Where
- 5 sites in United Kingdom
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Psychological, Physical Activity
Transtheoretical Model of Behavior Change and Anxiety
Examine the utility of the Transtheoretical Model in influencing anxiety among college students. Employ a randomized controlled intervention including a static and dynamic Facebook intervention.
- Trial name
- NCT03363737
- Testing
- Transtheoretical Model
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
Hepatocellular Carcinoma
Metabolic Signature of Healthy Lifestyle and HCC
Hepatocellular carcinoma (HCC) is the most common form of liver cancer and its incidence is increasing including in regions where hepatitis infection rates are low.
- Trial name
- NCT03356535
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Retinitis Pigmentosa
Safety and Efficacy of the Alpha AMS Subretinal Implant
The aim of this single-centre study is to assess the safety and efficacy of the Retina Implant Alpha AMS (Retina Implant AG, Reutlingen, Germany) in participants with severe visual impairment secondary to outer retinal…
- Trial name
- OX-RI (NCT02720640)
- Testing
- Implant 'on' vs implant 'off'
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Choroideremia
Gene Therapy for Blindness Caused by Choroideremia
Primary objective: To assess the safety and tolerability of the AAV.REP1 vector, administered at two different doses to the retina in 12 patients with a diagnosis of choroideremia.
- Trial name
- NCT01461213
- Testing
- rAAV2.REP1
- Where
- 4 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Oxford
Stroke
A New Rehabilitation Treatment Following Stroke
Stroke is the number one cause of disability in the United Nations with about 1 million new cases each year. Following stroke, patients with perceptual and cognitive impairments have the worst prognostic outcomes.
- Trial name
- NCT02482688
- Testing
- A New Rehabilitation Treatment following Stroke
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Oxford
Human Volunteers
A Study to Determine the Safety and Immunogenicity of the Candidate Influenza Vaccine MVA-NP+M1
This is a first in human, phase I, open label study of the MVA viral vector (produced in the novel immortalised duck retinal cell line AGE1.CR.pIX) expressing the influenza antigens NP and M1 as a fusion protein, in healthy adult…
- Trial name
- NCT03277456
- Testing
- MVA-NP+M1
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Barinthus Biotherapeutics
Carcinoma, Renal Cell
RGD-PET-CT in Cancer Angiogenesis
The goal of this clinical research study is to look at 2 new methods of scanning and see whether they can help researchers predict which tumours will respond to drugs that attack tumour blood supply.
- Trial name
- NCT01492192
- Testing
- 18F-RGD-PET-CT and perfusion CT scans on 3 occasions
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Oxford University Hospitals NHS Trust
Sepsis, Severe Sepsis
Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand
This is an observational study to identify the aetiology and factors associated with outcome of community-acquired sepsis and severe sepsis in Northeast Thailand.
- Trial name
- NCT02217592
- Where
- Thailand
- Volunteers
- 5,020 people
- Sponsor
- University of Oxford
Chronic Disease
Prioritising and Optimising Multi-medication in Multimorbidity
Objective: To investigate whether the complex intervention will improve the appropriateness of prescriptions in elderly multi-morbid patients with multi-medication in general practices.
- Trial name
- PRIMUM (NCT01171339)
- Testing
- Optimization strategy (complex intervention)
- Where
- Germany
- Volunteers
- 505 people
- Sponsor
- Goethe University
Irritable Bowel Syndrome
Mindfulness for Irritable Bowel Syndrome
This study investigates the effectiveness of a 6 week mindfulness intervention in reducing symptoms of Irritable Bowel Syndrome (IBS). All Participants will receive treatment.
- Trial name
- MIBS (NCT02794376)
- Testing
- Mindfulness Based Cognitive Therapy (MBCT), Waiting Period
- Volunteers
- 67 people
- Sponsor
- University of Oxford
Obesity, Impaired Health
Effectiveness of a Smartphone App for Adolescent Obesity Management
Though face-to-face treatment of childhood obesity can be effective, it is time consuming and costly. This study will test whether treatment can be delivered via an Android app and whether such treatment reduces obesity.
- Conditions
- Obesity, Impaired Health, Psychosocial Problem, Physical Activity
- Trial name
- NCT01804855
- Testing
- W82GO, smartphone application
- Where
- 2 sites in Ireland
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Children's University Hospital, Ireland
Breast Cancer, Neoadjuvant Therapy
A Study to Correlate Ultrasound Elastography With Histopathology to Monitor the Response of Locally Advanced Breast Cancer to Neoadjuvant Chemotherapy
This research proposal concerns a study to monitor the effects of chemotherapy on breast cancer tumour and peritumour stromal cells using ultrasound (US) elastography (also known as strain imaging).
- Trial name
- NCT01737970
- Volunteers
- 10 people
- Sponsor
- Oxford University Hospitals NHS Trust
Spatial Neglect, Stroke
Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation
The present study aims to compare the relative therapeutic efficacy of prism adaptation therapy combined with real versus sham tDCS.
- Conditions
- Spatial Neglect, Stroke, Cerebrovascular Disorders, Cerebral Infarction
- Trial name
- NCT02080286
- Testing
- Prism Adaptation, Anodal tDCS
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Bibliotherapy, Social Anxiety Disorder
RCT of Bibliotherapy for Social Anxiety Disorder as a Prelude to CBT in IAPT
The efficacy of high-intensity Cognitive-Behavioural Therapy (CBT) for social anxiety disorder is well established (Mayo-Wilson et al., 2014) and it is recommended by the National Institute of Health and Clinical Excellence…
- Conditions
- Bibliotherapy, Social Anxiety Disorder, Cognitive Behavioral Therapy
- Trial name
- RCT of CBB/CBT (NCT02307097)
- Testing
- Cognitive-Behavioural Bibliotherapy, Cognitive-Behavioural Therapy, WAIT
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Solent NHS Trust
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