Clinical trials: Phase 4, completed
Caffine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Strength Measures in Males
Tournament scheduling and environmental factors often require athletes to compete in the morning. Equally due to time constraints, athletes may choose to train in the morning.
- Conditions
- Caffine, Placebo - Control, No Pill
- Trial name
- NCT07466628
- Testing
- No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Antibiotic Enterocolitis
Effect of Antibiotics on Enteric Neurons and Glia
The interactions between bacteria and their products with the intestinal tissue are important for maintaining a healthy and balanced system.
- Trial name
- NCT05834036
- Testing
- Amoxicillin Oral Capsule
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Dysmenorrhea Primary, Vitamin E
Vitamin E Plus Mefenamic Acid Versus Mefenamic Acid Alone for Treating Primary Dysmenorrhea in Women
The goal of this clinical trial is to determine whether adding vitamin E to mefenamic acid reduces menstrual pain more effectively than mefenamic acid alone in women with primary dysmenorrhea.
- Conditions
- Dysmenorrhea Primary, Vitamin E, Mefenamic Acid
- Trial name
- NCT07466342
- Testing
- Mefenamic acid, Vitamin E capsule
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Post-ERCP Acute Pancreatitis
Rectal Indomethacin vs Intravenous Ketorolac
Endoscopic retrograde cholangiopancreatography (ERCP) is an essential procedure that can be complicated by post-ERCP pancreatitis (PEP). Indomethacin and ketorolac are two medications used to prevent PEP.
- Trial name
- NCT05664074
- Testing
- Rectal indomethacin, IV ketorolac
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- David Vitale MD
IBS, IBS - Irritable Bowel Syndrome
Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation
The aim of this study is to better understand how tenapanor affects the metagenomics and metabolomics of patients with irritable bowel syndrome with constipation (IBS-C). Tenapanor is the newest FDA-approved agent for IBS-C.
- Trial name
- NCT05995899
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Kyle Staller, MD, MPH
Lower Urinary Tract Symptoms
A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters
A urodynamic study (UDS) is a common procedure done to learn more about the cause of urinary symptoms. For some patients, UDS can be associated with anxiety or discomfort.
- Trial name
- NCT05883332
- Testing
- Self-Administered Nitrous Oxide, Oxygen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Renal Insufficiency
Biological and Clinical Measurements Following Systemic Leakage When a Citrate or Heparin Lock is Used
In the VERROUREA study, there were two cases of an abnormal increase in TCA. In theory no leakage of the lock into the bloodstream should have been seen.
- Trial name
- VERROU HEMOST (NCT02860299)
- Testing
- citrate 4%, unfractionated heparin, blood sample
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hematoma, Subdural, Fibrinolytic; Hemorrhage
Use of Tissue Plasminogen Activator in the Clearance of Chronic Subdural Hematomas
To determine the utility of tissue plasminogen activator (tPA) in the clearance of chronic subdural hematomas (CSDH). Intra-catheter tPA will be administered during surgical procedure and allowed to break down blood clot to…
- Trial name
- NCT05491356
- Testing
- Tissue Plasminogen Activator
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Hamilton Health Sciences Corporation
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
MIRAGE Study: Clinical Outcomes of the Mamba Sirolimus-Eluting PTCA Balloon
This Clinical Evaluation Report (CER) covers the Mamba Sirolimus-Eluting PTCA Balloon catheter intended for the treatment of coronary artery disease in de novo or in-stent restenosis lesions.
- Trial name
- NCT07326735
- Testing
- Mamba Sirolimus-Eluting PTCA Balloon, Percutaneous Coronary Angioplasty with Sirolimus-Coated Balloon
- Where
- 2 sites in Burma, Malaysia
- Volunteers
- 360 people
- Sponsor
- Frisch Medical Device Private Limited
Bowel Preparation Before Colonoscopy
MoviPrep® Versus GoLYTELY® Bowel Preparation in Hospitalized Patients Undergoing Colonoscopy
Adequate bowel cleansing is a critical component in the care of hospitalized patients undergoing colonoscopy. However, inpatient status is a well-established risk factor for inadequate bowel preparation.
- Trial name
- NCT05054036
- Testing
- MoviPrep, Golytely
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Yale University
Induction of Abortion, Scarred Uterus
Laminaria Japonicum Followed by Misoprostol Versus Misoprostol Alone for Mid-Trimester Abortion Induction in Scarred Uterus
The goal of this clinical trial is to compare the induction-to-abortion time interval between women receiving Laminaria tent followed by misoprostol and those receiving misoprostol alone for mid-trimester abortion induction in…
- Trial name
- Obstetrics (NCT07465016)
- Testing
- Misoprostol ( Cytotec) 200 microgram a tablet, Laminaria Tent
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Pavly Maged Jimmy Fouad
Healthy
Investigating the Effects of Nabilone on Endocannabinoid Metabolism
The purpose of this study is to learn about the effects of a cannabis-like substance, nabilone, on the levels of endocannabinoid enzyme fatty acid amide hydrolase (FAAH) in brain of healthy individuals.
- Trial name
- NABI (NCT05885685)
- Testing
- Nabilone Oral Capsule
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Coronary Arterial Disease (CAD)
Clinical Investigation for Everolimus Drug Eluting Stent
History of Device Development and Study Rationale: Drug-eluting stents (DES) revolutionized percutaneous coronary intervention (PCI) by significantly reducing restenosis and the need for repeat procedures compared to bare-metal…
- Trial name
- EverGreen (NCT06769217)
- Testing
- Drug Eluting Coronary Stent
- Where
- 5 sites in India, Indonesia
- Volunteers
- 888 people
- Sponsor
- Frisch Medical Device Private Limited
Liver Cirrhosis, Portal Hypertension Related to Cirrhosis
Clinical Evaluation of Simcyp-Guided Simvastatin Dosing in Patients With Liver Cirrhosis
This prospective open-label parallel pilot clinical study evaluated the efficacy and safety of physiologically based pharmacokinetic (PBPK)-guided simvastatin dosing in Child-Pugh A and B cirrhotic patients with portal…
- Trial name
- NCT07459972
- Testing
- Simvastatin 15 mg, Simvastatin 5 mg
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Kafrelsheikh University
Myocardial Infarction
Intravenous Atropine in Reducing Reperfusion Arrhythmias, Conduction Abnormalities and Hypotension in Inferior ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
People with acute inferior wall myocardial infarction will be given an intravenous drug called atropine that increases the heart rate to check if it prevents heart rhythm disturbances during performing coronary intervention
- Trial name
- NCT07268586
- Testing
- Intravenous atropine immediately before wire crossing during primary percutaneous coronary intervention
- Where
- Egypt
- Volunteers
- 158 people
- Sponsor
- Ain Shams University
PreDiabetes
The Effect of Lifestyle Modification on the Risk of Prediabetes Among Patients Attending Outpatient Clinic.
Diabetes mellitus is a major global health challenge, with type 2 diabetes (T2DM) accounting for nearly 90% of all cases worldwide.
- Trial name
- NCT07462078
- Testing
- Lifestyle modification
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Osteo Arthritis of the Knee
A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement
This study is conducted as a pilot trial to assess the added benefit of the VeraSeal fibrin sealant to TXA on postoperative outcomes following TKR.
- Trial name
- NCT07455591
- Testing
- fibrin sealant, Tranexamic Acid (TXA)
- Where
- Singapore
- Volunteers
- 78 people
- Sponsor
- Singapore General Hospital
Pediatric HD, Bleeding
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients
The aim of the current pilot study proposal is to compare the use of the purified human fibrinogen concentrate (Fibryga®, Octapharma USA) to cryoprecipitate for the treatment of cardiopulmonary bypass (CPB)-associated bleeding in…
- Trial name
- NCT04376762
- Testing
- Fibrinogen, Cryoprecipitate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Thyroid Neoplasms
A Study to Evaluate the Safety and Efficacy of Lenvatinib in Participants With Refractory Differentiated Thyroid Cancer
The purpose of this study is to evaluate the safety of lenvatinib in participants with recurrent, metastatic radio-iodine refractory differentiated thyroid cancer (DTC).
- Trial name
- NCT03573960
- Testing
- Lenvatinib
- Where
- 11 sites in India
- Volunteers
- 50 people
- Sponsor
- Eisai Pharmaceuticals India Pvt. Ltd
Supraventricular Tachycardia (SVT), Atrioventricular Nodal Re Entrant Tachycardia
Adenosine vs. Diltiazem
In this Emergency Department (ED)-based study, the investigators evaluated a standardized modified Valsalva maneuver (MVM) as first-line therapy and compared intravenous (IV) adenosine with IV diltiazem among patients with…
- Trial name
- AVNRTstdy (NCT07456423)
- Testing
- Adenosine intravenous, Diltiazem intravenous
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Haseki Training and Research Hospital